ES8606296A1 - Procedimiento para la preparacion de una 5-pirimidincarboxamida o tiocarboxamida - Google Patents
Procedimiento para la preparacion de una 5-pirimidincarboxamida o tiocarboxamidaInfo
- Publication number
- ES8606296A1 ES8606296A1 ES538829A ES538829A ES8606296A1 ES 8606296 A1 ES8606296 A1 ES 8606296A1 ES 538829 A ES538829 A ES 538829A ES 538829 A ES538829 A ES 538829A ES 8606296 A1 ES8606296 A1 ES 8606296A1
- Authority
- ES
- Spain
- Prior art keywords
- leukemia
- hydrogen
- pyrimidinecarboxamides
- fluoro
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
- C07D239/66—Thiobarbituric acids
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UNA 5-PIRIMIDINCARBOXAMIDA O TIOCARBOXAMIDA, DE FORMULA GENERAL (1), EN LA QUE R5 Y R6 PUEDEN SER CADA UNO DE ELLOS INDEPENDIENTEMENTE HIDROGENO O UN RESIDUO CARBOHIDRATO; R3 ES HIDROGENO O ALQUILO; R4 ES FENILO, NAFTILO O BENCILO; W ES OXIGENO O AZUFRE; X ES AZUFRE O SELENIO; E Y Y Z PUEDEN SER CADA UNO DE ELLOS INDEPENDIENTEMENTE OXIGENO, AZUFRE O SELENIO, Y SUS SALES DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN ACIDO 2-TIOBARBITURICO CON UN ISOCIANATO O ISOTIOCIANATO DE FORMULA GENERAL: R4 C N F C F W, EN PRESENCIA DE UN MEDIO DISOLVENTE O DISPERSANTE. DE APLICACION COMO AGENTE ANTI-CANCERIGENO POTENCIAL, UTILIZADO EN EL TRATAMIENTO DE LA LEUCEMIA Y DE LOS TUMORES.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US56269383A | 1983-12-19 | 1983-12-19 | |
US66526784A | 1984-10-26 | 1984-10-26 | |
US66520184A | 1984-10-26 | 1984-10-26 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8606296A1 true ES8606296A1 (es) | 1986-04-16 |
ES538829A0 ES538829A0 (es) | 1986-04-16 |
Family
ID=27415896
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES538829A Expired ES8606296A1 (es) | 1983-12-19 | 1984-12-19 | Procedimiento para la preparacion de una 5-pirimidincarboxamida o tiocarboxamida |
Country Status (19)
Country | Link |
---|---|
US (1) | US4634707A (es) |
JP (1) | JPH0660164B2 (es) |
AT (1) | AT394194B (es) |
AU (1) | AU580746B2 (es) |
BE (1) | BE901301A (es) |
CH (1) | CH671225A5 (es) |
DE (1) | DE3446371A1 (es) |
DK (1) | DK164055C (es) |
ES (1) | ES8606296A1 (es) |
FR (1) | FR2557108B1 (es) |
GB (1) | GB2152047B (es) |
GR (1) | GR82494B (es) |
IE (1) | IE57675B1 (es) |
IL (1) | IL73840A (es) |
IT (1) | IT1213257B (es) |
LU (1) | LU85696A1 (es) |
NL (1) | NL8403856A (es) |
NZ (2) | NZ220399A (es) |
SE (1) | SE469171B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2145087B (en) * | 1983-08-19 | 1987-02-04 | Ciba Geigy Ag | Barbituric acid derivatives |
EP0167491A3 (de) * | 1984-07-06 | 1986-12-30 | Ciba-Geigy Ag | Thiobarbitursäurederivate |
PH24423A (en) * | 1985-02-15 | 1990-06-25 | Ciba Geigy Ag | 5-(azolyloxyphenylcarbamoyl)barbituric acid derivatives as anthelmintics |
US4636508A (en) * | 1985-04-22 | 1987-01-13 | Uniroyal Chemical Company, Inc. | 5-pyrimidinecarboxyamides and treatment of leukemia therewith |
EP0202823A3 (en) * | 1985-05-17 | 1987-11-19 | Uniroyal Limited | Purification of 5-pyrimidinecarboxamides |
