KR840000515A - N-아릴-피페라진알칸아미드의 제조법 - Google Patents

N-아릴-피페라진알칸아미드의 제조법 Download PDF

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KR840000515A
KR840000515A KR1019820002642A KR820002642A KR840000515A KR 840000515 A KR840000515 A KR 840000515A KR 1019820002642 A KR1019820002642 A KR 1019820002642A KR 820002642 A KR820002642 A KR 820002642A KR 840000515 A KR840000515 A KR 840000515A
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lower alkyl
group
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aminocarbonyl
aryl
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KR870001521B1 (ko
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반 달레 죠오지
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폴 아드리안 쟌 쟈안센
쟈안센 파아마슈우티카 엔.브이
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
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    • C07C65/34—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing keto groups polycyclic
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    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

N-아릴-피페라진알칸아미드의 제조법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (4)

  1. 일반식
    의 시약 또는 이 물질들에 대응하는 카-보닐 산화형 시약을 일반식
    을 갖는 피페라진과 일반식
    인 물질로 각각 적합한 반응성-불활성 용매내에서 반응시켜서 광학이성체이면서 이물질의 산철가염임을 약제로서 사용 가능한 일반식
    인 N-아릴-피페라진알칸아미이드를 제조하는 방법.
  2. 카본산 유도체인
    이나
    을 적당한 반응성 불활성 용매내에서 일반식
    을 반응시킴을 특징으로 하는 상기 일반식(Ⅰ)을 제조하는 방법.
  3. 일반식
    이거나
    인 디아민을 일반식 (★스캔) (XI)나 W-CH2-CH2-W1(XⅢ)인 시악으로 반응성 불활성 용매내에서 반응시킴을 특징으로하는 상기 일반식(Ⅰ)을 제조하는 방법.
  4. 일반식
    이나 혹은 R-NH2(XⅥ)인 아민을 일반식
    인 시약으로 반응성 불활성 용매중에서 반응시킴을 특징으로 하는 상기 일반식(Ⅰ)을 제조하는 방법. (여기서, R1은 수소화 저급알킬로된 그룹에서 선택된 일원, X는 하이드록시 저급알킬, 저급알킬옥시, 저급알킬, 아미노카보닐, 모노 및 디(저급알킬(아미노카보닐, 카복실, 저급알킬옥시카보닐(아미노카보닐)저급알킬, [모노 및 디(저급알킬)아미노카보닐]-저급알킬, 카복시저급알킬, (저급알킬옥시카보닐)저급알킬 및 하이드록시 저급알킬)아미노카보닐로된 그룹으로부터 선택된 일원, m은 정수 1 혹은 2이고, R2은 수소와 저급알킬로된 그룹에서 선택된 일종, R3,R4와 R5는 각각 독립적으로 수소, 하이드록시 저급알킬, 저급알킬옥시, 할로, 삼불화메틸, 저급알킬카보닐, 아미노카보닐, 저급알킬옥시카보닐, 사이노, 아미노, 모노-와 디-(저급알킬)아미노, (저급알킬카보닐)아미노와 (아미노카보닐)아미노로된 그룹으로부터 선택되는데 R3및 또는 R4는 니트로일수도 있으며, R은 일반식
    (Ar1와 Ar2는 각기 아릴기)와 일반식
    Alk-Q 기 (b)
    로 구성된 그룹으로부터 선택된 일종인데 여기에서 Alk는 알카네디일기나 저급알카네디일기이며, Q는 아릴, 아릴옥시, 디아릴메톡시, 2,2-디아릴에테닐, 디아릴메틸카보닐, 아릴카보닐, 모노-와 디아릴아미노카보닐, 디아릴메틸, 디메틸의 일부로된 그룹에서 선택된 일종 W와 W'는 반응성 아탈기이다.)
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8202642A 1981-06-23 1982-06-14 N-아릴-피페라진알칸아미드의 제조법 KR870001521B1 (ko)

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KR1019870003317A KR880000043B1 (ko) 1981-06-23 1987-04-07 Ｎ－아릴－피레라진알칸아미드의 제조법

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US27662481A 1981-06-23 1981-06-23
US276624 1981-06-23
US06/362,814 US4766125A (en) 1981-06-23 1982-03-29 N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia
US362814 1982-03-29

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AU (1) AU547524B2 (ko)
CA (1) CA1210395A (ko)
CS (1) CS381991A3 (ko)
DE (1) DE3276482D1 (ko)
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ES (1) ES8307763A1 (ko)
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IE (1) IE53465B1 (ko)
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NO (1) NO163691C (ko)
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GR76088B (ko) 1984-08-03
DK280182A (da) 1982-12-24
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FI75810B (fi) 1988-04-29
FI822243A0 (fi) 1982-06-22
IE821476L (en) 1982-12-23
AU547524B2 (en) 1985-10-24
DE3276482D1 (en) 1987-07-09
EP0068544B1 (en) 1987-06-03
EP0068544A2 (en) 1983-01-05
DK149949B (da) 1986-11-03
NO163691C (no) 1990-07-04
KR870001521B1 (ko) 1987-08-22
NO163691B (no) 1990-03-26
PT75101A (en) 1982-07-01
NO822087L (no) 1982-12-27
HU189149B (en) 1986-06-30
ES513366A0 (es) 1983-08-01
ES8307763A1 (es) 1983-08-01
PT75101B (en) 1985-01-07
US4766125A (en) 1988-08-23
NZ200935A (en) 1984-11-09
AU8508482A (en) 1983-01-06
IE53465B1 (en) 1988-11-23
CA1210395A (en) 1986-08-26
DK149949C (da) 1987-06-15
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