KR830010112A - 9-(1,3-디하이드록시-2-프로폭시메틸)-구아닌의 제조방법 - Google Patents

9-(1,3-디하이드록시-2-프로폭시메틸)-구아닌의 제조방법 Download PDF

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Publication number
KR830010112A
KR830010112A KR1019820002204A KR820002204A KR830010112A KR 830010112 A KR830010112 A KR 830010112A KR 1019820002204 A KR1019820002204 A KR 1019820002204A KR 820002204 A KR820002204 A KR 820002204A KR 830010112 A KR830010112 A KR 830010112A
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South Korea
Prior art keywords
compound
formula
propoxymethyl
dihydroxy
guanine
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KR1019820002204A
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KR890004663B1 (ko
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피이. 페어하이든 줄리안
시이. 마틴 존
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원본미기재
신텍스 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

내용 없음

Description

9-(1,3-디하이드록시-2-프로폭시메틸)-구아닌의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 다음 일반식(Ⅸ) 화합물을 탈아실화하거나; 다음 일반식(Ⅹ)의 화합물을 탈아르알킬화하거나; 다음 일반식(Ⅷ) 화합물을 탈아르알킬화 및 탈아실화하거나; 9-(1,3-디하이드록시-2-프로폭시메틸) 구아닌을 그의 약학적으로 무독한 염으로 전환시키거나, 9-(1,3-디하이드록시-2-프로폭시메틸) 구아닌 염을 유리화합물로 전환시키거나, 9-(1,3-디하이드록시-2-프로폭시메틸) 구아닌염을 그의 약학적으로 무독한 염으로 전환시키는 것을 포함하여, 다음 구조식(Ⅰ)의 9-(1,3-디하이드록시-2-프로폭시메틸)-구아닌 및 그의 약학적으로 무독한 염을 제조하는 방법.
    상기식에서
    R은 아실그룹인로 정의되는데, 여기에서 R″는 탄소수 1 내지 10의 직쇄 또는 측쇄탄화수소이며
    R′는 하나 또는 두개의 알콕시그룹(여기서 알킬은 전술한 바와 같으며, 메톡시가 바람직하다) 또는 저급알킬그룹(여기서 알킬은 탄소수 1 내지 4의 직쇄 또는 측쇄탄화수소이며, 메틸이 바람직하다)으로 임의 치환된 벤질 같은 보호그룹으로 정의된다.
  2. 다음 일반식(Ⅷ)의 화합물을 탈아르알킬화하거나; 일반식(Ⅷ)의 화합물을 루이스산과 반응시키거나; 일반식(Ⅷ)의 화합물을 아세트산과 반응시키거나; 일반식(Ⅸ)의 화합물을 그염으로 전환시키거나; 그염을 상응하는 일반식(Ⅸ)의 유리화합물로 전환시키는 것을 포함하여 다음 일반식(Ⅸ)의 화합물 및 그 염을 제조하는 방법.
    상기식에서,
    R은 아실그룹인이며, 여기에서 R″는 탄소수 1 내지 10의 직쇄 또는 측쇄 탄화수소이며, R′는 하나 또는 두개의 알콕시그룹 또는 저급알킬(여기에서, 알킬은 탄소수 1 내지 4의 직쇄 또는 측쇄 탄화수소이다.)로 임의 치환된 벤질같은 보호그룹이다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR8202204A 1981-05-21 1982-05-20 9-(1,3-디하이드록시-2-프로폭시메틸)-구아닌 및 그의 제조방법 KR890004663B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US267210 1981-05-21
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (2)

Publication Number Publication Date
KR830010112A true KR830010112A (ko) 1983-12-26
KR890004663B1 KR890004663B1 (ko) 1989-11-24

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KR8202204A KR890004663B1 (ko) 1981-05-21 1982-05-20 9-(1,3-디하이드록시-2-프로폭시메틸)-구아닌 및 그의 제조방법

Country Status (33)

