DK168761B1 - Phenylethere og farmaceutisk acceptable salte deraf, fremgangsmåder til fremstilling heraf samt far maceutiske midler indeholdelde disse - Google Patents

Phenylethere og farmaceutisk acceptable salte deraf, fremgangsmåder til fremstilling heraf samt far maceutiske midler indeholdelde disse Download PDF

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Publication number
DK168761B1
DK168761B1 DK359986A DK359986A DK168761B1 DK 168761 B1 DK168761 B1 DK 168761B1 DK 359986 A DK359986 A DK 359986A DK 359986 A DK359986 A DK 359986A DK 168761 B1 DK168761 B1 DK 168761B1
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DK
Denmark
Prior art keywords
formula
compound
hydrogen
amino
hydroxy
Prior art date
Application number
DK359986A
Other languages
Danish (da)
English (en)
Other versions
DK359986D0 (da
DK359986A (da
Inventor
Brian Roy Holloway
Ralph Howe
Balbir Singh Rao
Donald Stribling
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DK359986D0 publication Critical patent/DK359986D0/da
Publication of DK359986A publication Critical patent/DK359986A/da
Application granted granted Critical
Publication of DK168761B1 publication Critical patent/DK168761B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
DK359986A 1985-07-30 1986-07-29 Phenylethere og farmaceutisk acceptable salte deraf, fremgangsmåder til fremstilling heraf samt far maceutiske midler indeholdelde disse DK168761B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8519154 1985-07-30
GB858519154A GB8519154D0 (en) 1985-07-30 1985-07-30 Aromatic ethers

Publications (3)

Publication Number Publication Date
DK359986D0 DK359986D0 (da) 1986-07-29
DK359986A DK359986A (da) 1987-01-31
DK168761B1 true DK168761B1 (da) 1994-06-06

Family

ID=10583042

Family Applications (1)

Application Number Title Priority Date Filing Date
DK359986A DK168761B1 (da) 1985-07-30 1986-07-29 Phenylethere og farmaceutisk acceptable salte deraf, fremgangsmåder til fremstilling heraf samt far maceutiske midler indeholdelde disse

Country Status (27)

