ATE283259T1 - 1,4-substituierte cyclische aminderivate - Google Patents
1,4-substituierte cyclische aminderivateInfo
- Publication number
- ATE283259T1 ATE283259T1 AT98911137T AT98911137T ATE283259T1 AT E283259 T1 ATE283259 T1 AT E283259T1 AT 98911137 T AT98911137 T AT 98911137T AT 98911137 T AT98911137 T AT 98911137T AT E283259 T1 ATE283259 T1 AT E283259T1
- Authority
- AT
- Austria
- Prior art keywords
- integer
- cyclic amine
- substituted cyclic
- amine derivatives
- represent
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 206010061533 Myotonia Diseases 0.000 abstract 1
- 206010041415 Spastic paralysis Diseases 0.000 abstract 1
- 230000008485 antagonism Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- -1 cyclic amine Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000001434 methanylylidene group Chemical group [H]C#[*] 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/26—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP9843397 | 1997-03-31 | ||
| JP36676497 | 1997-12-26 | ||
| PCT/JP1998/001481 WO1998043956A1 (en) | 1997-03-31 | 1998-03-31 | 1,4-substituted cyclic amine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE283259T1 true ATE283259T1 (de) | 2004-12-15 |
Family
ID=26439605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98911137T ATE283259T1 (de) | 1997-03-31 | 1998-03-31 | 1,4-substituierte cyclische aminderivate |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US6448243B1 (de) |
| EP (1) | EP0976732B1 (de) |
| CN (1) | CN1204121C (de) |
| AT (1) | ATE283259T1 (de) |
| AU (1) | AU748038B2 (de) |
| CA (1) | CA2280753C (de) |
| DE (1) | DE69827785T2 (de) |
| ES (1) | ES2230681T3 (de) |
| HU (1) | HUP0000434A3 (de) |
| NO (1) | NO314543B1 (de) |
| NZ (1) | NZ337651A (de) |
| RU (1) | RU2203275C2 (de) |
| TW (1) | TWI242011B (de) |
| WO (1) | WO1998043956A1 (de) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6123699A (en) * | 1998-10-16 | 2000-05-08 | Takeda Chemical Industries Ltd. | Nitrogenous fused heterocycle compounds, process for the preparation thereof andagents containing the same |
| CN1148188C (zh) * | 1998-10-19 | 2004-05-05 | 卫材株式会社 | 镇痛剂 |
| CA2348530A1 (en) * | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
| CA2348734A1 (en) * | 1998-10-30 | 2000-05-11 | Merck & Co., Inc. | Thrombin inhibitors |
| JP4011819B2 (ja) * | 1999-04-12 | 2007-11-21 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | インドール誘導体の製造法およびその中間体 |
| CA2378047A1 (en) * | 1999-07-15 | 2001-01-25 | Methvin Isaac | Heterocyclic compounds for the treatment of migraine |
| DE19952146A1 (de) * | 1999-10-29 | 2001-06-07 | Boehringer Ingelheim Pharma | Arylalkane, Arylalkene und Aryl-azaalkane, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| MXPA02007036A (es) | 2000-01-20 | 2002-12-13 | Eisai Co Ltd | Compuesto de piperidina novedoso y composicion farmaceutica del mismo. |
| US6693099B2 (en) * | 2000-10-17 | 2004-02-17 | The Procter & Gamble Company | Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance |
| US6376514B1 (en) * | 2000-10-17 | 2002-04-23 | The Procter & Gamble Co. | Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof |
| PT1379246E (pt) * | 2001-04-18 | 2009-01-14 | Euro Celtique Sa | Análogos de nociceptina |
| US7812035B2 (en) * | 2001-12-11 | 2010-10-12 | Sepracor Inc. | 4-substituted piperidines, and methods of use thereof |
