DK164055C - 2-thioxo-5-pyrimidincarboxamider, farmaceutisk middel indeholdende disse til at inducere regression af leukaemi og haemning af vaekst af tumorer og fremgangsmaader til deres fremstilling - Google Patents

2-thioxo-5-pyrimidincarboxamider, farmaceutisk middel indeholdende disse til at inducere regression af leukaemi og haemning af vaekst af tumorer og fremgangsmaader til deres fremstilling

Info

Publication number
DK164055C
DK164055C DK609184A DK609184A DK164055C DK 164055 C DK164055 C DK 164055C DK 609184 A DK609184 A DK 609184A DK 609184 A DK609184 A DK 609184A DK 164055 C DK164055 C DK 164055C
Authority
DK
Denmark
Prior art keywords
pyrimidincarboxamides
leukaemi
induct
thioxo
regression
Prior art date
Application number
DK609184A
Other languages
Danish (da)
English (en)
Other versions
DK609184D0 (da
DK164055B (da
DK609184A (da
Inventor
Arthur D Brewer
John A Minatelli
Original Assignee
Uniroyal Chem Co Inc
Uniroyal Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniroyal Chem Co Inc, Uniroyal Ltd filed Critical Uniroyal Chem Co Inc
Publication of DK609184D0 publication Critical patent/DK609184D0/da
Publication of DK609184A publication Critical patent/DK609184A/da
Publication of DK164055B publication Critical patent/DK164055B/da
Application granted granted Critical
Publication of DK164055C publication Critical patent/DK164055C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/557—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. orotic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK609184A 1983-12-19 1984-12-18 2-thioxo-5-pyrimidincarboxamider, farmaceutisk middel indeholdende disse til at inducere regression af leukaemi og haemning af vaekst af tumorer og fremgangsmaader til deres fremstilling DK164055C (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US56269383A 1983-12-19 1983-12-19
US56269383 1983-12-19
US66520184A 1984-10-26 1984-10-26
US66526784A 1984-10-26 1984-10-26
US66520184 1984-10-26
US66526784 1984-10-26

Publications (4)

Publication Number Publication Date
DK609184D0 DK609184D0 (da) 1984-12-18
DK609184A DK609184A (da) 1985-06-20
DK164055B DK164055B (da) 1992-05-04
DK164055C true DK164055C (da) 1992-09-28

Family

ID=27415896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK609184A DK164055C (da) 1983-12-19 1984-12-18 2-thioxo-5-pyrimidincarboxamider, farmaceutisk middel indeholdende disse til at inducere regression af leukaemi og haemning af vaekst af tumorer og fremgangsmaader til deres fremstilling

Country Status (19)

Country Link
US (1) US4634707A (fr)
JP (1) JPH0660164B2 (fr)
AT (1) AT394194B (fr)
AU (1) AU580746B2 (fr)
BE (1) BE901301A (fr)
CH (1) CH671225A5 (fr)
DE (1) DE3446371A1 (fr)
DK (1) DK164055C (fr)
ES (1) ES8606296A1 (fr)
FR (1) FR2557108B1 (fr)
GB (1) GB2152047B (fr)
GR (1) GR82494B (fr)
IE (1) IE57675B1 (fr)
IL (1) IL73840A (fr)
IT (1) IT1213257B (fr)
LU (1) LU85696A1 (fr)
NL (1) NL8403856A (fr)
NZ (2) NZ210599A (fr)
SE (1) SE469171B (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2145087B (en) * 1983-08-19 1987-02-04 Ciba Geigy Ag Barbituric acid derivatives
EP0167491A3 (fr) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Dérivés d'acide thiobarbiturique
PH24423A (en) * 1985-02-15 1990-06-25 Ciba Geigy Ag 5-(azolyloxyphenylcarbamoyl)barbituric acid derivatives as anthelmintics
US4636508A (en) * 1985-04-22 1987-01-13 Uniroyal Chemical Company, Inc. 5-pyrimidinecarboxyamides and treatment of leukemia therewith
US4845217A (en) * 1985-05-17 1989-07-04 Uniroyal Chemical Ltd./Ltee Purification of 5-pyrimidinecarboxamides
EP0202823A3 (fr) * 1985-05-17 1987-11-19 Uniroyal Limited Purification de 5-pyrimidinecarboxamides
US4880811A (en) * 1987-06-24 1989-11-14 Memorial Hospital For Cancer And Allied Diseases Use of C-5 mono-substituted barbiturates to treat disorders of uric acid metabolism
US4920126A (en) * 1988-05-10 1990-04-24 Uniroyal Chemical Ltd/Uniroyal Chemical Ltee Barbituric acid derivative and treatment of leukemia and tumors therewith
AU7540991A (en) * 1990-03-09 1991-10-10 Memorial Hospital For Cancer And Allied Diseases C-5 mono-substituted barbiturates in combination with therapeutic agents and uses thereof
AU2001257230B2 (en) * 2000-04-24 2006-09-14 Aryx Therapeutics Ultrashort acting hypnotic barbiturates
WO2015123003A1 (fr) * 2014-02-14 2015-08-20 Warrell Raymond P Composés bifonctionnels et leur utilisation pour réduire les taux d'acide urique
US10093658B2 (en) 2015-01-22 2018-10-09 Acquist Llc Bifunctional compounds and use for reducing uric acid levels
TWI771303B (zh) 2016-06-30 2022-07-21 美商艾克奎斯特有限責任公司 化合物及其於降低尿酸位準之用途(一)
WO2018009615A1 (fr) 2016-07-06 2018-01-11 Acquist Llc Composés et utilisation de ces derniers pour réduire les niveaux d'acide urique
IT201700028709A1 (it) * 2017-03-15 2018-09-15 Fondazione St Italiano Tecnologia Acidi-5-carbossamide-2-tiobarbiturici e loro uso come medicamenti