Country Link
US (1) US4772631A (ko)
EP (1) EP0210849B1 (ko)
JP (2) JPH0651661B2 (ko)
KR (1) KR870001142A (ko)
CN (1) CN1014516B (ko)
AR (1) AR242176A1 (ko)
AT (1) ATE55980T1 (ko)
AU (1) AU603987B2 (ko)
CA (1) CA1283122C (ko)
CS (1) CS266593B2 (ko)
DD (1) DD251551A5 (ko)
DE (1) DE3673722D1 (ko)
DK (1) DK168761B1 (ko)
ES (1) ES2002720A6 (ko)
FI (1) FI88030C (ko)
GB (1) GB8519154D0 (ko)
GR (1) GR861994B (ko)
HU (1) HUT44757A (ko)
IE (1) IE60157B1 (ko)
IL (1) IL79447A0 (ko)
NO (1) NO170480C (ko)
NZ (1) NZ217011A (ko)
PH (1) PH22503A (ko)
PL (1) PL152320B1 (ko)
PT (1) PT83085B (ko)
SU (1) SU1632370A3 (ko)
ZA (1) ZA865097B (ko)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0300290B1 (de) * 1987-07-21 1991-12-18 F. Hoffmann-La Roche Ag Phenoxypropanolamine
GB8801306D0 (en) * 1988-01-21 1988-02-17 Ici Plc Chemical compounds
GB8905336D0 (en) * 1989-03-08 1989-04-19 Ici Plc Chemical compounds
GB8910374D0 (en) * 1989-05-05 1989-06-21 Ici Plc Chemical compounds
KR920005952B1 (ko) * 1989-05-26 1992-07-25 이사무 이와이 오수정화조의 여과재 순환 정화장치
GB8925032D0 (en) * 1989-11-06 1989-12-28 Ici Plc Chemical compounds
GB8926083D0 (en) * 1989-11-17 1990-01-10 Ici Plc Therapeutic agents
GB9003185D0 (en) * 1990-02-13 1990-04-11 Ici Plc Pharmaceutical compositions
US5245053A (en) * 1990-05-04 1993-09-14 American Cyanamid Company Substituted 5-(2-(2-aryl-2-hydroxyethyl)-amino)propyl)-1,3-benzodioxoles
US5061727A (en) * 1990-05-04 1991-10-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
US5151439A (en) * 1990-05-04 1992-09-29 American Cyanamid Company Substituted 5-(2-((2-aryl-2-hydroxyethyl)amino)propyl)-1,3-benzodioxoles
US5106867A (en) * 1990-05-04 1992-04-21 American Cyanamid Company Method of increasing lean meat in edible animals
GB9016655D0 (en) * 1990-07-30 1990-09-12 Ici Plc Therapeutic agents
GB9111425D0 (en) * 1991-05-28 1991-07-17 Ici Plc Chemical compounds
GB9111426D0 (en) * 1991-05-28 1991-07-17 Ici Plc Chemical compounds
US5502078A (en) * 1991-05-28 1996-03-26 Zeneca Limited Chemical compounds
GB9224740D0 (en) * 1992-11-26 1993-01-13 Ici Plc Therapeutic agents
US5563171A (en) * 1993-11-05 1996-10-08 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3-adrenergic agonists
US5578638A (en) * 1993-11-05 1996-11-26 American Cyanamid Company Treatment of glaucoma and ocular hypertension with β3 -adrenergic agonists
US5776983A (en) * 1993-12-21 1998-07-07 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5488064A (en) * 1994-05-02 1996-01-30 Bristol-Myers Squibb Company Benzo 1,3 dioxole derivatives
US5491134A (en) * 1994-09-16 1996-02-13 Bristol-Myers Squibb Company Sulfonic, phosphonic or phosphiniic acid β3 agonist derivatives
US5541204A (en) * 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
ZA967892B (en) * 1995-09-21 1998-03-18 Lilly Co Eli Selective β3 adrenergic agonists.
US5770615A (en) * 1996-04-04 1998-06-23 Bristol-Myers Squibb Company Catecholamine surrogates useful as β3 agonists
US5808080A (en) * 1996-09-05 1998-09-15 Eli Lilly And Company Selective β3 adrenergic agonists
ES2171839T3 (es) 1996-09-05 2002-09-16 Lilly Co Eli Analogos de carbazol como agonistas adrenergicos selectivos de beta3.
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
GB9812709D0 (en) * 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds
US6344481B1 (en) 1999-03-01 2002-02-05 Pfizer Inc. Thyromimetic antiobesity agents
US7709677B2 (en) * 2001-01-31 2010-05-04 Glaxosmithkline Llc Process of preparing arylethanoldiamines
US7504435B2 (en) * 2001-01-31 2009-03-17 The Arizona Board Of Regents On Behalf Of The University Of Arizona Method for stimulating weight loss and/or for lowering triglycerides in patients
GB0102407D0 (en) 2001-01-31 2001-03-14 Glaxo Group Ltd Process
US7202222B2 (en) * 2003-01-06 2007-04-10 National Bioscience Corporation Methods for treatment of obesity and effective fat loss promotion
AU2008219585A1 (en) * 2007-02-27 2008-09-04 The Arizona Board Of Regents On Behalf Of The University Of Arizona Administration of 3,5-diiodothyropropionic acid for stimulating weight loss, and/or lowering triglyceride levels, and/or treatment of metabolic syndrome.
US8476227B2 (en) 2010-01-22 2013-07-02 Ethicon Endo-Surgery, Inc. Methods of activating a melanocortin-4 receptor pathway in obese subjects
US9044606B2 (en) 2010-01-22 2015-06-02 Ethicon Endo-Surgery, Inc. Methods and devices for activating brown adipose tissue using electrical energy
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
WO2013130968A1 (en) * 2012-03-01 2013-09-06 University Of Cincinnati Ros-activated compounds as selective anti-cancer therapeutics
MX2017007054A (es) 2014-12-03 2018-05-02 Velicept Therapeutics Inc Composiciones y métodos para usar solabegron de liberación modificada para sintomas del tracto urinario inferior.
US10080884B2 (en) 2014-12-29 2018-09-25 Ethicon Llc Methods and devices for activating brown adipose tissue using electrical energy
US10092738B2 (en) 2014-12-29 2018-10-09 Ethicon Llc Methods and devices for inhibiting nerves when activating brown adipose tissue
IL310527A (en) 2015-10-23 2024-03-01 B3Ar Therapeutics Inc Zwitterion solvegron and its uses

