AU4978690A - 2-amino-7-hydroxytetralin carboxyalkyl ethers - Google Patents

2-amino-7-hydroxytetralin carboxyalkyl ethers

Info

Publication number
AU4978690A
AU4978690A AU49786/90A AU4978690A AU4978690A AU 4978690 A AU4978690 A AU 4978690A AU 49786/90 A AU49786/90 A AU 49786/90A AU 4978690 A AU4978690 A AU 4978690A AU 4978690 A AU4978690 A AU 4978690A
Authority
AU
Australia
Prior art keywords
amino
carboxyalkyl ethers
hydroxytetralin
phenylethanolaminotetralins
xii
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU49786/90A
Other versions
AU642402B2 (en
Inventor
Roberto Cecchi
Umberto Guzzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Sanofi Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Synthelabo SA filed Critical Sanofi Synthelabo SA
Publication of AU4978690A publication Critical patent/AU4978690A/en
Application granted granted Critical
Publication of AU642402B2 publication Critical patent/AU642402B2/en
Assigned to SANOFI-SYNTHELABO reassignment SANOFI-SYNTHELABO Request to Amend Deed and Register Assignors: SANOFI
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

The invention relates to 2-amino-7-hydroxytetralin carboxyalkyl ethers of formula <IMAGE> in which Alk represents a straight- or branched-chain alkylene group having 3 to 5 carbon atoms and R is hydrogen or a C1-C4 alkyl group, which are useful as starting materials in the synthesis of 7-substituted phenylethanolaminotetralins of formula (XII) <IMAGE> in which X represents hydrogen, halogen or a C1-C4 alkyl or trifluoromethyl group, having spasmolytic activity. The new 7-substituted phenylethanolaminotetralins (XII) as well as the intermediates in the preparation of the compounds (I), the N-protected 2-amino-7-hydroxytetralin carboxyalkyl ethers, are also claimed.
AU49786/90A 1989-02-14 1990-02-14 2-amino-7-hydroxytetralin carboxyalkyl ethers Ceased AU642402B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR8901910 1989-02-14
FR8901910A FR2643076B1 (en) 1989-02-14 1989-02-14 CARBOXYALKYL-ETHERS OF 2-AMINO-7-HYDROXYTETRALINE

Publications (2)

Publication Number Publication Date
AU4978690A true AU4978690A (en) 1990-08-23
AU642402B2 AU642402B2 (en) 1993-10-21

Family

ID=9378776

Family Applications (1)

Application Number Title Priority Date Filing Date
AU49786/90A Ceased AU642402B2 (en) 1989-02-14 1990-02-14 2-amino-7-hydroxytetralin carboxyalkyl ethers

Country Status (13)

Country Link
EP (1) EP0383686B1 (en)
JP (1) JP2852681B2 (en)
AT (1) ATE92470T1 (en)
AU (1) AU642402B2 (en)
CA (1) CA2009992A1 (en)
DE (1) DE69002474T2 (en)
DK (1) DK0383686T3 (en)
ES (1) ES2060079T3 (en)
FR (1) FR2643076B1 (en)
IE (1) IE61811B1 (en)
NZ (1) NZ232543A (en)
PT (1) PT93126B (en)
ZA (1) ZA901121B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2669821A1 (en) * 1990-12-04 1992-06-05 Sanofi Sa USE OF PHENYLETHANOLAMINOTETRALINES FOR THE PREPARATION OF MEDICAMENTS FOR THE TREATMENT OF LOW PRESSURE.
EP0499755A1 (en) * 1991-02-18 1992-08-26 MIDY S.p.A. Phenylethanolaminotetralines, process for their preparation, intermediates of this process and pharmaceutical compositions containing them
GB9107827D0 (en) * 1991-04-12 1991-05-29 Fujisawa Pharmaceutical Co New ethanolamine derivatives,processes for the preparation thereof and pharmaceutical composition comprising the same
ATE215365T1 (en) * 1992-01-22 2002-04-15 Glaxo Group Ltd MEDICAL USE OF ATYPICAL BETA-ADRENOCEPTOR AGONISTS
IL104567A (en) * 1992-02-03 1997-03-18 Fujisawa Pharmaceutical Co Ethanolamine derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
JP3909864B2 (en) * 1995-07-26 2007-04-25 小野薬品工業株式会社 Naphthyloxyacetic acid derivatives and drugs containing them as active ingredients
WO1997015549A1 (en) * 1995-10-26 1997-05-01 Tokyo Tanabe Company Limited PHENYLETHANOLAMINE COMPOUNDS USEFUL AS β3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME
JP3708624B2 (en) * 1996-03-27 2005-10-19 キッセイ薬品工業株式会社 3,4-disubstituted phenylethanolaminotetralin carboxylic acid derivative
AUPO565997A0 (en) * 1997-03-17 1997-04-10 Fujisawa Pharmaceutical Co., Ltd. Propanolamine derivatives
FR2826651B1 (en) * 2001-06-28 2005-09-02 Sanofi Synthelabo CRYSTALLINE FORM OF PHENYLETHANOLAMINE, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
JP2007503362A (en) * 2003-08-25 2007-02-22 シモネク，ミロスラフ Wrapping paper for chewing gum after chewing

