ES486824A1 - Procedimiento para la preparacion de nuevos derivados de 4- (naftilmetil) piperidinas - Google Patents

Procedimiento para la preparacion de nuevos derivados de 4- (naftilmetil) piperidinas

Info

Publication number
ES486824A1
ES486824A1 ES486824A ES486824A ES486824A1 ES 486824 A1 ES486824 A1 ES 486824A1 ES 486824 A ES486824 A ES 486824A ES 486824 A ES486824 A ES 486824A ES 486824 A1 ES486824 A1 ES 486824A1
Authority
ES
Spain
Prior art keywords
neuroleptic
naphthylmethyl
piperidine derivatives
hydroxymethylene
carbonyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES486824A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richardson Vicks Inc
Original Assignee
Richardson Merrell Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richardson Merrell Inc filed Critical Richardson Merrell Inc
Publication of ES486824A1 publication Critical patent/ES486824A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la preparación de nuevos derivados de 4-naftimetil) pieridinas. Más particularmente se relaciona con nuevas naftil 4-piperidil cetonas , alfa.(naftil)-4- piperidinometanoles, y 4-(naftimetil)piperidinas, útiles como intermediarios químicos y sus derivados N-(omega-benzoilalquil) y N-(omega-hidroxi-omega-fenilalquil)derivados-útiles como tranquilizadores neurolépticos, cuyo uso no induce significativo efectos laterales extra- piramidales.
ES486824A 1979-02-09 1979-12-12 Procedimiento para la preparacion de nuevos derivados de 4- (naftilmetil) piperidinas Expired ES486824A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/010,555 US4246268A (en) 1979-02-09 1979-02-09 Neuroleptic-4-(naphthylmethyl)piperidine derivatives

Publications (1)

Publication Number Publication Date
ES486824A1 true ES486824A1 (es) 1980-10-01

Family

ID=21746302

Family Applications (1)

Application Number Title Priority Date Filing Date
ES486824A Expired ES486824A1 (es) 1979-02-09 1979-12-12 Procedimiento para la preparacion de nuevos derivados de 4- (naftilmetil) piperidinas

Country Status (22)

Country Link
US (1) US4246268A (es)
JP (1) JPS55105665A (es)
AT (1) AT374458B (es)
AU (1) AU526777B2 (es)
BE (1) BE881624A (es)
CA (1) CA1120036A (es)
CH (1) CH643542A5 (es)
DE (1) DE3002292A1 (es)
DK (1) DK152669C (es)
ES (1) ES486824A1 (es)
FR (1) FR2448531A1 (es)
GB (1) GB2041918B (es)
HK (1) HK96887A (es)
IE (1) IE48485B1 (es)
IL (1) IL58687A (es)
IT (1) IT1120639B (es)
NL (1) NL190193C (es)
NO (1) NO153725C (es)
NZ (1) NZ191709A (es)
PH (1) PH16648A (es)
SE (1) SE448725B (es)
ZA (1) ZA795131B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4443462A (en) * 1979-08-06 1984-04-17 Merrell Dow Pharmaceuticals Inc. Antipsychotic 4-(naphthalenyloxy)piperidine derivatives
FR2484415A1 (fr) * 1980-06-13 1981-12-18 Pharmindustrie Nouveaux derives de l'indene, procedes pour leur preparation, et leur utilisation comme medicaments
FR2560873B1 (fr) * 1984-03-09 1986-09-26 Rhone Poulenc Sante Medicaments a base de derives de la piperidine, nouveaux derives de la piperidine et leurs procedes de preparation
WO1987002359A1 (en) * 1985-10-14 1987-04-23 Maggioni-Winthrop S.P.A. Dihydrobenzothiophene and thiochromane aminoalcohols
US4757079A (en) * 1986-06-24 1988-07-12 Dynamac Corporaton Anti-hypertensive piperidine compounds
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
JP2573195B2 (ja) * 1986-09-30 1997-01-22 エーザイ株式会社 環状アミン誘導体
US5196439A (en) * 1987-11-27 1993-03-23 Eisai Co., Ltd. Piperidine compounds useful to treat cerebrovascular diseases
US5523307A (en) * 1987-11-27 1996-06-04 Eisai Co., Ltd. Cyclic amine and pharmacological composition
US4921863A (en) * 1988-02-17 1990-05-01 Eisai Co., Ltd. Cyclic amine derivatives
US5153206A (en) * 1988-12-02 1992-10-06 Pfizer Inc. Arylpiperidine derivatives
US5077035A (en) * 1990-05-14 1991-12-31 The University Of Michigan Radioiodinated benzovesamicol analogs for cholinergic nerve mapping
FR2662442A1 (fr) * 1990-05-23 1991-11-29 Midy Spa Trifluoromethylphenyltetrahydropyridines n-substituees procede pour leur preparation, intermediaires du procede et compositions pharmaceutiques les contenant.
FR2664592B1 (fr) * 1990-07-10 1994-09-02 Adir Nouveaux derives de la piperidine, de la tetrahydropyridine et de la pyrrolidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP0661266A1 (en) * 1993-12-27 1995-07-05 Toa Eiyo Ltd. Substituted cyclic amine compounds as 5HT2 antagonists
US6303627B1 (en) 1998-06-19 2001-10-16 Eli Lilly And Company Inhibitors of serotonin reuptake

