KR840001122A - 플루오르화 디아미노-헵텐 및-헵틴 유도체의 제조방법 - Google Patents

플루오르화 디아미노-헵텐 및-헵틴 유도체의 제조방법 Download PDF

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Publication number
KR840001122A
KR840001122A KR1019820003711A KR820003711A KR840001122A KR 840001122 A KR840001122 A KR 840001122A KR 1019820003711 A KR1019820003711 A KR 1019820003711A KR 820003711 A KR820003711 A KR 820003711A KR 840001122 A KR840001122 A KR 840001122A
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KR
South Korea
Prior art keywords
diamino
heptin
heptene
derivatives
general formula
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KR1019820003711A
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English (en)
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KR890000795B1 (ko
Inventor
당젱 샤를르 (외 1)
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삐에르 줄리앙
메렐토라우드 엘캄파니
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Publication of KR840001122A publication Critical patent/KR840001122A/ko
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Publication of KR890000795B1 publication Critical patent/KR890000795B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/02—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C211/09—Diamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/15—Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

플루오르화 디아미노-헵텐 및-헵틴 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 다음 일반식(Ⅱ)의 프로파길아민의 아미노-및 아세틸렌-보호유도체를 다음일반식(Ⅲ)의 할라이드의 아미노-보호유도체와 알킬화반응시킨 후, Y가 CH2=CH-인 일반식(I)화합물을 얻고자 할 경우에는 상응하는 일반식(I)의 아세틸렌성 화합물의 아미노-보호유도체를 환원시키고, 보호기를 제거하여 다음 일반식(I)의 플루오르화디아미노-헵텐 또는 -헵틴유도체 및 이의 약학적으로 무독한 염을 제조하는 방법.
    상기 일반식에서, Y는 CH2=CH-또는 CHC-이고 P는 1 또는 2이고 X는 브롬, 염소 또는 요드이다.
  2. 제1항에 있어서, P가 1인 방법.
  3. 제1항에 있어서, P가 2인 방법.
  4. 제2항에 있어서, 생성물이 1-플루오로-2,5-디아미노-6-헵틴 또는 이의 약학적으로 무독한 염인 방법.
  5. 제3항에 있어서, 생성물이 1,1-디플루오로-2,5-디아미노-6-헵틴 또는 이의 약학적으로 무독한 염인 방법.
  6. 제2항에 있어서, 생성물이 1-플루오로-2,5-디아미노-6-헵텐 또는 이의 약학적으로 무독한 염인 방법.
  7. 제3항에 있어서, 성생물이 1,1-디플루오로-2,5-디아미노-6-헵텐 또는 이의 약학적으로 무독한 염인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8203711A 1981-08-19 1982-08-18 플루오르화 디아미노-헵텐 및 -헵틴 유도체 및 이의 제조방법 KR890000795B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8125357 1981-08-19
GB8125357 1981-08-19

Publications (2)

Publication Number Publication Date
KR840001122A true KR840001122A (ko) 1984-03-28
KR890000795B1 KR890000795B1 (ko) 1989-04-07

Family

ID=10524041

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8203711A KR890000795B1 (ko) 1981-08-19 1982-08-18 플루오르화 디아미노-헵텐 및 -헵틴 유도체 및 이의 제조방법

Country Status (17)

Country Link
EP (1) EP0072760B1 (ko)
JP (1) JPS5841844A (ko)
KR (1) KR890000795B1 (ko)
AT (1) ATE29487T1 (ko)
AU (1) AU548094B2 (ko)
CA (1) CA1202985A (ko)
DE (1) DE3277199D1 (ko)
DK (1) DK161021C (ko)
ES (1) ES8308832A1 (ko)
GB (1) GB2104073B (ko)
GR (1) GR77601B (ko)
IE (1) IE54304B1 (ko)
IL (1) IL66569A0 (ko)
NO (1) NO153005C (ko)
NZ (1) NZ201588A (ko)
PH (1) PH18003A (ko)
ZA (1) ZA825898B (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4421768A (en) 1982-08-11 1983-12-20 Merrell Toraude Et Compagnie Fluorinated diamino-heptene and-heptyne derivatives
JPS60117791U (ja) * 1984-01-18 1985-08-09 有限会社　名倉製作所 カ−テン吊具
US4707498A (en) * 1986-01-14 1987-11-17 Merrell Dow Pharmaceuticals Inc. Fluorinated diaminoalkyne derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139563A (en) * 1977-07-01 1979-02-13 Merrell Toraude Et Compagnie α-ACETYLENIC DERIVATIVES OF AMINES
US4173971A (en) * 1977-08-29 1979-11-13 Karz Allen E Continuous electrocardiogram monitoring method and system for cardiac patients
US4134918A (en) * 1977-09-06 1979-01-16 Merrell Toraude Et Compagnie Alpha-halomethyl derivatives of amines

Also Published As

Publication number Publication date
NO153005B (no) 1985-09-23
ES515094A0 (es) 1983-10-16
IE821944L (en) 1983-02-19
DK161021B (da) 1991-05-21
NO153005C (no) 1986-01-02
GR77601B (ko) 1984-09-25
GB2104073B (en) 1985-02-06
GB2104073A (en) 1983-03-02
AU548094B2 (en) 1985-11-21
CA1202985A (en) 1986-04-08
IE54304B1 (en) 1989-08-16
NO822809L (no) 1983-02-21
ATE29487T1 (de) 1987-09-15
DK161021C (da) 1991-10-28
PH18003A (en) 1985-02-28
NZ201588A (en) 1985-02-28
EP0072760A1 (en) 1983-02-23
EP0072760B1 (en) 1987-09-09
JPH0244298B2 (ko) 1990-10-03
AU8724382A (en) 1983-02-24
JPS5841844A (ja) 1983-03-11
KR890000795B1 (ko) 1989-04-07
DE3277199D1 (de) 1987-10-15
ZA825898B (en) 1983-07-27
ES8308832A1 (es) 1983-10-16
DK370782A (da) 1983-02-20
IL66569A0 (en) 1982-12-31

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