RO87387B - Procedeu pentru prepararea unor n2-acil-9-(1,3-dixidroxi-2-propoximetil)-guanine - Google Patents

Procedeu pentru prepararea unor n2-acil-9-(1,3-dixidroxi-2-propoximetil)-guanine

Info

Publication number
RO87387B
RO87387B RO112367A RO11236782A RO87387B RO 87387 B RO87387 B RO 87387B RO 112367 A RO112367 A RO 112367A RO 11236782 A RO11236782 A RO 11236782A RO 87387 B RO87387 B RO 87387B
Authority
RO
Romania
Prior art keywords
acyl
carbon atoms
propoxymethyl
dihydroxy
degrees
Prior art date
Application number
RO112367A
Other languages
English (en)
Other versions
RO87387A (ro
Inventor
P. Julien Verheyden
C. John Martin
Original Assignee
Syntex Usa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RO87387(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Usa Inc filed Critical Syntex Usa Inc
Publication of RO87387B publication Critical patent/RO87387B/ro
Publication of RO87387A publication Critical patent/RO87387A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

Inventia se refera la un procedeu pentru prepararea unor N la puterea 2-acil-9-(1,3-dihidroxi-2-propoximetil)-guanine cu formula generala I: (vezi formula) în care radicalul R reprezinta o grupare acil, R1CO, în care R1 reprezinta o catena hidrocarbonata normala sau ramificata care contine un numar de la unu pîna la zece atomi de carbon, conform caruia, compusii cu formula generala II: (vezi formula) în care radicalul R este definit ca mai sus si radicalul R2 reprezinta o grupare de protectie si anume gruparea benzil substituita în mod facultativ cu una sau doua grupari alcoxi, cu grupari alchil inferior avînd catena hidrocarbonata normala sau ramificata continînd un numar de la unu pîna la patru atomi de carbon se dezalchileaza prin hidrogenare catalitica pe catalizator de paladiu, platina, rodiu sau nichel, pe suport de carbune, într-o solutie apoasa a unui alcool alifatic cu 1 la 4 atomi de carbon, la temperaturi între 0 degree si 50 degree C si presiuni între 1 si 15 at.
RO82112367A 1981-05-21 1982-05-20 Procedeu pentru prepararea unor n2-acil(1,3-dixidroxi-2-propoximetil)guanine RO87387A (ro)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (2)

Publication Number Publication Date
RO87387B true RO87387B (ro) 1985-08-31
RO87387A RO87387A (ro) 1985-08-31

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
RO107610A RO84860B (ro) 1981-05-21 1982-05-20 Procedeu pentru prepararea 9-(1, 3-dihidroxi-2-propeximetil)-guaninei
RO82112367A RO87387A (ro) 1981-05-21 1982-05-20 Procedeu pentru prepararea unor n2-acil(1,3-dixidroxi-2-propoximetil)guanine

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO107610A RO84860B (ro) 1981-05-21 1982-05-20 Procedeu pentru prepararea 9-(1, 3-dihidroxi-2-propeximetil)-guaninei

Country Status (33)

Country Link
US (1) US4355032B2 (ro)
EP (1) EP0066208B1 (ro)
JP (2) JPS57203086A (ro)
KR (1) KR890004663B1 (ro)
AR (1) AR244227A1 (ro)
AT (1) ATE15899T1 (ro)
AU (1) AU572086B2 (ro)
BR (1) BR8202931A (ro)
CA (3) CA1305141C (ro)
CS (4) CS235043B2 (ro)
DD (2) DD213218A5 (ro)
DE (1) DE3266644D1 (ro)
DK (2) DK150304C (ro)
ES (7) ES512414A0 (ro)
FI (1) FI73682C (ro)
GR (1) GR76459B (ro)
HK (1) HK67088A (ro)
HU (2) HU186514B (ro)
IE (1) IE53731B1 (ro)
IL (1) IL65836A (ro)
IN (1) IN156469B (ro)
LU (1) LU88334I2 (ro)
MY (1) MY8700793A (ro)
NL (2) NL930022I1 (ro)
NO (2) NO161740C (ro)
NZ (1) NZ200691A (ro)
PH (1) PH17975A (ro)
PL (4) PL136579B1 (ro)
PT (1) PT74934B (ro)
RO (2) RO84860B (ro)
SG (1) SG81687G (ro)
SU (1) SU1176841A3 (ro)
ZA (1) ZA823532B (ro)