US4845217A (en) * | 1985-05-17 | 1989-07-04 | Uniroyal Chemical Ltd./Ltee | Purification of 5-pyrimidinecarboxamides |
US4880811A (en) * | 1987-06-24 | 1989-11-14 | Memorial Hospital For Cancer And Allied Diseases | Use of C-5 mono-substituted barbiturates to treat disorders of uric acid metabolism |
US4920126A (en) * | 1988-05-10 | 1990-04-24 | Uniroyal Chemical Ltd/Uniroyal Chemical Ltee | Barbituric acid derivative and treatment of leukemia and tumors therewith |
AU7540991A (en) * | 1990-03-09 | 1991-10-10 | Memorial Hospital For Cancer And Allied Diseases | C-5 mono-substituted barbiturates in combination with therapeutic agents and uses thereof |
JP2003531196A (ja) * | 2000-04-24 | 2003-10-21 | アリックス セラピューティクス | 超短時間作用型催眠性バルビツール酸塩 |
US10093631B2 (en) * | 2014-02-14 | 2018-10-09 | Acquist Llc | Bifunctional compounds and use for reducing uric acid levels |
WO2016118611A1 (en) * | 2015-01-22 | 2016-07-28 | Warrell Raymond P Jr | Bifunctional compounds and use for reducing uric acid levels |
TWI772309B (zh) | 2016-06-30 | 2022-08-01 | 美商艾克奎斯特有限責任公司 | 化合物及其於降低尿酸位準之用途(二) |
CA3029883A1 (en) | 2016-07-06 | 2018-01-11 | Acquist Llc | Compounds and their use for reducing uric acid levels |
IT201700028709A1 (it) | 2017-03-15 | 2018-09-15 | Fondazione St Italiano Tecnologia | Acidi-5-carbossamide-2-tiobarbiturici e loro uso come medicamenti |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH602664A5 (en) * | 1973-06-14 | 1978-07-31 | Sandoz Ag | 2-Tert. amino-alkylamino-pyrimidine derivs. |
DE2405733C2 (de) * | 1974-02-07 | 1984-12-13 | Bayer Ag, 5090 Leverkusen | Amidocarbonylthiobarbitursäurederivate und deren Salze, Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Bekämpfung von Insekten, Milben und Pilzen |
DE2405732A1 (de) * | 1974-02-07 | 1975-08-21 | Bayer Ag | Ekto- und endoparasitenmittel |
CH614944A5 (en) * | 1974-04-16 | 1979-12-28 | Sandoz Ag | Process for the preparation of novel pyrimidine derivatives |
CH616563A5 (en) * | 1976-05-06 | 1980-04-15 | Ciba Geigy Ag | Pesticide containing a 5-phenylcarbamoylbarbituric acid as active ingredient |
PL103086B1 (pl) * | 1976-05-06 | 1979-05-31 | Ciba Geigy Ag | Srodek owadobojczy |
DE2624856A1 (de) * | 1976-06-03 | 1977-12-22 | Hoechst Ag | 2-thiohexahydropyrimidin-4,6-dion-derivate und verfahren zu ihrer herstellung |
US4283444A (en) * | 1978-09-12 | 1981-08-11 | Ciba-Geigy Corporation | Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds |
US4349552A (en) * | 1978-10-30 | 1982-09-14 | Fujisawa Pharmaceutical Company, Ltd. | 5-Fluorouracil derivatives, and their pharmaceutical compositions |
DE2962834D1 (en) * | 1978-10-30 | 1982-07-01 | Fujisawa Pharmaceutical Co | 5-fluorouracil derivatives, preparation thereof and their pharmaceutical compositions |
CH654720A5 (de) * | 1981-09-03 | 1986-03-14 | Ciba Geigy Ag | Lagerstabile mottenschutzformulierungen. |
US4410524A (en) * | 1982-06-01 | 1983-10-18 | American Cyanamid Company | Novel 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof |
