RO87387B - Procedeu pentru prepararea unor n2-acil-9-(1,3-dixidroxi-2-propoximetil)-guanine - Google Patents
Procedeu pentru prepararea unor n2-acil-9-(1,3-dixidroxi-2-propoximetil)-guanineInfo
- Publication number
- RO87387B RO87387B RO112367A RO11236782A RO87387B RO 87387 B RO87387 B RO 87387B RO 112367 A RO112367 A RO 112367A RO 11236782 A RO11236782 A RO 11236782A RO 87387 B RO87387 B RO 87387B
- Authority
- RO
- Romania
- Prior art keywords
- acyl
- carbon atoms
- propoxymethyl
- dihydroxy
- degrees
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor N la puterea 2-acil-9-(1,3-dihidroxi-2-propoximetil)-guanine cu formula generala I: (vezi formula) în care radicalul R reprezinta o grupare acil, R1CO, în care R1 reprezinta o catena hidrocarbonata normala sau ramificata care contine un numar de la unu pîna la zece atomi de carbon, conform caruia, compusii cu formula generala II: (vezi formula) în care radicalul R este definit ca mai sus si radicalul R2 reprezinta o grupare de protectie si anume gruparea benzil substituita în mod facultativ cu una sau doua grupari alcoxi, cu grupari alchil inferior avînd catena hidrocarbonata normala sau ramificata continînd un numar de la unu pîna la patru atomi de carbon se dezalchileaza prin hidrogenare catalitica pe catalizator de paladiu, platina, rodiu sau nichel, pe suport de carbune, într-o solutie apoasa a unui alcool alifatic cu 1 la 4 atomi de carbon, la temperaturi între 0 degree si 50 degree C si presiuni între 1 si 15 at.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06267210 US4355032B2 (en) | 1981-05-21 | 1981-05-21 | 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent |
Publications (2)
Publication Number | Publication Date |
---|---|
RO87387B true RO87387B (ro) | 1985-08-31 |
RO87387A RO87387A (ro) | 1985-08-31 |
Family
ID=23017790
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO82112367A RO87387A (ro) | 1981-05-21 | 1982-05-20 | Procedeu pentru prepararea unor n2-acil(1,3-dixidroxi-2-propoximetil)guanine |
RO107610A RO84860B (ro) | 1981-05-21 | 1982-05-20 | Procedeu pentru prepararea 9-(1, 3-dihidroxi-2-propeximetil)-guaninei |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO107610A RO84860B (ro) | 1981-05-21 | 1982-05-20 | Procedeu pentru prepararea 9-(1, 3-dihidroxi-2-propeximetil)-guaninei |
Country Status (33)
Country | Link |
---|---|
US (1) | US4355032B2 (ro) |
EP (1) | EP0066208B1 (ro) |
JP (2) | JPS57203086A (ro) |
KR (1) | KR890004663B1 (ro) |
AR (1) | AR244227A1 (ro) |
AT (1) | ATE15899T1 (ro) |
AU (1) | AU572086B2 (ro) |
BR (1) | BR8202931A (ro) |
CA (3) | CA1305141C (ro) |
CS (4) | CS235043B2 (ro) |
DD (2) | DD203052A5 (ro) |
DE (1) | DE3266644D1 (ro) |
DK (2) | DK150304C (ro) |
ES (7) | ES512414A0 (ro) |
FI (1) | FI73682C (ro) |
GR (1) | GR76459B (ro) |
HK (1) | HK67088A (ro) |
HU (2) | HU186514B (ro) |
IE (1) | IE53731B1 (ro) |
IL (1) | IL65836A (ro) |
IN (1) | IN156469B (ro) |
LU (1) | LU88334I2 (ro) |
MY (1) | MY8700793A (ro) |
NL (2) | NL930022I1 (ro) |
NO (2) | NO161740C (ro) |
NZ (1) | NZ200691A (ro) |
PH (1) | PH17975A (ro) |
PL (4) | PL136004B1 (ro) |
PT (1) | PT74934B (ro) |
RO (2) | RO87387A (ro) |
SG (1) | SG81687G (ro) |
