ES2055077T3 - Un procedimiento para preparar derivados de amida de acido carboxilico. - Google Patents

Un procedimiento para preparar derivados de amida de acido carboxilico.

Info

Publication number
ES2055077T3
ES2055077T3 ES89308639T ES89308639T ES2055077T3 ES 2055077 T3 ES2055077 T3 ES 2055077T3 ES 89308639 T ES89308639 T ES 89308639T ES 89308639 T ES89308639 T ES 89308639T ES 2055077 T3 ES2055077 T3 ES 2055077T3
Authority
ES
Spain
Prior art keywords
alkyl
group
hydrogen
procedure
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89308639T
Other languages
English (en)
Inventor
Atsusuke Terada
Yoshio Iizuka
Kazuyuki Wachi
Kenji Fujibayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Application granted granted Critical
Publication of ES2055077T3 publication Critical patent/ES2055077T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/12—1,4-Thiazines; Hydrogenated 1,4-thiazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

COMPUESTOS ANALGESICOS SON DE FORMULA GENERAL (I), DONDE R1 Y R2 CADA UNO ES H O ALQUILO C1-C6, O R1 Y R2 JUNTO CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO; E ES METILENO, AZUFRE, OXIGENO O GRUPO IMINO, OPCIONALMENTE SUSTITUIDO CON ALQUILO C1-C6 A ARALQUILO; EL ANILLO A ES ANILLO HETEROARILO, OPCIONALMENTE SUSTITUIDO; R3 ES H O ALQUILO C1-C6; Y R4 ES H; O R3 Y R4 JUNTOS REPRESENTAN UN GRUPO DE FORMULA (IV), DONDE RA ES ALQUILO C1-C6 O H, HASTA UN MAXIMO DE 3 GRUPOS ALQUILO; M ES 1, 2 O 3; E Y ES DOS HIDROGENOS U OXIGENO; PREVIENDO QUE, CUANDO E REPRESENTA UN GRUPO METILENO, ENTONCES R3 ES UN GRUPO ALQUILO C1-C6, O R3 Y R4 JUNTOS REPRESENTAN UN GRUPO DE FORMULA (IV).
ES89308639T 1988-08-24 1989-08-24 Un procedimiento para preparar derivados de amida de acido carboxilico. Expired - Lifetime ES2055077T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP21007488 1988-08-24

Publications (1)

Publication Number Publication Date
ES2055077T3 true ES2055077T3 (es) 1994-08-16

Family

ID=16583388

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89308639T Expired - Lifetime ES2055077T3 (es) 1988-08-24 1989-08-24 Un procedimiento para preparar derivados de amida de acido carboxilico.

Country Status (10)

