DK227782A - Antiviralt guaninderivat - Google Patents

Antiviralt guaninderivat Download PDF

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Publication number
DK227782A
DK227782A DK227782A DK227782A DK227782A DK 227782 A DK227782 A DK 227782A DK 227782 A DK227782 A DK 227782A DK 227782 A DK227782 A DK 227782A DK 227782 A DK227782 A DK 227782A
Authority
DK
Denmark
Prior art keywords
guanine derivative
antiviral
antiviral guanine
derivative
guanine
Prior art date
Application number
DK227782A
Other languages
English (en)
Other versions
DK150304C (da
DK150304B (da
Inventor
J P Verheyden
J C Martin
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23017790&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK227782(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of DK227782A publication Critical patent/DK227782A/da
Priority to DK504183A priority Critical patent/DK149001C/da
Publication of DK150304B publication Critical patent/DK150304B/da
Application granted granted Critical
Publication of DK150304C publication Critical patent/DK150304C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DK227782A 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf DK150304C (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26721081 1981-05-21
US06267210 US4355032B2 (en) 1981-05-21 1981-05-21 9-(1,3-dihydroxy-2-propoxymethyl)guanine as antiviral agent

Publications (3)

Publication Number Publication Date
DK227782A true DK227782A (da) 1982-11-22
DK150304B DK150304B (da) 1987-02-02
DK150304C DK150304C (da) 1988-01-04

Family

ID=23017790

Family Applications (2)

Application Number Title Priority Date Filing Date
DK227782A DK150304C (da) 1981-05-21 1982-05-19 Analogifremgangsmaade til fremstilling af 9-(1,3-dihydroxy-2-propoxymethyl)guanin eller farmaceutisk acceptable salte deraf
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK504183A DK149001C (da) 1981-05-21 1983-11-03 9-substituerede n2-acylguaniner eller syreadditionssalte eller uorganiske metalsalte deraf

Country Status (33)

Country Link
US (1) US4355032B2 (da)
EP (1) EP0066208B1 (da)
JP (2) JPS57203086A (da)
KR (1) KR890004663B1 (da)
AR (1) AR244227A1 (da)
AT (1) ATE15899T1 (da)
AU (1) AU572086B2 (da)
BR (1) BR8202931A (da)
CA (3) CA1305140C (da)
CS (4) CS235044B2 (da)
DD (2) DD213218A5 (da)
DE (1) DE3266644D1 (da)
DK (2) DK150304C (da)
ES (7) ES8404355A1 (da)
FI (1) FI73682C (da)
GR (1) GR76459B (da)
HK (1) HK67088A (da)
HU (2) HU188000B (da)
IE (1) IE53731B1 (da)
IL (1) IL65836A (da)
IN (1) IN156469B (da)
LU (1) LU88334I2 (da)
MY (1) MY8700793A (da)
NL (2) NL930022I1 (da)
NO (2) NO161740C (da)
NZ (1) NZ200691A (da)
PH (1) PH17975A (da)
PL (4) PL136332B1 (da)
PT (1) PT74934B (da)
RO (2) RO84860B (da)
SG (1) SG81687G (da)
SU (1) SU1176841A3 (da)
ZA (1) ZA823532B (da)