SU (1) | SU1176841A3 (ro) |
ZA (1) | ZA823532B (ro) |
Families Citing this family (73)
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US4347360A (en) * | 1980-09-16 | 1982-08-31 | Ens Bio Logicals Inc. | Ring open nucleoside analogues |
US4508898A (en) * | 1980-09-16 | 1985-04-02 | Ogilvie Kelvin K | Antiviral triazine compounds |
US5157120A (en) * | 1980-09-16 | 1992-10-20 | Syntex (U.S.A.) Inc. | Guanine derivatives |
US4423050A (en) * | 1981-05-21 | 1983-12-27 | Syntex (U.S.A.) Inc. | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent |
US4507305A (en) * | 1981-05-21 | 1985-03-26 | Syntex (U.S.A.) Inc. | 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent |
MC1475A1 (fr) * | 1981-08-11 | 1983-06-17 | Wellcome Found | Procede de preparation de derives de la purine a action anti-virale |
NZ201662A (en) * | 1981-08-26 | 1986-07-11 | Merck & Co Inc | 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation |
US5250535A (en) * | 1982-02-01 | 1993-10-05 | Syntex Inc. | Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent |
JPS58135885A (ja) * | 1982-02-01 | 1983-08-12 | シンテツクス(ユ−・エス・エイ)インコ−ポレイテツド | 置換されたプリン、その製造方法およびそれからなる抗ウイルス剤 |
US4902678A (en) * | 1982-02-12 | 1990-02-20 | Syntex (U.S.A.) Inc. | Anti-viral compositions |
US4609662A (en) * | 1982-10-14 | 1986-09-02 | Burroughs Wellcome Co. | Method for using purine derivatives |
US4462986A (en) * | 1982-11-04 | 1984-07-31 | Ens Bio Logicals, Inc. | Synergistic anti-herpes compositions |
US4814335A (en) * | 1982-12-30 | 1989-03-21 | Biomeasure, Incorporated | Antiviral compounds |
US4461757A (en) * | 1983-02-23 | 1984-07-24 | Ens Bio Logicals Inc. | Dimethylaminomethylenated anti-herpes compounds |
US5047533A (en) * | 1983-05-24 | 1991-09-10 | Sri International | Acyclic purine phosphonate nucleotide analogs |
US4880820A (en) * | 1983-06-24 | 1989-11-14 | Merck & Co., Inc. | Guanine derivatives |
GB8320308D0 (en) * | 1983-07-28 | 1983-09-01 | Wellcome Found | Antiviral combinations |
US4897479A (en) * | 1983-09-30 | 1990-01-30 | Merck & Co., Inc. | Arylsulfonyloxy purine intermediates |
EP0138683A3 (en) * | 1983-09-30 | 1988-01-20 | Merck & Co. Inc. | Purine derivatives, their application in anti-viral compositions |
IE842642L (en) * | 1983-10-31 | 1985-04-30 | Harvard College | Purine Derivatives |
US4806642A (en) * | 1984-10-05 | 1989-02-21 | Warner-Lambert Company | Purine derivatives |
IL73682A (en) * | 1983-12-20 | 1991-08-16 | Medivir Ab | Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation |
US4621140A (en) * | 1984-02-23 | 1986-11-04 | Syntex (U.S.A.) Inc. | Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives |
US4579849A (en) * | 1984-04-06 | 1986-04-01 | Merck & Co., Inc. | N-alkylguanine acyclonucleosides as antiviral agents |
EP0190123A1 (en) * | 1984-07-20 | 1986-08-13 | GAUNTT, Charles, O. | Immunoregulatory and anti-viral compound |
ES8705889A1 (es) * | 1984-12-12 | 1987-06-01 | Syntex Inc | Un metodo para preparar eteres alcaximetilicos y esteres alcoximetilicos de derivados de guananina. |
SE8406538D0 (sv) | 1984-12-21 | 1984-12-21 | Astra Laekemedel Ab | Novel derivatives of purine |
