ES485621A1 - Un procedimiento para la preparacion de derivados de diben- zopirano - Google Patents

Un procedimiento para la preparacion de derivados de diben- zopirano

Info

Publication number
ES485621A1
ES485621A1 ES485621A ES485621A ES485621A1 ES 485621 A1 ES485621 A1 ES 485621A1 ES 485621 A ES485621 A ES 485621A ES 485621 A ES485621 A ES 485621A ES 485621 A1 ES485621 A1 ES 485621A1
Authority
ES
Spain
Prior art keywords
preparation
amino
dibenzopyrans
pharmaceuticals
formulations containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES485621A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES485621A1 publication Critical patent/ES485621A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Esta invención proporciona un procedimiento para preparar 1- hidroxi-3-substituidos-tetrahidro y hexahidro-dibenzo [b,d]- piranos, que tienen un grupo amino o un derivado amino en la posición 9, útiles como analgésicos, antidepresivos, agentes contra la ansiedad, agentes hipotensores e intermediarios. Se proporcionan formulaciones farmacéuticas que contienen dichas derivados 9-amino, así como también un método para tratar la hipertensión. Se han hecho varias modificaciones de los compuestos conocidos de dibenzopirano, en un esfuerzo para descubrir nuevos compuestos que tengan una utilidad farmacológica mejorada o utilidades nuevas del todo.
ES485621A 1978-02-17 1979-11-01 Un procedimiento para la preparacion de derivados de diben- zopirano Expired ES485621A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/878,844 US4152450A (en) 1978-02-17 1978-02-17 9-Amino-dibenzopyrans

Publications (1)

Publication Number Publication Date
ES485621A1 true ES485621A1 (es) 1980-07-01

Family

ID=25372961

Family Applications (4)

Application Number Title Priority Date Filing Date
ES477832A Expired ES477832A1 (es) 1978-02-17 1979-02-16 Un procedimiento para la preparacion de derivados de diben- zopirano.
ES485621A Expired ES485621A1 (es) 1978-02-17 1979-11-01 Un procedimiento para la preparacion de derivados de diben- zopirano
ES485619A Granted ES485619A0 (es) 1978-02-17 1979-11-01 Un procedimiento para la preparacion de derivados de diben- zopirano
ES485620A Granted ES485620A0 (es) 1978-02-17 1979-11-01 Un procedimiento para la preparacion de derivados de diben- zopirano

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES477832A Expired ES477832A1 (es) 1978-02-17 1979-02-16 Un procedimiento para la preparacion de derivados de diben- zopirano.

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES485619A Granted ES485619A0 (es) 1978-02-17 1979-11-01 Un procedimiento para la preparacion de derivados de diben- zopirano
ES485620A Granted ES485620A0 (es) 1978-02-17 1979-11-01 Un procedimiento para la preparacion de derivados de diben- zopirano

Country Status (29)