| AU2002364590A1 (en) * | 2001-12-21 | 2003-07-30 | Eisai Co., Ltd. | Hydroxylated indole derivatives and uses thereof |
| GB0203811D0 (en) * | 2002-02-18 | 2002-04-03 | Glaxo Group Ltd | Compounds |
| US7153849B2 (en) * | 2002-09-12 | 2006-12-26 | Wyeth | Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans |
| US6939877B2 (en) * | 2002-09-12 | 2005-09-06 | Wyeth | Antidepressant piperidine derivatives of heterocycle-fused benzodioxans |
| GB0224830D0 (en) * | 2002-10-24 | 2002-12-04 | Sterix Ltd | Compound |
| CA2501228A1 (en) * | 2002-10-24 | 2004-05-06 | Sterix Limited | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2 |
| ES2222830B1 (es) | 2003-07-30 | 2006-02-16 | Laboratorios Del Dr. Esteve, S.A. | Derivados de 7-indolilsulfonamidas, su preparacion y su aplicacion como medicamentos. |
| CA2543089A1 (en) * | 2003-10-22 | 2005-05-12 | Georgetown University | Dopamine-, norepinephrine- and serotonin- transporter- selective heterocyclic compounds and their therapeutic applications |
| JP2007536302A (ja) * | 2004-05-05 | 2007-12-13 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ６受容体、５−ｈｔ２ａ受容体、又はその両方の調節に有用なアリールスルホニルベンゾジオキサン類 |
| TWI391387B (zh) * | 2004-05-12 | 2013-04-01 | Eisai R&D Man Co Ltd | 具有哌啶環之吲哚衍生物 |
| ES2317244T3 (es) | 2004-06-09 | 2009-04-16 | Glaxo Group Limited | Derivados de pirrolopiridina. |
| EP1831203A1 (de) | 2004-12-21 | 2007-09-12 | F. Hoffmann-Roche AG | Chromanderivate und deren anwendungen bei der behandlung von zns-erkrankungen |
| RU2388748C2 (ru) * | 2004-12-21 | 2010-05-10 | Ф. Хоффманн-Ля Рош Аг | Производные тетралина и индана и их применения в качестве антагонистов 5-нт |
| CN101124212A (zh) * | 2004-12-21 | 2008-02-13 | 弗·哈夫曼-拉罗切有限公司 | 色满衍生物及其作为5-ht受体配体的用途 |
| SI1831159T1 (sl) * | 2004-12-21 | 2010-04-30 | Hoffmann La Roche | Derivati tetralina in indana ter njune uporabe |
| MX2007007481A (es) * | 2004-12-21 | 2007-07-20 | Hoffmann La Roche | Derivados de tetralina e indano y usos de los mismos. |
| EP1676841A1 (de) * | 2004-12-30 | 2006-07-05 | Esteve Laboratorios Dr. Esteve S.A. | Substituierte Indazolsulfonamid- und 2,3-Dihydroindolyl-Sulfonamidverbindungen, deren Herstellung und Verwendung in Medikamenten |
| WO2006082872A1 (ja) * | 2005-02-04 | 2006-08-10 | Eisai R & D Management Co., Ltd. | １－（ピペリジン－４－イル）－１ｈ－インドール誘導体 |
| FR2884251B1 (fr) * | 2005-04-08 | 2007-07-13 | Servier Lab | Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2006244916B2 (en) * | 2005-05-11 | 2011-04-07 | Eisai R & D Management Co., Ltd. | Method for producing indole derivative having piperidine ring |
| JPWO2006121104A1 (ja) * | 2005-05-11 | 2008-12-18 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピペリジン環を有するインドール誘導体の結晶およびその製法 |
| KR20080007649A (ko) * | 2005-05-11 | 2008-01-22 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 피페리딘환을 가지는 인돌 유도체의 결정 및 그의 제조방법 |
| CN101175751B (zh) * | 2005-05-11 | 2011-03-23 | 卫材R&D管理有限公司 | 具有哌啶环的吲哚衍生物的晶体和其制备方法 |
| JP4932717B2 (ja) * | 2005-05-11 | 2012-05-16 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | ピペリジン環を有するインドール誘導体の製造方法 |
| EP1916239A4 (de) | 2005-08-10 | 2009-10-21 | Banyu Pharma Co Ltd | Pyridolverbindung |
| AU2005339865B2 (en) | 2005-09-23 | 2011-09-08 | M's Science Corporation | Piperidine and piperazine derivatives |
| DE602006020351D1 (en) * | 2005-11-03 | 2011-04-07 | Hoffmann La Roche | Arylsulfonylchromane als 5-ht6-inhibitoren |
