ES8202555A1 - Un procedimiento para la preparacion de nuevas s- triazolo 4,3-b piridazinas 3,6,7,8- sustituidas. - Google Patents

Un procedimiento para la preparacion de nuevas s- triazolo 4,3-b piridazinas 3,6,7,8- sustituidas.

Info

Publication number
ES8202555A1
ES8202555A1 ES496354A ES496354A ES8202555A1 ES 8202555 A1 ES8202555 A1 ES 8202555A1 ES 496354 A ES496354 A ES 496354A ES 496354 A ES496354 A ES 496354A ES 8202555 A1 ES8202555 A1 ES 8202555A1
Authority
ES
Spain
Prior art keywords
substituted
loweralkyl
triazolo
reacting
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES496354A
Other languages
English (en)
Other versions
ES496354A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dow Chemical Co
Original Assignee
Dow Chemical Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dow Chemical Co filed Critical Dow Chemical Co
Publication of ES8202555A1 publication Critical patent/ES8202555A1/es
Publication of ES496354A0 publication Critical patent/ES496354A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCESO PARA LA PREPARACION DE S-TRIAZOLO 4,3-B PIRIDAZINAS 3,6,7,8 -ISUSTITUIDAS, DE FORMULA (I), DONDE R3 REPRESENTA HIDROGENO O ALQUILO INFERIOR; R9 REPRESENTA AMINO, ALQUILAMINO INFERIOR O DIALQUILAMINO INFERIOR; R7 SIGNIFICA ALQUILO INFERIOR; Y R3 REPRESENTA HIDROGENO O ALQUILO INFERIOR. CONSISTE EN HACER REACCIONAR UNA PIRIDAZINA 3,6 -DIHALO -4,5 -SUSTITUIDA, DE FORMULA (II), DONDE R7 Y R8 TIENEN LOS SIGNIFICADOS INDICADOS ANTERIORMENTE; Y X ES HALO, CON UNA AMINA CORRESPONDIENTE AL RADICAL R6 DEFINIDO ANTERIORMENTE, EN UN DISOLVENTE INERTE Y EN PRESENCIA DE UN EXCESO DE UNA AMINA NO NOCLEOFILA, PARA TOMAR UNA 3 -HALOPIRIDAZINA QUE SE HACE REACCIONAR A CONTINUACION CON UN COMPUESTO R3CO-NHNH2, DONDE R3 TIENE EL SIGNIFICADO YA INDICADO.
ES496354A 1979-10-29 1980-10-28 Un procedimiento para la preparacion de nuevas s- triazolo 4,3-b piridazinas 3,6,7,8- sustituidas. Granted ES496354A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US8907179A 1979-10-29 1979-10-29

Publications (2)

Publication Number Publication Date
ES8202555A1 true ES8202555A1 (es) 1982-02-01
ES496354A0 ES496354A0 (es) 1982-02-01

Family

ID=22215530

Family Applications (2)

Application Number Title Priority Date Filing Date
ES496354A Granted ES496354A0 (es) 1979-10-29 1980-10-28 Un procedimiento para la preparacion de nuevas s- triazolo 4,3-b piridazinas 3,6,7,8- sustituidas.
ES506946A Expired ES8207178A1 (es) 1979-10-29 1981-11-06 Un procedimiento para la preparacion de nuevas s-triazolo 4,3-b piridazinas 3,6,7,8-sustituidas.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES506946A Expired ES8207178A1 (es) 1979-10-29 1981-11-06 Un procedimiento para la preparacion de nuevas s-triazolo 4,3-b piridazinas 3,6,7,8-sustituidas.

