KR850008165A - 헤테로사이클릭 유도체의 제조방법 - Google Patents

헤테로사이클릭 유도체의 제조방법 Download PDF

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KR850008165A
KR850008165A KR1019850003306A KR850003306A KR850008165A KR 850008165 A KR850008165 A KR 850008165A KR 1019850003306 A KR1019850003306 A KR 1019850003306A KR 850003306 A KR850003306 A KR 850003306A KR 850008165 A KR850008165 A KR 850008165A
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compound
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novel heterocyclic
heterocyclic compound
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뚜엘롱 쟝-마리에
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뚜엘롱 쟝-마리에
까르삐벰
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/70—Sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/10—1,4-Thiazines; Hydrogenated 1,4-thiazines
    • C07D279/14—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems
    • C07D279/16—1,4-Thiazines; Hydrogenated 1,4-thiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Abstract

내용 없음

Description

헤테로사이클릭 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (23)

1) 다음 일반식(Ⅱ)의 에스테르를 염기성 또는 산성매질중에서 가수분해한 후, 필요시 수득된 산을 염화시킴을 특징으로 하는 다음 일반식(Ⅰ)의 헤테로사이클릭 화합물 및 이들의 비독성 부가염의 제조방법.
상기 일반식에서 Z는 황원자를 나타내는데, 단 Y가 황원자를 나타내거나 또는 X=Y=N일 경우 산소원자를 나타낼 수 있고 Y는 산소 또는 황원자 또는 메틸렌을 나타내고, X가 질소인 경우 Y는 질소원자를 나타낼 수도 있으며, X는 CH 또는 질소원자를 나타내고, R₁ 및 R₂는 수소, 할로겐 또는 트리플루오로메틸, 메톡시, 티오메틸, 티오메틸, 티오트리플루오로메틸 또는 트리플루오로메톡시기를 나타낼 수 있고, R₃ 및 R₄는 수소, 저급알킬기(탄소수 1 내지 5의 직쇄 또는 측쇄) 또는 임의로 치환된 페닐 또는 피리딜핵을 나타낼 수 있고, R'는 직쇄측쇄의 탄소수 1 내지 5의 저급알킬기를 나타낸다.
제1항에 있어서, 가수분해를 수용성 알콜매질, 테트라하이드로푸란/물, 디옥산/물 또는 수-혼화성 용매중에서 수행함을 특징으로 하는 방법.
제1항에 있어서, 가수분해를 25 내지 100℃의 온도에서 수행함을 특징으로 하는 방법.
제1항에 있어서, Z가 황원자를 나타내는 일반식(Ⅱ)의 화합물을 가수분해시킴을 특징으로 하는 방법.
제1항 또는 4항에 있어서, Y가 황원자를 나타내는 일반식(Ⅱ)의 화합물을 가수분해시킴을 특징으로 하는 방법.
제1항, 4항 또는 5항중 어느 하나에 있어서, R₁이 수소를 나타내고 R₂가 불소를 나타내는 일반식(Ⅱ)의 화합물을 가수분해시킴을 특징으로 하는 방법.
제1항, 4항, 5항 또는 6항중 어느 하나에 있어서, R₃가 수소를 나타내고 R₄가 메틸 또는 페닐기를 나타내는 일반식(Ⅱ)의 화합물을 가수분해시킴을 특징으로 하는 방법.
제1항 내지 3항중 어느 하나에 있어서, X가 CH를 나타내고, R₁ 및 R₂가 수소이거나 또는 이들중 하나가 수소이면 다른 하나는 불소 또는 염소이며, R₃ 및 R₄가 수소이거나 이들중 하나가 수소이면 다른 하나는 메틸 또는 페닐기이고, Z는 황원자를 나타내며 Y는 황 또는 산소원자를 나타내는 일반식(Ⅱ)의 화합물을 가수분해시킴을 특징으로 하는 방법.
제1항에 있어서, Z가 산소원자를 나타내는 일반식(Ⅱ)의 화합물은 다음 일반식(Ⅷ)의 니트로 유도체를 수소화하여 다음 일반식(Ⅳ)의 화합물로 유도한 후 이 화합물을 폐환시켜 수득함을 특징으로 하는 방법.
상기 일반식에서 R₁,R₂.R₃,R₄X 및 Y는 상기에서 정의된 바와 같고 R"는 수소 또는 저급알킬기를 나타낸다.
제1항에 있어서, Z가 황원자를 나타내는 일반식(Ⅱ)의 화합물은 Z가 산소원자를 나타내는 일반식 (Ⅱ)의 화합물을 용매중에서 D₂S5와 반응시켜 수득함을 특징으로 하는 방법.
제1항에 있어서, 다음 일반식(Ⅰ)에 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
상기 일반식에서 R₁,R₂,R₃,R₄,X, Y 및 Z는 제1항에서 정의된 바와 같다.
제4항에 있어서, Z가 황원자를 나타내는 신규의 일반식(Ⅰ)의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제5항에 있어서, Y가 황원자를 나타내는 신규의 일반식(Ⅰ)의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제6항에 있어서, R₁이 수소를 나타내고 R₂가 불소를 나타내는 일반식(Ⅰ)의 신규인 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제7항에 있어서, R₂가 수소를 나타내고, R4가 메틸 또는 페닐기를 나타내는 일반식(Ⅰ)의 신규인 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제 항에 있어서, 다음 구조식에 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제8항에 있어서, 다음 구조식에 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제8항에 있어서, 다음 구조식에 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제8항에 있어서, 다음 구조식에서 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제8항에 있어서, 다음 구조식에서 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제8항에 있어서, 다음 구조식에서 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제8항에 있어서, 다음 구조식에서 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
제8항에 있어서, 다음 구조식에 상응하는 신규의 헤테로사이클릭 화합물을 수득함을 특징으로 하는 방법.
※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850003306A 1984-05-18 1985-05-15 헤테로 사이클릭 유도체의 제조방법 KR900004320B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR8407791A FR2564463B1 (fr) 1984-05-18 1984-05-18 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
FR84-07791 1984-05-18
FR8503236A FR2578542B2 (fr) 1985-03-05 1985-03-05 Nouveaux derives heterocycliques, leurs procedes de preparation, medicaments les contenant, utiles notamment comme inhibiteurs de l'aldose reductase
FR85-03236 1985-03-05

