KR830006228A - 이미다졸 유도체의 제조방법 - Google Patents
이미다졸 유도체의 제조방법 Download PDFInfo
- Publication number
- KR830006228A KR830006228A KR1019810001901A KR810001901A KR830006228A KR 830006228 A KR830006228 A KR 830006228A KR 1019810001901 A KR1019810001901 A KR 1019810001901A KR 810001901 A KR810001901 A KR 810001901A KR 830006228 A KR830006228 A KR 830006228A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- imidazole derivative
- compound
- acid addition
- represent hydrogen
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/76—Unsaturated compounds containing keto groups
- C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (1)
- 일반식(Ⅱ)의 화합물을 일반식(Ⅲ)의 알콜의 알카리 금속염과 반응시키고 경우에 따라 수득된 라세메이트를 광학적 이성체로 분해시키고 또한 경우에 따라 수득된 구조식(I)의 화합물을 약제학적으로 허용되는 산부가염으로 변환시킴을 특징으로 하는 일반식(I)의 이미다졸 유도체 및 그의 약제학적으로 허용되는 산부가염의 제조방법.상기 구조식중A는 다음 구조식(a) 또는 (b)의 그룹을 나타내며(이때 R1및 R2는 각기 수소 또는 할로겐원자를 나타냄)R3및 R4는 각기 수소 또는 할로겐원자를 나타내고X는 염소 또는 보롬원자를 나타낸다.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB8018691 | 1980-06-06 | ||
GB8018691 | 1980-06-06 | ||
GB8106459 | 1981-03-02 | ||
GB8106459 | 1981-03-02 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR830006228A true KR830006228A (ko) | 1983-09-20 |
KR840002434B1 KR840002434B1 (ko) | 1984-12-27 |
Family
ID=26275759
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019810001901A KR840002434B1 (ko) | 1980-06-06 | 1981-05-29 | 이미다졸 유도체의 제조방법 |
Country Status (18)
Country | Link |
---|---|
US (1) | US4402968A (ko) |
EP (1) | EP0041673B1 (ko) |
KR (1) | KR840002434B1 (ko) |
AR (1) | AR231137A1 (ko) |
AU (1) | AU539737B2 (ko) |
CA (1) | CA1155853A (ko) |
DE (1) | DE3166569D1 (ko) |
DK (1) | DK161581A (ko) |
ES (1) | ES8203883A1 (ko) |
FI (1) | FI69075C (ko) |
GR (1) | GR75675B (ko) |
HU (1) | HU188098B (ko) |
IE (1) | IE52118B1 (ko) |
IL (1) | IL63007A (ko) |
MC (1) | MC1389A1 (ko) |
NO (1) | NO811934L (ko) |
NZ (1) | NZ197246A (ko) |
PT (1) | PT73150B (ko) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4517194A (en) * | 1982-06-25 | 1985-05-14 | Ciba-Geigy Corporation | Azolylmandelic acid derivatives and use thereof for controlling microorganisms |
US5135943A (en) * | 1984-02-02 | 1992-08-04 | Ferrer Internacional S.A. | 1H-imidazole derivative compounds and pharmaceutical compositions containing the same |
US5693338A (en) * | 1994-09-29 | 1997-12-02 | Emisphere Technologies, Inc. | Diketopiperazine-based delivery systems |
US6221367B1 (en) | 1992-06-15 | 2001-04-24 | Emisphere Technologies, Inc. | Active agent transport systems |
US5714167A (en) * | 1992-06-15 | 1998-02-03 | Emisphere Technologies, Inc. | Active agent transport systems |
US5578323A (en) | 1992-06-15 | 1996-11-26 | Emisphere Technologies, Inc. | Proteinoid carriers and methods for preparation and use thereof |
US6099856A (en) * | 1992-06-15 | 2000-08-08 | Emisphere Technologies, Inc. | Active agent transport systems |
US5643957A (en) * | 1993-04-22 | 1997-07-01 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
WO1997036480A1 (en) | 1996-03-29 | 1997-10-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6001347A (en) * | 1995-03-31 | 1999-12-14 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
BR9604880A (pt) * | 1995-03-31 | 1998-05-19 | Emisphere Tech Inc | Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica |
US6090958A (en) * | 1995-03-31 | 2000-07-18 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5965121A (en) * | 1995-03-31 | 1999-10-12 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5989539A (en) * | 1995-03-31 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5750147A (en) | 1995-06-07 | 1998-05-12 | Emisphere Technologies, Inc. | Method of solubilizing and encapsulating itraconazole |
DE19681560T1 (de) * | 1995-09-11 | 1998-08-20 | Emisphere Tech Inc | Verfahren zur Herstellung von omega-Aminoalkansäure-Derivaten aus Cycloalkanonen |
EP0904065A4 (en) | 1996-06-14 | 2000-06-14 | Emisphere Tech Inc | MICRO-ENCLOSED FRAGRANCES AND PRODUCTION METHOD |