| AU2006311101A1 (en) * | 2005-11-11 | 2007-05-18 | F. Hoffmann-La Roche Ag | Carbocyclic fused cyclic amines as inhibitors of the coagulation factor Xa |
| EP2340835A1 (de) | 2006-01-27 | 2011-07-06 | M's Science Corporation | Piperidin- und Piperazinderivate |
| US7541371B2 (en) | 2006-02-20 | 2009-06-02 | Eisai R&D Management Co., Ltd. | Method for treating a motor neuron disease |
| JP2008169191A (ja) * | 2006-02-20 | 2008-07-24 | Eisai R & D Management Co Ltd | 運動ニューロン疾患治療剤 |
| AU2007263076A1 (en) * | 2006-06-20 | 2007-12-27 | F. Hoffmann-La Roche Ag | Arylsulfonyl naphthalene derivatives and uses thereof |
| BRPI0713502A2 (pt) * | 2006-06-20 | 2012-03-13 | F. Hoffmann-La Roche Ag | derivados de tetralina de arilsulfonamidil e empregos destes |
| EP2035370A2 (de) * | 2006-06-20 | 2009-03-18 | F. Hoffmann-Roche AG | Tetralin- und indanderivate und ihre verwendung |
| WO2008126886A1 (ja) * | 2007-04-12 | 2008-10-23 | Taisho Pharmaceutical Co., Ltd. | インドール又はインドリン誘導体 |
| US20100168114A1 (en) * | 2007-06-18 | 2010-07-01 | Yuan-Ping Pang | Invertebrate acetylcholinesterase inhibitors |
| EP2011786A1 (de) * | 2007-07-05 | 2009-01-07 | Laboratorios del Dr. Esteve S.A. | Indanamin-Derivate, ihre Herstellung und Verwendung als Arzneimittel |
| GB0715048D0 (en) * | 2007-08-02 | 2007-09-12 | Glaxo Group Ltd | Novel compounds |
| US20090306163A1 (en) * | 2008-06-10 | 2009-12-10 | Pamela Renee Lipkin | Topical compositions comprising imidazolidinedione analogs and their use to treat or prevent the appearance of skin wrinkling |
| JP5536781B2 (ja) * | 2008-09-17 | 2014-07-02 | スヴェン・ライフ・サイエンシズ・リミテッド | アリールスルホンアミドアミン化合物および５−ｈｔ６リガンドとしてのそれらの使用 |
| MX2011008857A (es) * | 2009-02-27 | 2011-09-30 | Raqualia Pharma Inc | Derivados de oxiindol con actividad agonistica del receptor de motilina. |
| CN103209704B (zh) * | 2010-04-22 | 2017-10-27 | 细胞内治疗公司 | 有机化合物 |
| DE102010028362A1 (de) * | 2010-04-29 | 2011-11-03 | Bayer Schering Pharma Aktiengesellschaft | Herstellverfahren |
| EA022046B1 (ru) | 2010-07-14 | 2015-10-30 | Новартис Аг | Гетероциклические соединения, агонисты рецептора ip |
| PL392436A1 (pl) * | 2010-09-17 | 2012-03-26 | Adamed Spółka Z Ograniczoną Odpowiedzialnością | Pochodne arylosulfonamidów do leczenia chorób odśrodkowego układu nerwowego |
| PL395470A1 (pl) | 2011-06-29 | 2013-01-07 | Adamed Spólka Z Ograniczona Odpowiedzialnoscia | Sulfonamidowe pochodne amin alicyklicznych do leczenia chorób osrodkowego ukladu nerwowego |
| CN104053659B (zh) | 2012-01-13 | 2016-11-09 | 诺华股份有限公司 | 用于治疗肺动脉高压(pah)及相关病症的作为ip 受体激动剂的稠合的吡咯类 |
| ES2727815T3 (es) | 2012-04-14 | 2019-10-18 | Intra Cellular Therapies Inc | Tratamiento del TEPT y de trastornos del control de impulsos |
| WO2014102588A2 (en) * | 2012-12-27 | 2014-07-03 | Purdue Pharma L.P. | Indole and indoline-type piperidine compounds and uses thereof |
| WO2014125413A1 (en) | 2013-02-13 | 2014-08-21 | Novartis Ag | Ip receptor agonist heterocyclic compounds |
| DK2968320T3 (da) | 2013-03-15 | 2021-02-01 | Intra Cellular Therapies Inc | Organiske forbindelser |
| KR102692169B1 (ko) | 2013-12-03 | 2024-08-05 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
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| GB8800795D0 (en) * | 1988-01-14 | 1988-02-17 | Fujisawa Pharmaceutical Co | New indolylpiperidine compounds processes for preparations thereof & pharmaceutical composition comprising same |
