ES8402590A1 - Un procedimiento de preparacion de antibioticos de 1-azabiciclo-3.2.0-hept-2-eno. - Google Patents

Un procedimiento de preparacion de antibioticos de 1-azabiciclo-3.2.0-hept-2-eno.

Info

Publication number
ES8402590A1
ES8402590A1 ES516808A ES516808A ES8402590A1 ES 8402590 A1 ES8402590 A1 ES 8402590A1 ES 516808 A ES516808 A ES 516808A ES 516808 A ES516808 A ES 516808A ES 8402590 A1 ES8402590 A1 ES 8402590A1
Authority
ES
Spain
Prior art keywords
preparing
acetic acid
acid derivatives
azabicyclo
hept
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES516808A
Other languages
English (en)
Other versions
ES516808A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gruppo Lepetit SpA
Original Assignee
Gruppo Lepetit SpA
Lepetit SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gruppo Lepetit SpA, Lepetit SpA filed Critical Gruppo Lepetit SpA
Publication of ES8402590A1 publication Critical patent/ES8402590A1/es
Publication of ES516808A0 publication Critical patent/ES516808A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/02—Preparation
    • C07D477/04—Preparation by forming the ring or condensed ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
    • C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 1-AZABICICLO3.2.0HEPT-2-ENO, DE FORMULA (I).CONSISTE EN LA TRANSFORMACION DE UN DERIVADO DE UN ACIDO BBB-LACTAMA-ACETICO, DE FORMULA (II), EN LA QUE R ES EL MISMO QUE EN LA FORMULA (I), O UNA DE SUS SALES, EN EL DERIVADO DE IMIDAZOLILO; SEGUIDA DE LA REACCION CON LA SAL MAGNESICA DE MALONATO DE MONO-BENCILO O DE MONO-P-NITROBENCILO; REACCION DE TRANSFERENCIA DE GRUPOS DIAZO;DESCOMPOSICION DEL PRODUCTO OBTENIDO EN PRESENCIA DE ACETATO DE RODIO; CONVERSION EN EL ENOL-FOSFATO, POR REACCION CON CLOROFOSFATO DE DIFENILO; REACCION CON RKKK SH; Y, FINALMENTE,DESPROTECCION CATALITICA DEL ESTER FORMADO.
ES516808A 1981-03-12 1982-10-25 Un procedimiento de preparacion de antibioticos de 1-azabiciclo-3.2.0-hept-2-eno. Granted ES516808A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8107865 1981-03-12

Publications (2)

Publication Number Publication Date
ES8402590A1 true ES8402590A1 (es) 1984-02-01
ES516808A0 ES516808A0 (es) 1984-02-01

Family

ID=10520350

Family Applications (2)

Application Number Title Priority Date Filing Date
ES510336A Expired ES8308540A1 (es) 1981-03-12 1982-03-11 "un procedimiento para preparar un derivado del acido b-lactama-acetico".
ES516808A Granted ES516808A0 (es) 1981-03-12 1982-10-25 Un procedimiento de preparacion de antibioticos de 1-azabiciclo-3.2.0-hept-2-eno.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES510336A Expired ES8308540A1 (es) 1981-03-12 1982-03-11 "un procedimiento para preparar un derivado del acido b-lactama-acetico".

Country Status (14)