Country Link
US (1) US4152450A (es)
EP (1) EP0003883B1 (es)
JP (1) JPS54122278A (es)
AR (2) AR224359A1 (es)
AT (1) AT366039B (es)
AU (1) AU518718B2 (es)
BE (1) BE873981A (es)
CA (1) CA1111425A (es)
CH (1) CH638800A5 (es)
CS (1) CS207769B2 (es)
DD (1) DD142190A5 (es)
DE (1) DE2963797D1 (es)
DK (1) DK68179A (es)
ES (4) ES477832A1 (es)
FI (1) FI790503A (es)
FR (1) FR2417510A1 (es)
GB (1) GB2014571B (es)
GR (1) GR71465B (es)
HU (1) HU180729B (es)
IE (1) IE47999B1 (es)
IL (1) IL56582A0 (es)
LU (1) LU80922A1 (es)
NZ (1) NZ189591A (es)
PH (1) PH14622A (es)
PL (5) PL121009B1 (es)
PT (1) PT69202A (es)
RO (5) RO82376A (es)
SU (1) SU812177A3 (es)
ZA (1) ZA79726B (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4351833A (en) * 1980-07-28 1982-09-28 Pfizer Inc. 9-Amino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof as analgesics and anti-emetics
US4309545A (en) * 1980-07-28 1982-01-05 Pfizer Inc. Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds
US4870084A (en) * 1982-03-16 1989-09-26 Pfizer Inc. Bicyclic benzo fused pyran compounds used for nausea treatment and prevention
US4863934A (en) * 1982-03-16 1989-09-05 Pfizer Inc. Bicyclic benzo fused pyran compounds used for producing analgesia
US4642373A (en) * 1982-03-16 1987-02-10 Pfizer Inc. Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
US4841078A (en) * 1982-03-16 1989-06-20 Pfizer Inc. Benzopyrans
US4473704A (en) * 1982-03-16 1984-09-25 Pfizer Inc. Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
US4442089A (en) * 1982-07-06 1984-04-10 E. R. Squibb & Sons, Inc. Method for treating glaucoma with topical or systemic ACE inhibitor compositions
US4680404A (en) * 1983-01-13 1987-07-14 Pfizer Inc. Benzopyrans
US5180736A (en) * 1989-03-23 1993-01-19 Warner-Lambert Company Polycyclic amines useful as cerebrovascular agents
ATE247097T1 (de) * 1998-05-04 2003-08-15 Univ Connecticut Analgetische und immunomodulierende cannabinoiden
US7897598B2 (en) * 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7589220B2 (en) * 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US8084467B2 (en) * 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7393842B2 (en) * 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US7741365B2 (en) * 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
MXPA02005103A (es) 1999-10-18 2003-09-25 Alexipharma Inc Ligandos selectivos del receptor de canabinoide (cb2) perifericos.
JP2004532185A (ja) * 2001-01-26 2004-10-21 ユニバーシティ オブ コネチカット 新規なカンナビミメティックリガンド
US7173027B2 (en) 2001-01-29 2007-02-06 University Of Connecticut Receptor selective cannabimimetic aminoalkylindoles
EP1414775B1 (en) 2001-07-13 2012-12-19 The University of Connecticut Bicyclic cannabinoid
EP1448557A4 (en) * 2001-10-26 2005-02-02 Univ Connecticut HETEROINDANE: A NEW CLASS OF HIGH-ACTIVITY CANNABIMIMETIC LIGANDS
JP2006511460A (ja) 2002-08-23 2006-04-06 ユニバーシティ オブ コネチカット 治療適応を持つケトカンナビノイド

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3676462A (en) * 1970-01-08 1972-07-11 Little Inc A 7,8,9,10-TETRAHYDRO (AND 7,8,9,10,11,12-HEXAHYDRO) 6H-DIBENZO {8 b,d{9 {0 PYRANS
US3649650A (en) * 1970-02-13 1972-03-14 Little Inc A Novel derivatives of tetrahydro-cannabinol
AU7612874A (en) * 1973-12-27 1976-06-10 Erba Carlo Spa Benzopyran derivatives

Also Published As

Publication number Publication date
FR2417510A1 (fr) 1979-09-14
PL120661B1 (en) 1982-03-31
PL118576B1 (en) 1981-10-31
AT366039B (de) 1982-03-10
JPS54122278A (en) 1979-09-21
RO82369A (ro) 1983-08-03
CS207769B2 (en) 1981-08-31
ES8502106A1 (es) 1980-07-16
RO76886A (ro) 1982-02-01
IE790304L (en) 1979-08-17
DD142190A5 (de) 1980-06-11
FR2417510B1 (es) 1980-08-14
PL213479A1 (es) 1980-03-10
RO82370B (ro) 1983-07-30
GB2014571A (en) 1979-08-30
US4152450A (en) 1979-05-01
PL121009B1 (en) 1982-04-30
FI790503A (fi) 1979-08-18
CH638800A5 (fr) 1983-10-14
PH14622A (en) 1981-10-12
EP0003883A1 (en) 1979-09-05
ES485620A0 (es) 1980-07-16
RO82376B (ro) 1983-07-30
ES8502105A1 (es) 1980-07-16
ZA79726B (en) 1980-10-29
BE873981A (fr) 1979-08-07
DK68179A (da) 1979-09-17
AR225939A1 (es) 1982-05-14
RO82370A (ro) 1983-08-03
ES477832A1 (es) 1980-04-01
RO82375A (ro) 1983-08-03
CA1111425A (en) 1981-10-27
IL56582A0 (en) 1979-05-31
LU80922A1 (fr) 1979-06-18
IE47999B1 (en) 1984-08-22
ATA123979A (de) 1981-07-15
PL120658B1 (en) 1982-03-31
RO82369B (ro) 1983-07-30
GB2014571B (en) 1982-11-17
PL120645B1 (en) 1982-03-31
SU812177A3 (ru) 1981-03-07
EP0003883B1 (en) 1982-10-06
GR71465B (es) 1983-05-30
DE2963797D1 (en) 1982-11-11
AU518718B2 (en) 1981-10-15
ES485619A0 (es) 1980-07-16
HU180729B (en) 1983-04-29
RO82376A (ro) 1983-08-03
AR224359A1 (es) 1981-11-30
AU4398379A (en) 1979-08-23
NZ189591A (en) 1980-10-08
PT69202A (en) 1979-03-01

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