DE3367090D1 - 4-aminoalkyl-2(3h)-indolones - Google Patents
4-aminoalkyl-2(3h)-indolonesInfo
- Publication number
- DE3367090D1 DE3367090D1 DE8383307289T DE3367090T DE3367090D1 DE 3367090 D1 DE3367090 D1 DE 3367090D1 DE 8383307289 T DE8383307289 T DE 8383307289T DE 3367090 T DE3367090 T DE 3367090T DE 3367090 D1 DE3367090 D1 DE 3367090D1
- Authority
- DE
- Germany
- Prior art keywords
- indolones
- aminoalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/447,564 US4452808A (en) | 1982-12-07 | 1982-12-07 | 4-Aminoalkyl-2(3H)-indolones |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3367090D1 true DE3367090D1 (de) | 1986-11-27 |
Family
ID=23776840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8383307289T Expired DE3367090D1 (de) | 1982-12-07 | 1983-11-30 | 4-aminoalkyl-2(3h)-indolones |
Country Status (27)
Country | Link |
---|---|
US (1) | US4452808A (de) |
EP (1) | EP0113964B1 (de) |
JP (1) | JPS59112964A (de) |
KR (1) | KR910001042B1 (de) |
AU (1) | AU560170B2 (de) |
BR (1) | BR1100036A (de) |
CA (1) | CA1208650A (de) |
CY (1) | CY1497A (de) |
CZ (1) | CZ398191A3 (de) |
DE (1) | DE3367090D1 (de) |
DK (1) | DK156514C (de) |
DZ (1) | DZ587A1 (de) |
EG (1) | EG16556A (de) |
ES (2) | ES527827A0 (de) |
FI (1) | FI77849C (de) |
GR (1) | GR79121B (de) |
HK (1) | HK82089A (de) |
IE (1) | IE56347B1 (de) |
IL (1) | IL70311A (de) |
LU (1) | LU90097I2 (de) |
NL (1) | NL970005I2 (de) |
NO (2) | NO160135C (de) |
NZ (1) | NZ206344A (de) |
PH (1) | PH22067A (de) |
PT (1) | PT77739B (de) |
ZA (1) | ZA839094B (de) |
ZW (1) | ZW25883A1 (de) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4588740A (en) * | 1982-12-07 | 1986-05-13 | Smithkline Beckman Corporation | Pharmaceutical methods using 4-aminoalkyl-2(3H)-indolones |
US4657929A (en) * | 1983-10-25 | 1987-04-14 | Fisons Plc | Compounds |
US4554284A (en) * | 1984-09-12 | 1985-11-19 | Smithkline Beckman Corporation | 7-(2-Aminoethyl)-1,3-benzthia- or oxa-zol-2(3H)-ones |
GB8621040D0 (en) * | 1986-08-30 | 1986-10-08 | Smith Kline French Lab | Process |
GB8712073D0 (en) * | 1987-05-21 | 1987-06-24 | Smith Kline French Lab | Medicament |
GB8714371D0 (en) * | 1987-06-19 | 1987-07-22 | Smith Kline French Lab | Process |
GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
GB9015095D0 (en) * | 1990-07-09 | 1990-08-29 | Smith Kline French Lab | Therapeutic method |
IE914003A1 (en) * | 1990-11-20 | 1992-05-20 | Astra Pharma Prod | Biologically Active Amines |
EP0641202A1 (de) * | 1992-05-18 | 1995-03-08 | Smithkline Beecham Plc | Verwendung von indolonderivaten zur behandlung von gedaechtnisstoerungen, sexuele fehlwirkungen und morbus parkinson |
GB9300309D0 (en) * | 1993-01-08 | 1993-03-03 | Smithkline Beecham Plc | Process |
TW356468B (en) * | 1995-09-15 | 1999-04-21 | Astra Pharma Prod | Benzothiazolone compounds useful as beta2-adrenoreceptor and dopamine DA2 receptor agonists process for preparing same and pharmaceutical compositions containing same |
US5807570A (en) * | 1995-09-29 | 1998-09-15 | Cygnus, Inc. | Transdermal administration of ropinirole and analogs thereof |
