ES2082971T3 - Esteres de fosfato de acilo y modificacion de proteinas con los mismos. - Google Patents

Esteres de fosfato de acilo y modificacion de proteinas con los mismos.

Info

Publication number
ES2082971T3
ES2082971T3 ES91905433T ES91905433T ES2082971T3 ES 2082971 T3 ES2082971 T3 ES 2082971T3 ES 91905433 T ES91905433 T ES 91905433T ES 91905433 T ES91905433 T ES 91905433T ES 2082971 T3 ES2082971 T3 ES 2082971T3
Authority
ES
Spain
Prior art keywords
phosphate esters
acil
image
alkenyl
protein modification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91905433T
Other languages
English (en)
Inventor
Ronald H Kluger
Andrew S Grant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Toronto Innovations Foundation
University of Toronto
Original Assignee
University of Toronto Innovations Foundation
University of Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Toronto Innovations Foundation, University of Toronto filed Critical University of Toronto Innovations Foundation
Application granted granted Critical
Publication of ES2082971T3 publication Critical patent/ES2082971T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/095—Compounds containing the structure P(=O)-O-acyl, P(=O)-O-heteroatom, P(=O)-O-CN
    • C07F9/096—Compounds containing the structure P(=O)-O-C(=X)- (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Cosmetics (AREA)

Abstract

SE PRESENTA UN PROCESO PARA LA PREPARACION DE ESTERES DE FOSFATO DE ACIL DE LA FORMULA (I) O LAS SALES DE LOS MISMOS, EN DONDE R Y R1 SON LO MISMO O DIFERENTE Y REPRESENTAN UN GRUPO ALQUIL LINEAL O RAMIFICADO QUE TIENE HASTA 4 ATOMOS DE CARBONO, FENIL O BENZIL; N ES UN ENTERO; CUANDO N ES 1, R2 REPRESENTA EL GRUPO ((ALFA)) EN DONDE R4 ES UN ALQUIL, ALQUENIL O ALQUINIL LINEAL O RAMIFICADO, UN CICLOALQUIL, UN ALQUENIL O ARIL CICLICO QUE PUEDE ESTAR SUSTITUIDO POR ALQUIL, ALQUENIL, ALQUINIL, ARIL, ARILALQUIL, ARILQUENIL O CUANDO N ES AL MENOS 1 R2 REPRESENTA EL GRUPO ((BETA)) EN EL QUE R4 ES SEGUN SE DEFINIO ANTERIORMENTE; EL PROCESO COMPRENDE A) LA REACCION DE UN COMPUESTO DE LA FORMULA (II) O UNA SAL DEL MISMO, EN DONDE R Y R1 SON SEGUN SE DEFINIERON ANTERIORMENTE Y R3 ES UN CONTRA ION, (I) CON UN COMPUESTO DE LA FORMULA (III), EN DONDE R4 ES SEGUN SE DEFINIO ANTERIORMENTE Y R5 ES UN GRUPO SALIENTE QUE ES CONOCIDO GENERALMENTE PARA REACCIONES DE ESTERIFICACION, EN LA PRESENCIA DE UN SOLVENTEDE ETER, CUANDO UN COMPUESTO DE LA FORMULA (I) LO REQUIERA O, II) CON UNA CANTIDAD ESTOICOMETRICA DE UN COMPUESTO DE LA FORMULA (IV), EN DONDE N ES AL MENOS 2, Y R4 Y R5 SON SEGUN SE DEFINIERON ANTERIORMENTE, EN LA PRESENCIA DE UN SOLVENTE DE ETER, CUANDO UN COMPUESTO DE LA FORMULA (I) EN DONDE N ES AL MENOS 2 SE REQUIERA, Y B) SI SE REQUIRIESE, LOS ESTERES DE FOSFATO DE ACIL DE LA FORMULA (I) ASI OBTENIDOS SE CONVIERTEN EN SALES DE LOS MISMOS. TAMBIEN SE PRESENTAN NUEVOS COMPUESTOS DE LA FORMULA (I) EN DONDE N ES AL MENOS 2, Y PROTEINAS MODIFICADAS OBTENIDAS USANDO LOS NUEVOS COMPUESTOS.
ES91905433T 1990-03-14 1991-03-12 Esteres de fosfato de acilo y modificacion de proteinas con los mismos. Expired - Lifetime ES2082971T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49352490A 1990-03-14 1990-03-14

Publications (1)

Publication Number Publication Date
ES2082971T3 true ES2082971T3 (es) 1996-04-01

Family

ID=23960593

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91905433T Expired - Lifetime ES2082971T3 (es) 1990-03-14 1991-03-12 Esteres de fosfato de acilo y modificacion de proteinas con los mismos.