Country Status (18)

Country Link
EP (1) EP0029130B1 (es)
JP (1) JPS5679690A (es)
KR (1) KR850001701B1 (es)
AR (2) AR227651A1 (es)
AT (1) ATE16808T1 (es)
AU (1) AU536351B2 (es)
CA (1) CA1144544A (es)
DE (1) DE3071278D1 (es)
DK (1) DK158353C (es)
ES (2) ES496354A0 (es)
FI (1) FI70413C (es)
GB (1) GB2061275B (es)
GR (1) GR70309B (es)
IL (1) IL61316A (es)
NO (1) NO156011C (es)
NZ (1) NZ195355A (es)
PT (1) PT71952B (es)
ZA (1) ZA806523B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH21834A (en) * 1982-01-18 1988-03-17 Lepetit Spa New 6-substituted-s-triazolo(3,4-a)phthalazine derivatives
US4485106A (en) * 1982-07-12 1984-11-27 The Dow Chemical Company Substituted tetrahydrotetrazolo[5,1-a]phthalazines
US4487930A (en) * 1982-09-07 1984-12-11 The Dow Chemical Company 6-[(Cyclic amino)alkylamino]-tetrahydrotriazolo[3,4-a]phthalazines
IT1194310B (it) * 1983-07-12 1988-09-14 Lepetit Spa Derivati triazolo (3,4-a) ftalazinici 3,6-disostituiti
US4578464A (en) * 1983-11-22 1986-03-25 Merrell Dow Pharmaceuticals Inc. 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
US5011835A (en) * 1990-02-07 1991-04-30 Merrell Dow Pharmaceuticals Inc. Substituted triazolopyridazines, pharmaceutical compositions and use
US9682991B2 (en) 2009-12-31 2017-06-20 Fundación Centro Nacional De Investigaciones Oncologicas Carlos Iii Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
CN103694244B (zh) * 2014-01-09 2016-03-30 郑州大学 3,6位取代-1,2,4-三氮唑并[3,4-a]酞嗪类化合物及其制备和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3708484A (en) * 1970-10-16 1973-01-02 Sandoz Ag Amino and substituted amino-s-triazolo-(4,3-b)-pyridazines
US3915968A (en) * 1973-09-21 1975-10-28 Lepetit Spa Triazolopyridazines
DE2418435A1 (de) * 1974-04-17 1975-10-30 Boehringer Mannheim Gmbh Nitroimidazolyl-triazolo-pyridazine und verfahren zu ihrer herstellung
US4136182A (en) * 1976-05-26 1979-01-23 The Dow Chemical Company Triazolopyridazines used to alleviate bronchial spasms
CA1080712A (en) * 1976-09-22 1980-07-01 Jay D. Albright Hypotensive agents

Also Published As

Publication number Publication date
GR70309B (es) 1982-09-08
ZA806523B (en) 1982-05-26
GB2061275B (en) 1983-08-10
ES506946A0 (es) 1982-09-01
EP0029130A1 (en) 1981-05-27
PT71952A (en) 1980-11-01
DK158353B (da) 1990-05-07
JPH0248558B2 (es) 1990-10-25
KR850001701B1 (ko) 1985-11-26
FI70413B (fi) 1986-03-27
KR830004301A (ko) 1983-07-09
PT71952B (en) 1982-03-31
FI803355L (fi) 1981-04-30
NO803218L (no) 1981-04-30
AR227651A1 (es) 1982-11-30
ES8207178A1 (es) 1982-09-01
CA1144544A (en) 1983-04-12
DK158353C (da) 1990-10-01
AR227087A1 (es) 1982-09-15
NO156011B (no) 1987-03-30
AU536351B2 (en) 1984-05-03
AU6356180A (en) 1981-05-07
FI70413C (fi) 1986-09-19
DK457480A (da) 1981-04-30
ES496354A0 (es) 1982-02-01
NZ195355A (en) 1984-09-28
JPS5679690A (en) 1981-06-30
IL61316A (en) 1984-03-30
EP0029130B1 (en) 1985-12-04
IL61316A0 (en) 1980-12-31
DE3071278D1 (en) 1986-01-16
GB2061275A (en) 1981-05-13
ATE16808T1 (de) 1985-12-15
NO156011C (no) 1987-07-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970401