KR830004217A - 약학적 활성이 있는 펩타이드 - Google Patents

약학적 활성이 있는 펩타이드 Download PDF

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Publication number
KR830004217A
KR830004217A KR1019800004793A KR800004793A KR830004217A KR 830004217 A KR830004217 A KR 830004217A KR 1019800004793 A KR1019800004793 A KR 1019800004793A KR 800004793 A KR800004793 A KR 800004793A KR 830004217 A KR830004217 A KR 830004217A
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KR
South Korea
Prior art keywords
hydrogen
alkyl
primary
protecting group
same
Prior art date
Application number
KR1019800004793A
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English (en)
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KR840001720B1 (ko
Inventor
데이빗 게젤첸 폴
리 스마일리 데이빗
Original Assignee
아더 알 웨일.
일라이 릴리 앤드 캄파니
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Application filed by 아더 알 웨일., 일라이 릴리 앤드 캄파니 filed Critical 아더 알 웨일.
Publication of KR830004217A publication Critical patent/KR830004217A/ko
Priority to KR8404642A priority Critical patent/KR840001735B1/ko
Application granted granted Critical
Publication of KR840001720B1 publication Critical patent/KR840001720B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/08—Endorphin or enkephalin; related peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

약학적 활성이 있는 펩타이드
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 다음 구조식(Ⅱ)의 화합물을 적합한 탈 차단제와 반응시켜 다음 구조식(I)의 화합물 및 이들의 약학적으로 가능한 비독성 산부가염을 제조하는 방법.
    상기 구조식에서
    L 및 D 는 편광성을 나타내며
    R1은 수소 또는 C1-31급알킬,
    R2는 C1-41급 또는 2급알킬, 알릴, 사이클로프로필메틸, C1-2하이드록시알킬 또는 -(CH2)m-U-CH3이며(여기서 U는 -S- 또는이며 m은 1또는 2이다),
    R3는 수소, C1-41급 또는 2급알킬, 사이클로프로필메틸, 또는 알릴
    X는 수소, 할로, 하이드록시, C1-3알콕시, 니트로, C1-3알킬 또는 트리플루오로메틸이며,
    Z는 -CH2OR4,이며 여기서 R4는 수소, C1-3알킬이고 R5는 C1-3알킬이며
    상기 구조식에서
    R3는 상기에서와 같고
    R6는 수소, C1-31급 알킬, 또는 아미노 보호그룹;
    R7은 상기 R2그룹과 같은 그룹을 의미하거나 C1-2하이드록시알킬부위의 하이드록시 보호그룹을 나타내며;
    R8은 수소 또는 하이두록시 보호그룹;
    X'는 상기 X에서와 같거나 하이드록시 보호그룹을 나타내며
    Z'는 상기 Z에서와 같거나 수지 지지체를 포함한 Z의 전구체를 나타내며
    단, R6,R7,R8,X' 또는 Z'중 적어도 하나는 보호된 부위이어야 한다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019800004793A 1979-12-17 1980-12-16 펩타이드의 제조방법 KR840001720B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR8404642A KR840001735B1 (en) 1979-12-17 1984-08-03 Process for the preparation of peptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/104,345 US4251439A (en) 1979-12-17 1979-12-17 Pharmacologically active peptides
US104345 1987-10-02

Publications (2)

Publication Number Publication Date
KR830004217A true KR830004217A (ko) 1983-07-06
KR840001720B1 KR840001720B1 (ko) 1984-10-17

Family

ID=22300004

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019800004793A KR840001720B1 (ko) 1979-12-17 1980-12-16 펩타이드의 제조방법
KR8404642A KR840001735B1 (en) 1979-12-17 1984-08-03 Process for the preparation of peptides

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR8404642A KR840001735B1 (en) 1979-12-17 1984-08-03 Process for the preparation of peptides

Country Status (15)

Country Link
US (1) US4251439A (ko)
EP (1) EP0030846B1 (ko)
JP (1) JPS5697258A (ko)
KR (2) KR840001720B1 (ko)
AR (1) AR230261A1 (ko)
BE (1) BE886676A (ko)
CA (1) CA1140539A (ko)
CH (1) CH646685A5 (ko)
DE (1) DE3067790D1 (ko)
FR (1) FR2471969A1 (ko)
GB (1) GB2065134B (ko)
HU (1) HU185230B (ko)
IE (1) IE50798B1 (ko)
IL (1) IL61701A (ko)
IT (1) IT1141134B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3163199D1 (en) * 1980-07-17 1984-05-24 Sandoz Ag Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
WO1983002272A1 (en) * 1981-12-28 1983-07-07 Beckman Instruments Inc Synthetic peptides having pituitary growth hormone releasing activity
DK134784A (da) * 1983-03-07 1984-09-08 Lilly Co Eli Farmakologisk virksomme tripeptid-derivater og fremgangsmaade til fremstilling deraf
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
CA2161108A1 (en) * 1993-04-23 1994-11-10 Herbert J. Evans Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1577115A (en) * 1976-07-27 1980-10-22 Reckitt & Colmann Prod Ltd Container closure units
CH619686A5 (en) * 1976-02-02 1980-10-15 Sandoz Ag Process for the preparation of novel peptides or peptide derivatives
FI770219A (ko) * 1976-02-02 1977-08-03 Sandoz Ag
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds

Also Published As

Publication number Publication date
EP0030846A3 (en) 1981-12-23
IT8026671A0 (it) 1980-12-16
HU185230B (en) 1984-12-28
GB2065134A (en) 1981-06-24
DE3067790D1 (en) 1984-06-14
IT1141134B (it) 1986-10-01
EP0030846A2 (en) 1981-06-24
CA1140539A (en) 1983-02-01
US4251439A (en) 1981-02-17
IE50798B1 (en) 1986-07-23
FR2471969A1 (fr) 1981-06-26
AR230261A1 (es) 1984-03-01
KR840001720B1 (ko) 1984-10-17
BE886676A (fr) 1981-06-16
FR2471969B1 (ko) 1982-11-05
IL61701A0 (en) 1981-01-30
EP0030846B1 (en) 1984-05-09
GB2065134B (en) 1983-06-02
KR840001735B1 (en) 1984-10-18
JPS5697258A (en) 1981-08-05
CH646685A5 (fr) 1984-12-14
IE802641L (en) 1981-06-17
IL61701A (en) 1984-05-31

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