KR870001142A - 페닐 에테르의 제법 - Google Patents

페닐 에테르의 제법 Download PDF

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Publication number
KR870001142A
KR870001142A KR1019860006278A KR860006278A KR870001142A KR 870001142 A KR870001142 A KR 870001142A KR 1019860006278 A KR1019860006278 A KR 1019860006278A KR 860006278 A KR860006278 A KR 860006278A KR 870001142 A KR870001142 A KR 870001142A
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South Korea
Prior art keywords
formula
carboxy
hydrogen
compound
alkoxy
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KR1019860006278A
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English (en)
Inventor
로이 홀로웨이 브라이안
하우워 랄프
신프 라오 발비르
스트리빌링 도날드
Original Assignee
알란 브라이안 벡
임페리알 케미칼 인더스트리스 피엘씨
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Application filed by 알란 브라이안 벡, 임페리알 케미칼 인더스트리스 피엘씨 filed Critical 알란 브라이안 벡
Publication of KR870001142A publication Critical patent/KR870001142A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)

Abstract

내용 없음.

Description

페닐 에테르의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. (a) 다음 일반식(2)의 페놀 유도체를 식중 X가 적당한 이탈 그룹인 일반식 X. CH2X의 알킬화제와 반응시키거나;
    (b) 다음 일반식(6)의 아민 유도체를 일반식(4)의 에폭시드와 반응시키거나;
    (c) 식중 Q가 적당한 보호그룹인 다음 일반식(7)의 보호된 유도체를 탈보호하거나;
    (d) Z가 카복시인 일반식(1)화합물은,
    식중 R6가 아미노, (1-6C) 알콕시, 페녹시 또는 벤질옥시인 일반식 -CO.R6라디칼로 Z가 치환된 일반식(1)의 에스테르 또는 아미드를 분해하여 얻거나; (e) Z가 카바모일인 일반식(1)의 화합물은 식중 R7이 (1-6C) 알콕시, 페녹시 또는 벤질옥시인 일반식 -CO.R7라디칼로 Z가 치환된 일반식(1)의 에스테르를 암모니아와 반응시켜 얻거나; (f) Z가 히드록시메틸인 일반식(1)의 화합물은, Z가 카복시인 일반식(1)의 당해 산 또는 식중 Z가 전술한 바와 같은 일반식 -CO.R7의 라디칼로 치환된 일반식(1)의 에스테르를 환원시켜 얻거나; 또는 (g) 식중 R2및 R3중 하나가 수소 또는 (1-3C)알킬이고 R2및 R3중 다른 하나가 수소인 일반식(1)의 화합물은, 식중 R8가 수소 또는 (1-3C)알킬인 일반식(8)의 아민을 환원시켜 얻거나;
    그 후에, 식중 Z가 카복시인 일반식(1)의 산이 통상적인 아미드화 또는 에스테르화 방법으로 당해 아미드(R4가 아미노) 또는 에스레르(R4가 (1-6C) 알콕시)로 전환될 수 있고, Z가 히드록시메틸인 일반식(1)의 알콜이 동상적인 방법으로 당해 산(Z가 카복시)으로 산화될 수 있고;
    제약학적으로 사용 가능할 염이 필요할때, 유리 염기형태로 또는 Z가 카복시일때 찌비터이온 형태로 일반식(1)의 화합물을 통상적인 방법으로 적절한 산 또는 염기와 반응시키고; 거울상이성질체가 필요할때, 일반식(1)의 당해 타세미체를 통상적인 방법 또는 광학적으로 활성인 개시 물질을 사용해서 행한 전술한 방법중의 하나로 분리하는 것으로 특징지어지는 다음의 일반식(1)의 페녹시아세트산 유도체 또는 제약학적으로 사용가능한 당해 염의 제조방법.
    식중, R1은 수소 또는 불소 R2및 R3는 독립적으로 수소 및 (1-3C)알킬에서 선택 Z는 히드록시메틸 또는 식중 R4가 히드록시인식 -CO.R4의 그룹(1-6C) 알콕시 또는 아미노.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019860006278A 1985-07-30 1986-07-30 페닐 에테르의 제법 KR870001142A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858519154A GB8519154D0 (en) 1985-07-30 1985-07-30 Aromatic ethers
GB8519154 1985-07-30

Publications (1)

Publication Number Publication Date
KR870001142A true KR870001142A (ko) 1987-03-11

Family

ID=10583042

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019860006278A KR870001142A (ko) 1985-07-30 1986-07-30 페닐 에테르의 제법

Country Status (27)

Country Link
US (1) US4772631A (ko)
EP (1) EP0210849B1 (ko)
JP (2) JPH0651661B2 (ko)
KR (1) KR870001142A (ko)
CN (1) CN1014516B (ko)
AR (1) AR242176A1 (ko)
AT (1) ATE55980T1 (ko)
AU (1) AU603987B2 (ko)
CA (1) CA1283122C (ko)
CS (1) CS266593B2 (ko)
DD (1) DD251551A5 (ko)
DE (1) DE3673722D1 (ko)
DK (1) DK168761B1 (ko)
ES (1) ES2002720A6 (ko)
FI (1) FI88030C (ko)
GB (1) GB8519154D0 (ko)
GR (1) GR861994B (ko)
HU (1) HUT44757A (ko)
IE (1) IE60157B1 (ko)
IL (1) IL79447A0 (ko)
NO (1) NO170480C (ko)
NZ (1) NZ217011A (ko)
PH (1) PH22503A (ko)
PL (1) PL152320B1 (ko)
PT (1) PT83085B (ko)
SU (1) SU1632370A3 (ko)
ZA (1) ZA865097B (ko)

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Also Published As

Publication number Publication date
IL79447A0 (en) 1986-10-31
PL260759A1 (en) 1988-09-15
FI862896A (fi) 1987-01-31
PL152320B1 (en) 1990-12-31
AR242176A1 (es) 1993-03-31
CN1014516B (zh) 1991-10-30
DK168761B1 (da) 1994-06-06
FI862896A0 (fi) 1986-07-09
CS573586A2 (en) 1989-04-14
ATE55980T1 (de) 1990-09-15
FI88030B (fi) 1992-12-15
CS266593B2 (en) 1990-01-12
DD251551A5 (de) 1987-11-18
GB8519154D0 (en) 1985-09-04
EP0210849B1 (en) 1990-08-29
DK359986A (da) 1987-01-31
NO170480B (no) 1992-07-13
AU6002986A (en) 1987-02-05
SU1632370A3 (ru) 1991-02-28
ES2002720A6 (es) 1988-10-01
IE60157B1 (en) 1994-06-15
JPH06340597A (ja) 1994-12-13
CA1283122C (en) 1991-04-16
CN86105400A (zh) 1987-03-11
GR861994B (en) 1986-11-26
NO863061L (no) 1987-02-02
DK359986D0 (da) 1986-07-29
EP0210849A1 (en) 1987-02-04
IE861827L (en) 1987-01-30
NZ217011A (en) 1990-02-26
JPH0651661B2 (ja) 1994-07-06
HUT44757A (en) 1988-04-28
US4772631A (en) 1988-09-20
AU603987B2 (en) 1990-12-06
JPH0819062B2 (ja) 1996-02-28
DE3673722D1 (en) 1990-10-04
JPS6277357A (ja) 1987-04-09
NO863061D0 (no) 1986-07-29
ZA865097B (en) 1987-03-25
PH22503A (en) 1988-09-12
PT83085A (en) 1986-08-01
NO170480C (no) 1992-10-21
PT83085B (pt) 1989-01-30
FI88030C (fi) 1993-03-25

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