ES8301481A1 - Procedimiento para la preparacion de nuevos compuestos heterociclos derivados de azepina. - Google Patents

Procedimiento para la preparacion de nuevos compuestos heterociclos derivados de azepina.

Info

Publication number
ES8301481A1
ES8301481A1 ES500150A ES500150A ES8301481A1 ES 8301481 A1 ES8301481 A1 ES 8301481A1 ES 500150 A ES500150 A ES 500150A ES 500150 A ES500150 A ES 500150A ES 8301481 A1 ES8301481 A1 ES 8301481A1
Authority
ES
Spain
Prior art keywords
group
carbon atoms
pharmaceutical compositions
represent
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500150A
Other languages
English (en)
Other versions
ES500150A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CH Boehringer Sohn AG and Co KG
Original Assignee
CH Boehringer Sohn AG and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CH Boehringer Sohn AG and Co KG filed Critical CH Boehringer Sohn AG and Co KG
Publication of ES8301481A1 publication Critical patent/ES8301481A1/es
Publication of ES500150A0 publication Critical patent/ES500150A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/20—Dibenz [b, e] azepines; Hydrogenated dibenz [b, e] azepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D281/16—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPUESTOS HETEROCICLICOS DERIVADOS DE LA AZEPINA, DE FORMULA GENERAL (I), EN LA QUE R , R , R Y R SIGNIFICAN HALOGENO, ALCOHILO O ALCOXI; Y X REPRESENTA O, S O CH ; Y SUS SALES DE ADICION DE ACIDOS. CONSISTE EN HACER REACCIONAR UNA DIAMINA CON UN ALOCIANOGENO, FORMANDOSE UN COMPUESTO INTERMEDIO DE FORMULA GENERAL (II), EN LA QUE R , R , R , R Y X TIENEN LOS SIGNIFICADOS YA INDICADOS, Y EN LA CUAL SE REALIZA UN CIERRE DE ANILLO POR REACCION INTRAMOLECULAR, EFECTUANDOSE DICHA REACCION A UNA TEMPERATURA COMPRENDIDA ENTRE LA TEMPERATURA AMBIENTE Y LA TEMPERATURA DE EBULLICION DE LA MEZCLA DE REACCION. DE APLICACION EN LA PREPARACION DE MEDICAMENTOS PARA TRATAMIENTOS TERAPEUTICOS.
ES500150A 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos compuestos heterociclos derivados de azepina. Granted ES500150A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803008944 DE3008944A1 (de) 1980-03-08 1980-03-08 Dibenzimidazoazepine, ihre herstellung und verwendung

Publications (2)

Publication Number Publication Date
ES8301481A1 true ES8301481A1 (es) 1982-12-01
ES500150A0 ES500150A0 (es) 1982-12-01

Family

ID=6096617

Family Applications (1)

Application Number Title Priority Date Filing Date
ES500150A Granted ES500150A0 (es) 1980-03-08 1981-03-06 Procedimiento para la preparacion de nuevos compuestos heterociclos derivados de azepina.

Country Status (29)

