ES551282A0 - Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno - Google Patents
Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofenoInfo
- Publication number
- ES551282A0 ES551282A0 ES551282A ES551282A ES551282A0 ES 551282 A0 ES551282 A0 ES 551282A0 ES 551282 A ES551282 A ES 551282A ES 551282 A ES551282 A ES 551282A ES 551282 A0 ES551282 A0 ES 551282A0
- Authority
- ES
- Spain
- Prior art keywords
- benzotiofen
- benzotiazole
- derivatives
- procedure
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848406906A GB8406906D0 (en) | 1984-03-16 | 1984-03-16 | Benzo-thiazole and benzothiophene derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8704924A1 ES8704924A1 (es) | 1987-04-16 |
ES551282A0 true ES551282A0 (es) | 1987-04-16 |
Family
ID=10558202
Family Applications (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541336A Expired ES8707223A1 (es) | 1984-03-16 | 1985-03-15 | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofen. |
ES551282A Expired ES8704924A1 (es) | 1984-03-16 | 1986-01-27 | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno |
ES551281A Expired ES8704926A1 (es) | 1984-03-16 | 1986-01-27 | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno |
ES551280A Expired ES8704925A1 (es) | 1984-03-16 | 1986-01-27 | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES541336A Expired ES8707223A1 (es) | 1984-03-16 | 1985-03-15 | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofen. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES551281A Expired ES8704926A1 (es) | 1984-03-16 | 1986-01-27 | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno |
ES551280A Expired ES8704925A1 (es) | 1984-03-16 | 1986-01-27 | Un procedimiento para la preparacion de derivados de benzotiazol y benzotiofeno |
Country Status (14)
Country | Link |
---|---|
US (2) | US4665206A (es) |
EP (1) | EP0158380B1 (es) |
JP (1) | JPS60209577A (es) |
KR (1) | KR870000920B1 (es) |
AU (1) | AU568428B2 (es) |
CA (1) | CA1254216A (es) |
DE (1) | DE3567459D1 (es) |
DK (1) | DK119285A (es) |
ES (4) | ES8707223A1 (es) |
FI (1) | FI80883C (es) |
GB (1) | GB8406906D0 (es) |
HU (1) | HU198030B (es) |
IE (1) | IE57977B1 (es) |
ZA (1) | ZA851807B (es) |
Families Citing this family (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE58555B1 (en) * | 1984-12-10 | 1993-10-06 | Warner Almbert Company | Novel benzothiophenes and benzofurans having antiallergy activity |
EP0253650A3 (en) * | 1986-07-18 | 1989-09-13 | Eli Lilly And Company | Improvements relating to benzothiophene derivatives |
US4873259A (en) * | 1987-06-10 | 1989-10-10 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
US4822809A (en) * | 1987-11-13 | 1989-04-18 | Abbott Laboratories | Benzazole lipoxygenase inhibiting compounds |
US4882354A (en) * | 1987-12-16 | 1989-11-21 | Norwich Eaton Pharmaceuticals, Inc. | N-hydroxy-5-phenyl-2-furancarboximidamides useful as cardiotonic agents |
ES2051986T3 (es) * | 1988-07-05 | 1994-07-01 | Akzo Nv | Compuestos con actividad broncodilatadora. |
IE913683A1 (en) * | 1990-10-26 | 1992-05-22 | Akzo Nv | USE OF A BENZO[b]THIOPHENE-2-CARBOXIMIDAMIDE DERIVATIVE |
US5276052A (en) * | 1990-10-26 | 1994-01-04 | Akzo N.V. | Use of a benzo[b]thiopene-2-carboximidamide derivative |
DE4128871A1 (de) * | 1991-08-30 | 1993-03-04 | Boehringer Mannheim Gmbh | Benzo(b)thiophenderivate, verfahren zu ihrer herstellung und arzneimittel |