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KR900004320B1 KR900004320B1 (ko) 1990-06-22

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU602641B2 (en) * 1986-04-17 1990-10-18 Senju Pharmaceutical Co., Ltd. Thiolactam-N-acetic acid derivatives, their production and use
EP0290863A3 (en) * 1987-05-09 1989-03-15 Nihon Tokushu Noyaku Seizo K.K. Benzoxazine derivative, process and intermediates for its preparation and its use as herbicide
IE914455A1 (en) * 1990-12-27 1992-07-01 Green Cross Corp 1,4-benzothiazine-2-acetic acid derivatives, processes for production thereof
CA2122370A1 (en) * 1992-08-31 1994-03-17 Yoichi Kawashima 3-oxo-1,4-benzothiazine derivatives
TW274550B (ko) * 1992-09-26 1996-04-21 Hoechst Ag
JPH06279453A (ja) * 1993-03-29 1994-10-04 Green Cross Corp:The ピリドチアジン酢酸誘導体，その製法及びその用途
WO1995013269A1 (fr) * 1993-11-12 1995-05-18 Santen Pharmaceutical Co., Ltd. Derive de 1,4-benzothiazine
US5556841A (en) * 1994-02-04 1996-09-17 Santen Pharmaceutical Co., Ltd. Thiazine or thiomorpholine derivatives
WO1997021689A1 (fr) * 1995-12-08 1997-06-19 Ube Industries, Ltd. Composes de n-phenylcarbamate, procede de production et bactericides agricoles ou horticoles
US6713477B1 (en) 2000-04-19 2004-03-30 Sumitomo Pharmaceuticals Company, Limited Hydroxamic acid derivatives
US7057046B2 (en) * 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
US7098235B2 (en) 2002-11-14 2006-08-29 Bristol-Myers Squibb Co. Triglyceride and triglyceride-like prodrugs of glycogen phosphorylase inhibiting compounds
US7598240B2 (en) * 2004-03-02 2009-10-06 Dainippon Sumitomo Pharma Co., Ltd. Benzothiazin-3-one compound and intermediate therefor
EP2702064A4 (en) * 2011-04-29 2014-10-08 Icahn School Med Mount Sinai Kinase Inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1173942A (en) * 1967-06-06 1969-12-10 Bellon Labor Sa Roger New 2,3-Dihydro-1,4-Benzoxazines
US3923709A (en) * 1974-08-30 1975-12-02 Monsanto Co 3,4-Dihydro-3-oxo-2H-1,4-benzothiazines and benzoxazines
US4512990A (en) * 1982-02-18 1985-04-23 Syntex (U.S.A.), Inc. Benzthiazine analogs as antiinflammatory agents
US4584300A (en) * 1983-02-07 1986-04-22 Santen Pharmaceutical Co., Ltd. Platelet anti-aggregative- and calcium antagonistic -1,4-benzothiazin-3-one derivatives, compositions, and methods of use therefor
JPS60166674A (ja) * 1984-02-09 1985-08-29 Santen Pharmaceut Co Ltd ベンゾチアジン誘導体

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DE3569529D1 (en) 1989-05-24
ES543266A0 (es) 1986-05-16
US4755509A (en) 1988-07-05
JPS6140264A (ja) 1986-02-26
ES8607263A1 (es) 1986-05-16
DK219685D0 (da) 1985-05-17
KR900004320B1 (ko) 1990-06-22
NZ212060A (en) 1989-10-27
JPH0692371B2 (ja) 1994-11-16
EP0162776B1 (fr) 1989-04-19
CA1306747C (en) 1992-08-25
AU586972B2 (en) 1989-08-03
DK219685A (da) 1985-11-19
PT80489A (fr) 1985-06-01
EP0162776A2 (fr) 1985-11-27
AU4251885A (en) 1985-11-21
GR851159B (ko) 1985-11-25
PH21118A (en) 1987-07-27
EP0162776A3 (en) 1987-05-06
IE851126L (en) 1985-11-18
IE58312B1 (en) 1993-09-08
PT80489B (fr) 1986-12-12

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