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US (1) US4355032B2 (ko)
EP (1) EP0066208B1 (ko)
JP (2) JPS57203086A (ko)
KR (1) KR890004663B1 (ko)
AR (1) AR244227A1 (ko)
AT (1) ATE15899T1 (ko)
AU (1) AU572086B2 (ko)
BR (1) BR8202931A (ko)
CA (3) CA1305140C (ko)
CS (4) CS235043B2 (ko)
DD (2) DD213218A5 (ko)
DE (1) DE3266644D1 (ko)
DK (2) DK150304C (ko)
ES (7) ES8404355A1 (ko)
FI (1) FI73682C (ko)
GR (1) GR76459B (ko)
HK (1) HK67088A (ko)
HU (2) HU188000B (ko)
IE (1) IE53731B1 (ko)
IL (1) IL65836A (ko)
IN (1) IN156469B (ko)
LU (1) LU88334I2 (ko)
MY (1) MY8700793A (ko)
NL (2) NL930022I1 (ko)
NO (2) NO161740C (ko)
NZ (1) NZ200691A (ko)
PH (1) PH17975A (ko)
PL (4) PL136579B1 (ko)
PT (1) PT74934B (ko)
RO (2) RO84860B (ko)
SG (1) SG81687G (ko)
SU (1) SU1176841A3 (ko)
ZA (1) ZA823532B (ko)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US5157120A (en) * 1980-09-16 1992-10-20 Syntex (U.S.A.) Inc. Guanine derivatives
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
DK154561C (da) * 1981-08-11 1989-04-24 Wellcome Found Analogifremgangsmaade til fremstilling af antivirale 9-substituerede 2-aminopurinderivater eller fysiologisk acceptable salte eller estere deraf
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
IE830186L (en) * 1982-02-01 1983-08-01 Syntex Inc Purines
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
GB8320308D0 (en) * 1983-07-28 1983-09-01 Wellcome Found Antiviral combinations
EP0138683A3 (en) * 1983-09-30 1988-01-20 Merck & Co. Inc. Purine derivatives, their application in anti-viral compositions
US4897479A (en) * 1983-09-30 1990-01-30 Merck & Co., Inc. Arylsulfonyloxy purine intermediates
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
EP0190123A1 (en) * 1984-07-20 1986-08-13 GAUNTT, Charles, O. Immunoregulatory and anti-viral compound
NO172183C (no) * 1984-12-12 1993-06-16 Syntex Inc Fremgangsmaate for fremstilling av derivater av 9-(1,3-dikydroksy-2-propoksymetyl)-guanin
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
JP2788084B2 (ja) * 1988-12-19 1998-08-20 ザ ウエルカム フアウンデーシヨン リミテツド 抗ウイルス化合物
US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
NZ268479A (en) * 1993-06-23 1997-07-27 Merrell Pharma Inc Carbo-acyclic nucleoside analogues and antiviral and antineoplastic compositions
US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5856481A (en) * 1994-07-28 1999-01-05 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
US5840763A (en) * 1994-12-12 1998-11-24 Smithkline Beecham Plc Treatment of a latent infection of herpes viruses
DE19536164A1 (de) * 1995-09-28 1997-04-03 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir)
US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
US5756736A (en) * 1996-01-26 1998-05-26 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US5840890A (en) * 1996-01-26 1998-11-24 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative
US6040446A (en) 1996-01-26 2000-03-21 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
IN179493B (ko) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
EP0806425B1 (en) * 1996-04-09 2001-08-29 Lupin Laboratories Limited An improved regiospecific process for synthesis of acyclic nucleosides
US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
AU2003274410A1 (en) * 2002-10-22 2004-05-13 Ranbaxy Laboratories Limited Pharmaceutical compositions of ganciclovir
US20060142574A1 (en) * 2002-10-31 2006-06-29 Babu Jayachandra S Process for the preparation of ganciclovir
US7078524B2 (en) * 2002-11-22 2006-07-18 Ranbaxy Laboratories Limited Process for the synthesis of ganciclovir
NZ540728A (en) * 2003-01-14 2008-08-29 Gilead Sciences Inc Compositions and methods for combination antiviral therapy
ITMI20031202A1 (it) * 2003-06-13 2004-12-14 Lyogen Ltd Forma di cristallina del ganciclovir
RU2006109365A (ru) * 2003-08-28 2007-10-10 Рэнбакси Лабораториз Лимитед (In) Аморфный гидрохлорид валганцикловира
JP4746866B2 (ja) * 2004-11-19 2011-08-10 Ｔｃｍ株式会社 キャリッジ用ガタ抑制装置
TWI375560B (en) * 2005-06-13 2012-11-01 Gilead Sciences Inc Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same
TWI471145B (zh) 2005-06-13 2015-02-01 Bristol Myers Squibb & Gilead Sciences Llc 單一式藥學劑量型
EP2085397A1 (en) 2008-01-21 2009-08-05 Esteve Quimica, S.A. Crystalline form of abacavir
WO2009120358A1 (en) * 2008-03-27 2009-10-01 Nektar Therapeutics Oligomer-nitrogenous base conjugates
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
PA8855601A1 (es) 2008-12-23 2010-07-27 Forformidatos de nucleósidos
CA2748034A1 (en) * 2008-12-23 2010-07-01 Pharmasset, Inc. Purified 2'-deoxy'2'-fluoro-2'-c-methyl-nucleoside-phosphoramidate prodrugs for the treatment of viral infections
CN102325783A (zh) 2008-12-23 2012-01-18 法莫赛特股份有限公司 嘌呤核苷的合成
CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
SG184323A1 (en) 2010-03-31 2012-11-29 Gilead Pharmasett Llc Stereoselective synthesis of phosphorus containing actives
US9550803B2 (en) * 2011-05-06 2017-01-24 University Of Southern California Method to improve antiviral activity of nucleotide analogue drugs
CN102627643B (zh) * 2012-04-10 2014-01-08 常州康丽制药有限公司 更昔洛韦的精制方法
JP2015536940A (ja) 2012-10-29 2015-12-24 シプラ・リミテッド 抗ウイルス性ホスホネート類似体及びその製造方法
US9505775B2 (en) * 2012-11-03 2016-11-29 Boehringer Ingelheim International Gmbh Inhibitors of cytomegalovirus
CN103059023B (zh) * 2012-12-31 2015-09-30 浙江车头制药股份有限公司 一种制备更昔洛韦晶型ⅱ的方法
US9486530B1 (en) 2013-08-30 2016-11-08 Exela Pharma Sciences, LLC Ganciclovir compositions and related methods
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus
CN113476413B (zh) * 2021-08-09 2022-06-28 海南海灵化学制药有限公司 一种注射用更昔洛韦钠冻干粉的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
DK154561C (da) * 1981-08-11 1989-04-24 Wellcome Found Analogifremgangsmaade til fremstilling af antivirale 9-substituerede 2-aminopurinderivater eller fysiologisk acceptable salte eller estere deraf

