KR860008148A - 헤테로 사이클릭 아미드 유도체의 제조방법 - Google Patents

헤테로 사이클릭 아미드 유도체의 제조방법 Download PDF

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KR860008148A
KR860008148A KR1019860002749A KR860002749A KR860008148A KR 860008148 A KR860008148 A KR 860008148A KR 1019860002749 A KR1019860002749 A KR 1019860002749A KR 860002749 A KR860002749 A KR 860002749A KR 860008148 A KR860008148 A KR 860008148A
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carbon atoms
optionally substituted
halogen
pyridin
compound
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KR1019860002749A
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홈름우드 그라함
바이스뮬러 요하임
브란데스 빌헬름
라이네케 폴
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요하힘 그렘, 칼-루드비히 슈미트
바이엘 아크티엔게젤샤프트
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Publication of KR860008148A publication Critical patent/KR860008148A/ko

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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/60—1,4-Diazines; Hydrogenated 1,4-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
    • A01N47/38—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< where at least one nitrogen atom is part of a heterocyclic ring; Thio analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Organic Chemistry (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
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  • Pest Control & Pesticides (AREA)
  • Health & Medical Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

헤테로 사이클릭 아미드 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기 일반식(Ⅱ)의 아민을 적절한 불활성 유기용매의 존재하에서 하기 일반식(Ⅲa)의 카보닐 또는 티오카보닐 화합물, 또는 하기 일반식(Ⅲb)의 카보닐 또는 티오카보닐 화합물과 반응시키거나, 하기 일반식(Ⅱ)의 아민을 적절한 불활성 유기용매의 존재하 및 산-결합제의 존재하에서 하기 일반식(Ⅳ)의 카바밀 클로라이드 화합물과 반응시키거나, 하기 일반식(Ⅴ)의 카바밀 클로라이드 또는 티오카바밀 클로라이드 유도체를 적절한 불활성 유기용매의 존재하 및, 필요한 경우, 산-결합제의 존재하에서 하기 일반식(Ⅵ)의 아졸과 반응시키거나, 하기 일반식(Ⅰa)의 카복스드메드를 불활성 유기용매의 존재하에서 오황화인과 반응시키고, 필요한 경우, 이렇게 수득된 일반식(Ⅰ)의 화합물에 산 또는 금속염을 첨가함을 특징으로 하여 하기 일반식(Ⅰ)의 헤테로사이클릭 아미드 유도체 및 이의 산부가염 및 금속염 복합체를 제조하는 방법.
    상기식에서 R1은 알킬, 탄소수 2이상이고 할로겐에 의해 임의로 치환된 알케닐, 탄소수 2이상이고 할로겐에 의해 임의호 치환된 알키닐, 알콕시알킬 또는 알킬티오알킬을 나타내고, R2는 임의로 치환된 나프틸, 임의로 치환된 테트라하이드로 나프틸, 또는 임의로 지환된 인다닐을 나타내며 ; A는 알킬렌 브릿지(bridge)을 나타내거나, 또는 X가 직접 결합을 나타내는 경우에는 알케닐렌 브릿지를 나타내고, X는 산소, 황 도는 직접 결합을 나타내며, Y는 산소 또는 황을 나타내고, B는 이미다졸-1-일, 피리딘-3-일, 피라딘-2-일, 피리미딘-5-일, 1,2,4-트리아졸-1-일 또는 1-메틸 이미다졸-5-일을 나타내며, B'는 이미다졸-1-일, 피리딘-3-일, 피라진-3-일, 피라진-2-일, 피리미딘-5-일 또는 1-메틸이미다졸-5-일을 나타내고, B"는 피리딘-3-일, 피라진-2-일, 피라미딘-5-일 또는 1-메틸이미다졸-5-일을 나타내며 Z는 질소원자 또는 CH그룹을 나타내고, M은 수소 또는 알카리 금속을 나타낸다.
  2. 제1항에 있어서, R1이 탄소수 1 내지 12의 알킬을 나타내거나, 각각 탄소수가 3 내지 12이고 불소 또는 염소에 의해 임의로 치환된 알케닐 또는 알키닐(여기에서, 각 경우에 다중결합은 질소원자에 대해 α-위치에 있지 않아야 한다)을 나타내거나, 각각의 경우에 알콕시 또는 알킬티오부분의 탄소수는 1내지 6이고 알킬부분의 탄소수는 2 내지 6인 알콕시알킬 또는 알킬티오알킬을 나타내고 R2는 탄소수 1 내지 4의 알킬, 할로겐 및 1내지 4개의 탄소원자와 동일하거나 상이한 할로겐 원자 1 내지 5개를 갖는 할로겐 알콕시에 의해 임의로 치환된 나프틸, 테트라하이드로 나프틸 또는 인극닐을 나타내며 A는 X가 직접 결합을 나타내는 경우, 탄소수 1 내지 8의 직쇄 또는 측쇄 알킬렌 브릿지를 나타내거나, X나 산소 또는 황을 나타내는 경우에는 탄소수 2 내지 8의 직쇄 또는 측쇄 알킬렌 브릿지(단, 여기에서 질소원자와 라디칼 X사이에는 적어도 2개의 탄소원자가 존재해야 한다)를 나타내거나, 탄소수 3 내지 8의 직쇄 또는 측쇄 알킬렌 브릿지(여기에서, 이중결합은 질소원자에 대해 α-위치에 있지 않아야 한다)를 나타내며 ; X는 산소, 황 또는 직접결합을 나타내고, Y는 산소를 나타내며, B는 이미다졸-1-일, 피리딘-3-일, 피라진-2-일, 피리미딘-5-일, 1,2,4-트리아졸-1-일, 또는 1-메틸이미다졸-5-일을 나타내는 일반식(Ⅰ)화합물을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860002749A 1985-04-13 1986-04-11 헤테로 사이클릭 아미드 유도체의 제조방법 KR860008148A (ko)

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DEP3513259.0 1985-04-13
DE19853513259 DE3513259A1 (de) 1985-04-13 1985-04-13 Heterocyclische amid-derivate

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EP (1) EP0198382B1 (ko)
JP (1) JPS61238778A (ko)
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AT (1) ATE46506T1 (ko)
AU (1) AU577459B2 (ko)
BR (1) BR8601653A (ko)
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NZ (1) NZ215772A (ko)
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ES553920A0 (es) 1987-02-16
PT82338B (pt) 1988-10-14
DD246697A5 (de) 1987-06-17
BR8601653A (pt) 1986-12-16
DE3513259A1 (de) 1986-10-23
HU199241B (en) 1990-02-28
US4840961A (en) 1989-06-20
DE3665712D1 (en) 1989-10-26
PT82338A (en) 1986-05-01
JPS61238778A (ja) 1986-10-24
AU5571586A (en) 1986-10-16
CN86102444A (zh) 1987-01-21
DK165586A (da) 1986-10-14
HUT42757A (en) 1987-08-28
EP0198382A3 (en) 1987-01-14
ATE46506T1 (de) 1989-10-15
ZA862725B (en) 1986-12-30
EP0198382B1 (de) 1989-09-20
GR860963B (en) 1986-08-12
AU577459B2 (en) 1988-09-22
US4952595A (en) 1990-08-28
DK165586D0 (da) 1986-04-11
ES8703432A1 (es) 1987-02-16
IL78460A0 (en) 1986-08-31
NZ215772A (en) 1989-02-24
EP0198382A2 (de) 1986-10-22

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