GB9526511D0 (en) * | 1995-12-23 | 1996-02-28 | Astra Pharma Prod | Pharmaceutically active compounds |
AU4088897A (en) * | 1996-08-27 | 1998-03-19 | American Home Products Corporation | 4-aminoethoxy indolone derivatives |
JP2002511450A (ja) * | 1998-04-13 | 2002-04-16 | アメリカン・ホーム・プロダクツ・コーポレイション | 4−アミノ−(エチルアミノ)−オキソインドールドパミン自己受容体作動薬 |
US6218421B1 (en) * | 1999-07-01 | 2001-04-17 | Smithkline Beecham P.L.C. | Method of promoting smoking cessation |
AR030557A1 (es) | 2000-04-14 | 2003-08-27 | Jagotec Ag | Una tableta en multicapa de liberacion controlada y metodo de tratamiento |
US6277875B1 (en) * | 2000-07-17 | 2001-08-21 | Andrew J. Holman | Use of dopamine D2/D3 receptor agonists to treat fibromyalgia |
DE10041478A1 (de) * | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
US20020165246A1 (en) * | 2001-03-05 | 2002-11-07 | Andrew Holman | Administration of sleep restorative agents |
FR2821843B1 (fr) * | 2001-03-12 | 2003-05-09 | Servier Lab | Nouveaux derives d'isoindoloindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US20030068356A1 (en) * | 2001-07-10 | 2003-04-10 | Pather S. Indiran | Sequential drug delivery systems |
JP4630665B2 (ja) * | 2002-09-13 | 2011-02-09 | モタック・ニューロサイエンス・リミテッド | 2,3−ベンゾジアゼピンによる基底核関連運動障害の治療 |
WO2004026299A1 (en) * | 2002-09-17 | 2004-04-01 | Motac Neuroscience Limited | Treatment of dyskinesia |
ES2237307B1 (es) | 2003-10-14 | 2006-11-01 | Urquima, S.A. | Procedimiento para la preparacion de ropinirol. |
WO2005074387A2 (en) * | 2003-12-30 | 2005-08-18 | Sun Pharmaceutical Industries Limited | Novel crystal forms of 4-[2-di-n-propylamino)ethyl]-2 (3h)- indolone hydrochloride |
US7378439B2 (en) * | 2004-01-20 | 2008-05-27 | Usv, Ltd. | Process for the preparation of 4-(2-dipropylaminoethyl)-1,3-dihydro-2H-indol-2-one hydrochloride |
WO2005105741A1 (en) * | 2004-02-11 | 2005-11-10 | Sun Pharmaceutical Industries Limited | Substantially pure 4-[2-(di-n-propylamino)ethyl]-2(3h)-indolone hydrochloride |
WO2005080333A1 (en) * | 2004-02-19 | 2005-09-01 | Torrent Pharmaceuticals Ltd | Process for purification of ropinirole |
HUP0400953A3 (en) * | 2004-05-11 | 2008-02-28 | Egis Gyogyszergyar Nyilvanosan | Piperazine derivatives of alkyl-oxindoles, pharmaceutical compositions containing them, process for producing them and their use |
KR20070011551A (ko) * | 2004-05-11 | 2007-01-24 | 에지스 지오기스제르기아르 엔와이알티. | 알킬 옥스인돌의 피페라진 유도체 |
US20050267096A1 (en) * | 2004-05-26 | 2005-12-01 | Pfizer Inc | New indazole and indolone derivatives and their use pharmaceuticals |
US20050288270A1 (en) * | 2004-05-27 | 2005-12-29 | Pfizer Inc | New aminopyridine derivatives and their use as pharmaceuticals |
JP2008533193A (ja) * | 2005-03-21 | 2008-08-21 | ファイザー・リミテッド | オキシトシン拮抗薬としての置換トリアゾール誘導体 |
CN100457711C (zh) * | 2005-06-27 | 2009-02-04 | 上海奥博生物医药技术有限公司 | 2-甲基-3-硝基苯基烷基胺衍生物或其盐的制备方法 |
WO2007010557A2 (en) * | 2005-07-22 | 2007-01-25 | Ind-Swift Laboratorie Limted | Process for the preparation of highly pure ropinirole |
ATE517865T1 (de) | 2006-03-29 | 2011-08-15 | Alembic Ltd | Verfahren zur aufreinigung von ropinirolhydrochlorid |
KR101446813B1 (ko) * | 2006-04-06 | 2014-10-01 | 뉴파쎄 인크. | 도파민 연관된 상태의 치료를 위한 이식체 |
