ATE209187T1 - Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen - Google Patents

Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen

Info

Publication number
ATE209187T1
ATE209187T1 AT95927535T AT95927535T ATE209187T1 AT E209187 T1 ATE209187 T1 AT E209187T1 AT 95927535 T AT95927535 T AT 95927535T AT 95927535 T AT95927535 T AT 95927535T AT E209187 T1 ATE209187 T1 AT E209187T1
Authority
AT
Austria
Prior art keywords
tumor cells
hypoxic tumor
nitroimidazole
fluorinated
analogue
Prior art date
Application number
AT95927535T
Other languages
English (en)
Inventor
Michael Tracy
Andrew B Kelson
Paul Workman
Alexander D Lewis
Eric O Aboagye
Original Assignee
Stanford Res Inst Int
Univ Glasgow
Cancer Res Campaign Tech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stanford Res Inst Int, Univ Glasgow, Cancer Res Campaign Tech filed Critical Stanford Res Inst Int
Application granted granted Critical
Publication of ATE209187T1 publication Critical patent/ATE209187T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT95927535T 1994-08-05 1995-07-31 Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen ATE209187T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28647794A 1994-08-05 1994-08-05
US08/458,178 US5721265A (en) 1994-08-05 1995-06-02 Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells
PCT/US1995/009611 WO1996004249A1 (en) 1994-08-05 1995-07-31 Fluorinated 2-nitroimidazole analogs for detecting hypoxic tumor cells

Publications (1)

Publication Number Publication Date
ATE209187T1 true ATE209187T1 (de) 2001-12-15

Family

ID=26963851

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95927535T ATE209187T1 (de) 1994-08-05 1995-07-31 Fluorinierte 2-nitroimidazole analoge zur detektion von hypoxischen tumorzellen

Country Status (10)

Country Link
US (1) US5721265A (de)
EP (1) EP0775117B1 (de)
JP (1) JP3872511B2 (de)
AT (1) ATE209187T1 (de)
CA (1) CA2196900C (de)
DE (1) DE69524103T2 (de)
DK (1) DK0775117T3 (de)
ES (1) ES2165430T3 (de)
PT (1) PT775117E (de)
WO (1) WO1996004249A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6252087B1 (en) * 1992-11-19 2001-06-26 The Trustees Of The University Of Pennsylvania Nitroaromatic compounds for the detection of hypoxia
US6855828B1 (en) 1992-11-19 2005-02-15 The Trustees Of The University Of Pennsylvania Detection of hypoxia
US20050026974A1 (en) * 1996-02-08 2005-02-03 Trustees Of The University Of Pennsylvania Detection of hypoxia
ES2123449B1 (es) * 1997-03-06 1999-09-16 Univ Madrid Nac Educacion Procedimiento para la obtencion de imagenes y espectros del ph extracelular por resonancia magnetica con indicadores extrinsecos conteniendo 1h o 19f.
AU9110798A (en) * 1997-08-21 1999-03-08 Quark Biotech, Inc. Hypoxia-regulated genes
AU6161099A (en) * 1998-09-25 2000-04-17 Monsanto Company Substituted n-aliphatic-n-aromatic (tertiary)-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US7230115B1 (en) 1999-07-21 2007-06-12 The Trustees Of The University Of Pennsylvania Preparation of compounds useful for the detection of hypoxia
DE60043616D1 (de) * 1999-07-21 2010-02-11 Univ Pennsylvania Herstellung von verbindungen zur bestimmung der hypoxie
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
EP1257268A2 (de) * 2000-02-14 2002-11-20 Novolytics Inc. Diagnostische und therapeutische zusammensetzungen sowie verfahren zur beeinflussung von tumorwachstum mit sauerstoff-mimetischen verbindungen
DE102005063244A1 (de) * 2005-12-21 2007-06-28 Eberhard-Karls-Universität Tübingen Modifiziertes 2-Nitroimidazol-Derivat
US9056136B2 (en) * 2006-10-06 2015-06-16 Natural Pharmacia International, Inc. Weakly basic 2-nitroimidazoles for the non-invasive detection of tissue hypoxia
JP5347164B2 (ja) * 2007-04-05 2013-11-20 スレッショルド ファーマスーティカルズ，インコーポレイテッド ニトロ−イミダゾール低酸素造影剤
EP2123620A1 (de) * 2008-05-20 2009-11-25 Bayer Schering Pharma Aktiengesellschaft {F-19}-markierte L-Glutaminsäure und L-Glutaminderivat (III), Verwendung davon und Verfahren zu deren Erhalt
WO2010073126A2 (en) * 2008-12-22 2010-07-01 The Governors Of The University Of Alberta Compounds useful in delivering anti-neoplastic therapy and diagnostic imaging to hypoxic cells and methods of use thereof
CN101624392B (zh) * 2009-08-10 2014-07-09 北京师范大学 F-三唑环-聚乙二醇-2-硝基咪唑化合物及其制备方法
WO2011068537A2 (en) 2009-12-01 2011-06-09 Fraser Cassandra L Mechanochromic luminescent difluoroboron beta-diketonates
CN113501789B (zh) * 2021-06-16 2023-03-31 首都医科大学脑重大疾病研究中心(北京脑重大疾病研究院) 一种硝基咪唑类衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3505349A (en) * 1966-04-18 1970-04-07 Hoffmann La Roche 2-nitro-imidazolyl-1-acetamides
CA1329206C (en) * 1987-06-10 1994-05-03 Tsutomu Kagiya Fluorine-containing nitroazole derivatives and radiosensitizer comprising the same
US5304654A (en) * 1987-06-10 1994-04-19 Yasunori Nishijima Fluorine-containing nitroimidazole compounds
IL92597A0 (en) * 1988-12-14 1990-08-31 Yasunori Nishijima President K Novel fluorine-containing 2-nitroimidazole derivatives and radiosensitizer comprising the same
CA2149770C (en) * 1992-11-19 2009-01-06 Cameron J. Koch Detection of hypoxia

Also Published As

Publication number Publication date
JP3872511B2 (ja) 2007-01-24
CA2196900A1 (en) 1996-02-15
DK0775117T3 (da) 2002-05-21
ES2165430T3 (es) 2002-03-16
DE69524103D1 (de) 2002-01-03
CA2196900C (en) 2009-02-24
EP0775117A1 (de) 1997-05-28
EP0775117B1 (de) 2001-11-21
US5721265A (en) 1998-02-24
PT775117E (pt) 2002-05-31
JPH10506104A (ja) 1998-06-16
DE69524103T2 (de) 2002-07-18
WO1996004249A1 (en) 1996-02-15

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee