KR840001165A - 시드논 이민 유도체의 제조방법 - Google Patents

시드논 이민 유도체의 제조방법 Download PDF

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Publication number
KR840001165A
KR840001165A KR1019820003615A KR820003615A KR840001165A KR 840001165 A KR840001165 A KR 840001165A KR 1019820003615 A KR1019820003615 A KR 1019820003615A KR 820003615 A KR820003615 A KR 820003615A KR 840001165 A KR840001165 A KR 840001165A
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KR
South Korea
Prior art keywords
cydnon
preparing
formula
imine derivative
benzoylalkyl
Prior art date
Application number
KR1019820003615A
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English (en)
Inventor
히로요시(외 3) 히다까
Original Assignee
히다까 히로요시
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 히다까 히로요시 filed Critical 히다까 히로요시
Publication of KR840001165A publication Critical patent/KR840001165A/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/28—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles

Abstract

내용 없음

Description

시드논 이민 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기식 (2)로 표시되는 4-(벤조일알킬)-1-(N-니트로소시아노메틸아미노)피페라진과 산을 접촉시킴을 특징으로하는 하기식(1)로 표시되는 3-[4-(벤조일알킬)피페라진-1-일]시드논이민 화합물의 제조방법.
    상기 식에서, R은 수소원자 또는 탄소원자수 1~8의 알킬기를 나타내고, n은 0또는 1~10의 정수를 나타낸다.
  2. 제1항에 있어서, 식(2)의 화합물이 니트로소기를 하기식(3)의 4-(벤조일알킬)-1-(시아노메틸아미노)피페라진 속으로 도입함으로써 수득됨을 특징으로 하는 방법.
    상기 식에서, R은 수소원자 또는 탄소원자수 1~8의 알킬기를 나타내고, n은 0 또는 1~10의 정수를 나타낸다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019820003615A 1981-08-24 1982-08-12 시드논 이민 유도체의 제조방법 KR840001165A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP131564/81 1981-08-24
JP56131564A JPS5832870A (ja) 1981-08-24 1981-08-24 新規なシドノンイミン誘導体及びその製法

Publications (1)

Publication Number Publication Date
KR840001165A true KR840001165A (ko) 1984-03-28

Family

ID=15061006

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019820003615A KR840001165A (ko) 1981-08-24 1982-08-12 시드논 이민 유도체의 제조방법

Country Status (4)

Country Link
US (1) US4421754A (ko)
EP (1) EP0073345A3 (ko)
JP (1) JPS5832870A (ko)
KR (1) KR840001165A (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3107933A1 (de) * 1981-03-02 1982-09-16 Cassella Ag, 6000 Frankfurt Substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE3732174A1 (de) * 1987-09-24 1989-04-06 Cassella Ag Substituierte 3-aminosydnonimine, verfahren zu ihrer herstellung und ihre verwendung
DE4117249C2 (de) * 1991-05-27 1998-05-14 Christian Dr Stief Linsidomin zur Behandlung erektiler Dysfunktionen
US20050065161A1 (en) * 1996-02-02 2005-03-24 Nitromed, Inc. Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds, compositions and their uses
US6472425B1 (en) * 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1695897C3 (de) * 1966-07-04 1979-02-15 Takeda Chemical Industries Ltd N-Acyl-sydnonimine, deren Salze, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
BE788052A (fr) * 1971-08-26 1973-02-26 Science Union & Cie Societe Fr Nouveaux derives de la sydnone imine
US3833589A (en) * 1972-07-31 1974-09-03 Sandoz Ag Substituted sydnonimine nitrate esters
DE2930736A1 (de) * 1979-07-28 1981-02-12 Cassella Ag Pharmakologisch wirksame, substituierte 3-amino-sydnonimine, verfahren zu ihrer herstellung und ihre verwendung
JPS57134471A (en) * 1981-02-13 1982-08-19 Hiroyoshi Hidaka Novel sydnonimine derivative, its preparation, and drug containing said derivative as active component

Also Published As

Publication number Publication date
JPS5832870A (ja) 1983-02-25
EP0073345A3 (en) 1984-03-21
EP0073345A2 (en) 1983-03-09
US4421754A (en) 1983-12-20

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