US20070254941A1 (en) * | 2006-04-21 | 2007-11-01 | Glenmark Pharmaceuticals Limited | Subtantially pure ropinirole hydrochloride, polymorphic form of ropinirole and process for their preparation |
CN100457732C (zh) * | 2006-05-25 | 2009-02-04 | 药源药物化学(上海)有限公司 | 罗匹尼罗的制备方法 |
WO2008001204A2 (en) * | 2006-06-29 | 2008-01-03 | Antares Pharma Ipl Ag | Transdermal compositions of pramipexole having enhanced permeation properties |
TW200815045A (en) * | 2006-06-29 | 2008-04-01 | Jazz Pharmaceuticals Inc | Pharmaceutical compositions of ropinirole and methods of use thereof |
US20100130569A1 (en) * | 2007-05-11 | 2010-05-27 | Saten Pharmaceutical Co., Ltd. | Prophylactic or therapeutic agent for posterior ocular disease comprising non-ergot selective d2 receptor agonist as active ingredient |
US20090076124A1 (en) * | 2007-09-14 | 2009-03-19 | Protia, Llc | Deuterium-enriched ropinirole |
US20090247537A1 (en) * | 2008-03-25 | 2009-10-01 | William Dale Overfield | Methods for preventing or treating bruxism using dopaminergic agents |
CN101574341B (zh) * | 2008-05-05 | 2012-12-19 | 北京德众万全医药科技有限公司 | 一种罗匹尼罗的口服固体药物组合物 |
WO2010023693A2 (en) * | 2008-09-01 | 2010-03-04 | Lupin Limited | Novel controlled release compositions of ropinirole |
EP2452677A1 (de) | 2008-09-29 | 2012-05-16 | Wockhardt Limited | Darreichungsform von Ropinirol mit verlängerter Freisetzung |
WO2010060070A2 (en) * | 2008-11-24 | 2010-05-27 | Auspex Pharmaceuticals, Inc. | Indolinone modulators of dopamine receptor |
EP2438917B1 (de) | 2009-05-21 | 2014-09-03 | Hisamitsu Pharmaceutical Co., Inc. | Transdermales präparat |
WO2011072704A1 (en) * | 2009-12-16 | 2011-06-23 | Pharmathen S.A. | Process for the preparation of ropinirole and salts thereof |
ES2608782T3 (es) | 2010-04-30 | 2017-04-17 | Teikoku Pharma Usa, Inc. | Composiciones transdérmicas de propinilaminoindano |
CN101891641B (zh) * | 2010-07-27 | 2015-06-10 | 北京华禧联合科技发展有限公司 | 盐酸罗匹尼罗关键中间体的稳定形态及其制备 |
TWI537274B (zh) | 2011-03-14 | 2016-06-11 | 橘生藥品工業股份有限公司 | 新穎之八氫噻吩并喹啉衍生物、含有其之醫藥組成物及該等之用途 |
KR101853082B1 (ko) | 2011-03-24 | 2018-04-27 | 테이코쿠 팔마 유에스에이, 인코포레이티드 | 활성제층 및 활성제 변환층을 포함하는 경피 조성물 |
EP2776020B1 (de) | 2011-11-09 | 2019-09-11 | Teikoku Seiyaku Co., Ltd. | Verfahren zur behandlung von neoplasmen der haut |
AU2013338243B2 (en) | 2012-11-02 | 2016-09-29 | Teikoku Seiyaku Co., Ltd. | Propynylaminoindan transdermal compositions |
JP6242811B2 (ja) | 2012-12-10 | 2017-12-06 | キッセイ薬品工業株式会社 | 新規なオクタヒドロピリドキナゾリン誘導体、それを含有する医薬組成物およびそれらの用途 |
US9155695B2 (en) | 2013-03-14 | 2015-10-13 | Medtronic, Inc. | Injectable ropinirole compositions and methods for making and using same |
EP3640240B1 (de) | 2017-06-16 | 2020-12-09 | Zhejiang Huahai Licheng Pharmaceutical Co., Ltd. | Verfahren zur aufreinigung von ropinirolhydrochlorid |
CN115466209A (zh) * | 2022-09-29 | 2022-12-13 | 南通大学 | 一种罗匹尼罗环戊烷并吲哚酮杂质的合成方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA895875A (en) * | 1972-03-21 | Bourdais Jacques | Mercapto indole derivatives | |
US3573310A (en) * | 1967-09-28 | 1971-03-30 | Miles Lab | 1-substituted derivatives of 2-indolinone |