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL79323A (en) * 1985-07-10 1990-03-19 Sanofi Sa Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
DE3623941A1 (en) * 1986-07-16 1988-01-28 Bayer Ag SUBSTITUTED AMINO-5,6,7,8-TETRAHYDRONAPHTHYL OXYACETIC ACIDS, METHOD FOR THE PRODUCTION THEREOF AND THE USE AS A MEDICINAL PRODUCT

Also Published As

Publication number Publication date
PT93126A (en) 1990-08-31
IE61811B1 (en) 1994-11-30
JPH0314548A (en) 1991-01-23
NZ232543A (en) 1992-07-28
IE900509L (en) 1990-08-14
EP0383686B1 (en) 1993-08-04
EP0383686A1 (en) 1990-08-22
ATE92470T1 (en) 1993-08-15
AU642402B2 (en) 1993-10-21
DE69002474T2 (en) 1994-03-10
FR2643076A1 (en) 1990-08-17
CA2009992A1 (en) 1990-08-14
DK0383686T3 (en) 1993-12-20
ES2060079T3 (en) 1994-11-16
PT93126B (en) 1995-12-29
FR2643076B1 (en) 1991-06-21
ZA901121B (en) 1990-11-28
JP2852681B2 (en) 1999-02-03
DE69002474D1 (en) 1993-09-09

Similar Documents

Publication Publication Date Title
AU585452B2 (en) Oxiranes
ES8503667A1 (en) 2-Oxo-imidazolidine compounds, a process for preparing the same and a pharmaceutical composition.
IE820401L (en) N-£4-(indolyl)-piperidino-alkyl|-benzimidazolines
AU4978690A (en) 2-amino-7-hydroxytetralin carboxyalkyl ethers
ES8505518A1 (en) Amino-acids derivatives, process for their preparation and their use.
AU565745B2 (en) Imidazo(1,2-c)pyrimidines
AU7156487A (en) 1,5-benzothiazepine derivatives, their preparation and compositions containing them
ES8607967A1 (en) Thiazolylacetic acid derivatives and their preparation.
ES8707530A1 (en) Octahydroindolizine compounds useful as analgesics.
DE3564426D1 (en) Polyprenyl compound, process of producing it and pharmaceutical use
ES2023760A6 (en) Benzothiazine derivatives, their preparation and their uses as medicines or as intermediates for the synthesis of medicines.
GR3006223T3 (en)
ES8607944A1 (en) Derivatives of 1-phenylimidazolidin-2-one, their preparation and their application.
ES8602620A1 (en) Omega- not (2-hydroxy-4-phenyl)methylene-amino -phenyl-alkanecarboxylic acids, their preparation and therapeutical use

Legal Events

Date Code Title Description
HB Alteration of name in register

Free format text: SANOFI-SYNTHELABO

MK14 Patent ceased section 143(a) (annual fees not paid) or expired