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| DK181190D0 (da) * | 1990-07-30 | 1990-07-30 | Lundbeck & Co As H | 3-aryl-indol- eller 3-aryl-indazolderivater |
| DK286990D0 (da) | 1990-12-04 | 1990-12-04 | Lundbeck & Co As H | Indanderivater |
| US5206366A (en) * | 1992-08-26 | 1993-04-27 | Pfizer Inc. | Process for preparing aryl piperazinyl-heterocyclic compounds |
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| IL114026A (en) * | 1994-06-08 | 1999-06-20 | Lundbeck & Co As H | 4-aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzo thiophenemethyl) piperidines tetrahydropyridines or piperazines and pharmaceutical compositions containing them |
| TW421649B (en) * | 1995-01-31 | 2001-02-11 | Janssen Pharmaceutica Nv | 4-(1H-indol-1yl)-1-piperidinyl derivatives |
| FR2737724B1 (fr) * | 1995-08-09 | 1997-09-05 | Synthelabo | Derives de 1-[2-(2,3-dihydro-1h-inden-1-yl)ethyl]-4- (naphtalen-1-yl) piperazine, leur preparation et leur application en therapeutique |
| US5883252A (en) * | 1996-01-26 | 1999-03-16 | Vertex Pharmaceuticals Incorporated | Aspartyl protease inhibitors |
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-
1998
- 1998-03-30 TW TW087104733A patent/TWI242011B/zh not_active IP Right Cessation
- 1998-03-31 HU HU0000434A patent/HUP0000434A3/hu unknown
- 1998-03-31 CN CNB988038617A patent/CN1204121C/zh not_active Expired - Fee Related
- 1998-03-31 NZ NZ337651A patent/NZ337651A/en unknown
- 1998-03-31 DE DE69827785T patent/DE69827785T2/de not_active Expired - Fee Related
- 1998-03-31 CA CA002280753A patent/CA2280753C/en not_active Expired - Fee Related
- 1998-03-31 ES ES98911137T patent/ES2230681T3/es not_active Expired - Lifetime
- 1998-03-31 RU RU99123039/04A patent/RU2203275C2/ru active
- 1998-03-31 US US09/367,227 patent/US6448243B1/en not_active Expired - Fee Related
- 1998-03-31 AT AT98911137T patent/ATE283259T1/de not_active IP Right Cessation
- 1998-03-31 AU AU65209/98A patent/AU748038B2/en not_active Ceased
- 1998-03-31 WO PCT/JP1998/001481 patent/WO1998043956A1/ja not_active Ceased
- 1998-03-31 EP EP98911137A patent/EP0976732B1/de not_active Expired - Lifetime
-
1999
- 1999-09-28 NO NO19994720A patent/NO314543B1/no not_active IP Right Cessation
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2001
- 2001-05-02 US US09/846,259 patent/US7071201B2/en not_active Expired - Fee Related
- 2001-05-18 US US09/859,517 patent/US6579881B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0000434A2 (hu) | 2000-06-28 |
| AU6520998A (en) | 1998-10-22 |
| EP0976732B1 (de) | 2004-11-24 |
| HK1026700A1 (en) | 2000-12-22 |
| NZ337651A (en) | 2002-04-26 |
| US6579881B2 (en) | 2003-06-17 |
| US7071201B2 (en) | 2006-07-04 |
| TWI242011B (en) | 2005-10-21 |
| NO314543B1 (no) | 2003-04-07 |
| JP3953115B1 (de) | 2007-08-08 |
| CN1204121C (zh) | 2005-06-01 |
| CN1253547A (zh) | 2000-05-17 |
| AU748038B2 (en) | 2002-05-30 |
| DE69827785D1 (de) | 2004-12-30 |
| ES2230681T3 (es) | 2005-05-01 |
| CA2280753A1 (en) | 1998-10-08 |
| RU2203275C2 (ru) | 2003-04-27 |
| NO994720D0 (no) | 1999-09-28 |
| HUP0000434A3 (en) | 2002-05-28 |
| DE69827785T2 (de) | 2005-12-22 |
| US6448243B1 (en) | 2002-09-10 |
| NO994720L (no) | 1999-11-30 |
| US20020086999A1 (en) | 2002-07-04 |
| US20020019531A1 (en) | 2002-02-14 |
| EP0976732A1 (de) | 2000-02-02 |
| EP0976732A4 (de) | 2000-06-14 |
| CA2280753C (en) | 2007-12-04 |
| WO1998043956A1 (en) | 1998-10-08 |
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