KR840001735B1 - Process for the preparation of peptides - Google Patents

Process for the preparation of peptides

Info

Publication number
KR840001735B1
KR840001735B1 KR8404642A KR840004642A KR840001735B1 KR 840001735 B1 KR840001735 B1 KR 840001735B1 KR 8404642 A KR8404642 A KR 8404642A KR 840004642 A KR840004642 A KR 840004642A KR 840001735 B1 KR840001735 B1 KR 840001735B1
Authority
KR
South Korea
Prior art keywords
alkyl
boc
ch2or5
deblocked
hobt
Prior art date
Application number
KR8404642A
Other languages
English (en)
Inventor
Paul D Gesellchen
David L Smiley
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of KR840001735B1 publication Critical patent/KR840001735B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/70—Enkephalins
    • C07K14/702—Enkephalins with at least 1 amino acid in D-form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/08—Endorphin or enkephalin; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR8404642A 1979-12-17 1984-08-03 Process for the preparation of peptides KR840001735B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/104,345 US4251439A (en) 1979-12-17 1979-12-17 Pharmacologically active peptides
KR1019800004793A KR840001720B1 (ko) 1979-12-17 1980-12-16 펩타이드의 제조방법

Publications (1)

Publication Number Publication Date
KR840001735B1 true KR840001735B1 (en) 1984-10-18

Family

ID=22300004

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1019800004793A KR840001720B1 (ko) 1979-12-17 1980-12-16 펩타이드의 제조방법
KR8404642A KR840001735B1 (en) 1979-12-17 1984-08-03 Process for the preparation of peptides

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1019800004793A KR840001720B1 (ko) 1979-12-17 1980-12-16 펩타이드의 제조방법

Country Status (15)

Country Link
US (1) US4251439A (ko)
EP (1) EP0030846B1 (ko)
JP (1) JPS5697258A (ko)
KR (2) KR840001720B1 (ko)
AR (1) AR230261A1 (ko)
BE (1) BE886676A (ko)
CA (1) CA1140539A (ko)
CH (1) CH646685A5 (ko)
DE (1) DE3067790D1 (ko)
FR (1) FR2471969A1 (ko)
GB (1) GB2065134B (ko)
HU (1) HU185230B (ko)
IE (1) IE50798B1 (ko)
IL (1) IL61701A (ko)
IT (1) IT1141134B (ko)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3163199D1 (en) * 1980-07-17 1984-05-24 Sandoz Ag Novel pentapeptides, processes for their production, pharmaceutical compositions comprising said pentapeptides and their use
WO1983002272A1 (en) * 1981-12-28 1983-07-07 Beckman Instruments Inc Synthetic peptides having pituitary growth hormone releasing activity
DK134784A (da) * 1983-03-07 1984-09-08 Lilly Co Eli Farmakologisk virksomme tripeptid-derivater og fremgangsmaade til fremstilling deraf
US5952465A (en) * 1993-04-23 1999-09-14 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5965698A (en) * 1993-04-23 1999-10-12 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6258550B1 (en) 1993-04-23 2001-07-10 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
CA2161108A1 (en) * 1993-04-23 1994-11-10 Herbert J. Evans Polypeptides that include conformation-constraining groups which flank a protein-protein interaction site
US5928896A (en) * 1993-04-23 1999-07-27 Virginia Commonwealth University Polypeptides that include conformation-constraining groups which flank a protein--protein interaction site
US6084066A (en) * 1993-10-29 2000-07-04 Virginia Commonwealth University Polypetides that include conformation-constraining groups which flank a protein-protein interaction site

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1577115A (en) * 1976-07-27 1980-10-22 Reckitt & Colmann Prod Ltd Container closure units
CH619686A5 (en) * 1976-02-02 1980-10-15 Sandoz Ag Process for the preparation of novel peptides or peptide derivatives
FI770219A (ko) * 1976-02-02 1977-08-03 Sandoz Ag
US4259234A (en) * 1976-09-27 1981-03-31 Eli Lilly And Company Analgesic compounds

Also Published As

Publication number Publication date
EP0030846A3 (en) 1981-12-23
IT8026671A0 (it) 1980-12-16
HU185230B (en) 1984-12-28
GB2065134A (en) 1981-06-24
DE3067790D1 (en) 1984-06-14
IT1141134B (it) 1986-10-01
EP0030846A2 (en) 1981-06-24
CA1140539A (en) 1983-02-01
US4251439A (en) 1981-02-17
IE50798B1 (en) 1986-07-23
FR2471969A1 (fr) 1981-06-26
AR230261A1 (es) 1984-03-01
KR840001720B1 (ko) 1984-10-17
BE886676A (fr) 1981-06-16
KR830004217A (ko) 1983-07-06
FR2471969B1 (ko) 1982-11-05
IL61701A0 (en) 1981-01-30
EP0030846B1 (en) 1984-05-09
GB2065134B (en) 1983-06-02
JPS5697258A (en) 1981-08-05
CH646685A5 (fr) 1984-12-14
IE802641L (en) 1981-06-17
IL61701A (en) 1984-05-31

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Legal Events

Date Code Title Description
E701 Decision to grant or registration of patent right