KR860000272A - 헤테로아릴옥시아세트아미드의 제조방법 - Google Patents

헤테로아릴옥시아세트아미드의 제조방법 Download PDF

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KR860000272A
KR860000272A KR1019850004370A KR850004370A KR860000272A KR 860000272 A KR860000272 A KR 860000272A KR 1019850004370 A KR1019850004370 A KR 1019850004370A KR 850004370 A KR850004370 A KR 850004370A KR 860000272 A KR860000272 A KR 860000272A
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South Korea
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optionally substituted
formula
benzthiazol
trifluoromethyl
heteroaryloxyacetamide
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KR1019850004370A
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English (en)
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KR920010393B1 (ko
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슈미트 토마스 (외 1)
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칼-루드비히 슈미트, 클라우스 데너
바이엘 아크티엔 게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
    • C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/34—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/08—1,2,4-Thiadiazoles; Hydrogenated 1,2,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/13—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

내용 없음

Description

헤테로아릴옥시아세트아미드의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 일반식(Ⅱ)의 실포닐화 헤테로방향족 화합물을 산수용채롯 무기염기 및 희석제로서 유기 또는 무기용매의존재하, 및 필요시 상전이 촉매 존재하에, -50℃ 내지 +150℃의 온도에서 일반식(Ⅲ)의 α- 옥시아세트아미드아 반응시킴을 특징으로 하여, 일반식(Ⅰ)의 헤테로아릴옥시아세트아미드를 제조하는 방법.
    상기식에서, R은 벤조 융합될 수도 있는 임의 치환된 5원 헤테로사이클이고; R1및 R2는 각기 독립적으로 수소, 알킬, 알케닐, 알키닐, 임의 치환된 사이클로알킬 또는 사이클로알케닐, 할로게노알킬, 알콕시알킬, 알콕시, 아르알킬 또는 임의 치환된 아릴이거나, R1및 R2는 이들이 결합되어 있는 질소원자와 함께 헤테로원자를 더 함유할 수 있는 임의 치환된, 포화되거나 불포화된 헤테로사이클이고; R'는 저급 알킬 또는 임의 치환된 벤질이며; R는 수소 또는 아실이다.
  2. 제1항에 있어서, 반응을 -20°내지 +100℃의 온도에서 수행하는 방법.
  3. 제1항에 있어서, 벤즈티아졸 -2-일 메틸 설폰 또는 벤즈티아졸 -2-일 에틸 설폰을 N-메틸하이드록시-아세트아닐리드와 반응시키는 방법.
  4. 제1항에 있어서, 2-메틸설포닐-5-트리플루오로메틸-1,3,4-티아디아졸 또는 2-에틸설포닐-5-트리플루오로메틸-1,3,4-티아디아졸을 N-메틸하이드록시아세트아닐리드와 반응시키는 방법.
    ※ 참고사항 : 최초출원내용에 의하여 공개하는 것임.
KR1019850004370A 1984-06-20 1985-06-20 헤테로아릴옥시아세트아미드의 제조방법 KR920010393B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3422861.6 1984-06-20
DE19843422861 DE3422861A1 (de) 1984-06-20 1984-06-20 Verfahren zur herstellung von heteroaryloxyacetamiden
DE3422861 1984-06-20

Publications (2)

Publication Number Publication Date
KR860000272A true KR860000272A (ko) 1986-01-27
KR920010393B1 KR920010393B1 (ko) 1992-11-27

Family

ID=6238800

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KR1019850004370A KR920010393B1 (ko) 1984-06-20 1985-06-20 헤테로아릴옥시아세트아미드의 제조방법

Country Status (7)

Country Link
US (1) US5101034A (ko)
EP (1) EP0165537B1 (ko)
JP (1) JPH0714925B2 (ko)
KR (1) KR920010393B1 (ko)
DE (2) DE3422861A1 (ko)
ES (1) ES8604542A1 (ko)
IL (1) IL75533A (ko)

Families Citing this family (27)

