AR245941A1 - Procedimiento para preparar derivados de 1,4-dihidropiridina - Google Patents

Procedimiento para preparar derivados de 1,4-dihidropiridina

Info

Publication number
AR245941A1
AR245941A1 AR84296185A AR29618584A AR245941A1 AR 245941 A1 AR245941 A1 AR 245941A1 AR 84296185 A AR84296185 A AR 84296185A AR 29618584 A AR29618584 A AR 29618584A AR 245941 A1 AR245941 A1 AR 245941A1
Authority
AR
Argentina
Prior art keywords
dihydropyridine derivatives
furoil
nitrofenil
formula
dihidropiridina
Prior art date
Application number
AR84296185A
Other languages
English (en)
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Application granted granted Critical
Publication of AR245941A1 publication Critical patent/AR245941A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/12Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

PREPARACION DE 3-(2-FUROIL)-5-2,6-DIMETIL-4-(2-NITROFENIL)-1,4- DIHIDROPIRIDINA DE FORMULA (I), DONDE R ES METILO, ETILO, N-PROPILO O ISOPROPILO, QUE COMPRENDE HACER REACCIONAR 2-(2-FUROIL)-1-(2-NITROFENIL)-3- OXOBUT-1-ENO CON UN COMPUESTO DE FORMULA (II), EN UN DISOLVENTE ORGANICO INERTE A UNA TEMPERATURA ENTRE 60*C Y 120*C.
AR84296185A 1983-04-06 1984-04-02 Procedimiento para preparar derivados de 1,4-dihidropiridina AR245941A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8309284 1983-04-06

Publications (1)

Publication Number Publication Date
AR245941A1 true AR245941A1 (es) 1994-03-30

Family

ID=10540692

Family Applications (1)

Application Number Title Priority Date Filing Date
AR84296185A AR245941A1 (es) 1983-04-06 1984-04-02 Procedimiento para preparar derivados de 1,4-dihidropiridina

Country Status (19)

Country Link
US (1) US4529733A (es)
EP (1) EP0124777B1 (es)
JP (1) JPS59193884A (es)
KR (1) KR880002510B1 (es)
AR (1) AR245941A1 (es)
AT (1) ATE23151T1 (es)
AU (1) AU557521B2 (es)
CA (1) CA1262906A (es)
DE (2) DE124777T1 (es)
DK (1) DK162442C (es)
ES (1) ES531254A0 (es)
GR (1) GR81903B (es)
IE (1) IE57182B1 (es)
IL (1) IL71432A (es)
NO (1) NO157575C (es)
NZ (1) NZ207716A (es)
PH (1) PH19451A (es)
PT (1) PT78370B (es)
ZA (1) ZA842456B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO883326L (no) * 1987-08-11 1989-02-13 Bayer Ag Dhp-retard-tilberedning.
US7150616B2 (en) * 2003-12-22 2006-12-19 Kimberly-Clark Worldwide, Inc Die for producing meltblown multicomponent fibers and meltblown nonwoven fabrics
CN114149360B (zh) * 2021-11-25 2024-03-01 天津太平洋化学制药有限公司 一种高纯度尼群地平原料药的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE2003146A1 (de) * 1970-01-24 1971-07-29 Bayer Ag Neue 1,4-Dihydropyridinderivate
DE2117573C3 (de) * 1971-04-10 1978-07-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel
DE3033919A1 (de) * 1980-09-09 1982-04-22 Bayer Ag, 5090 Leverkusen Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
AU557521B2 (en) 1986-12-24
NZ207716A (en) 1986-09-10
PT78370B (en) 1986-05-28
IE57182B1 (en) 1992-05-20
KR880002510B1 (ko) 1988-11-26
PT78370A (en) 1984-05-01
ES8505363A1 (es) 1985-05-16
AU2637584A (en) 1984-10-11
PH19451A (en) 1986-04-18
US4529733A (en) 1985-07-16
DE3461086D1 (en) 1986-12-04
EP0124777B1 (en) 1986-10-29
NO841341L (no) 1984-10-08
DK162442B (da) 1991-10-28
IL71432A0 (en) 1984-07-31
ZA842456B (en) 1984-11-28
ES531254A0 (es) 1985-05-16
GR81903B (es) 1984-12-12
DK179984A (da) 1984-10-07
DK162442C (da) 1992-03-23
DK179984D0 (da) 1984-04-05
NO157575B (no) 1988-01-04
CA1262906C (en) 1989-11-14
DE124777T1 (de) 1985-06-05
NO157575C (no) 1988-04-13
JPS59193884A (ja) 1984-11-02
JPH0465073B2 (es) 1992-10-16
IL71432A (en) 1988-03-31
KR840009105A (ko) 1984-12-24
IE840831L (en) 1984-10-06
EP0124777A1 (en) 1984-11-14
CA1262906A (en) 1989-11-14
ATE23151T1 (de) 1986-11-15

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