MX2007004783A - Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan. - Google Patents

Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan.

Info

Publication number
MX2007004783A
MX2007004783A MX2007004783A MX2007004783A MX2007004783A MX 2007004783 A MX2007004783 A MX 2007004783A MX 2007004783 A MX2007004783 A MX 2007004783A MX 2007004783 A MX2007004783 A MX 2007004783A MX 2007004783 A MX2007004783 A MX 2007004783A
Authority
MX
Mexico
Prior art keywords
inhibitors
compositions
hepatitis
treatments
same
Prior art date
Application number
MX2007004783A
Other languages
English (en)
Inventor
Michael Raymond Collins
Vijayalakshmi Natarajan
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of MX2007004783A publication Critical patent/MX2007004783A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

La presente invencion proporciona compuestos de formula I, II o IV, o sales y solvatos farmaceuticamente aceptables de los mismos, que son utiles como inhibidores de la enzima proteasa del virus de la hepatitis C (VHC) y tambien son utiles para el tratamiento de infecciones por VHC en mamiferos infectados con VHC, incluyendo seres humanos, la presente invencion tambien proporciona composiciones farmaceuticas que comprenden compuestos de formula I, II o IV, sus sales y solvatos farmaceuticamente aceptables, ademas, la presente invencion proporciona compuestos intermedios y procedimientos utiles en la preparacion de los compuestos de formula I, II y IV.
MX2007004783A 2004-10-21 2005-10-10 Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan. MX2007004783A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62130204P 2004-10-21 2004-10-21
US65015005P 2005-02-03 2005-02-03
US70555805P 2005-08-03 2005-08-03
PCT/IB2005/003085 WO2006043145A1 (en) 2004-10-21 2005-10-10 Inhibitors of hepatitis c virus protease, and compositions and treatments using the same

Publications (1)

Publication Number Publication Date
MX2007004783A true MX2007004783A (es) 2007-05-11

Family

ID=35587566

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007004783A MX2007004783A (es) 2004-10-21 2005-10-10 Inhibidores de la proteasa del virus de la hepatitis c, y composiciones y tratamientos que los usan.

Country Status (7)

Country Link
US (1) US20070249637A1 (es)
EP (1) EP1805187A1 (es)
JP (1) JP2008517896A (es)
BR (1) BRPI0517463A (es)
CA (1) CA2583152A1 (es)
MX (1) MX2007004783A (es)
WO (1) WO2006043145A1 (es)

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US8343477B2 (en) 2006-11-01 2013-01-01 Bristol-Myers Squibb Company Inhibitors of hepatitis C virus
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US7888464B2 (en) 2006-11-16 2011-02-15 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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BRPI0908021A2 (pt) 2008-02-04 2015-07-21 Idenix Pharmaceuticals Inc Composto, composição farmacêutica, e, usos do composto ou da composição farmacêutica
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UY32099A (es) 2008-09-11 2010-04-30 Enanta Pharm Inc Inhibidores macrocíclicos de serina proteasas de hepatitis c
US8044087B2 (en) 2008-09-29 2011-10-25 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8563505B2 (en) 2008-09-29 2013-10-22 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
US8283310B2 (en) 2008-12-15 2012-10-09 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
RU2011127080A (ru) 2009-01-07 2013-02-20 Сайнексис, Инк. Производное циклоспорина для применения в лечении заражения вирусом гепатита с и вич
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CN109081810A (zh) * 2018-09-20 2018-12-25 沈阳药科大学 1-甲基-3–((甲氨基)甲基)-1h-吡唑-5-腈的合成方法
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Also Published As

Publication number Publication date
JP2008517896A (ja) 2008-05-29
WO2006043145A1 (en) 2006-04-27
US20070249637A1 (en) 2007-10-25
BRPI0517463A (pt) 2008-10-07
CA2583152A1 (en) 2006-04-27
EP1805187A1 (en) 2007-07-11

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