KR830001952A - 세펄옥심(Cefuroxim)의 제조방법 - Google Patents
세펄옥심(Cefuroxim)의 제조방법 Download PDFInfo
- Publication number
- KR830001952A KR830001952A KR1019800000589A KR800000589A KR830001952A KR 830001952 A KR830001952 A KR 830001952A KR 1019800000589 A KR1019800000589 A KR 1019800000589A KR 800000589 A KR800000589 A KR 800000589A KR 830001952 A KR830001952 A KR 830001952A
- Authority
- KR
- South Korea
- Prior art keywords
- solvate
- cefuloxim
- manufacturing
- solvent medium
- sodium
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
- C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 구조식(Ⅰ)의 화합물을 거의 무수인 용매매질(substantially anhydrous solvent medium)중에서 이 용매매질에 가용성이고, PKa값이 3.5보다 큰 산이 나트륨염으로 구성되는 염기성 촉매 존재하에서 알콜분해시켜 제조되는 소디움 세펠옥심 또는 이의 용매화물(용매화물)을 제조하는 방법.상기 구조식에서,R1은 염기-불안정기(Base-labipe group)이다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7905456 | 1979-02-15 | ||
GB7905456 | 1979-02-15 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830001952A true KR830001952A (ko) | 1983-05-21 |
KR830001905B1 KR830001905B1 (ko) | 1983-09-19 |
Family
ID=10503234
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019800000589A KR830001905B1 (ko) | 1979-02-15 | 1980-02-14 | 소디움 세펄옥심의 제조방법 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4277601A (ko) |
JP (1) | JPS55111490A (ko) |
KR (1) | KR830001905B1 (ko) |
AT (1) | AT366051B (ko) |
AU (1) | AU542084B2 (ko) |
CH (1) | CH646706A5 (ko) |
DE (1) | DE3005564A1 (ko) |
DK (1) | DK159449C (ko) |
ES (1) | ES8101607A1 (ko) |
FI (1) | FI75168C (ko) |
FR (1) | FR2482104A1 (ko) |
GB (1) | GB2043070B (ko) |
HU (1) | HU182068B (ko) |
IT (1) | IT1144037B (ko) |
NL (1) | NL191844C (ko) |
SE (1) | SE451724B (ko) |
YU (1) | YU42325B (ko) |
ZA (1) | ZA80844B (ko) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS588086A (ja) * | 1981-07-07 | 1983-01-18 | Takeda Chem Ind Ltd | セフアロスポリン溶媒和物およびその製造法 |
GB8320520D0 (en) * | 1983-07-29 | 1983-09-01 | Glaxo Group Ltd | Chemical process |
AT411996B (de) * | 2000-09-11 | 2004-08-26 | Sandoz Ag | Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes |
WO2004050663A2 (en) * | 2002-12-05 | 2004-06-17 | Orchid Chemicals & Pharmaceuticals Ltd | An improved process for the preparation of cefuroxime sodium |
ITMI20050871A1 (it) * | 2005-05-13 | 2006-11-14 | Acs Dobfar Spa | Solvato cristallino di cefuroxima acido |
CN102617604A (zh) * | 2012-02-24 | 2012-08-01 | 天津大学 | 一种耦合反应结晶制备头孢呋辛钠的方法 |
CN104774211A (zh) * | 2015-04-27 | 2015-07-15 | 四川制药制剂有限公司 | 注射用头孢呋辛钠的制备工艺 |
WO2017191620A1 (en) * | 2016-05-06 | 2017-11-09 | Sun Pharmaceutical Industries Limited | A crystalline form of a salt of sacubitril and a process of its preparation |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3974153A (en) * | 1971-05-14 | 1976-08-10 | Glaxo Laboratories Limited | 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids |
US3905963A (en) * | 1972-01-25 | 1975-09-16 | Lilly Co Eli | Process for preparing primary 3-carbamoyloxymethyl cephalosporins |
GB1575905A (en) * | 1976-04-28 | 1980-10-01 | Glaxo Lab Ltd | Salt of cefuroxime |
-
1980
- 1980-02-14 JP JP1611880A patent/JPS55111490A/ja active Granted
- 1980-02-14 CH CH123480A patent/CH646706A5/de not_active IP Right Cessation
- 1980-02-14 ES ES488607A patent/ES8101607A1/es not_active Expired
- 1980-02-14 IT IT47899/80A patent/IT1144037B/it active
- 1980-02-14 GB GB8005088A patent/GB2043070B/en not_active Expired
- 1980-02-14 NL NL8000925A patent/NL191844C/xx not_active IP Right Cessation
- 1980-02-14 DE DE19803005564 patent/DE3005564A1/de active Granted
- 1980-02-14 KR KR1019800000589A patent/KR830001905B1/ko active
- 1980-02-14 FR FR8003269A patent/FR2482104A1/fr active Granted
- 1980-02-14 FI FI800453A patent/FI75168C/fi not_active IP Right Cessation
- 1980-02-14 AU AU55561/80A patent/AU542084B2/en not_active Ceased
- 1980-02-14 SE SE8001177A patent/SE451724B/sv not_active IP Right Cessation
- 1980-02-14 HU HU80332A patent/HU182068B/hu unknown
- 1980-02-14 ZA ZA00800844A patent/ZA80844B/xx unknown
- 1980-02-14 YU YU395/80A patent/YU42325B/xx unknown
- 1980-02-14 DK DK063280A patent/DK159449C/da not_active IP Right Cessation
- 1980-02-14 US US06/121,531 patent/US4277601A/en not_active Expired - Lifetime
- 1980-02-14 AT AT0081380A patent/AT366051B/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
NL191844C (nl) | 1996-09-03 |
ZA80844B (en) | 1981-08-26 |
GB2043070A (en) | 1980-10-01 |
GB2043070B (en) | 1983-03-23 |
KR830001905B1 (ko) | 1983-09-19 |
FI800453A (fi) | 1980-08-16 |
NL191844B (nl) | 1996-05-01 |
CH646706A5 (de) | 1984-12-14 |
IT1144037B (it) | 1986-10-29 |
AU5556180A (en) | 1980-08-21 |
DK159449B (da) | 1990-10-15 |
ES488607A0 (es) | 1980-12-16 |
AU542084B2 (en) | 1985-02-07 |
FI75168C (fi) | 1988-05-09 |
FI75168B (fi) | 1988-01-29 |
YU39580A (en) | 1983-04-30 |
ATA81380A (de) | 1981-07-15 |
DK63280A (da) | 1980-08-16 |
JPH0240676B2 (ko) | 1990-09-12 |
SE8001177L (sv) | 1980-08-16 |
ES8101607A1 (es) | 1980-12-16 |
IT8047899A0 (it) | 1980-02-14 |
AT366051B (de) | 1982-03-10 |
DE3005564C2 (ko) | 1989-05-24 |
FR2482104B1 (ko) | 1983-11-18 |
NL8000925A (nl) | 1980-08-19 |
FR2482104A1 (fr) | 1981-11-13 |
SE451724B (sv) | 1987-10-26 |
JPS55111490A (en) | 1980-08-28 |
DE3005564A1 (de) | 1980-09-11 |
HU182068B (en) | 1983-12-28 |
DK159449C (da) | 1991-03-04 |
YU42325B (en) | 1988-08-31 |
US4277601A (en) | 1981-07-07 |
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