US5340833A (en) * | 1992-05-01 | 1994-08-23 | Eisai Co., Ltd. | Urokinase inhibitors |
US5436246A (en) * | 1992-09-17 | 1995-07-25 | Merrell Dow Pharmaceuticals Inc. | Serotonin receptor agents |
ATE214059T1 (de) * | 1994-04-11 | 2002-03-15 | Chugai Pharmaceutical Co Ltd | 4,6-di-t-butyl-2,3-dihydrobenzothiophene, die ldl oxidation hemmen |
US5760062A (en) * | 1995-04-18 | 1998-06-02 | Geron Corporation | Telomerase inhibitors |
US5703116A (en) * | 1995-04-18 | 1997-12-30 | Geron Corporation | Telomerase Inhibitors |
US5656638A (en) * | 1995-04-18 | 1997-08-12 | Geron Corporation | Telomerase inhibitors |
US5863936A (en) * | 1995-04-18 | 1999-01-26 | Geron Corporation | Telomerase inhibitors |
US5770613A (en) * | 1995-09-29 | 1998-06-23 | Geron Corporation | Telomerase inhibitors |
US5767278A (en) * | 1995-10-06 | 1998-06-16 | Geron Corporation | Telomerase inhibitors |
US6362216B1 (en) | 1998-10-27 | 2002-03-26 | Array Biopharma Inc. | Compounds which inhibit tryptase activity |
EP2193808A1 (en) | 1999-08-21 | 2010-06-09 | Nycomed GmbH | Synergistic combination |
US20040146561A1 (en) | 2001-05-23 | 2004-07-29 | Naoki Sakurai | Compositions for promoting healing of bone fracture |
JP4510383B2 (ja) | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 軟骨疾患修復治療用組成物 |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
EA200501548A1 (ru) | 2003-04-01 | 2006-02-24 | Апплайд Резеч Системз Арс Холдинг Н.В. | Ингибиторы фосфодиэстераз при бесплодии |
CA2542096A1 (en) | 2003-10-09 | 2005-04-21 | Aton Pharma, Inc. | Thiophene and benzothiophene hydroxamic acid derivatives |
WO2006101454A1 (en) * | 2005-03-21 | 2006-09-28 | S*Bio Pte Ltd | Benzothiophene derivatives: preparation and pharmaceutical applications |
MY148644A (en) * | 2005-07-18 | 2013-05-15 | Orion Corp | New pharmaceutical compounds |
CA2643012A1 (en) * | 2006-02-21 | 2007-08-30 | Trigen Limited | Heterocyclic compounds and their use in the treatment of cardiovascular disease |
ES2627221T3 (es) | 2006-12-28 | 2017-07-27 | Rigel Pharmaceuticals, Inc. | Compuestos de heterocicloalquiloxibenzamida N-sustituidos y métodos de uso |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2730603C (en) | 2008-07-16 | 2019-09-24 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
WO2012118972A2 (en) | 2011-03-01 | 2012-09-07 | Synegy Pharmaceuticals Inc. | Process of preparing guanylate cyclase c agonists |
WO2014131024A2 (en) | 2013-02-25 | 2014-08-28 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CA2905435A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
EP2970384A1 (en) | 2013-03-15 | 2016-01-20 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
CN113388007A (zh) | 2013-06-05 | 2021-09-14 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
MX2016001714A (es) | 2013-08-09 | 2016-10-03 | Ardelyx Inc | Compuestos y metodos para inhibir el transporte de fosfato. |
US20200368223A1 (en) | 2019-05-21 | 2020-11-26 | Ardelyx, Inc. | Methods for inhibiting phosphate transport |
CN111296447B (zh) * | 2020-03-24 | 2021-09-17 | 东营施普瑞石油工程技术有限公司 | 一种油田用杀菌剂及其制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB438211A (en) * | 1934-06-01 | 1935-11-13 | Ig Farbenindustrie Ag | The manufacture of heterocyclic compounds |
US2775593A (en) * | 1948-10-01 | 1956-12-25 | Schenley Ind Inc | Thiosemicarbazones of aldehydes and ketones of the heterocyclic series |
GB1229580A (es) * | 1967-12-15 | 1971-04-28 | ||
