KR840006983A - 피페라진 유도체의 제조방법 - Google Patents

피페라진 유도체의 제조방법 Download PDF

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Publication number
KR840006983A
KR840006983A KR1019830003342A KR830003342A KR840006983A KR 840006983 A KR840006983 A KR 840006983A KR 1019830003342 A KR1019830003342 A KR 1019830003342A KR 830003342 A KR830003342 A KR 830003342A KR 840006983 A KR840006983 A KR 840006983A
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South Korea
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carbon atoms
group containing
group
hydrogen atom
lower alkoxy
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KR1019830003342A
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KR900003277B1 (ko
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미쯔오 마시끼
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우시야마 게이조
닛뽕 케미파 가부시끼 가이샤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

피페라진 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (25)

  1. 다음 일반식(II)의 화합물을 환원시켜 다음 일반식(I)의 화합물을 제조한 다음, 필요에 따라 공지된 방법으로 이 피페라진 유도체를 상응하는 염으로 전환시켜줌을 특징으로 한 다음 일반식(I)의 화합물 또는 약리학적으로 수락되는 이들의 염을 제조하는 방법.
  4. (상기 일반식에서
  5. R1은 수소원자 또는 저급알킬그룹이고;
  6. R2는 히드록실그룹, 아르알킬옥시그룹, 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹 또는 3내지 5개의 탄소원자를 함유하고 있는 저급알케닐옥시 그룹이고;
  7. R3는 수소원자, 아르알킬옥시그룹, 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹 또는 3내지 5개의 탄소원자를 함유하고 있는 저급알케닐옥시 그룹이며,
  8. R4는 수소원자 또는 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹인데, R3와 R4둘다가 수소원자일 경우에 R2는 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시 그룹이외의 그룹을 나타낸다.)
  9. 다음 일반식(III)의 화합물과 다음 일반식(IV)의 화합물을 반응시켜 다음 일반식(I′)의 화합물을 제조한 다음, 필요에 따라, 공지된 방법으로 이 피페라진 유도체를 상응하는 염으로 전환시켜줌을 특징으로 한 다음 일반식(I′)의 화합물 또는 약리학적으로 수락되는 화합물의 염을 제조하는 방법.
  11. (상기 일반식에서
  12. R1은 수소원자 또는 저급알킬그룹이고;
  13. R2는 아르알킬옥시그룹, 1내지 5개의 탄소원자를 함유하고 있는 저급 알콕시그룹 또는 3내지 5개의 탄소원자를 함유하고 있는 저급알케닐옥시 그룹이고;
  14. R3는 수소원자, 아르알킬옥시그룹, 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹 또는 3내지 5개의 탄소원자를 함유하고 있는 저급알케닐옥시 그룹이고;
  15. R4는 수소원자 또는 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹인데, R3와 R4둘다가 수소원자일 경우에 R2′는 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시 그룹 이외의 그룹을 나타낸다.)
  17. (상기 일반식에서
  18. R1은 수소원자 또는 저급알킬그룹이고;
  19. R5는 히드록실그룹, 아르알킬옥시그룹, 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹 또는 3내지 5개의 탄소원자를 함유하고 있는 저급알케닐옥시 그룹이고;
  20. R6는 수소원자, 히드록실그룹, 아르알킬옥시그룹, 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹 또는 3내지 5개의 탄소원자를 함유하고 있는 저급알케닐옥시 그룹이고;
  21. R7는 수소원자, 히드록실그룹 또는 1내지 5개의 탄소원자를 함유하고 있는 저급알콕시그룹인데, R5, R6및 R7중 적어도 한개는 히드록실그룹이다.)
  22. R8―X (IV)
  23. (상기 일반식에서
  24. R8은 아르알킬그룹, 1내지 5개의 탄소원자를 함유하고 있는 저급알킬그룹 또는 3내지 5개의 탄소원자를 함유하고 있는 저급알케닐그룹이고; X는 반응그룹이다).
  25. ※참고사항:최초출원 내용에 의하여 공개하는 것임.
KR1019830003342A 1982-12-02 1983-07-20 피페라진 유도체의 제조방법 KR900003277B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP212036 1982-12-02
JP57212036A JPS59101475A (ja) 1982-12-02 1982-12-02 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤

