IT1149259B - Derivati di acidi 6 beta-idrossialchilpenicillanici come inibitori della beta-lattamasi - Google Patents

Derivati di acidi 6 beta-idrossialchilpenicillanici come inibitori della beta-lattamasi

Info

Publication number
IT1149259B
IT1149259B IT25488/80A IT2548880A IT1149259B IT 1149259 B IT1149259 B IT 1149259B IT 25488/80 A IT25488/80 A IT 25488/80A IT 2548880 A IT2548880 A IT 2548880A IT 1149259 B IT1149259 B IT 1149259B
Authority
IT
Italy
Prior art keywords
beta
hydroxialkylpenicillanic
acid derivatives
lactamase inhibitors
lactamase
Prior art date
Application number
IT25488/80A
Other languages
English (en)
Other versions
IT8025488A0 (it
Inventor
Michael Stephen Kellogg
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IT8025488A0 publication Critical patent/IT8025488A0/it
Application granted granted Critical
Publication of IT1149259B publication Critical patent/IT1149259B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/04—Preparation
    • C07D499/08—Modification of a carboxyl radical directly attached in position 2, e.g. esterification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/74—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with carbocyclic rings directly attached to the carboxamido radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
IT25488/80A 1979-10-22 1980-10-21 Derivati di acidi 6 beta-idrossialchilpenicillanici come inibitori della beta-lattamasi IT1149259B (it)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/086,864 US4287181A (en) 1979-10-22 1979-10-22 Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Publications (2)

Publication Number Publication Date
IT8025488A0 IT8025488A0 (it) 1980-10-21
IT1149259B true IT1149259B (it) 1986-12-03

Family

ID=22201393

Family Applications (1)

Application Number Title Priority Date Filing Date
IT25488/80A IT1149259B (it) 1979-10-22 1980-10-21 Derivati di acidi 6 beta-idrossialchilpenicillanici come inibitori della beta-lattamasi

Country Status (38)

Country Link
US (1) US4287181A (it)
JP (2) JPS5665892A (it)
KR (1) KR840000797B1 (it)
AR (1) AR227164A1 (it)
AT (2) AT369372B (it)
AU (1) AU519578B2 (it)
BE (1) BE885812A (it)
BG (2) BG38639A3 (it)
CA (2) CA1144159A (it)
CH (2) CH646175A5 (it)
CS (2) CS219291B2 (it)
DD (1) DD154542A5 (it)
DE (1) DE3039504C2 (it)
DK (1) DK389480A (it)
ES (1) ES496166A0 (it)
FI (1) FI71156C (it)
FR (1) FR2467852A1 (it)
GB (3) GB2061930B (it)
GR (1) GR70714B (it)
GT (1) GT198065892A (it)
HU (1) HU183236B (it)
IE (3) IE51026B1 (it)
IL (1) IL61307A (it)
IN (1) IN154918B (it)
IT (1) IT1149259B (it)
LU (1) LU82880A1 (it)
MX (1) MX6094E (it)
NL (1) NL183358C (it)
NO (1) NO159019C (it)
NZ (1) NZ195307A (it)
PH (5) PH16219A (it)
PL (2) PL129638B1 (it)
PT (1) PT71946B (it)
RO (2) RO81225B (it)
SE (1) SE451455B (it)
SU (2) SU1122227A3 (it)
YU (2) YU41743B (it)
ZA (1) ZA806452B (it)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL59948A0 (en) * 1979-05-21 1980-06-30 Rech Applications Therap Penicillanic acid derivatives,their production and pharmaceutical compositions containing them
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
US4444687A (en) * 1981-06-08 1984-04-24 Bristol-Myers Company 2β-Chloromethyl-2α-methylpenam-3α-carboxylic acid sulfone methylene diol mixed esters
ZA826687B (en) * 1981-09-14 1983-07-27 Pfizer Beta-lactamase inhibiting 2-beta-substituted-2-alpha-methyl 5(r)penam-3-alpha-carboxylic acid 1,1-dioxides and intermediates therefor
US4351840A (en) * 1981-09-18 1982-09-28 Pfizer Inc. Antibacterial esters of resorcinol with ampicillin and penicillanic acid 1,1-dioxide derivatives
JPS58109490A (ja) * 1981-12-21 1983-06-29 Sankyo Co Ltd ペニシリン誘導体
RO87705A (ro) * 1982-01-11 1985-10-31 Pfizer Inc,Us Procedeu pentru prepararea unor derivati ai acidului 6-aminoalchilpenicilanic 1,1-dioxid
US4452796A (en) * 1982-06-14 1984-06-05 Pfizer Inc. 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4377590A (en) * 1982-05-10 1983-03-22 Pfizer Inc. Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4499017A (en) * 1983-06-06 1985-02-12 Pfizer Inc. Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
US4536393A (en) * 1983-06-06 1985-08-20 Pfizer Inc. 6-(Aminomethyl)penicillanic acid 1,1-dioxide esters and intermediates therefor
US4588527A (en) * 1983-06-06 1986-05-13 Pfizer Inc. Process for preparing penicillanic acid 1,1-dioxide derivatives
US4502990A (en) * 1983-06-06 1985-03-05 Pfizer Inc. Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
US4502988A (en) * 1983-08-08 1985-03-05 Eli Lilly And Company Oxidation process
EP0150984B1 (en) * 1984-01-30 1991-09-11 Pfizer Inc. 6-(substituted) methylenepenicillanic and 6-(substituted) hydroxymethylpenicillanic acids and derivatives thereof
US5015473A (en) * 1984-01-30 1991-05-14 Pfizer Inc. 6-(substituted)methylenepenicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
DD234015A5 (de) * 1984-01-30 1986-03-19 Pfizer Verfahren zur herstellung von 6-(subst.)-methylen-penicillan-und 6-(subst.)-hydroxymethyl-penicillansaeure und deren derivaten
US4826833A (en) * 1984-01-30 1989-05-02 Pfizer Inc. 6-(Substituted)methylene-penicillanic and 6-(substituted)hydroxymethylpenicillanic acids and derivatives thereof
US4503040A (en) * 1984-02-27 1985-03-05 Pfizer Inc. 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors
US4847247A (en) * 1984-07-30 1989-07-11 Merck & Co., Inc. Penicillin derivatives as anti-inflammatory and antidegenerative agents
US4590073A (en) * 1984-10-22 1986-05-20 Pfizer Inc. 6-substituted penicillanic acid 1,1-dioxide compounds
US4591459A (en) * 1984-12-03 1986-05-27 Pfizer Inc. Intermediates for 6-(aminoacyloxymethyl) penicillanic acid 1,1-dioxides
US4762921A (en) * 1985-04-18 1988-08-09 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US4675186A (en) * 1985-04-18 1987-06-23 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
US4613462A (en) * 1985-07-02 1986-09-23 Pfizer, Inc. 6-substituted penicillanic acid 1,1-dioxide compounds
DE3869630D1 (de) * 1987-01-27 1992-05-07 Pfizer 6-beta(substituierte)-(s)-hydroxymethylpenicillansaeure und deren derivate.
US4782050A (en) * 1987-01-27 1988-11-01 Pfizer Inc. 6-beta(substituted)-(S)-hydroxymethylpenicillanic acids and derivatives thereof
US6395726B1 (en) 1999-01-26 2002-05-28 American Cyanamid Company 3,6-disubstituted penam sulfone derivatives
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
BRPI0410936A (pt) * 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase
US8293893B2 (en) * 2007-03-09 2012-10-23 Otsuka Chemical Co., Ltd. Method for producing 6-hydroxyethylpenam compound
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5749555B2 (it) * 1973-04-04 1982-10-22
US4207323A (en) * 1975-11-21 1980-06-10 Merck & Co., Inc. 6-Substituted methyl penicillins, derivatives and analogues thereof
US4053468A (en) * 1976-02-25 1977-10-11 Smithkline Corporation Process for preparing 7-oxo cephalosporins and 6-oxo penicillins
US4093625A (en) * 1976-08-09 1978-06-06 Massachusetts Institute Of Technology 6-Sulfur analogs of penicillins and cephalosporins
US4123539A (en) * 1977-12-29 1978-10-31 Merck & Co., Inc. 6-Ethylpenicillanic acid
US4272439A (en) * 1978-06-02 1981-06-09 Schering Corporation 6-(Substituted-hydroxymethylene penams)
JPS5598186A (en) * 1979-01-10 1980-07-25 Beecham Group Ltd Manufacture of penicillin derivative
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use

Also Published As

Publication number Publication date
ATA10882A (de) 1983-09-15
FI71156C (fi) 1986-11-24
IN154918B (it) 1984-12-22
JPS61178988A (ja) 1986-08-11
SE451455B (sv) 1987-10-12
RO86176B (ro) 1985-03-31
HU183236B (en) 1984-04-28
IE852229L (en) 1981-04-22
AT374479B (de) 1984-04-25
CA1163924A (en) 1984-03-20
FR2467852A1 (fr) 1981-04-30
GR70714B (it) 1983-01-18
LU82880A1 (fr) 1981-06-04
ATA518580A (de) 1982-05-15
ES8204437A1 (es) 1982-05-01
IL61307A0 (en) 1980-12-31
FI803311L (fi) 1981-04-23
AU6354880A (en) 1981-04-30
NO803136L (no) 1981-04-23
AT369372B (de) 1982-12-27
PL235907A1 (it) 1982-09-13
CA1144159A (en) 1983-04-05
DD154542A5 (de) 1982-03-31
NO159019C (no) 1988-11-23
ZA806452B (en) 1981-10-28
PL129534B1 (en) 1984-05-31
NL183358C (nl) 1988-10-03
GB8316829D0 (en) 1983-07-27
NO159019B (no) 1988-08-15
BG35189A3 (en) 1984-02-15
PH17317A (en) 1984-07-20
GB8316830D0 (en) 1983-07-27
RO81225B (ro) 1983-02-28
SE8007354L (sv) 1981-04-23
NL183358B (nl) 1988-05-02
CS219292B2 (en) 1983-03-25
IT8025488A0 (it) 1980-10-21
DE3039504C2 (de) 1984-10-11
RO86176A (ro) 1985-03-15
PH17458A (en) 1984-08-29
CS219291B2 (en) 1983-03-25
IL61307A (en) 1984-03-30
JPS5665892A (en) 1981-06-03
FR2467852B1 (it) 1983-10-07
RO81225A (ro) 1983-02-15
GB2128986B (en) 1985-06-19
DK389480A (da) 1981-04-23
KR830004309A (ko) 1983-07-09
AU519578B2 (en) 1981-12-10
GB2129421B (en) 1984-11-14
PT71946A (en) 1980-11-01
YU67183A (en) 1984-02-29
GT198065892A (es) 1982-04-10
US4287181A (en) 1981-09-01
SU1122227A3 (ru) 1984-10-30
JPS6135197B2 (it) 1986-08-12
IE802174L (en) 1981-04-22
CH647242A5 (fr) 1985-01-15
PH17315A (en) 1984-07-20
SU1026654A3 (ru) 1983-06-30
GB2128986A (en) 1984-05-10
NL8005810A (nl) 1981-04-24
GB2061930B (en) 1984-06-13
MX6094E (es) 1984-11-12
NZ195307A (en) 1984-08-24
AR227164A1 (es) 1982-09-30
IE51026B1 (en) 1986-09-17
ES496166A0 (es) 1982-05-01
KR840000797B1 (ko) 1984-06-12
PH16219A (en) 1983-08-09
BE885812A (fr) 1981-04-21
CH646175A5 (fr) 1984-11-15
GB2061930A (en) 1981-05-20
PH18316A (en) 1985-05-29
IE51027B1 (en) 1986-09-17
PL227420A1 (it) 1982-08-30
PL129638B1 (en) 1984-05-31
YU41743B (en) 1987-12-31
YU267680A (en) 1983-09-30
BG38639A3 (en) 1986-01-15
DE3039504A1 (de) 1981-04-30
YU42075B (en) 1988-04-30
IE51028B1 (en) 1986-09-17
FI71156B (fi) 1986-08-14
PT71946B (en) 1981-08-31
GB2129421A (en) 1984-05-16
IE850293L (en) 1981-04-22

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