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US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
US4507305A (en) * 1981-05-21 1985-03-26 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
US4423050A (en) * 1981-05-21 1983-12-27 Syntex (U.S.A.) Inc. 9-(1,3-Dihydroxy-2-propoxymethyl)guanine as antiviral agent
MC1475A1 (fr) * 1981-08-11 1983-06-17 Wellcome Found Procede de preparation de derives de la purine a action anti-virale
NZ201662A (en) * 1981-08-26 1986-07-11 Merck & Co Inc 9-(1,3-(and 2,3)-dihydroxy-1-(and 2)-propoxy-methyl)guanine derivatives and methods for their preparation
JPS58135885A (ja) * 1982-02-01 1983-08-12 シンテツクス（ユ−・エス・エイ）インコ−ポレイテツド 置換されたプリン、その製造方法およびそれからなる抗ウイルス剤
US5250535A (en) * 1982-02-01 1993-10-05 Syntex Inc. Substituted 9-(1 or 3-monoacyloxy or 1,3-diacyloxy-2-propoxymethyl) purines as antiviral agent
US4902678A (en) * 1982-02-12 1990-02-20 Syntex (U.S.A.) Inc. Anti-viral compositions
US4609662A (en) * 1982-10-14 1986-09-02 Burroughs Wellcome Co. Method for using purine derivatives
US4462986A (en) * 1982-11-04 1984-07-31 Ens Bio Logicals, Inc. Synergistic anti-herpes compositions
US4814335A (en) * 1982-12-30 1989-03-21 Biomeasure, Incorporated Antiviral compounds
US4461757A (en) * 1983-02-23 1984-07-24 Ens Bio Logicals Inc. Dimethylaminomethylenated anti-herpes compounds
US5047533A (en) * 1983-05-24 1991-09-10 Sri International Acyclic purine phosphonate nucleotide analogs
US4880820A (en) * 1983-06-24 1989-11-14 Merck & Co., Inc. Guanine derivatives
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IE842642L (en) * 1983-10-31 1985-04-30 Harvard College Purine Derivatives
US4806642A (en) * 1984-10-05 1989-02-21 Warner-Lambert Company Purine derivatives
IL73682A (en) * 1983-12-20 1991-08-16 Medivir Ab Antiviral pharmaceutical compositions containing 9-hydroxy aliphatic derivatives of guanine,some new such derivatives and process for their preparation
US4621140A (en) * 1984-02-23 1986-11-04 Syntex (U.S.A.) Inc. Process for preparing 2,6-substituted-9-(1,3-dihydroxy-2-propoxymethyl)-purines and certain derivatives
US4579849A (en) * 1984-04-06 1986-04-01 Merck & Co., Inc. N-alkylguanine acyclonucleosides as antiviral agents
EP0190123A1 (en) * 1984-07-20 1986-08-13 GAUNTT, Charles, O. Immunoregulatory and anti-viral compound
NZ214520A (en) * 1984-12-12 1989-08-29 Syntex Inc Alkoxymethyl ether and ester derivatives in the production of guanine derivatives
SE8406538D0 (sv) 1984-12-21 1984-12-21 Astra Laekemedel Ab Novel derivatives of purine
US4642346A (en) * 1985-06-24 1987-02-10 Syntex (U.S.A.) Inc. Anhydrous crystalline 9-(1,3-dihydroxy-2-propoxymethyl)guanine
US4863927A (en) * 1987-05-11 1989-09-05 Merck & Co., Inc. 1-(2-hydroxymethyl)cycloalkylmethyl)-5-substituted uracils
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US5068119A (en) * 1990-09-28 1991-11-26 Nabisco Brands, Inc. Acid-hydrolyzable ester derivatives as low calorie fat mimetics
GB2260319B (en) 1991-10-07 1995-12-06 Norsk Hydro As Acyl derivatives of nucleosides and nucleoside analogues having anti-viral activity
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US5543414A (en) * 1994-07-28 1996-08-06 Syntex (Usa) Inc. Achiral amino acid acyl esters of ganciclovir and its derivatives
US5840891A (en) * 1994-07-28 1998-11-24 Syntex (U.S.A.) Inc. 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative
US5565565A (en) 1994-08-04 1996-10-15 Syntex (U.S.A.) Inc. Preparation of N-9 substituted guanine compounds
US5627185A (en) * 1994-11-23 1997-05-06 Gosselin; Gilles Acyclovir derivatives as antiviral agents
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US5700936A (en) * 1996-01-26 1997-12-23 Syntex (U.S.A.) Inc. Process for preparing a 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol valinate
IN179493B (da) * 1996-02-22 1997-10-11 Lupin Laboraties Ltd
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US5852208A (en) * 1996-08-30 1998-12-22 Dixie Chemical Company, Inc. Method of producing compounds containing acyloxyalkoxy groups from alcohols
CN1091445C (zh) * 1999-12-29 2002-09-25 湖北省医药工业研究院 抗病毒药物中间体、它们的制备及应用
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CN101851239B (zh) * 2009-04-03 2012-11-28 上海益威实业有限公司 一种更昔洛韦的回收方法
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Family Cites Families (7)

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GB1523865A (en) * 1974-09-02 1978-09-06 Wellcome Found Purine compunds and salts thereof
US4199574A (en) * 1974-09-02 1980-04-22 Burroughs Wellcome Co. Methods and compositions for treating viral infections and guanine acyclic nucleosides
US4060616A (en) * 1976-03-01 1977-11-29 Burroughs Wellcome Co. Purine derivatives with repeating unit
US4221910A (en) * 1978-09-15 1980-09-09 Newport Pharmaceuticals International, Inc. 9-(Hydroxy alkyl)purines
US4347360A (en) * 1980-09-16 1982-08-31 Ens Bio Logicals Inc. Ring open nucleoside analogues
AU7938482A (en) * 1980-12-22 1982-07-20 Astra Lakemedel Aktiebolag Novel derivatives of guanine
MC1475A1 (fr) * 1981-08-11 1983-06-17 Wellcome Found Procede de preparation de derives de la purine a action anti-virale