US4642346A (en) * | 1985-06-24 | 1987-02-10 | Syntex (U.S.A.) Inc. | Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine |
US4863927A (en) * | 1987-05-11 | 1989-09-05 | Merck & Co., Inc. | 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils |
US5043339A (en) * | 1988-12-19 | 1991-08-27 | Burroughs Wellcome Co. | Antiviral compounds |
US5068119A (en) * | 1990-09-28 | 1991-11-26 | Nabisco Brands, Inc. | Acid-hydrolyzable ester derivatives as low calorie fat mimetics |
GB2260319B (en) | 1991-10-07 | 1995-12-06 | Norsk Hydro As | Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity |
HUT73410A (en) * | 1993-06-23 | 1996-07-29 | Merrell Pharma Inc | Carbo-acyclic nucleoside derivatives as antiviral and antineoplastic agents |
US5543414A (en) * | 1994-07-28 | 1996-08-06 | Syntex (Usa) Inc. | Achiral amino acid acyl esters of ganciclovir and its derivatives |
US5840891A (en) * | 1994-07-28 | 1998-11-24 | Syntex (U.S.A.) Inc. | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative |
US5565565A (en) * | 1994-08-04 | 1996-10-15 | Syntex (U.S.A.) Inc. | Preparation of N-9 substituted guanine compounds |
US5627185A (en) * | 1994-11-23 | 1997-05-06 | Gosselin; Gilles | Acyclovir derivatives as antiviral agents |
US5840763A (en) * | 1994-12-12 | 1998-11-24 | Smithkline Beecham Plc | Treatment of a latent infection of herpes viruses |
DE19536164A1 (de) * | 1995-09-28 | 1997-04-03 | Boehringer Ingelheim Kg | Verbessertes Verfahren zur Herstellung von 9-[(2-Hyroxyethoxy)methyl]guanin (Acyclovir) |
US5756736A (en) * | 1996-01-26 | 1998-05-26 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
US5700936A (en) * | 1996-01-26 | 1997-12-23 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate |
US5840890A (en) * | 1996-01-26 | 1998-11-24 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative |
US6040446A (en) * | 1996-01-26 | 2000-03-21 | Syntex (U.S.A.) Inc. | Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative |
IN179493B (ro) * | 1996-02-22 | 1997-10-11 | Lupin Laboraties Ltd | |
EP0806425B1 (en) * | 1996-04-09 | 2001-08-29 | Lupin Laboratories Limited | An improved regiospecific process for synthesis of acyclic nucleosides |
US5852208A (en) * | 1996-08-30 | 1998-12-22 | Dixie Chemical Company, Inc. | Method of producing compounds containing acyloxyalkoxy groups from alcohols |
CN1091445C (zh) * | 1999-12-29 | 2002-09-25 | 湖北省医药工业研究院 | 抗病毒药物中间体、它们的制备及应用 |
IL163666A0 (en) | 2002-02-22 | 2005-12-18 | New River Pharmaceuticals Inc | Active agent delivery systems and methods for protecting and administering active agents |
EP1556050A1 (en) * | 2002-10-22 | 2005-07-27 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of ganciclovir |
AU2003278420A1 (en) * | 2002-10-31 | 2004-05-25 | Ranbaxy Laboratories Limited | Process for the preparation of ganciclovir |
WO2004048380A1 (en) * | 2002-11-22 | 2004-06-10 | Ranbaxy Laboratories Limited | Process for the synthesis of ganciclovir |
KR20090053867A (ko) | 2003-01-14 | 2009-05-27 | 길리애드 사이언시즈, 인코포레이티드 | 복합 항바이러스 치료를 위한 조성물 및 방법 |
ITMI20031202A1 (it) * | 2003-06-13 | 2004-12-14 | Lyogen Ltd | Forma di cristallina del ganciclovir |
WO2005021549A1 (en) * | 2003-08-28 | 2005-03-10 | Ranbaxy Laboratories Limited | Amorphous valganciclovir hydrochloride |