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Also Published As

Publication number Publication date
DK149001B (da) 1985-12-16
ZA823532B (en) 1983-03-30
US4355032B1 (ro) 1983-06-14
SU1176841A3 (ru) 1985-08-30
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
ES8505681A1 (es) 1985-06-16
NL930139I2 (nl) 1997-07-01
RO84860B (ro) 1984-10-30
NL930139I1 (nl) 1993-11-01
PL136637B1 (en) 1986-03-31
ES8701496A1 (es) 1987-01-01
ES8507549A1 (es) 1985-09-16
ES524900A0 (es) 1985-11-16
ES8404355A1 (es) 1984-05-01
LU88334I2 (fr) 1994-09-09
ES8606869A1 (es) 1986-05-16
DD203052A5 (de) 1983-10-12
ES512414A0 (es) 1984-05-01
PH17975A (en) 1985-02-22
CS235044B2 (en) 1985-04-16
ES529383A0 (es) 1986-05-16
AU8389282A (en) 1982-11-25
JPH046195B2 (ro) 1992-02-05
DK504183A (da) 1983-11-03
IE821210L (en) 1982-11-21
FI73682B (fi) 1987-07-31
KR890004663B1 (ko) 1989-11-24
NZ200691A (en) 1986-11-12
US4355032A (en) 1982-10-19
DK150304C (da) 1988-01-04
HK67088A (en) 1988-09-02
NL930022I1 (nl) 1993-05-03
GR76459B (ro) 1984-08-10
PL246770A1 (en) 1984-08-27
ES8601204A1 (es) 1985-11-16
ES533821A0 (es) 1985-06-16
PL136332B1 (en) 1986-02-28
NO161740C (no) 1989-09-20
RO87387A (ro) 1985-08-31
MY8700793A (en) 1987-12-31
PL242100A1 (en) 1984-04-24
AR244227A1 (es) 1993-10-29
PT74934B (en) 1984-05-08
CS235018B2 (en) 1985-04-16
BR8202931A (pt) 1983-05-03
PL236521A1 (en) 1984-01-02
ATE15899T1 (de) 1985-10-15
CS235042B2 (en) 1985-04-16
JPH0529399B2 (ro) 1993-04-30
DD213218A5 (de) 1984-09-05
IN156469B (ro) 1985-08-10
RO84860A (ro) 1984-09-29
DK504183D0 (da) 1983-11-03
SG81687G (en) 1989-07-07
HU188000B (en) 1986-03-28
IE53731B1 (en) 1989-02-01
ES8500276A1 (es) 1984-11-01
NO1994005I1 (no) 1994-07-29
CA1305139C (en) 1992-07-14
EP0066208A1 (en) 1982-12-08
DK149001C (da) 1988-11-28
FI821794A0 (fi) 1982-05-20
PT74934A (en) 1982-06-01
KR830010112A (ko) 1983-12-26
ES520849A0 (es) 1984-11-01
US4355032B2 (en) 1990-10-30
IL65836A (en) 1991-04-15
JPS57203086A (en) 1982-12-13
HU186514B (en) 1985-08-28
ES524899A0 (es) 1985-09-16
PL136004B1 (en) 1986-01-31
CA1305140C (en) 1992-07-14
FI73682C (fi) 1987-11-09
DK227782A (da) 1982-11-22
IL65836A0 (en) 1982-08-31
PL242101A1 (en) 1984-07-16
JPH04217983A (ja) 1992-08-07
CS235043B2 (en) 1985-04-16
NO821676L (no) 1982-11-22
DE3266644D1 (en) 1985-11-07
CA1305141C (en) 1992-07-14
NO161740B (no) 1989-06-12
PL136579B1 (en) 1986-02-28
ES529384A0 (es) 1987-01-01
AU572086B2 (en) 1988-05-05

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