IE801946L - 2-amino-3-benzoyl-phenylacetamides - Google Patents
2-amino-3-benzoyl-phenylacetamidesInfo
- Publication number
- IE801946L IE801946L IE801946A IE194680A IE801946L IE 801946 L IE801946 L IE 801946L IE 801946 A IE801946 A IE 801946A IE 194680 A IE194680 A IE 194680A IE 801946 L IE801946 L IE 801946L
- Authority
- IE
- Ireland
- Prior art keywords
- lower alkyl
- trifluoromethyl
- halogen
- amino
- phenylacetamides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
2-Amino-3-benzoyl-phenylacetamides are provided having the formula: <IMAGE> wherein: R represent hydrogen or lower alkyl, R<1> and R<2> represent hydrogen, lower alkyl, cycloalkyl, phenyl and phenyl substituted by lower alkyl, lower alkoxy, halogen, nitro and trifluoromethyl, and R<1> and R<2> when taken together with the adjacent nitrogen may form a heterocyclic residue; X represents hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; Y represents hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, lower alkylthio, lower alkyloxythio or lower alkyldioxythio; Am is primary amino (-NH2), methylamino or dimethylamino, and n is 1 to 2 inclusive. The compounds exhibit anti- inflammatory, antipyretic, anti-blood platelet aggregation and analgetic pharmacological activities.
[GB2059963A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7886079A | 1979-09-26 | 1979-09-26 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE801946L true IE801946L (en) | 1981-03-26 |
| IE50268B1 IE50268B1 (en) | 1986-03-19 |
Family
ID=22146633
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1946/80A IE50268B1 (en) | 1979-09-26 | 1980-09-17 | 2-amino-3-benzoyl-phenylacetamides and cyclic homologues |
Country Status (36)
| Country | Link |
|---|---|
| JP (1) | JPS5657751A (en) |
| KR (1) | KR840000763B1 (en) |
| AT (1) | AT374170B (en) |
| AU (1) | AU532359B2 (en) |
| BE (1) | BE885393A (en) |
| BR (1) | BR8006042A (en) |
| CA (1) | CA1128512A (en) |
| CH (1) | CH646138A5 (en) |
| CS (1) | CS227012B2 (en) |
| DE (1) | DE3035688A1 (en) |
| DK (1) | DK154136C (en) |
| EG (1) | EG15020A (en) |
| ES (2) | ES495329A0 (en) |
| FI (1) | FI72967C (en) |
| FR (1) | FR2465710A1 (en) |
| GB (1) | GB2059963B (en) |
| GR (1) | GR70049B (en) |
| HK (1) | HK59383A (en) |
| HU (1) | HU183215B (en) |
| IE (1) | IE50268B1 (en) |
| IL (1) | IL60999A (en) |
| IN (3) | IN151313B (en) |
| IT (1) | IT1133823B (en) |
| KE (1) | KE3307A (en) |
| LU (1) | LU82797A1 (en) |
| MX (1) | MX7159E (en) |
| NL (1) | NL8005346A (en) |
| NO (1) | NO152128C (en) |
| NZ (1) | NZ195061A (en) |
| PH (1) | PH22628A (en) |
| PL (1) | PL128998B1 (en) |
| PT (1) | PT71839B (en) |
| SE (1) | SE448626B (en) |
| SG (1) | SG42983G (en) |
| YU (3) | YU41734B (en) |
| ZA (1) | ZA805476B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
| US6646001B2 (en) | 1997-12-19 | 2003-11-11 | Alcon Manufacturing, Ltd. | Use of non-steroidal anti-inflammatory agents in combination with prostaglandin FP receptor agonists to treat glaucoma and ocular hypertension |
| US6066671A (en) | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
| GB9727523D0 (en) | 1997-12-31 | 1998-02-25 | Pharmacia & Upjohn Spa | Alpha-aminoamide derivatives useful as analgesic agents |
| AR030345A1 (en) * | 2000-08-14 | 2003-08-20 | Alcon Inc | METHOD OF TREATMENT OF DISORDERS RELATED TO ANGIOGENESIS |
| AU2002333374B2 (en) | 2001-09-03 | 2007-03-22 | Newron Pharmaceuticals S.P.A. | Pharmaceutical composition comprising gabapentin or an analogue thereof and an (alpha)- aminoamide and its analgesic use |