BE759237A (fr) * | 1969-11-21 | 1971-05-01 | Montedison Spa | Procede de preparation d'amides a partir de composes heterocycliques azotes |
BE786520A (fr) * | 1971-07-23 | 1973-01-22 | Bayer Ag | Nouveaux benzothiazoles substitues, leur preparation et leur application comme fongicides et bactericides |
DE2258036A1 (de) * | 1972-11-27 | 1974-05-30 | Goedecke Ag | Verfahren zur herstellung von benzo eckige klammer auf b eckige klammer zu thiophen-derivaten |
FR2305982A1 (fr) * | 1975-04-03 | 1976-10-29 | Innothera Lab Sa | Nouvelles benzothienyl amino (propyl et butyl) cetones, leur procede de preparation et leur application en therapeutique |
CH636866A5 (de) * | 1977-08-15 | 1983-06-30 | Lilly Co Eli | Thiadiazolylbenzamide und sie enthaltende insektizide mittel. |
US4140785A (en) * | 1978-05-08 | 1979-02-20 | E. I. Du Pont De Nemours And Company | N-(benzothienopyrazol)amide antirhinoviral agents |
JPS5936670A (ja) * | 1982-08-25 | 1984-02-28 | Takeda Chem Ind Ltd | ベンゾチアゾ−ル誘導体,その製造法およびそれを含有する摂食抑制剤 |
-
1984
- 1984-03-16 GB GB848406906A patent/GB8406906D0/en active Pending
-
1985
- 1985-03-06 EP EP85200325A patent/EP0158380B1/en not_active Expired
- 1985-03-06 DE DE8585200325T patent/DE3567459D1/de not_active Expired
- 1985-03-07 US US06/709,396 patent/US4665206A/en not_active Expired - Fee Related
- 1985-03-07 IE IE592/85A patent/IE57977B1/en not_active IP Right Cessation
- 1985-03-11 CA CA000476161A patent/CA1254216A/en not_active Expired
- 1985-03-11 ZA ZA851807A patent/ZA851807B/xx unknown
- 1985-03-14 AU AU39852/85A patent/AU568428B2/en not_active Ceased
- 1985-03-15 FI FI851038A patent/FI80883C/fi not_active IP Right Cessation
- 1985-03-15 JP JP60052167A patent/JPS60209577A/ja active Granted
- 1985-03-15 ES ES541336A patent/ES8707223A1/es not_active Expired
- 1985-03-15 HU HU85968A patent/HU198030B/hu not_active IP Right Cessation
- 1985-03-15 DK DK119285A patent/DK119285A/da not_active Application Discontinuation
- 1985-03-16 KR KR1019850001704A patent/KR870000920B1/ko not_active IP Right Cessation
-
1986
- 1986-01-27 ES ES551282A patent/ES8704924A1/es not_active Expired
- 1986-01-27 ES ES551281A patent/ES8704926A1/es not_active Expired
- 1986-01-27 ES ES551280A patent/ES8704925A1/es not_active Expired
-
1989
- 1989-04-06 US US07/333,806 patent/US4929636A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU3985285A (en) | 1985-09-19 |
ES8704924A1 (es) | 1987-04-16 |
US4929636A (en) | 1990-05-29 |
ES541336A0 (es) | 1987-07-16 |
CA1254216A (en) | 1989-05-16 |
IE57977B1 (en) | 1993-06-02 |
ES8704925A1 (es) | 1987-04-16 |
HUT37410A (en) | 1985-12-28 |
KR850006391A (ko) | 1985-10-05 |
HU198030B (en) | 1989-07-28 |
DK119285D0 (da) | 1985-03-15 |
ES551281A0 (es) | 1987-04-16 |
ES8707223A1 (es) | 1987-07-16 |
FI851038A0 (fi) | 1985-03-15 |
FI80883B (fi) | 1990-04-30 |
DE3567459D1 (en) | 1989-02-16 |
KR870000920B1 (ko) | 1987-05-07 |
FI80883C (fi) | 1990-08-10 |
ZA851807B (en) | 1985-10-30 |
GB8406906D0 (en) | 1984-04-18 |
US4665206A (en) | 1987-05-12 |
IE850592L (en) | 1985-09-16 |
FI851038L (fi) | 1985-09-17 |
ES8704926A1 (es) | 1987-04-16 |
DK119285A (da) | 1985-09-17 |
JPS60209577A (ja) | 1985-10-22 |
EP0158380B1 (en) | 1989-01-11 |
AU568428B2 (en) | 1987-12-24 |
ES551280A0 (es) | 1987-04-16 |
EP0158380A1 (en) | 1985-10-16 |
JPH0588232B2 (es) | 1993-12-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20020401 |