ES8600254A1 - Un procedimiento para preparar derivados de aminopirimidinona - Google Patents

Un procedimiento para preparar derivados de aminopirimidinona

Info

Publication number
ES8600254A1
ES8600254A1 ES534620A ES534620A ES8600254A1 ES 8600254 A1 ES8600254 A1 ES 8600254A1 ES 534620 A ES534620 A ES 534620A ES 534620 A ES534620 A ES 534620A ES 8600254 A1 ES8600254 A1 ES 8600254A1
Authority
ES
Spain
Prior art keywords
histamine
antagonists
hydrogen
zero
aminopyrimidinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES534620A
Other languages
English (en)
Other versions
ES534620A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Smith Kline and French Laboratories Ltd
Original Assignee
Smith Kline and French Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smith Kline and French Laboratories Ltd filed Critical Smith Kline and French Laboratories Ltd
Publication of ES8600254A1 publication Critical patent/ES8600254A1/es
Publication of ES534620A0 publication Critical patent/ES534620A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

PROCEDIMIENTO PARA PREPARAR DERIVADOS DE AMINOPIRIDIMIDINONA.CONSISTENTE EN: REDUCIR UN COMPUESTO DE FORMULA (II) O UNA SAL DEL MISMO, PARA OBTENER UN COMPUESTO DE FORMULA (I) EN DONDE RO ES 2-GUANIDINOTIAZOL-4-ILO O UN GRUPO R1R2N(CH2)N-Z- DONDE: R1 Y R2 SON H, ALQUILO C 1 A 6, ARILO-ALQUILO C 1 A 6 U OTROS, Y JUNTO SON -CH2)Q- DONDE Q ES DE 4 A 7 PARA FORMAR JUNTO CON EL ATOMO DE N AL QUE ESTAN UNIDOS UN ANILLO SATURADO DE 5-8 MIEMBROS; N ES UN NUMERO ENTERO DE 1 A 6, Z ES 2,5-FURANILIO, 2,5-TIENILO U OTROS, M ES O, Y ES O, S O METILIO, P ES 2, 3, 4, Q ES 0 O 1, R3 ES H O ALQUILO DE C 1 A 6.SE UTILIZAN COMO ANTAGONISTAS H2 DE LA HISTAMINA.
ES534620A 1983-07-29 1984-07-26 Un procedimiento para preparar derivados de aminopirimidinona Granted ES534620A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838320505A GB8320505D0 (en) 1983-07-29 1983-07-29 Chemical compounds

Publications (2)

Publication Number Publication Date
ES8600254A1 true ES8600254A1 (es) 1985-09-16
ES534620A0 ES534620A0 (es) 1985-09-16

Family

ID=10546495

Family Applications (1)

Application Number Title Priority Date Filing Date
ES534620A Granted ES534620A0 (es) 1983-07-29 1984-07-26 Un procedimiento para preparar derivados de aminopirimidinona

Country Status (21)

Country Link
EP (1) EP0134096B1 (es)
JP (1) JPS6051179A (es)
KR (1) KR850001174A (es)
AT (1) ATE40552T1 (es)
AU (1) AU564650B2 (es)
CA (1) CA1261831A (es)
CS (1) CS244448B2 (es)
DD (1) DD216933A5 (es)
DE (1) DE3476541D1 (es)
DK (1) DK368284A (es)
ES (1) ES534620A0 (es)
FI (1) FI842976A (es)
GB (1) GB8320505D0 (es)
GR (1) GR82226B (es)
HU (1) HUT34743A (es)
IL (1) IL72491A0 (es)
JO (1) JO1327B1 (es)
NO (1) NO843043L (es)
PT (1) PT78977B (es)
ZA (1) ZA845820B (es)
ZW (1) ZW11584A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4772704A (en) * 1983-09-21 1988-09-20 Bristol-Myers Company 2,5-disubstituted-4(3H)-pyrimidones having histamine H2 -receptor antagonist activity
GB8421427D0 (en) * 1984-08-23 1984-09-26 Smith Kline French Lab Chemical compounds
US7423147B2 (en) 2004-03-31 2008-09-09 Janssen Pharmaceutical, N.V. Pyridine compounds as histamine H3 modulators
CA2653940C (en) 2006-05-30 2015-07-14 Janssen Pharmaceutica N.V. Substituted pyridyl amide compounds as modulators of the histamine h3 receptor
CA2706328C (en) 2007-11-20 2016-04-19 Janssen Pharmaceutica N.V. Cycloalkyloxy- and heterocycloalkyloxypyridine compounds as modulators of the histamine h3 receptor
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN151188B (es) * 1978-02-13 1983-03-05 Smith Kline French Lab
ZA793443B (en) * 1978-07-26 1980-12-31 Glaxo Group Ltd Heterocyclic derivatives
US4496567A (en) * 1978-11-13 1985-01-29 Smith Kline & French Laboratories Limited Phenyl alkylaminopyrimidones
US4521418A (en) * 1979-02-21 1985-06-04 Smith Kline & French Laboratories Limited Guanidinothiazolyl derivatives
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions

Also Published As

Publication number Publication date
DK368284D0 (da) 1984-07-27
ATE40552T1 (de) 1989-02-15
KR850001174A (ko) 1985-03-16
AU564650B2 (en) 1987-08-20
CS244448B2 (en) 1986-07-17
JPS6051179A (ja) 1985-03-22
ZA845820B (en) 1985-06-26
JO1327B1 (en) 1986-11-30
FI842976A0 (fi) 1984-07-26
DK368284A (da) 1985-01-30
EP0134096A2 (en) 1985-03-13
PT78977B (en) 1986-06-05
NO843043L (no) 1985-01-30
DD216933A5 (de) 1985-01-02
EP0134096B1 (en) 1989-02-01
GB8320505D0 (en) 1983-09-01
HUT34743A (en) 1985-04-28
GR82226B (es) 1984-12-13
IL72491A0 (en) 1984-11-30
PT78977A (en) 1984-08-01
EP0134096A3 (en) 1985-12-18
ZW11584A1 (en) 1985-04-17
FI842976A (fi) 1985-01-30
DE3476541D1 (de) 1989-03-09
AU3099184A (en) 1985-01-31
ES534620A0 (es) 1985-09-16
CS581084A2 (en) 1985-08-15
CA1261831A (en) 1989-09-26

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