KR850004098A - 부타놀 유도체의 제조방법 - Google Patents

부타놀 유도체의 제조방법 Download PDF

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Publication number
KR850004098A
KR850004098A KR1019840007274A KR840007274A KR850004098A KR 850004098 A KR850004098 A KR 850004098A KR 1019840007274 A KR1019840007274 A KR 1019840007274A KR 840007274 A KR840007274 A KR 840007274A KR 850004098 A KR850004098 A KR 850004098A
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KR
South Korea
Prior art keywords
general formula
following general
preparing
carbon atoms
alkyl group
Prior art date
Application number
KR1019840007274A
Other languages
English (en)
Inventor
기요시(외 3) 기무로
Original Assignee
모리시다 히로시
닛본 신야꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 모리시다 히로시, 닛본 신야꾸 가부시기가이샤 filed Critical 모리시다 히로시
Publication of KR850004098A publication Critical patent/KR850004098A/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/10—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
    • C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
    • C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C07C215/32—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
    • C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
    • C07C217/72—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring

Abstract

내용 없음

Description

부타놀 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 하기 일반식(Ⅹ)의 화합물과 하기 일반식(ⅩⅠ)의 그리그나드시약 또는 하기일반식(ⅩⅡ)의 리듐 화합물을 반응시키는 것을 특징으로 하는 일반식(Ⅰ)의 4―디이소부틸아미노부타놀 유도체, 또는 이의 약리학적으로 허용되는 염의 제조방법.
    상기식에서, A와 B는 서로 상이한 또는 R3O―이며, 단 A가이고, B가 R3O―인 경우는 제외하며, R1및 R2는 서로 상이하거나 동일한 수소, 할로겐, 수산기, 탄소수 1―4의 알콕시기 또는 탄소수 1―4의 알킬기이며, R3는 알킬기이며, R은또는 이며, 단 R이인 경우 A 및 B는 각각이고, 또한 R이인 경우에는 A는이고 B는 R3O― 또는이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019840007274A 1983-11-21 1984-11-21 부타놀 유도체의 제조방법 KR850004098A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP58-220342 1983-11-21
JP58220342A JPS60132934A (ja) 1983-11-21 1983-11-21 ブタノ−ル誘導体

Publications (1)

Publication Number Publication Date
KR850004098A true KR850004098A (ko) 1985-07-01

Family

ID=16749640

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019840007274A KR850004098A (ko) 1983-11-21 1984-11-21 부타놀 유도체의 제조방법
KR1019850008133A KR860004008A (ko) 1983-11-21 1985-11-01 부타놀유도체의 제법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1019850008133A KR860004008A (ko) 1983-11-21 1985-11-01 부타놀유도체의 제법

Country Status (10)

Country Link
US (1) US5089529A (ko)
JP (1) JPS60132934A (ko)
KR (2) KR850004098A (ko)
CA (1) CA1241345A (ko)
CH (1) CH662111A5 (ko)
DE (1) DE3442648A1 (ko)
ES (1) ES8601095A1 (ko)
FR (1) FR2555168B1 (ko)
GB (1) GB2150134B (ko)
IT (1) IT1178255B (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA03000397A (es) * 2000-07-13 2003-05-27 Sankyo Co Derivados de aminoalcohol.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2441664A (en) * 1947-08-09 1948-05-18 Lucille E Hoagland Means for lengthening skirts
US2584429A (en) * 1950-12-29 1952-02-05 Rohm & Haas 1,1-diphenyl-4-tert.-amino-2-butyne-1-ols
US2682543A (en) * 1951-05-26 1954-06-29 Burroughs Wellcome Co Catalytic reduction of diphenyl alkanolamines and resulting products
GB993525A (en) * 1961-05-19 1965-05-26 Smith Kline French Lab Substituted propanolamines and process for preparing the same
BE623390A (ko) * 1961-10-10
DK114828B (da) * 1962-11-29 1969-08-11 Hoffmann La Roche Fremgangsmåde til fremstilling af 5-hydroxy-5-aminoalkyl-10,11-dihydro-5H-dibenzo-(a,d)-cykloheptener eller syreadditionssalte deraf.
AT255400B (de) * 1965-03-22 1967-07-10 Chemie Linz Ag Verfahren zur Herstellung von neuen basischen Äthern
AT316516B (de) * 1970-12-09 1974-07-10 Sumitomo Chemical Co Verfahren zur Herstellung von neuen Aminoalkoholen und von deren Säureadditionssalzen
US4277471A (en) * 1979-03-12 1981-07-07 Eli Lilly And Company 1,1-Biphenyl-2-yl alkylamines, formulations and antiarrhythmic treatment

Also Published As

Publication number Publication date
DE3442648A1 (de) 1985-05-30
JPS60132934A (ja) 1985-07-16
KR860004008A (ko) 1986-06-16
JPH0246024B2 (ko) 1990-10-12
IT8449192A0 (it) 1984-11-20
CH662111A5 (fr) 1987-09-15
ES537789A0 (es) 1985-10-16
ES8601095A1 (es) 1985-10-16
IT8449192A1 (it) 1986-05-20
US5089529A (en) 1992-02-18
GB2150134A (en) 1985-06-26
GB8427829D0 (en) 1984-12-12
GB2150134B (en) 1987-11-11
FR2555168B1 (fr) 1987-06-19
FR2555168A1 (fr) 1985-05-24
IT1178255B (it) 1987-09-09
CA1241345A (en) 1988-08-30

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