KR850006391A - 벤조치아졸 및 벤조치오펜 유도체의 제조방법 - Google Patents

벤조치아졸 및 벤조치오펜 유도체의 제조방법 Download PDF

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KR850006391A
KR850006391A KR1019850001704A KR850001704A KR850006391A KR 850006391 A KR850006391 A KR 850006391A KR 1019850001704 A KR1019850001704 A KR 1019850001704A KR 850001704 A KR850001704 A KR 850001704A KR 850006391 A KR850006391 A KR 850006391A
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compound
formula
general formula
benzothiazol
preparing
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KR1019850001704A
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English (en)
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KR870000920B1 (ko
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레드패드 제임스 (외 3)
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에이.디.도우미 프록시
아크조 엔.브이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/58—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

벤조치아졸 및 벤조치오펜 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (5)

  1. 일반식 Ⅰ인 산 또는 그 산할라이드나 그 산무수물과 일반식 Ⅲ 또는 일반식 V인 화합물을 반응시킴을 특징으로 하는 일반식 I의 벤조치아졸 및 벤조치오펜 유도체와 그의 약학적으로 허용되는 산부가염을 제조하는 방법.
    식중 R1은 알킬(Cl-6), 알콕시(C1-6) 하이드록시, 할로겐, NO2, CF3또는 -NR5R6중에서 선택된 동일 또는 서로 다른 1-4개의 치환기이거나 두개의 치환기가 메틸렌디옥시 그룹을 형성한 것이고 X는 니트로겐(N), 또는그룹이고, n은 0,1 또는 2이고, R3는,
    이고, R3가인 경우는 X가 니트로겐이고 R1이 하이드록시, 알콕시(Cl-6), 메틸렌디옥시로부터 선택된 치환기들로 제한되는 조건하에서만이며, R4,R6,R6는 수소 또는 알킬(Cl-6)이며, 일반식 Ⅲ,V화합물은 그 반응성 유도체와 수소가 알카리금속같은 좀더 반응성이 큰 것으로 치환된 것일 수 있다.
  2. 일반식 Ⅱ인 산 또는 그 산할라이드나 그 산무수물과 알카리금속아지드를 반응시켜 생성된 아지드화합물을 훤원시킴을 특징으로 하는 일반식 I의 벤조치아졸 및 벤조치아펜 유도체와 그의 약학적으로 허용되는 산부가염을 제조하는 방법.
    식중 R1,R3,n 및 X는 전술한 바와 같다.
  3. 일반식 Ⅳ화합물과 일반식 V화합물을 반응시킴을 특징으로 하는 일반식 I의 벤조치아졸 및 벤조치오펜 유도체와 그의 약학적으로 허용되는 산부가염을 제조하는 방법.
    식중, R1,R3,X,n 및 R5는 전술한 바와 같다.
  4. 일반식 Ⅵ화합물과 아미노구아니딘(Ⅶ) 또는 그의 염과 반응시킴을 특징으로 하는 일반식 I의 벤조치아졸 및 벤조치오펜 유도체와 그의 약학적으로 허용되는 산부가염을 제조하는 방법.
    식중 R1,R3,n 및 X는 전술한 바와 같다.
  5. 제1, 제2, 제3, 제4항에서 일반식 I의 화합물이 N-하이드록시-5,6-디메톡시-벤조(b)치오펜-2-카복시미드아미드, 4-클로로-N-하이드록시-5,6-디메톡시-벤조(b)치오펜-2-카복시미드아미드, 5,6-디메톡시-벤조(b)치오젠-2--카복사미드 또는 그들의 약학적으로 허용되는 산부가염인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850001704A 1984-03-16 1985-03-16 벤조 치오펜 유도체의 제조 방법 KR870000920B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848406906A GB8406906D0 (en) 1984-03-16 1984-03-16 Benzo-thiazole and benzothiophene derivatives
GB84.06906 1984-03-16

Publications (2)

Publication Number Publication Date
KR850006391A true KR850006391A (ko) 1985-10-05
KR870000920B1 KR870000920B1 (ko) 1987-05-07

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Country Link
US (2) US4665206A (ko)
EP (1) EP0158380B1 (ko)
JP (1) JPS60209577A (ko)
KR (1) KR870000920B1 (ko)
AU (1) AU568428B2 (ko)
CA (1) CA1254216A (ko)
DE (1) DE3567459D1 (ko)
DK (1) DK119285A (ko)
ES (4) ES8707223A1 (ko)
FI (1) FI80883C (ko)
GB (1) GB8406906D0 (ko)
HU (1) HU198030B (ko)
IE (1) IE57977B1 (ko)
ZA (1) ZA851807B (ko)

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Also Published As

Publication number Publication date
EP0158380B1 (en) 1989-01-11
ES8707223A1 (es) 1987-07-16
ES8704924A1 (es) 1987-04-16
US4929636A (en) 1990-05-29
DK119285A (da) 1985-09-17
CA1254216A (en) 1989-05-16
ES551282A0 (es) 1987-04-16
DE3567459D1 (en) 1989-02-16
KR870000920B1 (ko) 1987-05-07
ES551280A0 (es) 1987-04-16
ES541336A0 (es) 1987-07-16
EP0158380A1 (en) 1985-10-16
JPH0588232B2 (ko) 1993-12-21
HU198030B (en) 1989-07-28
AU3985285A (en) 1985-09-19
GB8406906D0 (en) 1984-04-18
FI80883C (fi) 1990-08-10
DK119285D0 (da) 1985-03-15
US4665206A (en) 1987-05-12
ZA851807B (en) 1985-10-30
JPS60209577A (ja) 1985-10-22
AU568428B2 (en) 1987-12-24
ES551281A0 (es) 1987-04-16
IE850592L (en) 1985-09-16
FI80883B (fi) 1990-04-30
ES8704926A1 (es) 1987-04-16
FI851038L (fi) 1985-09-17
FI851038A0 (fi) 1985-03-15
IE57977B1 (en) 1993-06-02
HUT37410A (en) 1985-12-28
ES8704925A1 (es) 1987-04-16

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