Also Published As

Publication number Publication date
ES8507549A1 (es) 1985-09-16
US4355032B1 (da) 1983-06-14
PH17975A (en) 1985-02-22
KR830010112A (ko) 1983-12-26
HK67088A (en) 1988-09-02
RO87387B (ro) 1985-08-31
NZ200691A (en) 1986-11-12
US4355032B2 (en) 1990-10-30
DK149001C (da) 1988-11-28
SG81687G (en) 1989-07-07
CS235018B2 (en) 1985-04-16
GR76459B (da) 1984-08-10
CS235043B2 (en) 1985-04-16
CA1305139C (en) 1992-07-14
ES529384A0 (es) 1987-01-01
IL65836A (en) 1991-04-15
EP0066208A1 (en) 1982-12-08
PL136004B1 (en) 1986-01-31
JPH04217983A (ja) 1992-08-07
PL242101A1 (en) 1984-07-16
CA1305140C (en) 1992-07-14
NO161740C (no) 1989-09-20
NL930139I2 (nl) 1997-07-01
HU188000B (en) 1986-03-28
IE821210L (en) 1982-11-21
AU8389282A (en) 1982-11-25
PL246770A1 (en) 1984-08-27
RO84860A (ro) 1984-09-29
NL930022I1 (nl) 1993-05-03
ES512414A0 (es) 1984-05-01
ES529383A0 (es) 1986-05-16
JPS57203086A (en) 1982-12-13
FI73682B (fi) 1987-07-31
JPH0529399B2 (da) 1993-04-30
PT74934A (en) 1982-06-01
ES8505681A1 (es) 1985-06-16
PL242100A1 (en) 1984-04-24
ES8601204A1 (es) 1985-11-16
IN156469B (da) 1985-08-10
FI821794A0 (fi) 1982-05-20
LU88334I2 (fr) 1994-09-09
DK504183D0 (da) 1983-11-03
DK504183A (da) 1983-11-03
ES520849A0 (es) 1984-11-01
ATE15899T1 (de) 1985-10-15
BR8202931A (pt) 1983-05-03
CS235042B2 (en) 1985-04-16
DK150304C (da) 1988-01-04
NO1994005I1 (no) 1994-07-29
ES8500276A1 (es) 1984-11-01
ES533821A0 (es) 1985-06-16
PL136637B1 (en) 1986-03-31
ES8701496A1 (es) 1987-01-01
NO161740B (no) 1989-06-12
NL930139I1 (nl) 1993-11-01
DD213218A5 (de) 1984-09-05
ES524899A0 (es) 1985-09-16
US4355032A (en) 1982-10-19
PL236521A1 (en) 1984-01-02
DK150304B (da) 1987-02-02
EP0066208B1 (en) 1985-10-02
CA1305141C (en) 1992-07-14
DK149001B (da) 1985-12-16
ES8404355A1 (es) 1984-05-01
PL136579B1 (en) 1986-02-28
IL65836A0 (en) 1982-08-31
ES8606869A1 (es) 1986-05-16
RO87387A (ro) 1985-08-31
AU572086B2 (en) 1988-05-05
HU186514B (en) 1985-08-28
DD203052A5 (de) 1983-10-12
PL136332B1 (en) 1986-02-28
DE3266644D1 (en) 1985-11-07
ES524900A0 (es) 1985-11-16
RO84860B (ro) 1984-10-30
PT74934B (en) 1984-05-08
IE53731B1 (en) 1989-02-01
AR244227A1 (es) 1993-10-29
FI73682C (fi) 1987-11-09
MY8700793A (en) 1987-12-31
CS235044B2 (en) 1985-04-16
SU1176841A3 (ru) 1985-08-30
KR890004663B1 (ko) 1989-11-24
ZA823532B (en) 1983-03-30
NO821676L (no) 1982-11-22
JPH046195B2 (da) 1992-02-05

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Legal Events

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CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1993 00004, 930104

CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1993 00004, 930104

PUP Patent expired