JPS5840539B2 (ja) * | 1976-03-31 | 1983-09-06 | 大塚製薬株式会社 | α−置換アミノアルカノイルオキシインド−ル誘導体 |
JPS5825673B2 (ja) * | 1976-03-31 | 1983-05-28 | 大塚製薬株式会社 | オキシインド−ル誘導体 |
JPS5919537B2 (ja) * | 1976-08-02 | 1984-05-07 | 大塚製薬株式会社 | オキシインド−ル誘導体 |
US4317944A (en) * | 1980-08-15 | 1982-03-02 | General Electric Company | Preparation of 2,2-bis(4-hydroxyphenyl) propane |
US4314944A (en) * | 1980-08-22 | 1982-02-09 | Smithkline Corporation | 4-Aminoalkyl-7-hydroxy-2(3H)-indolones |
-
1982
- 1982-12-07 US US06/447,564 patent/US4452808A/en not_active Expired - Lifetime
-
1983
- 1983-11-17 CA CA000441416A patent/CA1208650A/en not_active Expired
- 1983-11-21 NZ NZ206344A patent/NZ206344A/en unknown
- 1983-11-22 AU AU21585/83A patent/AU560170B2/en not_active Expired
- 1983-11-23 IL IL70311A patent/IL70311A/xx not_active IP Right Cessation
- 1983-11-25 ZW ZW258/83A patent/ZW25883A1/xx unknown
- 1983-11-25 PT PT77739A patent/PT77739B/pt unknown
- 1983-11-28 PH PH29901A patent/PH22067A/en unknown
- 1983-11-30 CY CY1497A patent/CY1497A/xx unknown
- 1983-11-30 LU LU90097C patent/LU90097I2/fr unknown
- 1983-11-30 DE DE8383307289T patent/DE3367090D1/de not_active Expired
- 1983-11-30 EP EP83307289A patent/EP0113964B1/de not_active Expired
- 1983-12-02 FI FI834421A patent/FI77849C/fi not_active IP Right Cessation
- 1983-12-05 GR GR73156A patent/GR79121B/el unknown
- 1983-12-05 EG EG753/83A patent/EG16556A/xx active
- 1983-12-06 IE IE2866/83A patent/IE56347B1/en not_active IP Right Cessation
- 1983-12-06 JP JP58231215A patent/JPS59112964A/ja active Granted
- 1983-12-06 NO NO834485A patent/NO160135C/no unknown
- 1983-12-06 ES ES527827A patent/ES527827A0/es active Granted
- 1983-12-06 DK DK562183A patent/DK156514C/da not_active IP Right Cessation
- 1983-12-07 KR KR1019830005790A patent/KR910001042B1/ko not_active IP Right Cessation
- 1983-12-07 ZA ZA839094A patent/ZA839094B/xx unknown
-
1984
- 1984-12-07 DZ DZ847014A patent/DZ587A1/fr active
-
1985
- 1985-05-29 ES ES543593A patent/ES8604143A1/es not_active Expired
-
1989
- 1989-10-12 HK HK820/89A patent/HK82089A/xx not_active IP Right Cessation
-
1991
- 1991-12-20 CZ CS913981A patent/CZ398191A3/cs unknown
-
1996
- 1996-08-30 BR BR1100036-8A patent/BR1100036A/pt active IP Right Grant
-
1997
- 1997-02-05 NL NL970005C patent/NL970005I2/nl unknown
-
1999
- 1999-06-18 NO NO1999011C patent/NO1999011I1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
V448 | Application of spc |
Free format text: PRODUCT NAME: ROPINIROLHYDROCHLORID; REGISTRATION NO/DATE: 38707.00.00, 38707.01.00, 38707.02.00, 38707.03.00, 38707.04.00; 19961218 Spc suppl protection certif: 197 75 005 Filing date: 19970206 |
|
V457 | Spc granted |
Free format text: PRODUCT NAME: ROPINIROLHYDROCHLORID; REGISTRATION NO/DATE: 38707.00.00, 38707.01.00, 38707.02.00, 38707.03.00, 38707.04.00; 19961218 Spc suppl protection certif: 197 75 005 Filing date: 19970206 |
|
V464 | Spc expired |
Free format text: PRODUCT NAME: ROPINIROLHYDROCHLORID; REGISTRATION NO/DATE: 38707.00.00, 38707.01.00, 38707.02.00, 38707.03.00, 38707.04.00; 19961218 Spc suppl protection certif: 197 75 005 Filing date: 19970206 |