US5990166A (en) * | 1997-02-07 | 1999-11-23 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6060513A (en) * | 1997-02-07 | 2000-05-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5879681A (en) * | 1997-02-07 | 1999-03-09 | Emisphere Technolgies Inc. | Compounds and compositions for delivering active agents |
US5939381A (en) * | 1997-02-07 | 1999-08-17 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5876710A (en) * | 1997-02-07 | 1999-03-02 | Emisphere Technologies Inc. | Compounds and compositions for delivering active agents |
US6358504B1 (en) | 1997-02-07 | 2002-03-19 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5804688A (en) * | 1997-02-07 | 1998-09-08 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US6313088B1 (en) | 1997-02-07 | 2001-11-06 | Emisphere Technologies, Inc. | 8-[(2-hydroxy-4-methoxy benzoyl) amino]-octanoic acid compositions for delivering active agents |
US5863944A (en) * | 1997-04-30 | 1999-01-26 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
US5962710A (en) * | 1997-05-09 | 1999-10-05 | Emisphere Technologies, Inc. | Method of preparing salicyloylamino acids |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1475271A (en) * | 1975-04-30 | 1977-06-01 | Pfizer Ltd | 1-aryl-2-1-imidazolyl-alkyl ethers and thioethers and their use as antifungal agents |
MX3866E (es) * | 1975-07-28 | 1981-08-26 | Syntex Inc | Metodo mejorado para preparar derivados de imidazoles n-alquil sustituidos |
US4045568A (en) * | 1975-07-28 | 1977-08-30 | Syntex (U.S.A.) Inc. | Derivatives of substituted N-alkyl imidazoles |
GB1511390A (en) * | 1975-12-04 | 1978-05-17 | Pfizer Ltd | Imidazolylalkyl sulphide antifungal agents |
IT1096361B (it) * | 1978-05-18 | 1985-08-26 | Recordati Chem Pharm | Dibenzileteri sostituiti terapeuticamente attivi |
US4221803A (en) * | 1979-05-09 | 1980-09-09 | Recordati, S.A. | Substituted dibenzyl ethers and pharmaceutical compositions containing said ethers for the treatment of infections |
US4248881A (en) * | 1979-12-20 | 1981-02-03 | E. R. Squibb & Sons, Inc. | Imidazolylethoxymethyl derivatives of pyrazole |
-
1981
- 1981-04-03 CA CA000374678A patent/CA1155853A/en not_active Expired
- 1981-04-09 DK DK161581A patent/DK161581A/da not_active IP Right Cessation
- 1981-05-15 AR AR285348A patent/AR231137A1/es active
- 1981-05-28 FI FI811646A patent/FI69075C/fi not_active IP Right Cessation
- 1981-05-29 KR KR1019810001901A patent/KR840002434B1/ko active IP Right Grant
- 1981-05-29 NZ NZ197246A patent/NZ197246A/en unknown
- 1981-05-29 US US06/268,304 patent/US4402968A/en not_active Expired - Fee Related
- 1981-06-01 IL IL63007A patent/IL63007A/xx unknown
- 1981-06-01 DE DE8181104168T patent/DE3166569D1/de not_active Expired
- 1981-06-01 AU AU71213/81A patent/AU539737B2/en not_active Ceased
- 1981-06-01 EP EP81104168A patent/EP0041673B1/de not_active Expired
- 1981-06-03 HU HU811645A patent/HU188098B/hu unknown
- 1981-06-04 MC MC811519A patent/MC1389A1/xx unknown
- 1981-06-04 GR GR65150A patent/GR75675B/el unknown
- 1981-06-05 PT PT73150A patent/PT73150B/pt unknown
- 1981-06-05 ES ES502792A patent/ES8203883A1/es not_active Expired
- 1981-06-05 IE IE1250/81A patent/IE52118B1/en unknown
- 1981-06-05 NO NO811934A patent/NO811934L/no unknown
Also Published As
Publication number | Publication date |
---|---|
FI69075B (fi) | 1985-08-30 |
GR75675B (ko) | 1984-08-02 |
FI811646L (fi) | 1981-12-07 |
DK161581A (da) | 1981-12-07 |
ES502792A0 (es) | 1982-05-01 |
IL63007A (en) | 1985-04-30 |
MC1389A1 (fr) | 1982-04-27 |
KR840002434B1 (ko) | 1984-12-27 |
ES8203883A1 (es) | 1982-05-01 |
PT73150B (en) | 1983-05-11 |
EP0041673B1 (de) | 1984-10-10 |
AR231137A1 (es) | 1984-09-28 |
IE811250L (en) | 1981-12-06 |
AU7121381A (en) | 1981-12-10 |
NO811934L (no) | 1981-12-07 |
EP0041673A1 (de) | 1981-12-16 |
IE52118B1 (en) | 1987-06-24 |
FI69075C (fi) | 1985-12-10 |
US4402968A (en) | 1983-09-06 |
IL63007A0 (en) | 1981-09-13 |
PT73150A (en) | 1981-07-01 |
DE3166569D1 (en) | 1984-11-15 |
HU188098B (en) | 1986-03-28 |
CA1155853A (en) | 1983-10-25 |
NZ197246A (en) | 1984-09-28 |
AU539737B2 (en) | 1984-10-11 |
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