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR86403E (fr) * 1959-05-01 1966-02-04 May & Baker Ltd Nouveaux dérivés de la phényl-4 pipéridine et leur préparation
GB925429A (en) * 1960-04-01 1963-05-08 Irwin Neisler & Co Indole derivatives
US3386996A (en) * 1965-12-30 1968-06-04 Abbott Lab Process for producing certain 8-hydroxy or lower-alkoxy-(4-pyridyl lower-alkylidene)-, 2, 3, 4-tetrahydro-naphthalenes; 8-hydroxy or lower-alkoxy-(4-pyridyl lower-alkyl)-3, 4-dihydro-naphthalenes and derivatives thereof
US3576810A (en) * 1968-06-20 1971-04-27 Robins Co Inc A H 1-substituted-3-(-4)-aroylpiperidines
ZA717147B (en) * 1970-11-27 1972-07-26 Richardson Merrell Inc 4-(4-(alpha-hydroxybenzyl)piperidino)-4'-fluorobutyrophenone derivatives
BE791088A (fr) * 1971-11-09 1973-03-01 Richardson Merrell Inc Nouveaux derives d'aryl (piperidyl-4) cetone, utiles notamment comme analgesiques et anticoagulants, et leur procede de preparation
BE794333A (fr) * 1972-01-20 1973-07-19 Wyeth John & Brother Ltd Composes heterocycliques azotes therapeutiques
US3806526A (en) * 1972-01-28 1974-04-23 Richardson Merrell Inc 1-aroylalkyl-4-diphenylmethyl piperidines
US3888867A (en) * 1972-05-03 1975-06-10 Richardson Merrell Inc 4-(4-(alpha-hydroxybenzyl)piperidino)4'-fluorobutyrophenone derivatives
US4101662A (en) * 1973-05-03 1978-07-18 A. H. Robins Company, Incorporated Method for inhibiting emesis and compositions therefor
SE7409245L (es) * 1973-07-19 1975-01-20 Robins Co Inc A H
US3956296A (en) * 1974-12-11 1976-05-11 A. H. Robins Company, Incorporated 1-Substituted-4-benzylpiperidines
DE2718405A1 (de) * 1977-04-26 1978-11-02 Boehringer Sohn Ingelheim Neue n- eckige klammer auf 1-(3-benzoylpropyl)-4-piperidyl eckige klammer zu -sulfonsaeureamide und verfahren zu deren herstellung

Also Published As

Publication number Publication date
NO153725C (no) 1986-05-14
AU526777B2 (en) 1983-01-27
IL58687A (en) 1983-07-31
GB2041918A (en) 1980-09-17
CH643542A5 (de) 1984-06-15
IE48485B1 (en) 1985-02-06
JPS55105665A (en) 1980-08-13
SE448725B (sv) 1987-03-16
SE8000920L (sv) 1980-08-10
NO800338L (no) 1980-08-11
DE3002292C2 (es) 1990-01-25
DK152669B (da) 1988-04-11
NO153725B (no) 1986-02-03
DK55980A (da) 1980-08-10
FR2448531A1 (fr) 1980-09-05
NL190193B (nl) 1993-07-01
PH16648A (en) 1983-12-06
BE881624A (fr) 1980-05-30
DE3002292A1 (de) 1980-08-21
JPS6341901B2 (es) 1988-08-19
ATA54880A (de) 1983-09-15
CA1120036A (en) 1982-03-16
GB2041918B (en) 1983-03-23
IT7950921A0 (it) 1979-11-27
DK152669C (da) 1988-08-22
NL7907686A (nl) 1980-08-12
IT1120639B (it) 1986-03-26
HK96887A (en) 1987-12-24
IE791851L (en) 1980-08-09
FR2448531B1 (es) 1983-09-09
ZA795131B (en) 1980-10-29
NL190193C (nl) 1993-12-01
NZ191709A (en) 1981-12-15
US4246268A (en) 1981-01-20
AT374458B (de) 1984-04-25
AU5161079A (en) 1980-08-14
IL58687A0 (en) 1980-02-29

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303