PA8579701A1 - Profarmaco inhibidor de beta-lactamasa - Google Patents

Profarmaco inhibidor de beta-lactamasa

Info

Publication number
PA8579701A1
PA8579701A1 PA20038579701A PA8579701A PA8579701A1 PA 8579701 A1 PA8579701 A1 PA 8579701A1 PA 20038579701 A PA20038579701 A PA 20038579701A PA 8579701 A PA8579701 A PA 8579701A PA 8579701 A1 PA8579701 A1 PA 8579701A1
Authority
PA
Panama
Prior art keywords
beta
same
lactamasa
profarmaco
inhibitor
Prior art date
Application number
PA20038579701A
Other languages
English (en)
Inventor
Dale Gordon Mcleod
Anthony Marfat
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PA8579701A1 publication Critical patent/PA8579701A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical

Abstract

SE DESCRIBEN PROFARMACOS DE SULFONA DEL ACIDO 6-BETA-HIDROXIMETILPENICILANICO QUE TIENEN LA ESTRUCTURA EN LA QUE R ES H O METILO, Y SOLVATOS DE LOS MISMOS. TAMBIEN SE DESCRIBEN COMPOSICIONES FARMACEUTICAS QUE COMPRENDEN UN PROFARMACO DE LA PRESENTE INVENCION, O UN SOLVATO DEL MISMO, UN ANTIBIOTICO BETA-LACTAMICO OPCIONAL Y AL MENOS UN VEHICULO FARMACEUTICAMENTE ACEPTABLE. ADEMAS SE DESCRIBE UN PROCEDIMIENTO PARA INCREMENTAR LA EFICACIA TERAPEUTICA DE UN ANTIBIOTICO BETA-LACTAMICO EN UN MAMIFERO POR LA ADMINISTRACION DE UNA CANTIDAD EFICAZ DE UN ANTIBIOTICO BETA-LACTAMICO Y UNA CANTIDAD QUE INCREMENTA LA EFICACIA DE UN PROFARMACO DE LA PRESENTE INVENCION, O UN SOLVATO DEL MISMO. ADEMAS SE DESCRIBE UN PROCEDIMIENTO PARA EL TRATAMIENTO DE UNA INFECCION BACTERIANA POR LA ADMINISTRACION DE UNA CANTIDAD TERAPEUTICAMENTE EFICAZ DE UNA COMPOSICION FARMACEUTICA DE LA PRESENTE INVENCION A UN MAMIFERO EN NECESIDAD DEL MISMO.
PA20038579701A 2002-08-23 2003-08-06 Profarmaco inhibidor de beta-lactamasa PA8579701A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40564002P 2002-08-23 2002-08-23

Publications (1)

Publication Number Publication Date
PA8579701A1 true PA8579701A1 (es) 2005-05-24

Family

ID=31946909

Family Applications (1)

Application Number Title Priority Date Filing Date
PA20038579701A PA8579701A1 (es) 2002-08-23 2003-08-06 Profarmaco inhibidor de beta-lactamasa

Country Status (31)

Country Link
US (1) US7091197B2 (es)
EP (1) EP1534717B1 (es)
JP (1) JP2005539037A (es)
KR (1) KR20050037583A (es)
CN (1) CN1688589A (es)
AP (1) AP2005003231A0 (es)
AR (1) AR041028A1 (es)
AT (1) ATE349452T1 (es)
AU (1) AU2003250489A1 (es)
BR (1) BR0313683A (es)
CA (1) CA2494953A1 (es)
DE (1) DE60310733D1 (es)
EA (1) EA007540B1 (es)
EC (1) ECSP055625A (es)
GT (1) GT200300179A (es)
HR (1) HRP20050162A2 (es)
IL (1) IL166719A0 (es)
IS (1) IS7693A (es)
MA (1) MA27387A1 (es)
MX (1) MXPA05001446A (es)
NO (1) NO20051497L (es)
NZ (1) NZ538340A (es)
OA (1) OA12909A (es)
PA (1) PA8579701A1 (es)
PE (1) PE20040899A1 (es)
PL (1) PL375988A1 (es)
TN (1) TNSN05054A1 (es)
TW (1) TWI250162B (es)
UY (1) UY27947A1 (es)
WO (1) WO2004018484A1 (es)
ZA (1) ZA200501513B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
WO2007012319A1 (de) * 2005-07-29 2007-02-01 Sigma-Aldrich Production Gmbh Ionisierungsadditive enthaltende lc/ms-blends
WO2010118968A1 (en) 2009-04-16 2010-10-21 Nicox S.A. No-donor aspirin derivatives
WO2013056163A1 (en) 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
AU2013207510A1 (en) * 2012-01-06 2014-07-31 The Regents Of The University Of California Compositions, methods of use, and methods of treatment
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34011B1 (en) * 1969-03-13 1975-01-08 Leo Pharm Prod Ltd New penicillin esters
IE34019B1 (en) * 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
GB1267936A (en) 1969-05-28 1972-03-22 Beecham Group Ltd DERIVATIVES OF alpha-AMINOPENICILLINS
US3957764A (en) * 1969-11-11 1976-05-18 Lovens Kemiske Fabrik Produktionsaktieselskab 6-aminopenicillanic acid derivatives
US3862181A (en) * 1970-10-28 1975-01-21 Squibb & Sons Inc Process for preparing cephalosporins
GB1315566A (en) 1970-11-06 1973-05-02 Leo Pharm Prod Ltd Penicillanic acid derivatives
CA996929A (en) 1971-04-05 1976-09-14 Kohzi Nakano Acyloxyalkyl ester derivatives of penicillin
GB1426717A (en) 1972-03-13 1976-03-03 Astra Laekemedel Ab Penicillins
GB1433131A (en) * 1972-03-13 1976-04-22 Astra Laekemedel Ab Penicillins
US4397783A (en) * 1979-03-05 1983-08-09 Pfizer Inc. Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4432970A (en) * 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
JPS5849387A (ja) 1981-09-17 1983-03-23 Sankyo Co Ltd ７−メトキシセフアロスポリン化合物およびその製法
AU559689B2 (en) * 1981-09-22 1987-03-19 Kureha Kagaku Kogyo K.K. Penicillin derivative
US4406887A (en) * 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4521533A (en) * 1984-07-12 1985-06-04 Pfizer Inc. Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
DE3901405A1 (de) 1989-01-19 1990-07-26 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
JPH03206038A (ja) 1990-01-08 1991-09-09 Yoshitomi Pharmaceut Ind Ltd 抗菌剤
GB9001405D0 (en) * 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
GB9208492D0 (en) * 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
WO2004108733A1 (en) * 2003-06-05 2004-12-16 Pfizer Products Inc. Beta-lactamase inhibitor prodrug

Also Published As

Publication number Publication date
UY27947A1 (es) 2004-03-31
GT200300179A (es) 2004-05-18
OA12909A (en) 2006-10-13
NO20051497D0 (no) 2005-03-21
IL166719A0 (en) 2006-01-15
DE60310733D1 (de) 2007-02-08
PE20040899A1 (es) 2004-12-28
BR0313683A (pt) 2005-06-21
MA27387A1 (fr) 2005-06-01
AR041028A1 (es) 2005-04-27
EP1534717A1 (en) 2005-06-01
ZA200501513B (en) 2006-09-27
TW200417548A (en) 2004-09-16
PL375988A1 (en) 2005-12-12
WO2004018484A1 (en) 2004-03-04
ECSP055625A (es) 2005-04-18
MXPA05001446A (es) 2005-06-06
EP1534717B1 (en) 2006-12-27
AU2003250489A1 (en) 2004-03-11
TNSN05054A1 (fr) 2007-05-14
KR20050037583A (ko) 2005-04-22
US7091197B2 (en) 2006-08-15
NO20051497L (no) 2005-03-21
CN1688589A (zh) 2005-10-26
EA007540B1 (ru) 2006-10-27
NZ538340A (en) 2006-10-27
HRP20050162A2 (en) 2005-06-30
EA200500398A1 (ru) 2005-08-25
IS7693A (is) 2005-02-10
JP2005539037A (ja) 2005-12-22
US20040110740A1 (en) 2004-06-10
CA2494953A1 (en) 2004-03-04
TWI250162B (en) 2006-03-01
AP2005003231A0 (en) 2005-03-31
ATE349452T1 (de) 2007-01-15

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