Country Status (10)

Country Link
US (1) US5334707A (es)
EP (1) EP0519953B1 (es)
JP (1) JP3021041B2 (es)
AT (1) ATE133955T1 (es)
AU (1) AU658821B2 (es)
CA (1) CA2078141C (es)
DE (1) DE69117054T2 (es)
DK (1) DK0519953T3 (es)
ES (1) ES2082971T3 (es)
WO (1) WO1991013891A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
US6599889B2 (en) 1997-12-24 2003-07-29 Methylgere, Inc. Acyl phosphonate inhibitors of β-lactamases
DE69805548T2 (de) * 1997-12-24 2003-01-09 Methylgene, Inc. Acylphosph(on)at beta-lactamase inhibitoren
JP5514973B2 (ja) * 2010-04-30 2014-06-04 独立行政法人産業技術総合研究所 ホスホン酸ジエステル誘導体の製造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2748153A (en) * 1951-05-05 1956-05-29 Du Pont Preparation of acyl phosphoric esters
US2625536A (en) * 1951-05-05 1953-01-13 Du Pont Neutral esters of dicarboxylic acid orthophosphoric acid mixed anhydrides and condensation polymerization process utilizing the same
DE1044073B (de) * 1957-03-20 1958-11-20 Basf Ag Verfahren zur Herstellung von O, O-Dialkylphosphorsaeure- bzw. -thiophosphorsaeureverbindungen
US3835203A (en) * 1970-11-10 1974-09-10 Us Agriculture Phosphoric-carboxylic acid anhydrides
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
US4473496A (en) * 1981-09-14 1984-09-25 The United States Of America As Represented By The Secretary Of The Army Intramolecularly crosslinked hemoglobin
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
EP0206448B1 (en) * 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hemoglobin combined with a poly(alkylene oxide)
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
GB8712240D0 (en) * 1987-05-23 1987-07-01 Fisons Plc Pharmaceutical formulation
IL87708A (en) * 1988-09-08 1994-04-12 Technion Inst For Research And Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof

Also Published As

Publication number Publication date
DK0519953T3 (da) 1996-07-01
ATE133955T1 (de) 1996-02-15
JP3021041B2 (ja) 2000-03-15
WO1991013891A1 (en) 1991-09-19
AU658821B2 (en) 1995-05-04
EP0519953B1 (en) 1996-02-07
EP0519953A1 (en) 1992-12-30
US5334707A (en) 1994-08-02
JPH05505604A (ja) 1993-08-19
CA2078141C (en) 1996-10-08
DE69117054T2 (de) 1996-06-27
CA2078141A1 (en) 1991-09-15
AU7447791A (en) 1991-10-10
DE69117054D1 (de) 1996-03-21

Similar Documents

Publication Publication Date Title
ES2059069T3 (es) Nuevos derivados de 1-alcoxi-(2-acilamino-etil)-naftalenos y su procedimiento de preparacion.
PT97993A (pt) Processo para a preparacao de derivados de amidas ciclicas e de composicoes farmaceuticas que os contem
ES8703869A1 (es) Procedimiento para preparar compuestos de 5-alaquil-1-fenil-2-piperazinoalquilpirazolin-3-ona.
ES2082971T3 (es) Esteres de fosfato de acilo y modificacion de proteinas con los mismos.
ATE14428T1 (de) Verfahren zur herstellung von bromhaltigen 1,3dioxolen-2-ones.
MA21752A1 (fr) Procede de preparation de nouveaux derives de la i - arylsulfonyl 2 - piperidinone .
ES524524A0 (es) Procedimiento para la preparacion de un aducto de un diisocianato
ATE123286T1 (de) Verfahren zur herstellung von 3-alkoxymethyl cephalosporinderivate.
PT87819A (pt) Procede de preparation de nouveaux derives de la 1-benzoyl 2-oxo 5-alcoxy pyrrolidine
ES453997A1 (es) Procedimiento para la preparacion de acetatos de eteraminas secundarias.
ES2062469T3 (es) Derivados de amino-acidos sustituidos, procedimiento de preparacion y composiciones farmaceuticas que los contienen.
SE8702986D0 (sv) Isokinolinderivat
ES455841A1 (es) Procedimiento para preparar composiciones insecticidas a ba-se de ditiofo-fatos-(-fonatos) de formamidina.
SE7714526L (sv) Sett att framstella 2-amino-cyklopent-1-en-1-tiokarbonyl-disulfider
IE41062L (en) O-triazolylphosphoric (phosphonic) acid esters and amides;¹insecticides
IT1248068B (it) Derivati dell'eseridina ad attivita' anticolinesterasi, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 519953

Country of ref document: ES