| EP1438956A1 (en) | 2003-01-16 | 2004-07-21 | Newron Pharmaceuticals S.p.A. | Alpha-aminoamide derivatives useful as antimigraine agents |
| CZ2009367A3 (en) * | 2009-06-08 | 2010-06-16 | Farmak, A.S. | Process for preparing 2-amino-3-benzoylphenylacetamide (nepafenac) with minimum of by-products |
| CN112794809B (en) * | 2019-11-14 | 2023-12-29 | 南京济群医药科技股份有限公司 | Preparation method of high-purity nepafenac intermediate |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1226344A (en) * | 1967-07-31 | 1971-03-24 | ||
| SE400966B (en) * | 1975-08-13 | 1978-04-17 | Robins Co Inc A H | PROCEDURE FOR PREPARING 2-AMINO-3- (OR 5-) BENZOYL-PHENYLETIC ACIDS |
| IL61945A (en) * | 1980-02-19 | 1984-09-30 | Robins Co Inc A H | 2-amino-3-(hydroxy(phenyl)methyl)phenylacetic acids,esters and amides and pharmaceutical compositions containing them |
-
1980
- 1980-09-04 ZA ZA00805476A patent/ZA805476B/en unknown
- 1980-09-08 IL IL60999A patent/IL60999A/en unknown
- 1980-09-08 AU AU62116/80A patent/AU532359B2/en not_active Ceased
- 1980-09-11 CS CS806196A patent/CS227012B2/en unknown
- 1980-09-17 IE IE1946/80A patent/IE50268B1/en unknown
- 1980-09-20 EG EG80573A patent/EG15020A/en active
- 1980-09-22 GR GR62936A patent/GR70049B/el unknown
- 1980-09-22 DE DE19803035688 patent/DE3035688A1/en active Granted
- 1980-09-22 BR BR8006042A patent/BR8006042A/en unknown
- 1980-09-23 AT AT0474580A patent/AT374170B/en not_active IP Right Cessation
- 1980-09-23 PH PH24613A patent/PH22628A/en unknown
- 1980-09-24 FI FI803002A patent/FI72967C/en not_active IP Right Cessation
- 1980-09-24 LU LU82797A patent/LU82797A1/en unknown
- 1980-09-24 SE SE8006668A patent/SE448626B/en not_active IP Right Cessation
- 1980-09-25 FR FR8020596A patent/FR2465710A1/en active Granted
- 1980-09-25 KR KR1019800003740A patent/KR840000763B1/en active
- 1980-09-25 CA CA361,068A patent/CA1128512A/en not_active Expired
- 1980-09-25 BE BE0/202226A patent/BE885393A/en not_active IP Right Cessation
- 1980-09-25 MX MX809050U patent/MX7159E/en unknown
- 1980-09-25 YU YU2450/80A patent/YU41734B/en unknown
- 1980-09-25 CH CH719180A patent/CH646138A5/en not_active IP Right Cessation
- 1980-09-25 GB GB8030955A patent/GB2059963B/en not_active Expired
- 1980-09-25 HU HU802347A patent/HU183215B/en not_active IP Right Cessation
- 1980-09-25 NL NL8005346A patent/NL8005346A/en not_active Application Discontinuation
- 1980-09-25 DK DK405780A patent/DK154136C/en not_active IP Right Cessation
- 1980-09-25 PT PT71839A patent/PT71839B/en unknown
- 1980-09-25 NO NO802834A patent/NO152128C/en unknown
- 1980-09-25 PL PL1980226919A patent/PL128998B1/en unknown
- 1980-09-25 ES ES495329A patent/ES495329A0/en active Granted
- 1980-09-26 IT IT24948/80A patent/IT1133823B/en active
- 1980-09-26 NZ NZ195061A patent/NZ195061A/en unknown
- 1980-09-26 JP JP13415280A patent/JPS5657751A/en active Granted
- 1980-09-26 IN IN1092/CAL/80A patent/IN151313B/en unknown
-
1981
- 1981-06-12 ES ES503019A patent/ES503019A0/en active Granted
-
1982
- 1982-12-30 IN IN1508/CAL/82A patent/IN156254B/en unknown
- 1982-12-30 IN IN1509/CAL/82A patent/IN156255B/en unknown
-
1983
- 1983-03-28 YU YU731/83A patent/YU43306B/en unknown
- 1983-03-28 YU YU730/83A patent/YU43305B/en unknown
- 1983-07-19 SG SG42983A patent/SG42983G/en unknown
- 1983-07-21 KE KE3307A patent/KE3307A/en unknown
- 1983-11-24 HK HK593/83A patent/HK59383A/en unknown
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