KR840006963A - 4-아미노알킬-2(3h)-인돌론을 제조하는 방법 - Google Patents

4-아미노알킬-2(3h)-인돌론을 제조하는 방법 Download PDF

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KR840006963A
KR840006963A KR1019830005790A KR830005790A KR840006963A KR 840006963 A KR840006963 A KR 840006963A KR 1019830005790 A KR1019830005790 A KR 1019830005790A KR 830005790 A KR830005790 A KR 830005790A KR 840006963 A KR840006963 A KR 840006963A
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acid addition
preparing
addition salt
indole
optionally
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KR1019830005790A
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KR910001042B1 (ko
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쥬니어 그레고리 갤러거
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리챠드 도미니크 포기오
스미스 클라인 베크만 코퍼레이션
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

4―아미노알킬―2(3H)―인돌론을 제조하는 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (13)

  1. 다음 구조식의 화합물을 제조하는 방법:
  3. 이 구조식에서:
  4. 각 R는 수소, C1_6저급알킬, 벤질, 알릴, 펜에틸 또는 4―하이드록시펜에틸이고, R1'R2와 R3는 각각, 수소 또는 C1_4저급알킬이거나 그것의 산부가염이고, 이 방법은 다음의 (1) 또는 (2)의 단계를 포함한다.
  5. (1) 다음 구조식의 화합물을 환원 조건하에서 고리화한다:
  7. 이 구조 식에서 n와 R은 위에서 정의된 바와 같고, 임의로 고리화 반응을 한 생성물을 알킬화하고, 임의로 사계에 알려진 방법으로 어떤 보호그룹을 제거하고, 임의로 생성물로부터 산부가염을 형성하며, 또는 (2) 다음 구조식의 화합물을 반응시킨다:
  9. 이 구조식에서 n, R1, R2와 R3는 앞서 정의된 바와 같고, R는 수소 아닌 다른 화합물인데, 산 결합제존재하에서 5―할로―1―페닐―1H―테트라졸과 반응하여 7―(1―페닐―1H―테트라졸―5―일옥시―인돌론)을 산출하고 나서, 수소화 반응조건하에서 이른바 인돌론과 반응하고, 임의로 생성물로부터 산부가염을 형성한다.
  10. 청구범위 1에서 (1)의 과정을 사용해서 4―(2―)―n―디프로필아미노에틸)―2(3H)―인돌론 또는 그것의 산부가염을 제조하는 방법.
  11. 청구범위 1에서 (2)의 과정을 사용해서 4―(2―아미노에틸)―2(3H)―인돌론 또는 그것의 산부가염을 제조하는 방법.
  12. 청구범위 1에서 (1)의 과정을 사용해서 4―(n―프로필―4―하이드록시펜에틸―아미노에틸)―2(3H)―인돌론 또는 그것의 산부가염을 제조하는 방법.
  13. ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019830005790A 1982-12-07 1983-12-07 4-아미노알킬-2(3h)-인돌론 및 이의 제조방법 KR910001042B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US06/447,564 US4452808A (en) 1982-12-07 1982-12-07 4-Aminoalkyl-2(3H)-indolones
US447.564 1982-12-07
US447564 1982-12-07

Publications (2)

Publication Number Publication Date
KR840006963A true KR840006963A (ko) 1984-12-04
KR910001042B1 KR910001042B1 (ko) 1991-02-21

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KR1019830005790A KR910001042B1 (ko) 1982-12-07 1983-12-07 4-아미노알킬-2(3h)-인돌론 및 이의 제조방법

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US (1) US4452808A (ko)
EP (1) EP0113964B1 (ko)
JP (1) JPS59112964A (ko)
KR (1) KR910001042B1 (ko)
AU (1) AU560170B2 (ko)
BR (1) BR1100036A (ko)
CA (1) CA1208650A (ko)
CY (1) CY1497A (ko)
CZ (1) CZ398191A3 (ko)
DE (1) DE3367090D1 (ko)
DK (1) DK156514C (ko)
DZ (1) DZ587A1 (ko)
EG (1) EG16556A (ko)
ES (2) ES8600239A1 (ko)
FI (1) FI77849C (ko)
GR (1) GR79121B (ko)
HK (1) HK82089A (ko)
IE (1) IE56347B1 (ko)
IL (1) IL70311A (ko)
LU (1) LU90097I2 (ko)
NL (1) NL970005I2 (ko)
NO (2) NO160135C (ko)
NZ (1) NZ206344A (ko)
PH (1) PH22067A (ko)
PT (1) PT77739B (ko)
ZA (1) ZA839094B (ko)
ZW (1) ZW25883A1 (ko)

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CZ398191A3 (en) 1993-02-17
ES527827A0 (es) 1985-10-01
JPH0150703B2 (ko) 1989-10-31
HK82089A (en) 1989-10-20
CY1497A (en) 1990-02-16
FI77849B (fi) 1989-01-31
ES8600239A1 (es) 1985-10-01
PT77739B (en) 1986-03-27
DK562183D0 (da) 1983-12-06
EP0113964A1 (en) 1984-07-25
ES8604143A1 (es) 1986-01-16
NZ206344A (en) 1987-03-31
IL70311A (en) 1986-11-30
FI77849C (fi) 1989-05-10
JPS59112964A (ja) 1984-06-29
ZW25883A1 (en) 1984-04-18
US4452808A (en) 1984-06-05
FI834421A0 (fi) 1983-12-02
NO834485L (no) 1984-06-08
GR79121B (ko) 1984-10-02
IE832866L (en) 1984-06-07
PH22067A (en) 1988-05-20
DE3367090D1 (de) 1986-11-27
PT77739A (en) 1983-12-01
AU2158583A (en) 1984-06-14
DK156514B (da) 1989-09-04
ES543593A0 (es) 1986-01-16
IE56347B1 (en) 1991-07-03
CA1208650A (en) 1986-07-29
ZA839094B (en) 1985-02-27
DZ587A1 (fr) 2004-09-13
EG16556A (en) 1989-01-30
EP0113964B1 (en) 1986-10-22
BR1100036A (pt) 2000-01-11
DK156514C (da) 1990-03-12
NO160135B (no) 1988-12-05
IL70311A0 (en) 1984-02-29
FI834421A (fi) 1984-06-08
LU90097I2 (fr) 1997-07-16
NL970005I2 (nl) 1997-10-01
DK562183A (da) 1984-06-08
NO160135C (no) 1989-03-15
KR910001042B1 (ko) 1991-02-21
NL970005I1 (nl) 1997-04-01
NO1999011I1 (no) 1999-06-18
AU560170B2 (en) 1987-04-02

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