KR840009105A - 1,4-디하이드로피리딘 유도체의 제조방법 - Google Patents

1,4-디하이드로피리딘 유도체의 제조방법 Download PDF

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Publication number
KR840009105A
KR840009105A KR1019840001814A KR840001814A KR840009105A KR 840009105 A KR840009105 A KR 840009105A KR 1019840001814 A KR1019840001814 A KR 1019840001814A KR 840001814 A KR840001814 A KR 840001814A KR 840009105 A KR840009105 A KR 840009105A
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South Korea
Prior art keywords
reaction
formula
preparing
dihydropyridine derivative
furoyl
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KR1019840001814A
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English (en)
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KR880002510B1 (ko
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워드 기토시 모리스
Original Assignee
개리 디이. 스트리트
메렐 다우 파마슈티컬스 인코포레이티드
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Publication of KR840009105A publication Critical patent/KR840009105A/ko
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Publication of KR880002510B1 publication Critical patent/KR880002510B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

내용 없음

Description

1,4-디아히드로피리딘 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 구조식(Ⅲ)의 2-(2-푸로일)-1-)2-니트로페닐)-3-옥소부트-1-엔을 일반식(Ⅱ)의 화합물과 불활성 유기 용매중에서 60℃ 내지 120℃로 4 내지 48시간 반응시킴을 특징으로 하여 일반식(Ⅰ)의 3-(2-푸로일)-5-알콕시-2,6-디메틸-4-)2-니트로페닐-1,4-디하이드로피리딘을 제조하는 방법.
    상기식에서 R은 메틸, 에틸, n-프로필, 이소프로필 또는 메톡시프로필이다.
  2. 제1항에 있어, 에탄올중 환류온도에서 반응을 수행하는 방법.
  3. 제1항에 있어서, 반응 시간이 약 16시간인 방법.
  4. 제1항에 있어서, 메탄올중 환류온도에서 반응을 수행하는 방법
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840001814A 1983-04-06 1984-04-06 1,4-디하이드로피리딘 유도체 및 이의 제조방법 KR880002510B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8309284 1983-04-06
GB8309284 1983-04-06

Publications (2)

Publication Number Publication Date
KR840009105A true KR840009105A (ko) 1984-12-24
KR880002510B1 KR880002510B1 (ko) 1988-11-26

Family

ID=10540692

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840001814A KR880002510B1 (ko) 1983-04-06 1984-04-06 1,4-디하이드로피리딘 유도체 및 이의 제조방법

Country Status (19)

Country Link
US (1) US4529733A (ko)
EP (1) EP0124777B1 (ko)
JP (1) JPS59193884A (ko)
KR (1) KR880002510B1 (ko)
AR (1) AR245941A1 (ko)
AT (1) ATE23151T1 (ko)
AU (1) AU557521B2 (ko)
CA (1) CA1262906A (ko)
DE (2) DE124777T1 (ko)
DK (1) DK162442C (ko)
ES (1) ES531254A0 (ko)
GR (1) GR81903B (ko)
IE (1) IE57182B1 (ko)
IL (1) IL71432A (ko)
NO (1) NO157575C (ko)
NZ (1) NZ207716A (ko)
PH (1) PH19451A (ko)
PT (1) PT78370B (ko)
ZA (1) ZA842456B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO883326L (no) * 1987-08-11 1989-02-13 Bayer Ag Dhp-retard-tilberedning.
US7150616B2 (en) * 2003-12-22 2006-12-19 Kimberly-Clark Worldwide, Inc Die for producing meltblown multicomponent fibers and meltblown nonwoven fabrics
CN114149360B (zh) * 2021-11-25 2024-03-01 天津太平洋化学制药有限公司 一种高纯度尼群地平原料药的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
ZA7152B (en) * 1970-01-24 1971-10-27 Bayer Ag New pharmaceutically active 1,4-dihydropyridines
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
PT78370A (en) 1984-05-01
EP0124777B1 (en) 1986-10-29
PH19451A (en) 1986-04-18
ES8505363A1 (es) 1985-05-16
ES531254A0 (es) 1985-05-16
NO157575B (no) 1988-01-04
NO841341L (no) 1984-10-08
JPH0465073B2 (ko) 1992-10-16
NO157575C (no) 1988-04-13
CA1262906C (en) 1989-11-14
IE57182B1 (en) 1992-05-20
DE124777T1 (de) 1985-06-05
JPS59193884A (ja) 1984-11-02
IL71432A0 (en) 1984-07-31
NZ207716A (en) 1986-09-10
ZA842456B (en) 1984-11-28
IE840831L (en) 1984-10-06
PT78370B (en) 1986-05-28
DK179984A (da) 1984-10-07
DK162442B (da) 1991-10-28
ATE23151T1 (de) 1986-11-15
KR880002510B1 (ko) 1988-11-26
CA1262906A (en) 1989-11-14
GR81903B (ko) 1984-12-12
DE3461086D1 (en) 1986-12-04
IL71432A (en) 1988-03-31
AU557521B2 (en) 1986-12-24
AR245941A1 (es) 1994-03-30
AU2637584A (en) 1984-10-11
EP0124777A1 (en) 1984-11-14
US4529733A (en) 1985-07-16
DK179984D0 (da) 1984-04-05
DK162442C (da) 1992-03-23

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