KR830006288A - 카바펜암과 카바펜-2-엠의 제조방법 - Google Patents
카바펜암과 카바펜-2-엠의 제조방법 Download PDFInfo
- Publication number
- KR830006288A KR830006288A KR1019810001651A KR810001651A KR830006288A KR 830006288 A KR830006288 A KR 830006288A KR 1019810001651 A KR1019810001651 A KR 1019810001651A KR 810001651 A KR810001651 A KR 810001651A KR 830006288 A KR830006288 A KR 830006288A
- Authority
- KR
- South Korea
- Prior art keywords
- hydrogen
- carbafen
- methyl
- preparing
- arm
- Prior art date
Links
- -1 5-methyl-3-phenylisoxazole-4-carboxamido Chemical group 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000002431 hydrogen Chemical class 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000000738 acetamido group Chemical group [H]C([H])([H])C(=O)N([H])[*] 0.000 claims 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 1
- 239000011941 photocatalyst Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/26—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cephalosporin Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 다음 일반식(I)의 화합물을 반응 불활성 용매중 -100°C내지 35°C의 온도에서 다음 일반식(II)의 화합물로 전위시키는 광촉매법상기 식에서R7은 수소, 일치환 또은 이치환된 아세트아미도(이때 카복시 및 아미노기는 통상제으로 보호된다), 5-메틸-3-페닐이속사졸-4-카복스아미도, 또는(R5는 수소, 아세틸, 벤질옥시카보닐 또는 p-니트로벤질옥시카보닐이며 R6는 수소 또는 (C1-C5)알킬이고 R12는 수소 또는 메틸이다)이며, R2는 수소 또는 메톡시인데, 단 R2가 메톡시일 때 R7은 2-펜옥시아세트아미도이며 R8은 통상의 카복시보호기이며 R9는 메틸, 아세톡시메틸, 메탈설포닐옥시, OR10또는 SR10(R10은 (C1-C3)알킬, 2-벤질옥시카보닐아미노에틸, 2-아세트아미도에틸 또는 2-(p-니트로벤질옥시카보닐아미노)에틸이다)이다.※참고사항:최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14960480A | 1980-05-14 | 1980-05-14 | |
US149604 | 1980-05-14 | ||
US06/232,156 US4348264A (en) | 1980-05-14 | 1981-02-09 | Photocatalyzed process for producing carbapenams and carbapen-2-ems |
US232156 | 1981-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830006288A true KR830006288A (ko) | 1983-09-20 |
KR840000722B1 KR840000722B1 (ko) | 1984-05-24 |
Family
ID=26846880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810001651A KR840000722B1 (ko) | 1980-05-14 | 1981-05-13 | 카바펜암과 카바펜-2-엠의 제조방법 |
Country Status (17)
Country | Link |
---|---|
US (1) | US4348264A (ko) |
EP (1) | EP0040494B1 (ko) |
KR (1) | KR840000722B1 (ko) |
AR (1) | AR227425A1 (ko) |
AU (1) | AU524882B2 (ko) |
CA (1) | CA1171415A (ko) |
DE (1) | DE3162245D1 (ko) |
DK (1) | DK169892B1 (ko) |
ES (1) | ES502204A0 (ko) |
FI (1) | FI72518C (ko) |
IE (1) | IE51268B1 (ko) |
IL (1) | IL62848A (ko) |
NO (1) | NO157143C (ko) |
NZ (1) | NZ197072A (ko) |
PH (1) | PH16363A (ko) |
PT (1) | PT73026B (ko) |
YU (1) | YU43031B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4429128A (en) | 1981-02-09 | 1984-01-31 | Pfizer Inc. | Carbapenams and carbapen-2-ems and process therefor |
EP0160876A1 (en) * | 1984-04-23 | 1985-11-13 | Merck & Co. Inc. | 1-Hetero-6-/1-Hydroxyethyl/-2-SR8-1-carbadethiapen-2-EM-3-carboxylic acids |
DK270685A (da) * | 1984-06-29 | 1985-12-30 | Hoffmann La Roche | Carbapenemderivater |
US4675186A (en) | 1985-04-18 | 1987-06-23 | Pfizer Inc. | 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives |
US5395931A (en) * | 1988-06-30 | 1995-03-07 | Merck & Co., Inc. | 6-amido-1-methyl-2-(substituted-thio)carbapenems |
