FR2557108B1 - 5-pyrimidinecarboxamide ou thiocarboxamide, composition pharmaceutique pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs le contenant, procede de production de 5-pyrimidinecarboxamide ou thiocarboxamide et procede pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs en l'utilisant - Google Patents

5-pyrimidinecarboxamide ou thiocarboxamide, composition pharmaceutique pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs le contenant, procede de production de 5-pyrimidinecarboxamide ou thiocarboxamide et procede pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs en l'utilisant

Info

Publication number
FR2557108B1
FR2557108B1 FR8419455A FR8419455A FR2557108B1 FR 2557108 B1 FR2557108 B1 FR 2557108B1 FR 8419455 A FR8419455 A FR 8419455A FR 8419455 A FR8419455 A FR 8419455A FR 2557108 B1 FR2557108 B1 FR 2557108B1
Authority
FR
France
Prior art keywords
thiocarboxide
pyrimidinecarboxamide
growth
thiocarboxamide
tumors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8419455A
Other languages
English (en)
Other versions
FR2557108A1 (fr
Inventor
Arthur D Brewer
John A Minatelli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Uniroyal Inc
Original Assignee
Uniroyal Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Inc filed Critical Uniroyal Inc
Publication of FR2557108A1 publication Critical patent/FR2557108A1/fr
Application granted granted Critical
Publication of FR2557108B1 publication Critical patent/FR2557108B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids
FR8419455A 1983-12-19 1984-12-19 5-pyrimidinecarboxamide ou thiocarboxamide, composition pharmaceutique pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs le contenant, procede de production de 5-pyrimidinecarboxamide ou thiocarboxamide et procede pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs en l'utilisant Expired FR2557108B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56269383A 1983-12-19 1983-12-19
US66526784A 1984-10-26 1984-10-26
US66520184A 1984-10-26 1984-10-26

Publications (2)

Publication Number Publication Date
FR2557108A1 FR2557108A1 (fr) 1985-06-28
FR2557108B1 true FR2557108B1 (fr) 1988-11-18

Family

ID=27415896

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8419455A Expired FR2557108B1 (fr) 1983-12-19 1984-12-19 5-pyrimidinecarboxamide ou thiocarboxamide, composition pharmaceutique pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs le contenant, procede de production de 5-pyrimidinecarboxamide ou thiocarboxamide et procede pour induire la regression de la leucemie et l'inhibition de la croissance des tumeurs en l'utilisant

Country Status (19)

Country Link
US (1) US4634707A (fr)
JP (1) JPH0660164B2 (fr)
AT (1) AT394194B (fr)
AU (1) AU580746B2 (fr)
BE (1) BE901301A (fr)
CH (1) CH671225A5 (fr)
DE (1) DE3446371A1 (fr)
DK (1) DK164055C (fr)
ES (1) ES8606296A1 (fr)
FR (1) FR2557108B1 (fr)
GB (1) GB2152047B (fr)
GR (1) GR82494B (fr)
IE (1) IE57675B1 (fr)
IL (1) IL73840A (fr)
IT (1) IT1213257B (fr)
LU (1) LU85696A1 (fr)
NL (1) NL8403856A (fr)
NZ (2) NZ220399A (fr)
SE (1) SE469171B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2145087B (en) * 1983-08-19 1987-02-04 Ciba Geigy Ag Barbituric acid derivatives
EP0167491A3 (fr) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Dérivés d'acide thiobarbiturique
PH24423A (en) * 1985-02-15 1990-06-25 Ciba Geigy Ag 5-(azolyloxyphenylcarbamoyl)barbituric acid derivatives as anthelmintics
US4636508A (en) * 1985-04-22 1987-01-13 Uniroyal Chemical Company, Inc. 5-pyrimidinecarboxyamides and treatment of leukemia therewith
EP0202823A3 (fr) * 1985-05-17 1987-11-19 Uniroyal Limited Purification de 5-pyrimidinecarboxamides
US4845217A (en) * 1985-05-17 1989-07-04 Uniroyal Chemical Ltd./Ltee Purification of 5-pyrimidinecarboxamides
US4880811A (en) * 1987-06-24 1989-11-14 Memorial Hospital For Cancer And Allied Diseases Use of C-5 mono-substituted barbiturates to treat disorders of uric acid metabolism
US4920126A (en) * 1988-05-10 1990-04-24 Uniroyal Chemical Ltd/Uniroyal Chemical Ltee Barbituric acid derivative and treatment of leukemia and tumors therewith
AU7540991A (en) * 1990-03-09 1991-10-10 Memorial Hospital For Cancer And Allied Diseases C-5 mono-substituted barbiturates in combination with therapeutic agents and uses thereof
JP2003531196A (ja) * 2000-04-24 2003-10-21 アリックス セラピューティクス 超短時間作用型催眠性バルビツール酸塩
US10093631B2 (en) * 2014-02-14 2018-10-09 Acquist Llc Bifunctional compounds and use for reducing uric acid levels
WO2016118611A1 (fr) * 2015-01-22 2016-07-28 Warrell Raymond P Jr Composés bifonctionnels et leur utilisation pour la réduction des niveaux de l'acide urique
TWI772309B (zh) 2016-06-30 2022-08-01 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途(二)
CA3029883A1 (fr) 2016-07-06 2018-01-11 Acquist Llc Composes et utilisation de ces derniers pour reduire les niveaux d'acide urique
IT201700028709A1 (it) 2017-03-15 2018-09-15 Fondazione St Italiano Tecnologia Acidi-5-carbossamide-2-tiobarbiturici e loro uso come medicamenti