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH602664A5 (en) * 1973-06-14 1978-07-31 Sandoz Ag 2-Tert. amino-alkylamino-pyrimidine derivs.
DE2405732A1 (de) * 1974-02-07 1975-08-21 Bayer Ag Ekto- und endoparasitenmittel
DE2405733C2 (de) * 1974-02-07 1984-12-13 Bayer Ag, 5090 Leverkusen Amidocarbonylthiobarbitursäurederivate und deren Salze, Verfahren zu ihrer Herstellung sowie ihre Verwendung zur Bekämpfung von Insekten, Milben und Pilzen
CH614944A5 (en) * 1974-04-16 1979-12-28 Sandoz Ag Process for the preparation of novel pyrimidine derivatives
PL103086B1 (pl) * 1976-05-06 1979-05-31 Ciba Geigy Ag Srodek owadobojczy
CH616563A5 (en) * 1976-05-06 1980-04-15 Ciba Geigy Ag Pesticide containing a 5-phenylcarbamoylbarbituric acid as active ingredient
DE2624856A1 (de) * 1976-06-03 1977-12-22 Hoechst Ag 2-thiohexahydropyrimidin-4,6-dion-derivate und verfahren zu ihrer herstellung
US4283444A (en) * 1978-09-12 1981-08-11 Ciba-Geigy Corporation Method of protecting keratinous material from attack by insects that feed on keratin by treatment with 5-phenylcarbamoylbarbituric acid compounds
US4349552A (en) * 1978-10-30 1982-09-14 Fujisawa Pharmaceutical Company, Ltd. 5-Fluorouracil derivatives, and their pharmaceutical compositions
EP0010941B1 (fr) * 1978-10-30 1982-05-12 Fujisawa Pharmaceutical Co., Ltd. Dérivés de 5-fluorouracil, leur préparation et leurs compositions pharmaceutiques
CH654720A5 (de) * 1981-09-03 1986-03-14 Ciba Geigy Ag Lagerstabile mottenschutzformulierungen.
US4410524A (en) * 1982-06-01 1983-10-18 American Cyanamid Company Novel 1,4-bis(substituted-amino)-5,8-dihydroxyanthraquinones and leuco bases thereof
EP0105029A3 (fr) * 1982-08-26 1985-05-22 Ciba-Geigy Ag Dérivés de l'acide barbiturique comme anthelmintiques
CH658770A5 (de) * 1982-08-26 1986-12-15 Ciba Geigy Ag Motten- und kaeferschutzmittel.
ZA849819B (en) * 1983-12-19 1985-07-31 Uniroyal Inc 5-pyrimidinecarboxamides and thiocarboxamides and treatment of leukemia and tumors therewith
EP0167491A3 (fr) * 1984-07-06 1986-12-30 Ciba-Geigy Ag Dérivés d'acide thiobarbiturique
JPS641445A (en) 1987-06-22 1989-01-05 Toshiba Corp Manufacture of stator coil

Also Published As

Publication number Publication date
CH671225A5 (fr) 1989-08-15
SE8406450D0 (sv) 1984-12-18
IE57675B1 (en) 1993-02-24
NL8403856A (nl) 1985-07-16
DK609184D0 (da) 1984-12-18
DE3446371A1 (de) 1985-06-27
ES538829A0 (es) 1986-04-16
IL73840A0 (en) 1985-03-31
JPS62174058A (ja) 1987-07-30
DK164055B (da) 1992-05-04
NZ220399A (en) 1987-09-30
IT1213257B (it) 1989-12-14
NZ210599A (en) 1987-09-30
ATA402684A (de) 1991-08-15
US4634707A (en) 1987-01-06
IT8424104A0 (it) 1984-12-18
GB2152047B (en) 1988-04-27
SE469171B (sv) 1993-05-24
IE843237L (en) 1985-06-19
BE901301A (fr) 1985-06-18
DE3446371C2 (fr) 1990-08-16
IL73840A (en) 1988-11-15
SE8406450L (sv) 1985-06-20
JPH0660164B2 (ja) 1994-08-10
GB2152047A (en) 1985-07-31
AU580746B2 (en) 1989-02-02
AU3690884A (en) 1985-07-04
LU85696A1 (fr) 1985-09-12
GR82494B (en) 1985-04-19
GB8432112D0 (en) 1985-01-30
AT394194B (de) 1992-02-10
FR2557108A1 (fr) 1985-06-28
ES8606296A1 (es) 1986-04-16
FR2557108B1 (fr) 1988-11-18
DK609184A (da) 1985-06-20

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PBP Patent lapsed