KR850000034A - 테트라하이드로-β-카르보린 유도체의 제조방법 - Google Patents

테트라하이드로-β-카르보린 유도체의 제조방법 Download PDF

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Publication number
KR850000034A
KR850000034A KR1019840002970A KR840002970A KR850000034A KR 850000034 A KR850000034 A KR 850000034A KR 1019840002970 A KR1019840002970 A KR 1019840002970A KR 840002970 A KR840002970 A KR 840002970A KR 850000034 A KR850000034 A KR 850000034A
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South Korea
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group
formula
compound
alkyl group
pharmaceutically acceptable
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KR1019840002970A
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KR870001239B1 (ko
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이꾸오(외 4) 이이지마
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마쓰바라 이찌로오
다나베 세이야꾸 가부시기 가이샤
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G67/00—Macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing oxygen or oxygen and carbon, not provided for in groups C08G2/00 - C08G65/00
    • C08G67/02—Copolymers of carbon monoxide and aliphatic unsaturated compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polymers & Plastics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음.

Description

테트라하이드로-β-카르보린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 일반식(II)의 화합물을 이유화탄소 또는 이유화탄소 및 다음 일반식(III)의 화합물과 반응시켜 다음 일반식(I)의 화합물 또는 이의 약제학적 허용 염을 제조하는 방법.
    상기 일반식(I), (II) 및 (III)에서 R1는 수소원자, 저급알킬기, 사이클로알킬기, 페닐기 또는 하이드록시 치환 저급알킬기이고, R2는 수소원자, 알킬기 또는 일반식 -(CH2)mY의 기로서 이때 Y는 티에닐기 또는 치환된 또는 비치환된 페닐기이며, m 및 n의 각각은 1 또는 2의 정수이고, R3는 알킬기 또는 Y 및 m이 상기 정의와 동일한 일반식 -(CH2)mY의 기이고, 또 X는 할로겐원자이다.
  2. 제1항에 있어서, R2가 수소원자 또는 일반식 -(CH2)mY의 기이고 또 Y가 아미노페닐인 일반식(I)의 화합물을 추가로 이의 약제학적 허용염으로 변환시키는 제조방법.
  3. 제1항에 있어서, R2가 일반식 -(CH2)mY의 기이고 또 Y가 보호 아미노페닐인 일반식(I)의 화합물로부터 보호기를 제거하는 단계를 추가로 포함하며 또 필요한 경우 이같이 수득된 생성물을 이의 약제학적 허용염으로 변환시키는 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840002970A 1983-06-04 1984-05-29 테트라하이드로-β-카르보린 유도체의 제조방법 KR870001239B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP15403 1983-06-04
GB08315403A GB2140797A (en) 1983-06-04 1983-06-04 Tetrahydro-b-carboline derivatives

Publications (2)

Publication Number Publication Date
KR850000034A true KR850000034A (ko) 1985-02-25
KR870001239B1 KR870001239B1 (ko) 1987-06-26

Family

ID=10543822

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002970A KR870001239B1 (ko) 1983-06-04 1984-05-29 테트라하이드로-β-카르보린 유도체의 제조방법

Country Status (13)

Country Link
US (1) US4612317A (ko)
EP (1) EP0128021B1 (ko)
JP (1) JPS59225187A (ko)
KR (1) KR870001239B1 (ko)
AT (1) ATE29496T1 (ko)
AU (1) AU563923B2 (ko)
CA (1) CA1251449A (ko)
DE (1) DE3465995D1 (ko)
DK (1) DK272684A (ko)
ES (1) ES8702909A1 (ko)
GB (1) GB2140797A (ko)
HU (1) HU198928B (ko)
SU (1) SU1382401A3 (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040253891A1 (en) * 2000-09-12 2004-12-16 Schierenbeck Alan W. Composite structure for protective garment
US20050101623A1 (en) * 2003-07-23 2005-05-12 Pharmacia Corporation Beta-carboline compounds and analogues thereof as mitogen-activated protein kinase-activated protein kinase-2 inhibitors
FR2869540B1 (fr) * 2004-04-30 2008-05-16 Centre Nat Rech Scient Cnrse Compositions pharmaceutiques contenant des derives de b-carboline, et leur utilisation pour le traitement des cancers
JP5649170B2 (ja) * 2010-11-26 2015-01-07 国立大学法人 千葉大学 テトラヒドロ−β−カルボリン誘導体及びその製造方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE20923C (de) * H. LAMPRECHT In Gnarrenburg und G. HlRDES in Bremen Neuerungen an Tropfenzählern
DD20923A (ko) *
CA668301A (en) * 1963-08-06 Leonard Frederick PROCESS FOR THE PREPARATION OF NEW .beta.-CARBOLINE DERIVATIVES
US2187719A (en) * 1938-06-10 1940-01-23 Du Pont Derivative of hexamethylene-di-thio-carbamic acid
ES273769A1 (es) * 1961-01-18 1962-06-01 Geigy Ag J R Procedimiento para la preparaciën de nuevos derivados de amidas de acido beta-carbolin-carboxilico
JPS5826755B2 (ja) * 1975-09-01 1983-06-04 オオキ サダオ ３− ヒドロキシメチル − ベ−タ − カルボリンユウドウタイノ セイゾウホウ

Also Published As

Publication number Publication date
US4612317A (en) 1986-09-16
ATE29496T1 (de) 1987-09-15
ES533080A0 (es) 1987-01-16
EP0128021B1 (en) 1987-09-09
KR870001239B1 (ko) 1987-06-26
SU1382401A3 (ru) 1988-03-15
AU563923B2 (en) 1987-07-30
JPS59225187A (ja) 1984-12-18
DK272684A (da) 1984-12-05
DE3465995D1 (en) 1987-10-15
EP0128021A1 (en) 1984-12-12
DK272684D0 (da) 1984-06-01
CA1251449A (en) 1989-03-21
GB2140797A (en) 1984-12-05
AU2887484A (en) 1984-12-06
ES8702909A1 (es) 1987-01-16
HUT34191A (en) 1985-02-28
HU198928B (en) 1989-12-28
GB8315403D0 (en) 1983-07-06

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