Country Link
US (1) US4313931A (es)
EP (1) EP0035749B1 (es)
JP (1) JPS56139484A (es)
AU (1) AU535359B2 (es)
BG (1) BG33886A3 (es)
CA (1) CA1150253A (es)
CS (2) CS221288B2 (es)
DD (1) DD156708A5 (es)
DE (2) DE3008944A1 (es)
DK (1) DK154299C (es)
ES (1) ES500150A0 (es)
FI (1) FI70898C (es)
GB (1) GB2071095B (es)
GR (1) GR74805B (es)
HK (1) HK63186A (es)
HU (1) HU180628B (es)
IE (1) IE51015B1 (es)
IL (1) IL62309A (es)
MX (1) MX6869E (es)
NO (1) NO162073C (es)
NZ (1) NZ196446A (es)
PH (1) PH15839A (es)
PL (1) PL132141B1 (es)
PT (1) PT72631B (es)
RO (1) RO81652B (es)
SU (1) SU1015829A3 (es)
UA (1) UA8041A1 (es)
YU (1) YU42557B (es)
ZA (1) ZA811500B (es)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3134672A1 (de) * 1981-09-02 1983-03-17 Boehringer Ingelheim KG, 6507 Ingelheim Heterocyclische verbindungen, ihre herstellung und verwendung
JPS60500176A (ja) * 1982-12-30 1985-02-07 ビ−チヤム　グル−プ　ピ−エルシ− 四環式化合物
DE4102148A1 (de) * 1991-01-25 1992-07-30 Boehringer Ingelheim Kg Verfahren zur herstellung von 3-amino-9,13b-dihydro-1h-dibenz-(c,f)imidazol(1,5-a)azepin-hydrochlorid
DE19542281C2 (de) * 1995-11-14 1997-12-04 Boehringer Ingelheim Kg Verwendung von Epinastin für die Behandlung der Migräne
DE19954516A1 (de) * 1999-11-12 2001-05-17 Boehringer Ingelheim Int Epinastin-haltige Lösungen
DE19958460A1 (de) * 1999-12-03 2001-06-07 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Epinastine-Hydrochlorid in der hochschmelzenden Kristallmodifikation
US7776315B2 (en) * 2000-10-31 2010-08-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions based on anticholinergics and additional active ingredients
US20100310477A1 (en) * 2000-11-28 2010-12-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg. Pharmaceutical compositions based on anticholingerics and additional active ingredients
DE10152973A1 (de) * 2001-10-26 2003-05-08 Boehringer Ingelheim Int Neue trockene und wässrige Epinastin-Sirup-Formulierung
JP4298212B2 (ja) * 2002-03-29 2009-07-15 大日本印刷株式会社 塩酸エピナスチン高融点型結晶の製造法
CN100341857C (zh) * 2002-04-11 2007-10-10 柯尼卡美能达化学株式会社 6－氨甲基－6,11－二氢－5H－二苯并[b,e]氮杂䓬的制造方法
JP4514017B2 (ja) * 2003-03-27 2010-07-28 大日本印刷株式会社 塩酸エピナスチンの製造方法
US8758816B2 (en) * 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
LT2486942T (lt) 2004-11-24 2019-01-25 Meda Pharmaceuticals Inc. Kompozicijos, apimančios azelastiną ir jų panaudojimo būdai
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
EP1901724A1 (en) * 2005-07-08 2008-03-26 Senju Pharmaceutical Co., Ltd. Percutaneously absorptive ophthalmic preparation comprising epinastine
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101386530B1 (ko) 2006-12-29 2014-04-18 케이피엑스 라이프사이언스 주식회사 순도 및 수율이 향상된3-아미노-9,13ｂ디하이드로-1Ｈ-디벤즈-[ｃ,ｆ]이미다조[1,5-ａ]-아제핀 염산염의 제조방법
WO2009063504A2 (en) * 2007-09-24 2009-05-22 Usv Limited Novel crystal modification of epinastine or salts thereof and process for preparation thereof
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
JP2010120960A (ja) * 2010-02-17 2010-06-03 Dainippon Printing Co Ltd 塩酸エピナスチンの製造方法
JP6006634B2 (ja) * 2011-12-28 2016-10-12 東和薬品株式会社 イソウレア化合物を用いるエピナスチンの製造方法
CN103172638B (zh) * 2013-03-13 2015-09-16 北京朗依制药有限公司 一种盐酸依匹斯汀的制备方法
CN104098575B (zh) * 2013-04-15 2016-06-01 四川科瑞德凯华制药有限公司 一种盐酸依匹斯汀晶型及其制备方法和用途
KR102041389B1 (ko) 2017-12-12 2019-11-27 (주)프론트바이오 N-(9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일)-2-하이드록시벤즈아미드 및 2-((9,13b-디하이드로-1H-디벤조[c,f]이미다조[1,5-a]아제핀-3-일) 카바모일)페닐 아세테이트의 화합물, 이의 제조방법 및 이를 포함하는 항염증 및 진통제 조성물
KR102080239B1 (ko) 2019-08-06 2020-02-21 한양대학교 에리카산학협력단 에피나스틴의 신규 제조방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE789410A (fr) * 1971-10-05 1973-01-15 Akzo Nv Nieuwe imidazolidine derivaten
NL7202963A (es) * 1972-03-07 1973-09-11
NL7414038A (nl) * 1974-10-28 1976-05-03 Akzo Nv Nieuwe tetracyclische pyrrolidino derivaten.

Also Published As

Publication number Publication date
BG33886A3 (en) 1983-05-16
DD156708A5 (de) 1982-09-15
NZ196446A (en) 1984-07-06
YU42557B (en) 1988-10-31
CS221288B2 (en) 1983-04-29
JPH0366311B2 (es) 1991-10-16
GB2071095B (en) 1983-06-02
GB2071095A (en) 1981-09-16
JPS56139484A (en) 1981-10-30
PT72631B (fr) 1982-12-30
NO810762L (no) 1981-09-09
AU535359B2 (en) 1984-03-15
PT72631A (fr) 1981-04-01
EP0035749A1 (de) 1981-09-16
DK103581A (da) 1981-09-09
GR74805B (es) 1984-07-12
IE51015B1 (en) 1986-09-03
DK154299B (da) 1988-10-31
YU56881A (en) 1983-10-31
IE810485L (en) 1981-09-08
US4313931A (en) 1982-02-02
UA8041A1 (uk) 1995-12-26
HU180628B (en) 1983-03-28
FI70898C (fi) 1986-10-27
ES500150A0 (es) 1982-12-01
FI810712L (fi) 1981-09-09
EP0035749B1 (de) 1984-06-06
HK63186A (en) 1986-09-05
CS410491A3 (en) 1992-05-13
NO162073B (no) 1989-07-24
FI70898B (fi) 1986-07-18
ZA811500B (en) 1982-11-24
DE3008944A1 (de) 1981-09-24
MX6869E (es) 1986-09-11
CA1150253A (en) 1983-07-19
PH15839A (en) 1983-04-08
DE3163938D1 (en) 1984-07-12
SU1015829A3 (ru) 1983-04-30
PL132141B1 (en) 1985-02-28
RO81652B (ro) 1983-04-30
NO162073C (no) 1989-11-01
IL62309A0 (en) 1981-05-20
AU6815881A (en) 1981-09-17
RO81652A (ro) 1983-04-29
DK154299C (da) 1989-03-28
IL62309A (en) 1984-06-29
PL230036A1 (es) 1982-05-24

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