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DE3505902A1 (de) * 1985-02-21 1986-08-21 Bayer Ag, 5090 Leverkusen 4,5-disubstituierte 1,3-thiazol-2-yloxyacetamide
DE3724467A1 (de) * 1987-07-24 1989-02-02 Bayer Ag 6-chlorbenzoxazolyl-oxyacetanilide
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
DE3821600A1 (de) 1988-06-27 1989-12-28 Bayer Ag Heteroaryloxyessigsaeure-n-isopropylanilide
DE4003436A1 (de) * 1990-02-06 1991-08-08 Bayer Ag Verfahren zur herstellung von 2-alkylthio-1,3,4-thiadiazolen
DE4133673A1 (de) * 1991-10-11 1993-04-15 Bayer Ag Neue 2- (2-benzoxazolyl-oxy)-acetamide
DE4225024A1 (de) 1992-07-29 1994-02-03 Bayer Ag Chlorthiazolderivate
US5547967A (en) * 1993-12-08 1996-08-20 Kali-Chemie Pharma Gmbh (Phenylalkylaminoalkyloxy)-heteroaryl-compounds, processes and intermediates for their production and pharmaceutical compositions containing them
DE19530767A1 (de) * 1995-08-22 1997-02-27 Bayer Ag N-(1-Isopropyl-2-methyl-1-propenyl) -heteroaryloxyacetamide
EP1047679A1 (en) * 1997-11-18 2000-11-02 American Cyanamid Company Herbicidal n-alkenyl heteroarylyloxyacetamides
CA2254579C (en) * 1997-12-12 2007-10-30 Bayer Corporation Synthesis of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole via oxidation of 2-(methylthio)-5-(trifluoromethyl)-1,3,4-thiadiazole with a molybdenum or tungsten catalyst
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US6005114A (en) * 1997-12-12 1999-12-21 Bayer Corporation Process for making 2-(methylthio)-5(trifluoromethyl)-1,3,4,-thiadiazole using methyldithiocarbazinate with trifluoroacetic acid with selective removal of 2,5-bis(methylthio)-1,3,4-thiadiazole
US5895818A (en) * 1997-12-12 1999-04-20 Bayer Corporation Process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2- (5-trifuloromethyl)-1,3,4-thiadiazol-2-yl)oxy!acetamide using an aprotic, aromatic solvent
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US6031108A (en) * 1998-09-16 2000-02-29 Bayer Corporation Process for the preparation of 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole (TDA sulfone)
DE19935964A1 (de) 1999-07-30 2001-02-01 Bayer Ag 5-Chlordifluormethyl-1,3,4-thiadiazol-2-yl-oxyacetanilide
US6339042B1 (en) 1999-11-29 2002-01-15 American Cyanamid Co. Herbicidal N-cyclohexadienyl heteroaryloxyacetamides
JP4513251B2 (ja) * 2002-10-11 2010-07-28 住友化学株式会社 チアジアゾール化合物およびその用途
US8916550B2 (en) * 2005-05-09 2014-12-23 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
AU2006244074B2 (en) * 2005-05-09 2012-12-13 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
US7998980B2 (en) * 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
CN106478547B (zh) * 2016-08-30 2019-02-01 京博农化科技股份有限公司 一种2-甲砜基-5-三氟甲基-1,3,4-噻二唑的合成方法
WO2021154966A1 (en) 2020-01-29 2021-08-05 Kamari Pharma Ltd. Compounds and compositions for use in treating skin disorders

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DE3038636A1 (de) * 1980-10-13 1982-05-27 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von substituierten oxyessigsaeureamiden
DE3148839A1 (de) * 1981-12-10 1983-06-23 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von hetaryloxyacetamiden
DE3400168A1 (de) * 1984-01-04 1985-07-11 Bayer Ag, 5090 Leverkusen 5-halogenalkyl-1,3,4-thiadiazol-2-yloxyacetamide
DE3418168A1 (de) * 1984-05-16 1985-11-21 Bayer Ag, 5090 Leverkusen 6-chlorbenzazolyloxyacetamide

Also Published As

Publication number Publication date
IL75533A0 (en) 1985-10-31
ES8604542A1 (es) 1986-02-01
KR920010393B1 (ko) 1992-11-27
DE3422861A1 (de) 1986-01-02
EP0165537A3 (en) 1987-03-04
DE3575423D1 (de) 1990-02-22
JPH0714925B2 (ja) 1995-02-22
EP0165537A2 (de) 1985-12-27
EP0165537B1 (de) 1990-01-17
JPS6117575A (ja) 1986-01-25
IL75533A (en) 1990-01-18
US5101034A (en) 1992-03-31
ES544341A0 (es) 1986-02-01

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