DE69117054D1 - Acylphosphatester und modifikation von proteinen damit - Google Patents

Acylphosphatester und modifikation von proteinen damit

Info

Publication number
DE69117054D1
DE69117054D1 DE69117054T DE69117054T DE69117054D1 DE 69117054 D1 DE69117054 D1 DE 69117054D1 DE 69117054 T DE69117054 T DE 69117054T DE 69117054 T DE69117054 T DE 69117054T DE 69117054 D1 DE69117054 D1 DE 69117054D1
Authority
DE
Germany
Prior art keywords
image
alkenyl
group
acylphosphate
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69117054T
Other languages
English (en)
Other versions
DE69117054T2 (de
Inventor
Ronald Kluger
Andrew Grant
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Innovations Foundation of University of Toronto
University of Toronto
Original Assignee
Innovations Foundation of University of Toronto
University of Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Innovations Foundation of University of Toronto, University of Toronto filed Critical Innovations Foundation of University of Toronto
Publication of DE69117054D1 publication Critical patent/DE69117054D1/de
Application granted granted Critical
Publication of DE69117054T2 publication Critical patent/DE69117054T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/095—Compounds containing the structure P(=O)-O-acyl, P(=O)-O-heteroatom, P(=O)-O-CN
    • C07F9/096—Compounds containing the structure P(=O)-O-C(=X)- (X = O, S, Se)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69117054T 1990-03-14 1991-03-12 Acylphosphatester und modifikation von proteinen damit Expired - Fee Related DE69117054T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49352490A 1990-03-14 1990-03-14
PCT/CA1991/000073 WO1991013891A1 (en) 1990-03-14 1991-03-12 Acyl phosphate esters and modification of proteins therewith

Publications (2)

Publication Number Publication Date
DE69117054D1 true DE69117054D1 (de) 1996-03-21
DE69117054T2 DE69117054T2 (de) 1996-06-27

Family

ID=23960593

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69117054T Expired - Fee Related DE69117054T2 (de) 1990-03-14 1991-03-12 Acylphosphatester und modifikation von proteinen damit

Country Status (10)

Country Link
US (1) US5334707A (de)
EP (1) EP0519953B1 (de)
JP (1) JP3021041B2 (de)
AT (1) ATE133955T1 (de)
AU (1) AU658821B2 (de)
CA (1) CA2078141C (de)
DE (1) DE69117054T2 (de)
DK (1) DK0519953T3 (de)
ES (1) ES2082971T3 (de)
WO (1) WO1991013891A1 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250665A (en) * 1991-05-31 1993-10-05 The University Of Toronto Innovations Foundation Specifically β-β cross-linked hemoglobins and method of preparation
AU755799B2 (en) * 1997-12-24 2002-12-19 Methylgene, Inc. Novel beta-lactamase and DD-peptidase inhibitors
US6599889B2 (en) 1997-12-24 2003-07-29 Methylgere, Inc. Acyl phosphonate inhibitors of β-lactamases
JP5514973B2 (ja) * 2010-04-30 2014-06-04 独立行政法人産業技術総合研究所 ホスホン酸ジエステル誘導体の製造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2748153A (en) * 1951-05-05 1956-05-29 Du Pont Preparation of acyl phosphoric esters
US2625536A (en) * 1951-05-05 1953-01-13 Du Pont Neutral esters of dicarboxylic acid orthophosphoric acid mixed anhydrides and condensation polymerization process utilizing the same
DE1044073B (de) * 1957-03-20 1958-11-20 Basf Ag Verfahren zur Herstellung von O, O-Dialkylphosphorsaeure- bzw. -thiophosphorsaeureverbindungen
US3835203A (en) * 1970-11-10 1974-09-10 Us Agriculture Phosphoric-carboxylic acid anhydrides
US4061736A (en) * 1975-02-02 1977-12-06 Alza Corporation Pharmaceutically acceptable intramolecularly cross-linked, stromal-free hemoglobin
US4001401A (en) * 1975-02-02 1977-01-04 Alza Corporation Blood substitute and blood plasma expander comprising polyhemoglobin
US4001200A (en) * 1975-02-27 1977-01-04 Alza Corporation Novel polymerized, cross-linked, stromal-free hemoglobin
US4053590A (en) * 1975-02-27 1977-10-11 Alza Corporation Compositions of matter comprising macromolecular hemoglobin
US4473496A (en) * 1981-09-14 1984-09-25 The United States Of America As Represented By The Secretary Of The Army Intramolecularly crosslinked hemoglobin
DE3144705C2 (de) * 1981-11-11 1983-12-08 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Herstellung eines lagerstabilen, vernetzten Hämoglobinpräparates mit hoher Sauerstoff-Transportkapazität, sowie das nach diesem Verfahren hergestellte Hämoglobinpräparat
US4529719A (en) * 1983-05-04 1985-07-16 Tye Ross W Modified crosslinked stroma-free tetrameric hemoglobin
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
US4600531A (en) * 1984-06-27 1986-07-15 University Of Iowa Research Foundation Production of alpha-alpha cross-linked hemoglobins in high yield
US4598064A (en) * 1984-06-27 1986-07-01 University Of Iowa Research Foundation Alpha-alpha cross-linked hemoglobins
US4584130A (en) * 1985-03-29 1986-04-22 University Of Maryland Intramolecularly cross-linked hemoglobin and method of preparation
EP0206448B1 (de) * 1985-06-19 1990-11-14 Ajinomoto Co., Inc. Hämoglobin, das an ein Poly(alkenylenoxid) gebunden ist
GB8710598D0 (en) * 1987-05-05 1987-06-10 Star Medical Diagnostics Ltd Hemoglobin based blood substitute
GB8712240D0 (en) * 1987-05-23 1987-07-01 Fisons Plc Pharmaceutical formulation
IL87708A (en) * 1988-09-08 1994-04-12 Technion Inst For Research And Hemoglobin-based blood substitute possessing a colloid oncotic pressure substantially similar to human blood and method for the preparation thereof

Also Published As

Publication number Publication date
JPH05505604A (ja) 1993-08-19
ES2082971T3 (es) 1996-04-01
EP0519953A1 (de) 1992-12-30
ATE133955T1 (de) 1996-02-15
JP3021041B2 (ja) 2000-03-15
CA2078141A1 (en) 1991-09-15
DE69117054T2 (de) 1996-06-27
AU658821B2 (en) 1995-05-04
WO1991013891A1 (en) 1991-09-19
US5334707A (en) 1994-08-02
EP0519953B1 (de) 1996-02-07
CA2078141C (en) 1996-10-08
AU7447791A (en) 1991-10-10
DK0519953T3 (da) 1996-07-01

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee