IT1130301B - Acidi penicillanici 6-beta-sostituiti come inibitori della-beta-lattamasi - Google Patents

Acidi penicillanici 6-beta-sostituiti come inibitori della-beta-lattamasi

Info

Publication number
IT1130301B
IT1130301B IT20368/80A IT2036880A IT1130301B IT 1130301 B IT1130301 B IT 1130301B IT 20368/80 A IT20368/80 A IT 20368/80A IT 2036880 A IT2036880 A IT 2036880A IT 1130301 B IT1130301 B IT 1130301B
Authority
IT
Italy
Prior art keywords
beta
lactamase
inhibitors
substituted
penicillanic acids
Prior art date
Application number
IT20368/80A
Other languages
English (en)
Other versions
IT8020368A0 (it
Inventor
Michael Stephen Kellogg
Ernest Seiichi Hamanaka
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of IT8020368A0 publication Critical patent/IT8020368A0/it
Application granted granted Critical
Publication of IT1130301B publication Critical patent/IT1130301B/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
IT20368/80A 1979-03-05 1980-03-05 Acidi penicillanici 6-beta-sostituiti come inibitori della-beta-lattamasi IT1130301B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1780979A 1979-03-05 1979-03-05
US06/096,832 US4397783A (en) 1979-03-05 1979-11-23 Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners

Publications (2)

Publication Number Publication Date
IT8020368A0 IT8020368A0 (it) 1980-03-05
IT1130301B true IT1130301B (it) 1986-06-11

Family

ID=26690341

Family Applications (1)

Application Number Title Priority Date Filing Date
IT20368/80A IT1130301B (it) 1979-03-05 1980-03-05 Acidi penicillanici 6-beta-sostituiti come inibitori della-beta-lattamasi

Country Status (29)

Country Link
US (1) US4397783A (it)
KR (1) KR840000589B1 (it)
AR (1) AR225758A1 (it)
AT (1) AT369744B (it)
AU (1) AU518472B2 (it)
CA (1) CA1154011A (it)
CH (1) CH648850A5 (it)
DD (1) DD149366A5 (it)
DE (1) DE3008316C2 (it)
DK (1) DK157136C (it)
ES (1) ES8103095A1 (it)
FI (1) FI71739C (it)
FR (1) FR2450837A1 (it)
GB (1) GB2047684B (it)
GR (1) GR67697B (it)
HK (1) HK66687A (it)
IE (1) IE51931B1 (it)
IL (1) IL59514A (it)
IT (1) IT1130301B (it)
KE (1) KE3456A (it)
LU (1) LU82219A1 (it)
MY (1) MY8500320A (it)
NL (1) NL8001286A (it)
NO (1) NO800617L (it)
OA (1) OA06496A (it)
PH (2) PH18550A (it)
PT (1) PT70898A (it)
SE (1) SE451329B (it)
SG (1) SG56484G (it)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518530A (en) * 1979-03-05 1985-05-21 Pfizer Inc. 6-β-Substituted penicillanic acids as β-lactamase inhibitors
IE49770B1 (en) 1979-05-21 1985-12-11 Leo Pharm Prod Ltd 6beta-halopenicillanic acid derivatives
US4511512A (en) * 1980-05-01 1985-04-16 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Produktionsaktiensel skab) Substantially pure dicyclohexyl ammonium 6-β-bromo-penicillanate
IE51846B1 (en) * 1980-11-17 1987-04-15 Leo Pharm Prod Ltd Pharmaceutical preparation for veterinary use and an appliance containing it
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
GB8522156D0 (en) * 1985-09-06 1985-10-09 Leo Pharm Prod Ltd Producing chemical compounds
ATE77821T1 (de) * 1986-04-10 1992-07-15 Leo Pharm Prod Ltd Verfahren zur herstellung von penicillansaeurederivaten.
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
EP1636240A1 (en) * 2003-06-05 2006-03-22 Pfizer Products Inc. Beta-lactamase inhibitor prodrug

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5749555B2 (it) * 1973-04-04 1982-10-22
US4093625A (en) * 1976-08-09 1978-06-06 Massachusetts Institute Of Technology 6-Sulfur analogs of penicillins and cephalosporins
US4180506A (en) * 1978-01-18 1979-12-25 Rex Pratt 6β-Bromo penicillanic acid
CA1158639A (en) * 1978-12-11 1983-12-13 Eric M. Gordon 6-bromopenicillanic acid sulfone
US4203992A (en) * 1978-12-11 1980-05-20 E. R. Squibb & Sons, Inc. β-Bromopenicillanic acid sulfone
DE3068390D1 (en) * 1979-01-10 1984-08-09 Beecham Group Plc Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them

Also Published As

Publication number Publication date
GB2047684A (en) 1980-12-03
AU518472B2 (en) 1981-10-01
PT70898A (en) 1980-04-01
KR830001941A (ko) 1983-05-19
ES489186A0 (es) 1981-02-16
IE800428L (en) 1980-09-05
US4397783A (en) 1983-08-09
FI71739B (fi) 1986-10-31
DK157136B (da) 1989-11-13
LU82219A1 (fr) 1980-09-24
DD149366A5 (de) 1981-07-08
DE3008316A1 (de) 1980-09-25
HK66687A (en) 1987-09-25
GB2047684B (en) 1983-09-28
ES8103095A1 (es) 1981-02-16
AR225758A1 (es) 1982-04-30
AT369744B (de) 1983-01-25
NL8001286A (nl) 1980-09-09
FI71739C (fi) 1987-02-09
GR67697B (it) 1981-09-07
PH18550A (en) 1985-08-09
IE51931B1 (en) 1987-04-29
FR2450837B1 (it) 1984-01-13
ATA118980A (de) 1982-06-15
SE8001689L (sv) 1980-09-06
DK92880A (da) 1980-09-06
IL59514A (en) 1984-01-31
PH17879A (en) 1985-01-14
KE3456A (en) 1984-10-12
DE3008316C2 (de) 1982-12-16
AU5610580A (en) 1980-09-18
CH648850A5 (de) 1985-04-15
SE451329B (sv) 1987-09-28
OA06496A (fr) 1981-07-31
FI800662A (fi) 1980-09-06
SG56484G (en) 1985-03-08
MY8500320A (en) 1985-12-31
CA1154011A (en) 1983-09-20
IL59514A0 (en) 1980-06-30
IT8020368A0 (it) 1980-03-05
NO800617L (no) 1980-09-08
DK157136C (da) 1990-04-16
FR2450837A1 (fr) 1980-10-03
KR840000589B1 (ko) 1984-04-24

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19940121