IT1162913B - Nuovi derivati della piperazina o di suoi sali procedimento per la loro produzione e farmaco per migliorare la circolazione sanguigna celebrale che li utilizza - Google Patents

Nuovi derivati della piperazina o di suoi sali procedimento per la loro produzione e farmaco per migliorare la circolazione sanguigna celebrale che li utilizza

Info

Publication number
IT1162913B
IT1162913B IT67776/83A IT6777683A IT1162913B IT 1162913 B IT1162913 B IT 1162913B IT 67776/83 A IT67776/83 A IT 67776/83A IT 6777683 A IT6777683 A IT 6777683A IT 1162913 B IT1162913 B IT 1162913B
Authority
IT
Italy
Prior art keywords
piperazine
drug
circulation
salts
procedure
Prior art date
Application number
IT67776/83A
Other languages
English (en)
Other versions
IT8367776A0 (it
Inventor
Masaki Mitsuo
Original Assignee
Nippon Chemiphar Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nippon Chemiphar Co filed Critical Nippon Chemiphar Co
Publication of IT8367776A0 publication Critical patent/IT8367776A0/it
Application granted granted Critical
Publication of IT1162913B publication Critical patent/IT1162913B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT67776/83A 1982-12-02 1983-07-19 Nuovi derivati della piperazina o di suoi sali procedimento per la loro produzione e farmaco per migliorare la circolazione sanguigna celebrale che li utilizza IT1162913B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP57212036A JPS59101475A (ja) 1982-12-02 1982-12-02 新規ピペラジン誘導体およびその製造法ならびにこれを含有する脳循環改善剤

Publications (2)

Publication Number Publication Date
IT8367776A0 IT8367776A0 (it) 1983-07-19
IT1162913B true IT1162913B (it) 1987-04-01

Family

ID=16615802

Family Applications (1)

Application Number Title Priority Date Filing Date
IT67776/83A IT1162913B (it) 1982-12-02 1983-07-19 Nuovi derivati della piperazina o di suoi sali procedimento per la loro produzione e farmaco per migliorare la circolazione sanguigna celebrale che li utilizza

Country Status (11)

Country Link
US (1) US4528194A (it)
JP (1) JPS59101475A (it)
KR (1) KR900003277B1 (it)
BR (1) BR8304319A (it)
CH (1) CH655719A5 (it)
DE (1) DE3326148A1 (it)
ES (2) ES8604911A1 (it)
FR (1) FR2541275B1 (it)
GB (2) GB8318683D0 (it)
IT (1) IT1162913B (it)
SE (1) SE464707B (it)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3424685A1 (de) * 1984-07-05 1986-02-06 Beiersdorf Ag, 2000 Hamburg Neue substituierte phenylpiperazinyl-propanole, verfahren zu ihrer herstellung und ihre verwendung sowie diese verbindungen enthaltende zubereitungen
JPS61161272A (ja) * 1985-01-11 1986-07-21 Kanebo Ltd 新規なピペラジン誘導体および該化合物を有効成分とする医薬組成物
JPH08776B2 (ja) * 1986-08-20 1996-01-10 日本ケミフア株式会社 脳細胞保護作用を有する医薬組成物
EP0354068B1 (en) * 1988-08-05 1994-06-15 Nippon Chemiphar Co., Ltd. Optically active piperazine derivative
JP2679872B2 (ja) * 1989-04-28 1997-11-19 明治製菓株式会社 Ｎ−置換ピペラジン誘導体を含む脳機能障害改善剤
WO1990013539A1 (en) * 1989-04-28 1990-11-15 Meiji Seika Kaisha, Ltd. New n-substituted piperazine derivatives and drug for improving functional disorder of brain
DE4108527A1 (de) * 1991-03-15 1992-09-17 Basf Ag Neue 1-(4-cyano-4-aryl-cyclohexyl)piperazine, ihre herstellung und verwendung
DE4404249C2 (de) * 1994-02-10 2001-10-18 Basf Ag Substituierte Cycloalkyl-piperazinyl-ethanol, ihre Herstellung und diese enthaltende Arzneimittel
KR100472086B1 (ko) * 2001-11-23 2005-02-21 한국화학연구원 항산화 활성을 갖는 3,5-디알콕시-4-히드록시페닐기로치환된 피페라진 유도체, 그의 제조방법 및 이를 포함하는약학적 조성물
US8186436B2 (en) * 2009-09-10 2012-05-29 Warren Carlos Thermal insulating packer fluid

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL131192C (it) * 1965-06-16
FR2081579B1 (it) * 1970-03-18 1973-04-06 Delalande Sa
FR2163358A1 (en) * 1971-12-15 1973-07-27 Synthelabo Phenylalkanolamine derivs - with effects on the smooth musculature
NL7306771A (it) * 1972-06-02 1973-12-04
JPS504087A (it) * 1973-05-17 1975-01-16

Also Published As

Publication number Publication date
GB2131016A (en) 1984-06-13
ES543397A0 (es) 1986-01-01
KR840006983A (ko) 1984-12-04
CH655719A5 (fr) 1986-05-15
FR2541275A1 (fr) 1984-08-24
SE8304071L (sv) 1984-06-03
GB2131016B (en) 1985-11-20
US4528194A (en) 1985-07-09
GB8318683D0 (en) 1983-08-10
ES8604911A1 (es) 1986-03-16
JPH0254832B2 (it) 1990-11-22
KR900003277B1 (ko) 1990-05-12
ES524283A0 (es) 1986-03-16
DE3326148A1 (de) 1984-06-07
DE3326148C2 (it) 1989-11-16
ES8603449A1 (es) 1986-01-01
SE8304071D0 (sv) 1983-07-20
IT8367776A0 (it) 1983-07-19
GB8319317D0 (en) 1983-08-17
BR8304319A (pt) 1984-11-06
JPS59101475A (ja) 1984-06-12
SE464707B (sv) 1991-06-03
FR2541275B1 (fr) 1986-02-07

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19950731