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1245148A (en) * 1968-11-18 1971-09-08 Pfizer Ltd Propanolamine derivatives
SE368197B (ko) * 1968-11-18 1974-06-24 Pfizer
SE354851B (ko) * 1970-02-18 1973-03-26 Haessle Ab
US4146638A (en) * 1976-02-17 1979-03-27 Boehringer Ingelheim Gmbh N-(3-phenoxy-2-hydroxy-propyl)-n-(2-phenyl-2-hydroxy-ethyl)-amines
US4191765A (en) * 1976-05-25 1980-03-04 Hoechst Aktiengesellschaft 1-Aryloxy-2-hydroxy-3-aminopropanes
CH632987A5 (en) * 1976-10-07 1982-11-15 Haessle Ab Process for preparing novel amines
SE416545B (sv) * 1976-10-07 1981-01-19 Haessle Ab Forfarande for framstellning av nya hjertaktiva 1-frnoxi-3-aminopropan-2-ol-derivat
EP0006735B1 (en) * 1978-06-28 1983-06-15 Beecham Group Plc Secondary amines, their preparation, pharmaceutical compositions containing them and their use
SE7807408L (sv) * 1978-06-30 1979-12-31 Haessle Ab Hjertaktiva foreningar
DE3061334D1 (en) * 1979-06-16 1983-01-20 Beecham Group Plc Ethanamine derivatives, their preparation and use in pharmaceutical compositions
ATE2265T1 (de) * 1979-10-25 1983-02-15 Beecham Group Plc Sekundaere amine, ihre herstellung und verwendung in pharmazeutischen zusammensetzungen.
IL65541A0 (en) * 1981-05-06 1982-07-30 Haessle Ab Alkylamino-2-propanols,process for their preparation and pharmaceutical preparations containing same
GB8415377D0 (en) * 1984-06-15 1984-07-18 Beecham Group Plc Compounds
GB8510146D0 (en) * 1985-04-20 1985-05-30 Smith Kline French Lab Chemical compounds & processes

Also Published As

Publication number Publication date
EP0210849B1 (en) 1990-08-29
AU603987B2 (en) 1990-12-06
FI862896A (fi) 1987-01-31
AR242176A1 (es) 1993-03-31
PT83085A (en) 1986-08-01
NZ217011A (en) 1990-02-26
GR861994B (en) 1986-11-26
NO863061D0 (no) 1986-07-29
CA1283122C (en) 1991-04-16
JPS6277357A (ja) 1987-04-09
EP0210849A1 (en) 1987-02-04
PH22503A (en) 1988-09-12
NO170480B (no) 1992-07-13
IE60157B1 (en) 1994-06-15
CN1014516B (zh) 1991-10-30
FI88030B (fi) 1992-12-15
ZA865097B (en) 1987-03-25
IL79447A0 (en) 1986-10-31
HUT44757A (en) 1988-04-28
NO863061L (no) 1987-02-02
ATE55980T1 (de) 1990-09-15
KR870001142A (ko) 1987-03-11
GB8519154D0 (en) 1985-09-04
CS573586A2 (en) 1989-04-14
PL152320B1 (en) 1990-12-31
ES2002720A6 (es) 1988-10-01
DD251551A5 (de) 1987-11-18
DE3673722D1 (en) 1990-10-04
IE861827L (en) 1987-01-30
AU6002986A (en) 1987-02-05
DK359986D0 (da) 1986-07-29
PL260759A1 (en) 1988-09-15
PT83085B (pt) 1989-01-30
SU1632370A3 (ru) 1991-02-28
JPH0651661B2 (ja) 1994-07-06
JPH0819062B2 (ja) 1996-02-28
JPH06340597A (ja) 1994-12-13
CS266593B2 (en) 1990-01-12
CN86105400A (zh) 1987-03-11
FI88030C (fi) 1993-03-25
DK359986A (da) 1987-01-31
NO170480C (no) 1992-10-21
US4772631A (en) 1988-09-20
FI862896A0 (fi) 1986-07-09

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PBP Patent lapsed