Publications (2)

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KR840006983A true KR840006983A (ko) 1984-12-04
KR900003277B1 KR900003277B1 (ko) 1990-05-12

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KR1019830003342A KR900003277B1 (ko) 1982-12-02 1983-07-20 피페라진 유도체의 제조방법

Country Status (11)

Country Link
US (1) US4528194A (ko)
JP (1) JPS59101475A (ko)
KR (1) KR900003277B1 (ko)
BR (1) BR8304319A (ko)
CH (1) CH655719A5 (ko)
DE (1) DE3326148A1 (ko)
ES (2) ES8604911A1 (ko)
FR (1) FR2541275B1 (ko)
GB (2) GB8318683D0 (ko)
IT (1) IT1162913B (ko)
SE (1) SE464707B (ko)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424685A1 (de) * 1984-07-05 1986-02-06 Beiersdorf Ag, 2000 Hamburg Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPH08776B2 (ja) * 1986-08-20 1996-01-10 日本ケミフア株式会社 脳細胞保護作用を有する医薬組成物
EP0354068B1 (en) * 1988-08-05 1994-06-15 Nippon Chemiphar Co., Ltd. Optically active piperazine derivative
JP2679872B2 (ja) * 1989-04-28 1997-11-19 明治製菓株式会社 Ｎ−置換ピペラジン誘導体を含む脳機能障害改善剤
WO1990013539A1 (en) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. New n-substituted piperazine derivatives and drug for improving functional disorder of brain
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
DE4404249C2 (de) * 1994-02-10 2001-10-18 Basf Ag Substituierte Cycloalkyl-piperazinyl-ethanol, ihre Herstellung und diese enthaltende Arzneimittel
KR100472086B1 (ko) * 2001-11-23 2005-02-21 한국화학연구원 항산화 활성을 갖는 3,5-디알콕시-4-히드록시페닐기로치환된 피페라진 유도체, 그의 제조방법 및 이를 포함하는약학적 조성물
US8186436B2 (en) * 2009-09-10 2012-05-29 Warren Carlos Thermal insulating packer fluid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL131192C (ko) * 1965-06-16
FR2081579B1 (ko) * 1970-03-18 1973-04-06 Delalande Sa
FR2163358A1 (en) * 1971-12-15 1973-07-27 Synthelabo Phenylalkanolamine derivs - with effects on the smooth musculature
NL7306771A (ko) * 1972-06-02 1973-12-04
JPS504087A (ko) * 1973-05-17 1975-01-16

Also Published As

Publication number Publication date
GB2131016A (en) 1984-06-13
ES543397A0 (es) 1986-01-01
CH655719A5 (fr) 1986-05-15
IT1162913B (it) 1987-04-01
FR2541275A1 (fr) 1984-08-24
SE8304071L (sv) 1984-06-03
GB2131016B (en) 1985-11-20
US4528194A (en) 1985-07-09
GB8318683D0 (en) 1983-08-10
ES8604911A1 (es) 1986-03-16
JPH0254832B2 (ko) 1990-11-22
KR900003277B1 (ko) 1990-05-12
ES524283A0 (es) 1986-03-16
DE3326148A1 (de) 1984-06-07
DE3326148C2 (ko) 1989-11-16
ES8603449A1 (es) 1986-01-01
SE8304071D0 (sv) 1983-07-20
IT8367776A0 (it) 1983-07-19
GB8319317D0 (en) 1983-08-17
BR8304319A (pt) 1984-11-06
JPS59101475A (ja) 1984-06-12
SE464707B (sv) 1991-06-03
FR2541275B1 (fr) 1986-02-07

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