ES8103095A1 - Un procedimiento para la preparacion de derivados del acido penicilamico 6-b-sustituidos. - Google Patents

Un procedimiento para la preparacion de derivados del acido penicilamico 6-b-sustituidos.

Info

Publication number
ES8103095A1
ES8103095A1 ES489186A ES489186A ES8103095A1 ES 8103095 A1 ES8103095 A1 ES 8103095A1 ES 489186 A ES489186 A ES 489186A ES 489186 A ES489186 A ES 489186A ES 8103095 A1 ES8103095 A1 ES 8103095A1
Authority
ES
Spain
Prior art keywords
beta
penicillanic acid
acid derivatives
converting
congeners
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES489186A
Other languages
English (en)
Other versions
ES489186A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES8103095A1 publication Critical patent/ES8103095A1/es
Publication of ES489186A0 publication Critical patent/ES489186A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL ACIDO PENICILANICO 6-BETA-SUSTITUIDOS. DICHOS DERIVADOS TIENEN LA FORMULA GENERAL (I), DONDE R15 PUEDE SER UN HALOGENO, UN ALCOXI INFERIOR O UN ALQUILITIO INFERIOR; "N" ES UN NUMERO ENTERO DE 0 A 2, Y R13 PUEDE SER HIDROGENO O RESTOS FORMADORES DE ESTERES HIDROLIZABLES "IN VIVO". EL PROCEDIMIENTO CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN MONOHIDRURO DE ORGANOESTAÑO A UNA TEMPERATURA COMPRENDIDA ENTRE 0 Y 110GC. EN LA FORMULA (II) EL SIMBOLO X SIGNIFICA CLORO, BROMO O YODO Y R19 ES UN RESTO FORMADOR DE ESTER HIDROLIZABLE "IN VIVO" O UN GRUPO PROTECTOR DEL CABOXI PENICILINICO. ESTOS COMPUESTOS SON POTENCIADORES DE LA ACTIVIDAD DE LOS ANTIBIOTICOS DE BETA-LACTAMA. *FORMULA*
ES489186A 1979-03-05 1980-03-04 Un procedimiento para la preparacion de derivados del acido penicilamico 6-b-sustituidos. Granted ES489186A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1780979A 1979-03-05 1979-03-05
US06/096,832 US4397783A (en) 1979-03-05 1979-11-23 Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners

Publications (2)

Publication Number Publication Date
ES8103095A1 true ES8103095A1 (es) 1981-02-16
ES489186A0 ES489186A0 (es) 1981-02-16

Family

ID=26690341

Family Applications (1)

Application Number Title Priority Date Filing Date
ES489186A Granted ES489186A0 (es) 1979-03-05 1980-03-04 Un procedimiento para la preparacion de derivados del acido penicilamico 6-b-sustituidos.

Country Status (29)

Country Link
US (1) US4397783A (es)
KR (1) KR840000589B1 (es)
AR (1) AR225758A1 (es)
AT (1) AT369744B (es)
AU (1) AU518472B2 (es)
CA (1) CA1154011A (es)
CH (1) CH648850A5 (es)
DD (1) DD149366A5 (es)
DE (1) DE3008316C2 (es)
DK (1) DK157136C (es)
ES (1) ES489186A0 (es)
FI (1) FI71739C (es)
FR (1) FR2450837A1 (es)
GB (1) GB2047684B (es)
GR (1) GR67697B (es)
HK (1) HK66687A (es)
IE (1) IE51931B1 (es)
IL (1) IL59514A (es)
IT (1) IT1130301B (es)
KE (1) KE3456A (es)
LU (1) LU82219A1 (es)
MY (1) MY8500320A (es)
NL (1) NL8001286A (es)
NO (1) NO800617L (es)
OA (1) OA06496A (es)
PH (2) PH18550A (es)
PT (1) PT70898A (es)
SE (1) SE451329B (es)
SG (1) SG56484G (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4518530A (en) * 1979-03-05 1985-05-21 Pfizer Inc. 6-β-Substituted penicillanic acids as β-lactamase inhibitors
IL59948A0 (en) * 1979-05-21 1980-06-30 Rech Applications Therap Penicillanic acid derivatives,their production and pharmaceutical compositions containing them
US4511512A (en) * 1980-05-01 1985-04-16 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Produktionsaktiensel skab) Substantially pure dicyclohexyl ammonium 6-β-bromo-penicillanate
IE51846B1 (en) * 1980-11-17 1987-04-15 Leo Pharm Prod Ltd Pharmaceutical preparation for veterinary use and an appliance containing it
EP0139047A1 (en) * 1983-10-18 1985-05-02 Gist-Brocades N.V. Process for the preparation of 6,6-dibromopenicillanic acid 1,1-dioxide
GB8522156D0 (en) * 1985-09-06 1985-10-09 Leo Pharm Prod Ltd Producing chemical compounds
US4816580A (en) * 1986-04-10 1989-03-28 Leo Pharmaceutical Products Ltd. A/S Improved method for preparing penicillanic acid derivatives
PA8579701A1 (es) * 2002-08-23 2005-05-24 Pfizer Prod Inc Profarmaco inhibidor de beta-lactamasa
BRPI0410936A (pt) * 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5749555B2 (es) * 1973-04-04 1982-10-22
US4093625A (en) * 1976-08-09 1978-06-06 Massachusetts Institute Of Technology 6-Sulfur analogs of penicillins and cephalosporins
US4180506A (en) * 1978-01-18 1979-12-25 Rex Pratt 6β-Bromo penicillanic acid
CA1158639A (en) * 1978-12-11 1983-12-13 Eric M. Gordon 6-bromopenicillanic acid sulfone
US4203992A (en) * 1978-12-11 1980-05-20 E. R. Squibb & Sons, Inc. β-Bromopenicillanic acid sulfone
DE3068390D1 (en) * 1979-01-10 1984-08-09 Beecham Group Plc Penicillin derivatives, process for their preparation and pharmaceutical compositions containing certain of these compounds
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them

Also Published As

Publication number Publication date
SG56484G (en) 1985-03-08
IL59514A (en) 1984-01-31
IT1130301B (it) 1986-06-11
PH17879A (en) 1985-01-14
IT8020368A0 (it) 1980-03-05
HK66687A (en) 1987-09-25
KR840000589B1 (ko) 1984-04-24
AR225758A1 (es) 1982-04-30
FI800662A (fi) 1980-09-06
CH648850A5 (de) 1985-04-15
DD149366A5 (de) 1981-07-08
DK92880A (da) 1980-09-06
DE3008316A1 (de) 1980-09-25
FI71739C (fi) 1987-02-09
GR67697B (es) 1981-09-07
IE800428L (en) 1980-09-05
ES489186A0 (es) 1981-02-16
FI71739B (fi) 1986-10-31
ATA118980A (de) 1982-06-15
LU82219A1 (fr) 1980-09-24
AU5610580A (en) 1980-09-18
OA06496A (fr) 1981-07-31
IL59514A0 (en) 1980-06-30
KR830001941A (ko) 1983-05-19
CA1154011A (en) 1983-09-20
GB2047684A (en) 1980-12-03
MY8500320A (en) 1985-12-31
PH18550A (en) 1985-08-09
SE8001689L (sv) 1980-09-06
DK157136C (da) 1990-04-16
SE451329B (sv) 1987-09-28
DK157136B (da) 1989-11-13
US4397783A (en) 1983-08-09
GB2047684B (en) 1983-09-28
IE51931B1 (en) 1987-04-29
NO800617L (no) 1980-09-08
AU518472B2 (en) 1981-10-01
PT70898A (en) 1980-04-01
AT369744B (de) 1983-01-25
KE3456A (en) 1984-10-12
DE3008316C2 (de) 1982-12-16
NL8001286A (nl) 1980-09-09
FR2450837B1 (es) 1984-01-13
FR2450837A1 (fr) 1980-10-03

Similar Documents

Publication Publication Date Title
ES8204437A1 (es) Un procedimiento para la preparacion de acidos 6-b-hidroxialquilpenicilanicos y sus derivados.
IE781140L (en) Penicillanic acid s-oxides
IE43840L (en) Clavulanic acid derivatives
ES8103095A1 (es) Un procedimiento para la preparacion de derivados del acido penicilamico 6-b-sustituidos.
ES8402590A1 (es) Un procedimiento de preparacion de antibioticos de 1-azabiciclo-3.2.0-hept-2-eno.
ES8308566A1 (es) Un procedimiento para la preparacion de 1,1-dioxidos de acidos penam-3-carboxilicos.
EP0222022A4 (en) MANUFACTURING METHOD OF BETA LACTAM COMBS.
JPS55111463A (en) Beta-lactam compound and its preparation
ATE82291T1 (de) Clavamderivate, herstellung und zwischenprodukte.
ES8402157A1 (es) Un procedimiento para la preparacion de ciertos carbonatos de 6-(2-amino-2-fenil-acetamido-penicilanoiloximetil)-1,1-dioxopenicilanoiloximetilo como agentes antibacterianos.
ES476259A1 (es) Un procedimiento para la preparacion de un compuesto.
ES464000A1 (es) Un procedimiento para preparar nuevas beta-lactamas monoci- clicas con actividad antibacteriana.
JPS5671092A (en) Optical active cephalosporin analogous derivative
JPS5446799A (en) Penicillins and cephalosporins
HUT45262A (en) New process for producing penicillin derivatives
MY105176A (en) Process for optically active 3-thiolanyl sulfonate esters.
ES477209A1 (es) Metodo para la preparacion del ester pivaloilloximetilico decefalexina.
JPS54141795A (en) Penicillin and cephalosporin
JPS5664795A (en) Preparation of cephalosporin analog

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001