DE69524103T2 - Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen - Google Patents

Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen

Info

Publication number
DE69524103T2
DE69524103T2 DE69524103T DE69524103T DE69524103T2 DE 69524103 T2 DE69524103 T2 DE 69524103T2 DE 69524103 T DE69524103 T DE 69524103T DE 69524103 T DE69524103 T DE 69524103T DE 69524103 T2 DE69524103 T2 DE 69524103T2
Authority
DE
Germany
Prior art keywords
tumor cells
hypoxic tumor
fluorinated
detecting hypoxic
nitroimidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69524103T
Other languages
English (en)
Other versions
DE69524103D1 (de
Inventor
Michael Tracy
B Kelson
Paul Workman
D Lewis
O Aboagye
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Research Campaign Technology Ltd
SRI International Inc
Original Assignee
Cancer Research Campaign Technology Ltd
University of Glasgow
SRI International Inc
Stanford Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Campaign Technology Ltd, University of Glasgow, SRI International Inc, Stanford Research Institute filed Critical Cancer Research Campaign Technology Ltd
Publication of DE69524103D1 publication Critical patent/DE69524103D1/de
Application granted granted Critical
Publication of DE69524103T2 publication Critical patent/DE69524103T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69524103T 1994-08-05 1995-07-31 Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen Expired - Fee Related DE69524103T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28647794A 1994-08-05 1994-08-05
US08/458,178 US5721265A (en) 1994-08-05 1995-06-02 Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
PCT/US1995/009611 WO1996004249A1 (en) 1994-08-05 1995-07-31 Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells

Publications (2)

Publication Number Publication Date
DE69524103D1 DE69524103D1 (de) 2002-01-03
DE69524103T2 true DE69524103T2 (de) 2002-07-18

Family

ID=26963851

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69524103T Expired - Fee Related DE69524103T2 (de) 1994-08-05 1995-07-31 Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen

Country Status (10)

Country Link
US (1) US5721265A (de)
EP (1) EP0775117B1 (de)
JP (1) JP3872511B2 (de)
AT (1) ATE209187T1 (de)
CA (1) CA2196900C (de)
DE (1) DE69524103T2 (de)
DK (1) DK0775117T3 (de)
ES (1) ES2165430T3 (de)
PT (1) PT775117E (de)
WO (1) WO1996004249A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US6252087B1 (en) * 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
ES2123449B1 (es) * 1997-03-06 1999-09-16 Univ Madrid Nac Educacion Procedimiento para la obtencion de imagenes y espectros del ph extracelular por resonancia magnetica con indicadores extrinsecos conteniendo 1h o 19f.
EP1015471A1 (de) * 1997-08-21 2000-07-05 Quark Biotech, Inc. Hypoxieregulierte gene
CA2345108A1 (en) * 1998-09-25 2000-04-06 Monsanto Company Substituted n-aliphatic-n-aromatic tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
WO2001007414A1 (en) * 1999-07-21 2001-02-01 The Trustees Of The University Of Pennsylvania Preparation of compounds useful for the detection of hypoxia
US7230115B1 (en) 1999-07-21 2007-06-12 The Trustees Of The University Of Pennsylvania Preparation of compounds useful for the detection of hypoxia
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
CA2400092A1 (en) * 2000-02-14 2001-08-16 Virexx Research, Inc. Diagnostic and therapeutic compositions and methods for affecting tumor growth using oxygen mimetic agents
DE102005063244A1 (de) * 2005-12-21 2007-06-28 Eberhard-Karls-Universität Tübingen Modifiziertes 2-Nitroimidazol-Derivat
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
KR101523257B1 (ko) * 2007-04-05 2015-05-27 쓰레솔드 파마슈티컬스, 인코포레이티드 니트로-이미다졸 저산소증 영상화제
EP2123620A1 (de) * 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft {F-19}-markierte L-Glutaminsäure und L-Glutaminderivat (III), Verwendung davon und Verfahren zu deren Erhalt
WO2010073126A2 (en) * 2008-12-22 2010-07-01 The Governors Of The University Of Alberta Compounds useful in delivering anti-neoplastic therapy and diagnostic imaging to hypoxic cells and methods of use thereof
CN101624392B (zh) * 2009-08-10 2014-07-09 北京师范大学 F-三唑环-聚乙二醇-2-硝基咪唑化合物及其制备方法
WO2011068537A2 (en) 2009-12-01 2011-06-09 Fraser Cassandra L Mechanochromic luminescent difluoroboron beta-diketonates
CN113501789B (zh) * 2021-06-16 2023-03-31 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 一种硝基咪唑类衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505349A (en) * 1966-04-18 1970-04-07 Hoffmann La Roche 2-nitro-imidazolyl-1-acetamides
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
IL92597A0 (en) * 1988-12-14 1990-08-31 Yasunori Nishijima President K Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
JP4169782B2 (ja) * 1992-11-19 2008-10-22 ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア 低酸素症の検出

Also Published As

Publication number Publication date
ATE209187T1 (de) 2001-12-15
EP0775117A1 (de) 1997-05-28
JPH10506104A (ja) 1998-06-16
CA2196900C (en) 2009-02-24
WO1996004249A1 (en) 1996-02-15
JP3872511B2 (ja) 2007-01-24
ES2165430T3 (es) 2002-03-16
PT775117E (pt) 2002-05-31
CA2196900A1 (en) 1996-02-15
DE69524103D1 (de) 2002-01-03
DK0775117T3 (da) 2002-05-21
EP0775117B1 (de) 2001-11-21
US5721265A (en) 1998-02-24

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SRI INTERNATIONAL, MENLO PARK, CALIF., US

Owner name: CANCER RESEARCH CAMPAIGN TECHNOLOGY LTD., LONDON,

8339 Ceased/non-payment of the annual fee