US5138050A (en) * | 1988-06-30 | 1992-08-11 | Merck & Co., Inc. | 6-amido-1-methyl carbapenems |
US5055463A (en) * | 1989-02-02 | 1991-10-08 | Merck & Co., Inc. | Spirocyclic 6-amido carbapenems |
JP2003525298A (ja) * | 2000-02-28 | 2003-08-26 | ニューバイオティックス インコーポレイテッド | 抗−感染性ectatm |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3592751A (en) * | 1969-04-14 | 1971-07-13 | Lilly Co Eli | Penicillin sulfoxide conversion process |
US4234596A (en) * | 1976-11-19 | 1980-11-18 | Merck & Co., Inc. | 3-(2-Aminoethylthio)-6-(1-hydroxyethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
BE867227A (fr) | 1977-10-31 | 1978-11-20 | Merck & Co Inc | Preparation de l'acide 6-(alpha-hydroxyethyl)-7-oxo-1-azabicyclo (3,2,0) hept-2-ene-carboxylique et derives a activite antibiotique |
US4208422A (en) * | 1978-10-24 | 1980-06-17 | Merck & Co., Inc. | 1-Substituted-pen-2-em-3-carboxylic acids |
US4262010A (en) * | 1979-12-03 | 1981-04-14 | Merck & Co., Inc. | 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids |
-
1981
- 1981-02-09 US US06/232,156 patent/US4348264A/en not_active Expired - Lifetime
- 1981-05-07 DE DE8181302004T patent/DE3162245D1/de not_active Expired
- 1981-05-07 EP EP81302004A patent/EP0040494B1/en not_active Expired
- 1981-05-08 AR AR285243A patent/AR227425A1/es active
- 1981-05-11 CA CA000377287A patent/CA1171415A/en not_active Expired
- 1981-05-12 PT PT73026A patent/PT73026B/pt unknown
- 1981-05-12 IL IL62848A patent/IL62848A/xx unknown
- 1981-05-12 NZ NZ197072A patent/NZ197072A/xx unknown
- 1981-05-12 PH PH25618A patent/PH16363A/en unknown
- 1981-05-13 IE IE1070/81A patent/IE51268B1/en unknown
- 1981-05-13 NO NO811628A patent/NO157143C/no unknown
- 1981-05-13 AU AU70513/81A patent/AU524882B2/en not_active Ceased
- 1981-05-13 ES ES502204A patent/ES502204A0/es active Granted
- 1981-05-13 KR KR1019810001651A patent/KR840000722B1/ko active
- 1981-05-13 FI FI811471A patent/FI72518C/fi not_active IP Right Cessation
- 1981-05-13 DK DK211381A patent/DK169892B1/da not_active IP Right Cessation
- 1981-05-13 YU YU1221/81A patent/YU43031B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PT73026A (en) | 1981-06-01 |
ES8203373A1 (es) | 1982-04-01 |
IE51268B1 (en) | 1986-11-26 |
EP0040494A1 (en) | 1981-11-25 |
NO157143C (no) | 1988-01-27 |
DE3162245D1 (en) | 1984-03-22 |
YU43031B (en) | 1989-02-28 |
FI72518B (fi) | 1987-02-27 |
ES502204A0 (es) | 1982-04-01 |
AU524882B2 (en) | 1982-10-07 |
PT73026B (en) | 1983-02-08 |
KR840000722B1 (ko) | 1984-05-24 |
NO811628L (no) | 1981-11-16 |
FI72518C (fi) | 1987-06-08 |
AR227425A1 (es) | 1982-10-29 |
IL62848A (en) | 1984-05-31 |
CA1171415A (en) | 1984-07-24 |
DK169892B1 (da) | 1995-03-27 |
NO157143B (no) | 1987-10-19 |
EP0040494B1 (en) | 1984-02-15 |
DK211381A (da) | 1981-11-15 |
NZ197072A (en) | 1983-12-16 |
AU7051381A (en) | 1981-11-19 |
PH16363A (en) | 1983-09-08 |
IL62848A0 (en) | 1981-07-31 |
FI811471L (fi) | 1981-11-15 |
YU122181A (en) | 1983-06-30 |
IE811070L (en) | 1981-11-14 |
US4348264A (en) | 1982-09-07 |
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