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602664A5 (en) * 1973-06-14 1978-07-31 Sandoz Ag 2-Tert. amino-alkylamino-pyrimidine derivs.
DE2405733C2 (de) * 1974-02-07 1984-12-13 Bayer Ag, 5090 Leverkusen Amidocarbonylthiobarbitursäurederivate und deren Salze, Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Bekämpfung von Insekten, Milben und Pilzen
DE2405732A1 (de) * 1974-02-07 1975-08-21 Bayer Ag Ekto- und endoparasitenmittel
CH614944A5 (en) * 1974-04-16 1979-12-28 Sandoz Ag Process for the preparation of novel pyrimidine derivatives
CH616563A5 (en) * 1976-05-06 1980-04-15 Ciba Geigy Ag Pesticide containing a 5-phenylcarbamoylbarbituric acid as active ingredient
PL103086B1 (pl) * 1976-05-06 1979-05-31 Ciba Geigy Ag Srodek owadobojczy
DE2624856A1 (de) * 1976-06-03 1977-12-22 Hoechst Ag 2-thiohexahydropyrimidin-4,6-dion-derivate und verfahren zu ihrer herstellung
US4283444A (en) * 1978-09-12 1981-08-11 Ciba-Geigy Corporation Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds
US4349552A (en) * 1978-10-30 1982-09-14 Fujisawa Pharmaceutical Company, Ltd. 5-Fluorouracil derivatives, and their pharmaceutical compositions
DE2962834D1 (en) * 1978-10-30 1982-07-01 Fujisawa Pharmaceutical Co 5-fluorouracil derivatives, preparation thereof and their pharmaceutical compositions
CH654720A5 (de) * 1981-09-03 1986-03-14 Ciba Geigy Ag Lagerstabile mottenschutzformulierungen.
US4410524A (en) * 1982-06-01 1983-10-18 American Cyanamid Company Novel 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
GB2126582B (en) * 1982-08-26 1986-03-05 Ciba Geigy Ag Phenyl carbamoyl barbituric acid anthelmintics
CH658770A5 (de) * 1982-08-26 1986-12-15 Ciba Geigy Ag Motten- und kaeferschutzmittel.
GB8431832D0 (en) * 1983-12-19 1985-01-30 Uniroyal Inc 5-pyrimidinecarboxamides
EP0167491A3 (fr) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Dérivés d'acide thiobarbiturique
JPS641445A (en) 1987-06-22 1989-01-05 Toshiba Corp Manufacture of stator coil

Also Published As

Publication number Publication date
NZ210599A (en) 1987-09-30
IL73840A (en) 1988-11-15
FR2557108A1 (fr) 1985-06-28
DK164055B (da) 1992-05-04
DK164055C (da) 1992-09-28
BE901301A (fr) 1985-06-18
CH671225A5 (fr) 1989-08-15
US4634707A (en) 1987-01-06
NL8403856A (nl) 1985-07-16
ATA402684A (de) 1991-08-15
ES8606296A1 (es) 1986-04-16
GB8432112D0 (en) 1985-01-30
JPS62174058A (ja) 1987-07-30
SE8406450D0 (sv) 1984-12-18
IT8424104A0 (it) 1984-12-18
IE843237L (en) 1985-06-19
ES538829A0 (es) 1986-04-16
AT394194B (de) 1992-02-10
SE469171B (sv) 1993-05-24
GB2152047A (en) 1985-07-31
IE57675B1 (en) 1993-02-24
AU3690884A (en) 1985-07-04
SE8406450L (sv) 1985-06-20
DE3446371C2 (fr) 1990-08-16
DK609184D0 (da) 1984-12-18
JPH0660164B2 (ja) 1994-08-10
DK609184A (da) 1985-06-20
IT1213257B (it) 1989-12-14
AU580746B2 (en) 1989-02-02
GR82494B (en) 1985-04-19
IL73840A0 (en) 1985-03-31
NZ220399A (en) 1987-09-30
LU85696A1 (fr) 1985-09-12
GB2152047B (en) 1988-04-27
DE3446371A1 (de) 1985-06-27

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TP Transmission of property
ST Notification of lapse