GB2126582B (en) * | 1982-08-26 | 1986-03-05 | Ciba Geigy Ag | Phenyl carbamoyl barbituric acid anthelmintics |
CH658770A5 (de) * | 1982-08-26 | 1986-12-15 | Ciba Geigy Ag | Motten- und kaeferschutzmittel. |
GB8431832D0 (en) * | 1983-12-19 | 1985-01-30 | Uniroyal Inc | 5-pyrimidinecarboxamides |
EP0167491A3 (de) * | 1984-07-06 | 1986-12-30 | Ciba-Geigy Ag | Thiobarbitursäurederivate |
JPS641445A (en) | 1987-06-22 | 1989-01-05 | Toshiba Corp | Manufacture of stator coil |
-
1984
- 1984-12-17 IL IL73840A patent/IL73840A/xx not_active IP Right Cessation
- 1984-12-18 IE IE3237/84A patent/IE57675B1/en not_active IP Right Cessation
- 1984-12-18 GR GR82494A patent/GR82494B/el unknown
- 1984-12-18 NZ NZ220399A patent/NZ220399A/en unknown
- 1984-12-18 BE BE0/214179A patent/BE901301A/fr not_active IP Right Cessation
- 1984-12-18 IT IT8424104A patent/IT1213257B/it active
- 1984-12-18 SE SE8406450A patent/SE469171B/sv not_active IP Right Cessation
- 1984-12-18 NZ NZ210599A patent/NZ210599A/en unknown
- 1984-12-18 DK DK609184A patent/DK164055C/da not_active IP Right Cessation
- 1984-12-19 AU AU36908/84A patent/AU580746B2/en not_active Ceased
- 1984-12-19 CH CH6089/84A patent/CH671225A5/de not_active IP Right Cessation
- 1984-12-19 NL NL8403856A patent/NL8403856A/nl not_active Application Discontinuation
- 1984-12-19 ES ES538829A patent/ES8606296A1/es not_active Expired
- 1984-12-19 DE DE19843446371 patent/DE3446371A1/de active Granted
- 1984-12-19 LU LU85696A patent/LU85696A1/fr unknown
- 1984-12-19 FR FR8419455A patent/FR2557108B1/fr not_active Expired
- 1984-12-19 AT AT0402684A patent/AT394194B/de not_active IP Right Cessation
- 1984-12-19 GB GB08432112A patent/GB2152047B/en not_active Expired
-
1985
- 1985-02-08 US US06/699,776 patent/US4634707A/en not_active Expired - Lifetime
-
1986
- 1986-12-03 JP JP61288650A patent/JPH0660164B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
NZ210599A (en) | 1987-09-30 |
IL73840A (en) | 1988-11-15 |
FR2557108A1 (fr) | 1985-06-28 |
DK164055B (da) | 1992-05-04 |
DK164055C (da) | 1992-09-28 |
BE901301A (fr) | 1985-06-18 |
CH671225A5 (es) | 1989-08-15 |
US4634707A (en) | 1987-01-06 |
NL8403856A (nl) | 1985-07-16 |
ATA402684A (de) | 1991-08-15 |
GB8432112D0 (en) | 1985-01-30 |
JPS62174058A (ja) | 1987-07-30 |
SE8406450D0 (sv) | 1984-12-18 |
IT8424104A0 (it) | 1984-12-18 |
IE843237L (en) | 1985-06-19 |
ES538829A0 (es) | 1986-04-16 |
AT394194B (de) | 1992-02-10 |
SE469171B (sv) | 1993-05-24 |
GB2152047A (en) | 1985-07-31 |
IE57675B1 (en) | 1993-02-24 |
AU3690884A (en) | 1985-07-04 |
SE8406450L (sv) | 1985-06-20 |
DE3446371C2 (es) | 1990-08-16 |
DK609184D0 (da) | 1984-12-18 |
JPH0660164B2 (ja) | 1994-08-10 |
DK609184A (da) | 1985-06-20 |
IT1213257B (it) | 1989-12-14 |
AU580746B2 (en) | 1989-02-02 |
GR82494B (en) | 1985-04-19 |
IL73840A0 (en) | 1985-03-31 |
NZ220399A (en) | 1987-09-30 |
LU85696A1 (fr) | 1985-09-12 |
GB2152047B (en) | 1988-04-27 |
DE3446371A1 (de) | 1985-06-27 |
FR2557108B1 (fr) | 1988-11-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19990503 |