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DD203052A5 (de) 1983-10-12
DE3266644D1 (en) 1985-11-07
DK149001B (da) 1985-12-16
ZA823532B (en) 1983-03-30
AU572086B2 (en) 1988-05-05
NO1994005I1 (no) 1994-07-29
PL236521A1 (en) 1984-01-02
GR76459B (ko) 1984-08-10
CA1305139C (en) 1992-07-14
ES512414A0 (es) 1984-05-01
IL65836A (en) 1991-04-15
PL136332B1 (en) 1986-02-28
KR890004663B1 (ko) 1989-11-24
IL65836A0 (en) 1982-08-31
NO161740C (no) 1989-09-20
RO87387A (ro) 1985-08-31
HK67088A (en) 1988-09-02
MY8700793A (en) 1987-12-31
AR244227A1 (es) 1993-10-29
ES8606869A1 (es) 1986-05-16
LU88334I2 (fr) 1994-09-09
PT74934A (en) 1982-06-01
CS235043B2 (en) 1985-04-16
FI73682C (fi) 1987-11-09
AU8389282A (en) 1982-11-25
IE821210L (en) 1982-11-21
IN156469B (ko) 1985-08-10
ES533821A0 (es) 1985-06-16
CS235042B2 (en) 1985-04-16
DK504183A (da) 1983-11-03
DK149001C (da) 1988-11-28
PT74934B (en) 1984-05-08
CS235044B2 (en) 1985-04-16
JPS57203086A (en) 1982-12-13
HU186514B (en) 1985-08-28
ES8701496A1 (es) 1987-01-01
PL136579B1 (en) 1986-02-28
RO84860A (ro) 1984-09-29
ES524900A0 (es) 1985-11-16
DK504183D0 (da) 1983-11-03
US4355032B2 (en) 1990-10-30
PL246770A1 (en) 1984-08-27
IE53731B1 (en) 1989-02-01
BR8202931A (pt) 1983-05-03
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
HU188000B (en) 1986-03-28
PL136004B1 (en) 1986-01-31
US4355032A (en) 1982-10-19
ES8601204A1 (es) 1985-11-16
ES529384A0 (es) 1987-01-01
ES8507549A1 (es) 1985-09-16
CS235018B2 (en) 1985-04-16
PL136637B1 (en) 1986-03-31
CA1305140C (en) 1992-07-14
PL242100A1 (en) 1984-04-24
ATE15899T1 (de) 1985-10-15
EP0066208A1 (en) 1982-12-08
NZ200691A (en) 1986-11-12
ES520849A0 (es) 1984-11-01
DD213218A5 (de) 1984-09-05
PL242101A1 (en) 1984-07-16
JPH046195B2 (ko) 1992-02-05
ES529383A0 (es) 1986-05-16
ES8505681A1 (es) 1985-06-16
RO84860B (ro) 1984-10-30
SG81687G (en) 1989-07-07
DK150304C (da) 1988-01-04
NL930022I1 (nl) 1993-05-03
CA1305141C (en) 1992-07-14
DK227782A (da) 1982-11-22
JPH04217983A (ja) 1992-08-07
NL930139I2 (nl) 1997-07-01
JPH0529399B2 (ko) 1993-04-30
FI821794A0 (fi) 1982-05-20
PH17975A (en) 1985-02-22
NL930139I1 (nl) 1993-11-01
US4355032B1 (ko) 1983-06-14
FI73682B (fi) 1987-07-31
ES8404355A1 (es) 1984-05-01
RO87387B (ro) 1985-08-31
ES524899A0 (es) 1985-09-16
NO161740B (no) 1989-06-12
ES8500276A1 (es) 1984-11-01
NO821676L (no) 1982-11-22
SU1176841A3 (ru) 1985-08-30

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