Country Link
US (1) US5021413B1 (es)
EP (1) EP0356247B1 (es)
KR (2) KR0145704B1 (es)
CN (4) CN1022185C (es)
AT (1) ATE86991T1 (es)
CA (1) CA1340541C (es)
DE (1) DE68905407T2 (es)
ES (1) ES2055077T3 (es)
HU (1) HU211471A9 (es)
IE (1) IE63873B1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5428042A (en) * 1990-04-28 1995-06-27 Dr Lo Zambeletti S.P.A. 1-(2H-1-oxo-3,4-dihydronaphtyl-6-yl)-acetyl-piperidines as kappa agonists
GB9011656D0 (en) * 1990-05-24 1990-07-11 Zambeletti Spa L Novel compounds
JPH06122677A (ja) * 1992-08-28 1994-05-06 Sankyo Co Ltd 光学活性なカルボン酸アミド誘導体
CN1054379C (zh) * 1994-01-31 2000-07-12 三共株式会社 止痛化合物,它们的制备及其应用
IT1273751B (it) * 1994-02-11 1997-07-10 Smithkline Beecham Farma Derivati azaciclici
RU2157210C2 (ru) * 1995-12-28 2000-10-10 Проктер энд Гэмбл Компани Замещенные 6h-1,3,4-тиадиазин-2-амины, их применение в качестве анестезирующих, сердечно-сосудистых и гипометаболических средств и содержащие их фармацевтические композиции
US6028068A (en) * 1995-12-28 2000-02-22 The Procter & Gamble Company Substituted 6H-1,3,4-thiadiazine-2-amines, the use thereof as anaesthetising, cardiovascular and hypometabolic agents, and a pharmaceutical composition containing them
DE69523640T2 (de) * 1995-12-28 2002-11-21 Nauchno-Tekhnologicheskoe Predpriyatie "Ligand" (Obschestvo S Ogranichennoi Otvetstvennostju), Ekaterinburg Substituierte 6-r-1,3,4-thiadiazin-2-amine, deren verwendung als anaesthetische, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung
DE69525548T2 (de) 1995-12-28 2002-10-31 Nauchno-Tekhnologicheskoe Predpriyatie "Ligand" (Obschestvo S Ogranichennoi Otvetstvennostju), Ekaterinburg Substituierte 6-h-1,3,4,-thiadiazin-2-amine, deren verwendung als anaesthetisierende, cardiovaskulare und hypometabolische mittel, und eine sie enthaltende pharmazeutische zubereitung
US5763445A (en) 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US6303611B1 (en) * 1996-03-08 2001-10-16 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US6239154B1 (en) 1996-03-08 2001-05-29 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5834487A (en) * 1996-09-24 1998-11-10 Cv Therapeutics Inhibition of 26S and 20S proteasome by indanones
KR100557801B1 (ko) * 1996-11-25 2006-04-21 도레이 가부시끼가이샤 소양증치료제
US5760023A (en) * 1997-07-14 1998-06-02 Adolor Corporation Kappa agonist anti-pruritic pharmaceutical formulations and method of treating pruritus therewith
IL132363A (en) * 1997-07-14 2004-02-19 Adolor Corp Capa agonist compounds for use in the prevention or treatment of itching and antipruritic pharmaceutical preparations containing them
WO2025067475A1 (zh) * 2023-09-28 2025-04-03 四川大学华西医院 一类镇痛的化合物及其制备方法和用途

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3917617A (en) * 1973-10-01 1975-11-04 Sharps Ass 1-{8 2,6-Dihydroxy-4-hydrocarbyl-benzoyl{9 polymethyleneimines and derivatives
US4339576A (en) * 1980-11-19 1982-07-13 Sterling Drug Inc. Anti-asthmatic, anti-allergic, anti-cholinergic, bronchodilator and anti-inflammatory 1-[(benzoylphenyl)-lower-alkyl]piperidines and analogs thereof
DE3670080D1 (de) * 1985-12-23 1990-05-10 Zambeletti Spa L Azacyclische verbindungen, verfahren zur ihrer herstellung und ihre verwendung als pharmazeutika.
EP0240233B1 (en) * 1986-03-29 1991-01-23 Suntory Limited Derivatives of benzoquinonyl-phenyl alkanoic acid amide
EP0260041B1 (en) * 1986-09-02 1991-01-30 Dr. Lo. Zambeletti S.p.A. 1-acyl-substituted piperidine derivatives

Also Published As

Publication number Publication date
CA1340541C (en) 1999-05-11
CN1022185C (zh) 1993-09-22
CN1079740A (zh) 1993-12-22
HU211471A9 (en) 1995-11-28
IE63873B1 (en) 1995-06-14
HK1003002A1 (en) 1998-09-30
ATE86991T1 (de) 1993-04-15
KR900003156A (ko) 1990-03-23
CN1040791A (zh) 1990-03-28
CN1079741A (zh) 1993-12-22
EP0356247B1 (en) 1993-03-17
CN1078461A (zh) 1993-11-17
KR0182220B1 (ko) 1999-10-01
KR0145704B1 (ko) 1998-08-17
EP0356247A1 (en) 1990-02-28
IE892710L (en) 1990-02-24
CN1034731C (zh) 1997-04-30
DE68905407D1 (de) 1993-04-22
US5021413A (en) 1991-06-04
CN1030450C (zh) 1995-12-06
DE68905407T2 (de) 1993-09-23
US5021413B1 (en) 1994-12-13
CN1036004C (zh) 1997-10-01

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