JP4746866B2 (ja) * | 2004-11-19 | 2011-08-10 | Tcm株式会社 | キャリッジ用ガタ抑制装置 |
TWI375560B (en) | 2005-06-13 | 2012-11-01 | Gilead Sciences Inc | Composition comprising dry granulated emtricitabine and tenofovir df and method for making the same |
TWI471145B (zh) | 2005-06-13 | 2015-02-01 | Bristol Myers Squibb & Gilead Sciences Llc | 單一式藥學劑量型 |
EP2085397A1 (en) | 2008-01-21 | 2009-08-05 | Esteve Quimica, S.A. | Crystalline form of abacavir |
WO2009120358A1 (en) * | 2008-03-27 | 2009-10-01 | Nektar Therapeutics | Oligomer-nitrogenous base conjugates |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
TW201031675A (en) | 2008-12-23 | 2010-09-01 | Pharmasset Inc | Synthesis of purine nucleosides |
EP2376088B1 (en) * | 2008-12-23 | 2017-02-22 | Gilead Pharmasset LLC | 6-O-Substituted-2-amino-purine nucleoside phosphoramidates |
EP2376514A2 (en) * | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Nucleoside analogs |
CN101851239B (zh) * | 2009-04-03 | 2012-11-28 | 上海益威实业有限公司 | 一种更昔洛韦的回收方法 |
UY33311A (es) | 2010-03-31 | 2011-10-31 | Pharmasset Inc | Fosforamidatos de nucleosidos |
US9550803B2 (en) * | 2011-05-06 | 2017-01-24 | University Of Southern California | Method to improve antiviral activity of nucleotide analogue drugs |
CN102627643B (zh) * | 2012-04-10 | 2014-01-08 | 常州康丽制药有限公司 | 更昔洛韦的精制方法 |
US9227990B2 (en) | 2012-10-29 | 2016-01-05 | Cipla Limited | Antiviral phosphonate analogues and process for preparation thereof |
US9505775B2 (en) * | 2012-11-03 | 2016-11-29 | Boehringer Ingelheim International Gmbh | Inhibitors of cytomegalovirus |
CN103059023B (zh) * | 2012-12-31 | 2015-09-30 | 浙江车头制药股份有限公司 | 一种制备更昔洛韦晶型ⅱ的方法 |
US9486530B1 (en) | 2013-08-30 | 2016-11-08 | Exela Pharma Sciences, LLC | Ganciclovir compositions and related methods |
WO2021209563A1 (en) | 2020-04-16 | 2021-10-21 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus |
CN113476413B (zh) * | 2021-08-09 | 2022-06-28 | 海南海灵化学制药有限公司 | 一种注射用更昔洛韦钠冻干粉的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1523865A (en) * | 1974-09-02 | 1978-09-06 | Wellcome Found | Purine compunds and salts thereof |
US4199574A (en) * | 1974-09-02 | 1980-04-22 | Burroughs Wellcome Co. | Methods and compositions for treating viral infections and guanine acyclic nucleosides |
US4060616A (en) * | 1976-03-01 | 1977-11-29 | Burroughs Wellcome Co. | Purine derivatives with repeating unit |
US4221910A (en) * | 1978-09-15 | 1980-09-09 | Newport Pharmaceuticals International, Inc. | 9-(Hydroxy alkyl)purines |
US4347360A (en) * | 1980-09-16 | 1982-08-31 | Ens Bio Logicals Inc. | Ring open nucleoside analogues |
AU7938482A (en) * | 1980-12-22 | 1982-07-20 | Astra Lakemedel Aktiebolag | Novel derivatives of guanine |
MC1475A1 (fr) * | 1981-08-11 | 1983-06-17 | Wellcome Found | Procede de preparation de derives de la purine a action anti-virale |
-
1981
- 1981-05-21 US US06267210 patent/US4355032B2/en not_active Expired - Lifetime
-
1982
- 1982-05-19 NO NO821676A patent/NO161740C/no not_active IP Right Cessation
- 1982-05-19 EP EP82104433A patent/EP0066208B1/en not_active Expired
- 1982-05-19 DE DE8282104433T patent/DE3266644D1/de not_active Expired
