FR2163358A1 - Phenylalkanolamine derivs - with effects on the smooth musculature - Google Patents
Phenylalkanolamine derivs - with effects on the smooth musculatureInfo
- Publication number
- FR2163358A1 FR2163358A1 FR7145106A FR7145106A FR2163358A1 FR 2163358 A1 FR2163358 A1 FR 2163358A1 FR 7145106 A FR7145106 A FR 7145106A FR 7145106 A FR7145106 A FR 7145106A FR 2163358 A1 FR2163358 A1 FR 2163358A1
- Authority
- FR
- France
- Prior art keywords
- alkyl
- nr3r4
- benzyl
- derivs
- phenylalkanolamine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/02—Preparation by ring-closure or hydrogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/092—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings with aromatic radicals attached to the chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Title derivs. of formula (I): (where R1 is H, 1-4C alkyl or benzyl; R2 is H, OH, 1-2C alkoxy or benzyloxy; n is 1 or 2 (the chain being branched or linear when n is 2); and NR3R4 is -NH-CnH2n-X-N(R6)2 in which X is CH2, CO or a single bond and R6 is 1-3C alkyl, or NR3R4 is a (un)satd. 6-membered heterocycle opt. contg. another hetero atom and carrying in the 4-position 1 or 2 substits. selected from 1-3C alkyl, phenyl, benzyl, 1-3C hydroxyalkyl or (1-3C alkoxy) carbonyl; NR3R4 not being 4-alkyl -phenyl- or -benzyl-piperazino when R2 is OH and R1 is H) and their addition salts with pharmaceutically suitable acids are useful as bronchodilators and/or vasodilators (esp. coronary vasodilators).
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7145106A FR2163358A1 (en) | 1971-12-15 | 1971-12-15 | Phenylalkanolamine derivs - with effects on the smooth musculature |
JP47126011A JPS4867234A (en) | 1971-12-15 | 1972-12-15 | |
DE19722261506 DE2261506A1 (en) | 1971-12-15 | 1972-12-15 | BASIC DERIVATIVES OF PHENYL-1 ALKANOLS, THEIR MANUFACTURING AND MEDICINES CONTAINING THEM |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR7145106A FR2163358A1 (en) | 1971-12-15 | 1971-12-15 | Phenylalkanolamine derivs - with effects on the smooth musculature |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2163358A1 true FR2163358A1 (en) | 1973-07-27 |
FR2163358B1 FR2163358B1 (en) | 1975-03-14 |
Family
ID=9087537
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR7145106A Granted FR2163358A1 (en) | 1971-12-15 | 1971-12-15 | Phenylalkanolamine derivs - with effects on the smooth musculature |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPS4867234A (en) |
DE (1) | DE2261506A1 (en) |
FR (1) | FR2163358A1 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534580A1 (en) * | 1982-10-13 | 1984-04-20 | Synthelabo | PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM |
FR2541275A1 (en) * | 1982-12-02 | 1984-08-24 | Nippon Chemiphar Co | NOVEL DERIVATIVES OF PIPERAZINE AND THEIR SALTS, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION |
EP0288563A1 (en) * | 1986-09-30 | 1988-11-02 | Eisai Co., Ltd. | Cyclic amine derivatives |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5830306B2 (en) * | 1972-07-18 | 1983-06-28 | ヒサミツセイヤク カブシキカイシヤ | Amino alcohol usage information |
US4022784A (en) * | 1974-01-31 | 1977-05-10 | Otsuka Pharmaceutical Company Limited | 5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives |
US4022776A (en) * | 1974-01-31 | 1977-05-10 | Otsuka Pharmaceutical Company Limited | 5-[1-Hydroxy-2-(substituted-amino)]ethyl-8-hydroxycarbostyril derivatives |
GB1508208A (en) | 1975-12-05 | 1978-04-19 | Ici Ltd | Amide derivatives |
JPS6034951B2 (en) * | 1979-09-13 | 1985-08-12 | 東洋フアルマ−株式会社 | Method for producing 1-(4-hydroxyphenyl)-2-(4-benzylpiperidino)propan-1-ol |
JPS5677258A (en) * | 1979-11-28 | 1981-06-25 | Grelan Pharmaceut Co Ltd | Preparation of erythro 2- 4-benzylpiperidino -1- 4-hydroxyphenyl propanol |
JPS5679666A (en) * | 1979-12-04 | 1981-06-30 | Grelan Pharmaceut Co Ltd | Erythro 1- 4-benzyloxyphenyl -2- 4-benzylpiperidino propanol and its preparation |
JPS5679667A (en) * | 1979-12-04 | 1981-06-30 | Grelan Pharmaceut Co Ltd | Preparation of erythro 2- 4-benzylpiperidino -1- 4- hydroxyphenyl propanol |
JPS591467A (en) * | 1983-02-09 | 1984-01-06 | Grelan Pharmaceut Co Ltd | Piperidinoalkanones, its salt and their preparation |
JPS601165A (en) * | 1984-05-22 | 1985-01-07 | Grelan Pharmaceut Co Ltd | Piperidinoalkanol compound |
WO1987000433A1 (en) * | 1985-07-24 | 1987-01-29 | Grelan Pharmaceutical Co., Ltd. | Circulation improving agent |
JP2573195B2 (en) * | 1986-09-30 | 1997-01-22 | エーザイ株式会社 | Cyclic amine derivative |
-
1971
- 1971-12-15 FR FR7145106A patent/FR2163358A1/en active Granted
-
1972
- 1972-12-15 JP JP47126011A patent/JPS4867234A/ja active Pending
- 1972-12-15 DE DE19722261506 patent/DE2261506A1/en active Pending
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2534580A1 (en) * | 1982-10-13 | 1984-04-20 | Synthelabo | PHENYL-1 PIPERIDINO-2 PROPANOL DERIVATIVES, THEIR PREPARATION, AND MEDICINES THAT CONTAIN THEM |
EP0109317A2 (en) * | 1982-10-13 | 1984-05-23 | Synthelabo | Phenyl-1-piperidino-2-propanol derivatives, their preparation and medicaments containing them |
EP0109317A3 (en) * | 1982-10-13 | 1984-08-08 | Synthelabo | Phenyl-1-piperidino-2-propanol derivatives, their preparation and medicaments containing them |
FR2541275A1 (en) * | 1982-12-02 | 1984-08-24 | Nippon Chemiphar Co | NOVEL DERIVATIVES OF PIPERAZINE AND THEIR SALTS, PROCESS FOR PREPARING THEM AND THEIR THERAPEUTIC APPLICATION |
EP0288563A1 (en) * | 1986-09-30 | 1988-11-02 | Eisai Co., Ltd. | Cyclic amine derivatives |
EP0288563A4 (en) * | 1986-09-30 | 1990-09-26 | Eisai Co., Ltd. | Cyclic amine derivatives |
Also Published As
Publication number | Publication date |
---|---|
DE2261506A1 (en) | 1973-06-28 |
FR2163358B1 (en) | 1975-03-14 |
JPS4867234A (en) | 1973-09-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |