BR0313683A - Pró-droga inibidora de beta-lactamase - Google Patents

Pró-droga inibidora de beta-lactamase

Info

Publication number
BR0313683A
BR0313683A BR0313683-3A BR0313683A BR0313683A BR 0313683 A BR0313683 A BR 0313683A BR 0313683 A BR0313683 A BR 0313683A BR 0313683 A BR0313683 A BR 0313683A
Authority
BR
Brazil
Prior art keywords
beta
mammal
present
lactam antibiotic
prodrug
Prior art date
Application number
BR0313683-3A
Other languages
English (en)
Inventor
Anthony Marfat
Dale Gordon Mcleod
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of BR0313683A publication Critical patent/BR0313683A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

"PRó-DROGA INIBIDORA DE BETA-LACTAMASE". Pró-drogas de sulfona do ácido 6-<225>-hidroximetilpenicilânico tendo a estrutura em que R é H ou metila, e seus solvatos, são descritas. São também descritas composições farmacêuticas compreendendo uma pró-droga da presente invenção, ou um seu solvato, um antibiótico beta-lactâmico e pelo menos um veículo farmaceuticamente aceitável. é ainda descrito um método para o aumento da eficácia terapêutica de um antibiótico beta-lactâmico em um mamífero pela administração de uma quantidade eficaz de um antibiótico beta-lactâmico e uma quantidade aumentadora de eficácia de uma pró-droga da presente invenção, ou um seu solvato. é adicionalmente descrito um método para o tratamento de uma infecção bacteriana em um mamífero pela administração de uma quantidade terapeuticamente eficaz de uma composição farmacêutica da presente invenção a um mamífero com necessidade dele.
BR0313683-3A 2002-08-23 2003-08-11 Pró-droga inibidora de beta-lactamase BR0313683A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40564002P 2002-08-23 2002-08-23
PCT/IB2003/003582 WO2004018484A1 (en) 2002-08-23 2003-08-11 Beta-lactamase inhibitor prodrug

Publications (1)

Publication Number Publication Date
BR0313683A true BR0313683A (pt) 2005-06-21

Family

ID=31946909

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0313683-3A BR0313683A (pt) 2002-08-23 2003-08-11 Pró-droga inibidora de beta-lactamase

Country Status (31)

Country Link
US (1) US7091197B2 (pt)
EP (1) EP1534717B1 (pt)
JP (1) JP2005539037A (pt)
KR (1) KR20050037583A (pt)
CN (1) CN1688589A (pt)
AP (1) AP2005003231A0 (pt)
AR (1) AR041028A1 (pt)
AT (1) ATE349452T1 (pt)
AU (1) AU2003250489A1 (pt)
BR (1) BR0313683A (pt)
CA (1) CA2494953A1 (pt)
DE (1) DE60310733D1 (pt)
EA (1) EA007540B1 (pt)
EC (1) ECSP055625A (pt)
GT (1) GT200300179A (pt)
HR (1) HRP20050162A2 (pt)
IL (1) IL166719A0 (pt)
IS (1) IS7693A (pt)
MA (1) MA27387A1 (pt)
MX (1) MXPA05001446A (pt)
NO (1) NO20051497L (pt)
NZ (1) NZ538340A (pt)
OA (1) OA12909A (pt)
PA (1) PA8579701A1 (pt)
PE (1) PE20040899A1 (pt)
PL (1) PL375988A1 (pt)
TN (1) TNSN05054A1 (pt)
TW (1) TWI250162B (pt)
UY (1) UY27947A1 (pt)
WO (1) WO2004018484A1 (pt)
ZA (1) ZA200501513B (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0410936A (pt) * 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase
US20060105941A1 (en) * 2004-11-12 2006-05-18 Allergan, Inc. Mixed antibiotic codrugs
WO2007012319A1 (de) * 2005-07-29 2007-02-01 Sigma-Aldrich Production Gmbh Ionisierungsadditive enthaltende lc/ms-blends
WO2010118968A1 (en) 2009-04-16 2010-10-21 Nicox S.A. No-donor aspirin derivatives
WO2013056163A1 (en) * 2011-10-14 2013-04-18 The Regents Of The University Of California Beta-lactamase inhibitors
CA2860672A1 (en) * 2012-01-06 2013-07-11 University Of South Florida Compositions, methods of use, and methods of treatment
CN109422765B (zh) * 2017-09-05 2020-08-28 香港理工大学深圳研究院 C类β-内酰胺酶抑制剂及其制备方法和应用

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE34011B1 (en) 1969-03-13 1975-01-08 Leo Pharm Prod Ltd New penicillin esters
IE34019B1 (en) 1969-03-18 1975-01-08 Leo Pharm Prod Ltd New semi-synthetic penicillin esters
GB1267936A (en) 1969-05-28 1972-03-22 Beecham Group Ltd DERIVATIVES OF alpha-AMINOPENICILLINS
US3957764A (en) 1969-11-11 1976-05-18 Lovens Kemiske Fabrik Produktionsaktieselskab 6-aminopenicillanic acid derivatives
US3862181A (en) 1970-10-28 1975-01-21 Squibb & Sons Inc Process for preparing cephalosporins
GB1315566A (en) 1970-11-06 1973-05-02 Leo Pharm Prod Ltd Penicillanic acid derivatives
CA996929A (en) 1971-04-05 1976-09-14 Kohzi Nakano Acyloxyalkyl ester derivatives of penicillin
GB1433131A (en) 1972-03-13 1976-04-22 Astra Laekemedel Ab Penicillins
GB1426717A (en) 1972-03-13 1976-03-03 Astra Laekemedel Ab Penicillins
US4397783A (en) 1979-03-05 1983-08-09 Pfizer Inc. Process for converting 6,6-disubstituted penicillanic acid derivatives to the 6-β-congeners
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors
US4432970A (en) 1979-11-23 1984-02-21 Pfizer Inc. 6-beta-Halopenicillanic acid 1,1-dioxides as beta-lactamase inhibitors
GB2076812A (en) * 1980-05-22 1981-12-09 Ciba Geigy Ag Penam-dioxide compounds, processes for their manufacture, and their use
JPS5849387A (ja) 1981-09-17 1983-03-23 Sankyo Co Ltd ７−メトキシセフアロスポリン化合物およびその製法
AU559689B2 (en) * 1981-09-22 1987-03-19 Kureha Kagaku Kogyo K.K. Penicillin derivative
US4406887A (en) 1981-10-13 1983-09-27 Bristol-Myers Company Method for treating resistant bacteria including anaerobes
US4428935A (en) * 1982-05-24 1984-01-31 Pfizer Inc. Penicillanic acid dioxide prodrug
US4521533A (en) 1984-07-12 1985-06-04 Pfizer Inc. Salts of 6-alpha-(aminomethyl)penicillanic acid 1,1-dioxide esters and beta-lactam antibiotics
DE3901405A1 (de) 1989-01-19 1990-07-26 Hoechst Ag Cephalosporinderivate und verfahren zu ihrer herstellung
JPH03206038A (ja) 1990-01-08 1991-09-09 Yoshitomi Pharmaceut Ind Ltd 抗菌剤
GB9001405D0 (en) 1990-01-22 1990-03-21 Leo Pharm Prod Ltd New intermediates,their production and use
GB9208492D0 (en) 1992-04-16 1992-06-03 Glaxo Spa Heterocyclic compounds
BRPI0410936A (pt) 2003-06-05 2006-06-27 Pfizer Prod Inc pró-fármaco inibidor da beta-lactamase

Also Published As

Publication number Publication date
MA27387A1 (fr) 2005-06-01
TW200417548A (en) 2004-09-16
US7091197B2 (en) 2006-08-15
IS7693A (is) 2005-02-10
EA200500398A1 (ru) 2005-08-25
NO20051497D0 (no) 2005-03-21
EP1534717A1 (en) 2005-06-01
US20040110740A1 (en) 2004-06-10
HRP20050162A2 (en) 2005-06-30
WO2004018484A1 (en) 2004-03-04
AP2005003231A0 (en) 2005-03-31
KR20050037583A (ko) 2005-04-22
EP1534717B1 (en) 2006-12-27
ZA200501513B (en) 2006-09-27
JP2005539037A (ja) 2005-12-22
MXPA05001446A (es) 2005-06-06
CN1688589A (zh) 2005-10-26
ATE349452T1 (de) 2007-01-15
ECSP055625A (es) 2005-04-18
TNSN05054A1 (fr) 2007-05-14
GT200300179A (es) 2004-05-18
NZ538340A (en) 2006-10-27
AU2003250489A1 (en) 2004-03-11
UY27947A1 (es) 2004-03-31
PE20040899A1 (es) 2004-12-28
CA2494953A1 (en) 2004-03-04
NO20051497L (no) 2005-03-21
DE60310733D1 (de) 2007-02-08
EA007540B1 (ru) 2006-10-27
OA12909A (en) 2006-10-13
PL375988A1 (en) 2005-12-12
PA8579701A1 (es) 2005-05-24
TWI250162B (en) 2006-03-01
IL166719A0 (en) 2006-01-15
AR041028A1 (es) 2005-04-27

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 5A,6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2069 DE 31/08/2010.