Country Link
US (1) US4576746A (es)
EP (1) EP0060416B1 (es)
JP (1) JPS57159761A (es)
KR (1) KR880001847B1 (es)
AT (1) ATE21509T1 (es)
AU (1) AU548727B2 (es)
CA (1) CA1185244A (es)
DE (1) DE3272660D1 (es)
DK (1) DK103982A (es)
ES (2) ES8308540A1 (es)
IE (1) IE52609B1 (es)
IL (1) IL65232A (es)
PH (1) PH23415A (es)
ZA (1) ZA821252B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU187424B (en) * 1982-11-05 1986-01-28 Richter Gedeon Vegyeszeti Gyar Rt,Hu Process for preparing new azetidinyl-acetic acids
JPS60224672A (ja) * 1984-04-23 1985-11-09 Sumitomo Chem Co Ltd β−ラクタム誘導体の製造法
JPS62209079A (ja) * 1986-03-11 1987-09-14 Sanraku Inc 二置換アミノカルバペナム類
JP2618271B2 (ja) * 1989-04-26 1997-06-11 日本化薬株式会社 モノｐ―ニトロベンジルマロネートマグネシウム塩の結晶変態及びその製法
SK282164B6 (sk) * 1992-09-18 2001-11-06 Merck & Co., Inc. Spôsob výroby beta-metylkarbapenémových medziproduktov, medziprodukty na vykonávanie tohto postupu a spôsob výroby medziproduktov
US5516934A (en) * 1994-08-05 1996-05-14 Nippon Kayaku Kabushiki Kaisha Process for producing mono-P-nitrobenzyl malonate
US20040148868A1 (en) * 2003-02-05 2004-08-05 3M Innovative Properties Company Methods of making ceramics
WO2006061854A2 (en) * 2004-12-10 2006-06-15 Pharmed Medicare Private Limited CONTROL OF pH BY DIRECT ADDITION OF CARBONATES AND BICARBONATES DURING CONCENTRATION OF ORGANIC SOLVENT EXTRACTS OF 6- ACETYL- 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE AND 4,1 ‘, 6' TRICHLOROGALACTOSUCROSE
CN104548089B (zh) 2009-09-03 2017-09-26 辉瑞疫苗有限责任公司 Pcsk9疫苗
WO2011048583A1 (en) * 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
CN103483202B (zh) * 2013-06-26 2015-01-21 华北水利水电大学 一种对硝基苄醇丙二酸单酯镁的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1570278A (en) * 1975-10-06 1980-06-25 Fujisawa Pharmaceutical Co O-substituted-2-azetidinone derivatives and the preparation thereof
US4138400A (en) * 1975-12-20 1979-02-06 Hoechst Aktiengesellschaft Omega-alkoxy derivatives of lactams
GB1584762A (en) * 1977-04-01 1981-02-18 Beecham Group Ltd Azabicycloheptenes
EP0082133A3 (en) * 1979-04-19 1983-07-20 Merck & Co. Inc. A process for preparing intermediates useful for preparing 2-substituted-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4290947A (en) * 1979-04-27 1981-09-22 Merck & Co., Inc. Process for the preparation of thienamycin and intermediates
US4312871A (en) * 1979-12-03 1982-01-26 Merck & Co., Inc. 6-, 1- And 2-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US4262010A (en) * 1979-12-03 1981-04-14 Merck & Co., Inc. 6-(1-Hydroxyethyl)-2-(2-aminoethylthio)-1,1-disubstituted-1-carbadethiapen-2-em-3-carboxylic acids
US4282148A (en) * 1980-01-14 1981-08-04 Merck & Co., Inc. Synthesis of thienamycin via esters of (3SR, 4RS)-3-[(SR)-1-hydroxyethyl]-β,2-dioxo-4-azetidinebutanoic acid
US4269772A (en) * 1980-01-14 1981-05-26 Merck & Co., Inc. Synthesis of thienamycin via trans-3-carboxymethylene-4-carboxy-5-methyl-Δ2 -isoxazoline
US4287123A (en) * 1980-01-14 1981-09-01 Merck & Co., Inc. Synthesis of thienamycin via (3SR, 4RS)-3-((RS)-1-acyloxyethyl)-2-oxo-4-azetidineacetate

Also Published As

Publication number Publication date
KR880001847B1 (ko) 1988-09-22
IL65232A0 (en) 1982-05-31
ES510336A0 (es) 1983-09-01
EP0060416B1 (en) 1986-08-20
EP0060416A1 (en) 1982-09-22
ATE21509T1 (de) 1986-09-15
IE820554L (en) 1982-09-12
DE3272660D1 (en) 1986-09-25
IE52609B1 (en) 1987-12-23
IL65232A (en) 1986-01-31
AU8076582A (en) 1982-09-16
ES8308540A1 (es) 1983-09-01
PH23415A (en) 1989-08-07
JPS57159761A (en) 1982-10-01
KR830009020A (ko) 1983-12-17
DK103982A (da) 1982-09-13
CA1185244A (en) 1985-04-09
AU548727B2 (en) 1986-01-02
US4576746A (en) 1986-03-18
ZA821252B (en) 1983-01-26
ES516808A0 (es) 1984-02-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981201