- 1982-05-19 DK DK227782A patent/DK150304C/da not_active IP Right Cessation
- 1982-05-19 AT AT82104433T patent/ATE15899T1/de active
- 1982-05-20 CS CS834403A patent/CS235043B2/cs unknown
- 1982-05-20 BR BR8202931A patent/BR8202931A/pt unknown
- 1982-05-20 CA CA000604470A patent/CA1305141C/en not_active Expired - Lifetime
- 1982-05-20 GR GR68199A patent/GR76459B/el unknown
- 1982-05-20 ES ES512414A patent/ES512414A0/es active Granted
- 1982-05-20 AU AU83892/82A patent/AU572086B2/en not_active Expired
- 1982-05-20 JP JP57085655A patent/JPS57203086A/ja active Granted
- 1982-05-20 RO RO82112367A patent/RO87387A/ro unknown
- 1982-05-20 CS CS823735A patent/CS235018B2/cs unknown
- 1982-05-20 RO RO107610A patent/RO84860B/ro unknown
- 1982-05-20 PL PL1982242101A patent/PL136004B1/pl unknown
- 1982-05-20 PL PL1982242100A patent/PL136637B1/pl unknown
- 1982-05-20 PT PT74934A patent/PT74934B/pt unknown
- 1982-05-20 SU SU823443852A patent/SU1176841A3/ru active
- 1982-05-20 HU HU821614A patent/HU186514B/hu unknown
- 1982-05-20 FI FI821794A patent/FI73682C/fi not_active IP Right Cessation
- 1982-05-20 CA CA000403368A patent/CA1305139C/en not_active Expired - Lifetime
- 1982-05-20 NZ NZ200691A patent/NZ200691A/en unknown
- 1982-05-20 PL PL1982246770A patent/PL136579B1/pl unknown
- 1982-05-20 IN IN564/CAL/82A patent/IN156469B/en unknown
- 1982-05-20 AR AR82289466A patent/AR244227A1/es active
- 1982-05-20 IL IL65836A patent/IL65836A/xx not_active IP Right Cessation
- 1982-05-20 PL PL1982236521A patent/PL136332B1/pl unknown
- 1982-05-20 CA CA000495721A patent/CA1305140C/en not_active Expired - Lifetime
- 1982-05-20 IE IE1210/82A patent/IE53731B1/en active Protection Beyond IP Right Term
- 1982-05-20 KR KR8202204A patent/KR890004663B1/ko active
- 1982-05-20 PH PH27320A patent/PH17975A/en unknown
- 1982-05-20 HU HU844011A patent/HU188000B/hu unknown
- 1982-05-20 CS CS834402A patent/CS235042B2/cs unknown
- 1982-05-20 CS CS834404A patent/CS235044B2/cs unknown
- 1982-05-21 DD DD82240075A patent/DD203052A5/de not_active IP Right Cessation
- 1982-05-21 ZA ZA823532A patent/ZA823532B/xx unknown
- 1982-05-21 DD DD82256251A patent/DD213218A5/de not_active IP Right Cessation
-
1983
- 1983-03-22 ES ES520849A patent/ES520849A0/es active Granted
- 1983-08-12 ES ES524900A patent/ES524900A0/es active Granted
- 1983-08-12 ES ES524899A patent/ES8507549A1/es not_active Expired
- 1983-11-03 DK DK504183A patent/DK149001C/da not_active IP Right Cessation
-
1984
- 1984-02-01 ES ES529384A patent/ES8701496A1/es not_active Expired
- 1984-02-01 ES ES529383A patent/ES8606869A1/es not_active Expired
- 1984-06-28 ES ES533821A patent/ES533821A0/es active Granted
-
1987
- 1987-10-09 SG SG816/87A patent/SG81687G/en unknown
- 1987-12-30 MY MY793/87A patent/MY8700793A/xx unknown
-
1988
- 1988-08-25 HK HK670/88A patent/HK67088A/xx not_active IP Right Cessation
-
1991
- 1991-04-16 JP JP3084045A patent/JPH04217983A/ja active Granted
-
1993
- 1993-03-23 NL NL9300022C patent/NL930022I1/nl unknown
- 1993-06-24 LU LU88334C patent/LU88334I2/fr unknown
- 1993-07-01 NL NL930139C patent/NL930139I2/nl unknown
-
1994
- 1994-07-29 NO NO1994005C patent/NO1994005I1/no unknown
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